{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:37:35Z","timestamp":1760384255063},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1991,8,1]],"date-time":"1991-08-01T00:00:00Z","timestamp":681004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuron"],"published-print":{"date-parts":[[1991,8]]},"DOI":"10.1016\/0896-6273(91)90262-x","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T12:29:33Z","timestamp":1083673773000},"page":"239-247","source":"Crossref","is-referenced-by-count":82,"title":["Retinoic acid can mimic endogenous signals involved in transformation of the xenopus nervous system"],"prefix":"10.1016","volume":"7","author":[{"given":"Colin R.","family":"Sharpe","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/0896-6273(91)90262-X_BIB1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/333669a0","article-title":"A new retinoic acid receptor identified from a hepatocellular carcinoma","volume":"333","author":"Benbrook","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB2","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/332850a0","article-title":"Identification of a second human retinoic acid receptor","volume":"332","author":"Brand","year":"1989","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1242\/dev.106.3.611","article-title":"Expression of an engrailed-related protein is induced in the anterior neural ectoderm of early Xenopus embryos","volume":"106","author":"Brivanlou","year":"1989","journal-title":"Development"},{"key":"10.1016\/0896-6273(91)90262-X_BIB4","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/0896-6273(89)90066-4","article-title":"Retinoids, homeobox genes, and limb morphogenesis","volume":"2","author":"Brockes","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/0896-6273(91)90262-X_BIB5","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1101\/gad.4.11.1910","article-title":"Differential activation of Xenopus homeobox genes by mesoderm-inducing growth factors and retinoic acid","volume":"4","author":"Cho","year":"1990","journal-title":"Genes Dev."},{"key":"10.1016\/0896-6273(91)90262-X_BIB6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1242\/dev.106.4.749","article-title":"Cellular contacts required for neural induction in Xenopus embryos: evidence for two signals","volume":"106","author":"Dixon","year":"1989","journal-title":"Development"},{"key":"10.1016\/0896-6273(91)90262-X_BIB7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/340140a0","article-title":"Retinoic acid causes an anteroposterior transformation in the developing central nervous system","volume":"340","author":"Durston","year":"1989","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/330624a0","article-title":"Identification of a receptor for the morphogen retinoic acid","volume":"330","author":"Giguerre","year":"1987","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/306471a0","article-title":"Cell lineage and the induction of second nervous systems in amphibian development","volume":"306","author":"Gimlich","year":"1983","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0091-679X(08)60096-5","article-title":"Methods for nuclear transplantation in Amphibia","volume":"16","author":"Gurdon","year":"1977","journal-title":"Meth. Cell Biol."},{"key":"10.1016\/0896-6273(91)90262-X_BIB11","series-title":"The Heritage of Experimental Embryology: Hans Spemann and the Organizer","author":"Hamburger","year":"1988"},{"key":"10.1016\/0896-6273(91)90262-X_BIB12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0012-1606(86)90153-3","article-title":"Induction of neural cell adhesion molecule (NCAM) in Xenopus laevis","volume":"116","author":"Jacobson","year":"1986","journal-title":"Dev. Biol."},{"key":"10.1016\/0896-6273(91)90262-X_BIB13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0012-1606(76)90127-5","article-title":"Vital dye mapping of the gastrula and neurula of Xenopus laevis. II. Prospective areas and morphogenetic movements in the deep region","volume":"51","author":"Keller","year":"1976","journal-title":"Dev. Biol."},{"key":"10.1016\/0896-6273(91)90262-X_BIB14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1242\/dev.99.3.311","article-title":"Expression of Xenopus N-CAM RNA in ectoderm as an early response to neural induction","volume":"99","author":"Kintner","year":"1987","journal-title":"Development"},{"key":"10.1016\/0896-6273(91)90262-X_BIB15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0076-6879(87)55027-3","article-title":"In vitro RNA synthesis with SP6 RNA polymerase","volume":"155","author":"Krieg","year":"1987","journal-title":"Meth. Enzymol."},{"key":"10.1016\/0896-6273(91)90262-X_BIB16","first-page":"5310","article-title":"A third human retinoic acid receptor, H RAR\u03b3","volume":"86","author":"Krust","year":"1989"},{"key":"10.1016\/0896-6273(91)90262-X_BIB17","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/295672a0","article-title":"Vitamin A and pattern formation in the regenerating limb","volume":"295","author":"Maden","year":"1982","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB18","first-page":"109","article-title":"The role of retinoid binding proteins in the generation of pattern in the developing limb, the regenerating limb and the nervous system","volume":"107","author":"Maden","year":"1989","journal-title":"Development (Suppl.)"},{"key":"10.1016\/0896-6273(91)90262-X_BIB19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/345224a0","article-title":"Nuclear receptor that identifies a novel retinoic acid response pathway","volume":"345","author":"Mangelsdorf","year":"1990","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB20","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/311716a0","article-title":"Cell type specific activation of actin genes in the early amphibian embryo","volume":"311","author":"Mohun","year":"1984","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB21","first-page":"3","article-title":"Abnormal hind limb regeneration in tadpoles of the toad, Bufo andersoni, exposed to excess vitamin A","volume":"26","author":"Niazi","year":"1978","journal-title":"Folia Biol. (Krakow)."},{"key":"10.1016\/0896-6273(91)90262-X_BIB22","first-page":"262","article-title":"Independent and dependent development in the formation of the central nervous system in amphibians","volume":"3","author":"Nieuwkoop","year":"1955","journal-title":"Exp. Cell Res. (Suppl.)"},{"key":"10.1016\/0896-6273(91)90262-X_BIB23","first-page":"13","article-title":"Neural competence of the gastrula ectoderm in Ambystoma mexicanum. An attempt at quantitative analysis of morphogenesis","volume":"2","author":"Nieuwkoop","year":"1958","journal-title":"Acta Embryol. Morphol."},{"key":"10.1016\/0896-6273(91)90262-X_BIB24","series-title":"Normal Table of Xenopus laevis (Daudin)","author":"Nieuwkoop","year":"1967"},{"key":"10.1016\/0896-6273(91)90262-X_BIB25","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/330444a0","article-title":"A human retinoic acid receptor which belongs to the family of nuclear receptors","volume":"330","author":"Petkovich","year":"1987","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/341654a0","article-title":"Identification of a novel retinoic acid receptor in regenerative tissue of the newt","volume":"341","author":"Ragsdale","year":"1989","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB27","first-page":"8086","article-title":"Gene expression in the embryonic nervous system of Xenopus laevis","volume":"85","author":"Richter","year":"1988"},{"key":"10.1016\/0896-6273(91)90262-X_BIB28","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1242\/dev.108.4.595","article-title":"Neural expression of the Xenopus homeobox gene, Xhox3: evidence for a patterning signal that spreads through the ectoderm","volume":"108","author":"Ruiz i Altaba","year":"1990","journal-title":"Development"},{"key":"10.1016\/0896-6273(91)90262-X_BIB29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0012-1606(89)90307-2","article-title":"Signals from the dorsal blastopore lip region during gastrulation bias the ectoderm toward a non-epidermal pathway of differentiation in Xenopus laevis","volume":"133","author":"Savage","year":"1989","journal-title":"Dev. Biol"},{"key":"10.1016\/0896-6273(91)90262-X_BIB30","first-page":"21","article-title":"Neural induction","volume":"33","author":"Saxen","year":"1989","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/0896-6273(91)90262-X_BIB31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1242\/dev.103.2.269","article-title":"Developmental expression of a neurofilament-M and two vimentin-like genes in Xenopus laevis","volume":"103","author":"Sharpe","year":"1988","journal-title":"Development"},{"key":"10.1016\/0896-6273(91)90262-X_BIB32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/bies.950121206","article-title":"Regional neural induction in Xenopus laevis","volume":"12","author":"Sharpe","year":"1990","journal-title":"Bioessays"},{"key":"10.1016\/0896-6273(91)90262-X_BIB33","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1242\/dev.109.4.765","article-title":"The induction of anterior and posterior neural genes in Xenopus laevis","volume":"109","author":"Sharpe","year":"1990","journal-title":"Development"},{"key":"10.1016\/0896-6273(91)90262-X_BIB34","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0092-8674(87)90333-3","article-title":"A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction","volume":"50","author":"Sharpe","year":"1987","journal-title":"Cell"},{"key":"10.1016\/0896-6273(91)90262-X_BIB35","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1242\/dev.107.4.701","article-title":"XIF3, a Xenopus peripherin gene requires an inductive signal for enhanced expression in anterior neural tissue","volume":"107","author":"Sharpe","year":"1989","journal-title":"Development"},{"key":"10.1016\/0896-6273(91)90262-X_BIB36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0092-8674(89)90413-3","article-title":"Progressive determination during the formation of the anteroposterior axis in Xenopus laevis","volume":"58","author":"Sive","year":"1989","journal-title":"Cell"},{"key":"10.1016\/0896-6273(91)90262-X_BIB37","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1101\/gad.4.6.932","article-title":"Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis","volume":"4","author":"Sive","year":"1990","journal-title":"Genes Dev."},{"key":"10.1016\/0896-6273(91)90262-X_BIB38","first-page":"121","article-title":"Molecular approaches to vertebrate limb morphogenesis","volume":"107","author":"Smith","year":"1989","journal-title":"Development (Suppl.)"},{"key":"10.1016\/0896-6273(91)90262-X_BIB39","first-page":"269","article-title":"The effect of focal application of retinoic acid to the anterior margin of the developing chick limb","volume":"78","author":"Summerbell","year":"1983","journal-title":"J. Embryol. Exp. Morphol."},{"key":"10.1016\/0896-6273(91)90262-X_BIB40","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/327625a0","article-title":"Identification and spatial distribution of retinoids in the developing chick limb bud","volume":"327","author":"Thaller","year":"1987","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB41","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/296564a0","article-title":"Local application of retinoic acid to the limb bud mimics the action of the polarizing region","volume":"296","author":"Tickle","year":"1982","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB42","first-page":"346","article-title":"The simultaneous inducing action of liver and bone-marrow of the guinea pig in implantation and explantation experiments with embryos of Triturus","volume":"3","author":"Toivonen","year":"1955","journal-title":"Exp. Cell Res. (Suppl.)"},{"key":"10.1016\/0896-6273(91)90262-X_BIB43","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/345819a0","article-title":"Polarising activity and retinoid synthesis in the floor plate of the neural tube","volume":"345","author":"Wagner","year":"1990","journal-title":"Nature"},{"key":"10.1016\/0896-6273(91)90262-X_BIB44","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1242\/dev.109.1.225","article-title":"The XIHbox6 homeo protein, a marker of posterior neural induction in Xenopus, is expressed in proliferating neuroblasts","volume":"109","author":"Wright","year":"1990","journal-title":"Development"},{"key":"10.1016\/0896-6273(91)90262-X_BIB45","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0092-8674(91)90247-V","article-title":"Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord","volume":"64","author":"Yamada","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0896-6273(91)90262-X_BIB46","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/339714a0","article-title":"Cloning of murine \u03b1 and \u03b2 retinoic acid receptors and a novel receptor \u03b3 predominantly expressed in skin","volume":"339","author":"Zelent","year":"1989","journal-title":"Nature"}],"container-title":["Neuron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:089662739190262X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:089662739190262X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T08:46:48Z","timestamp":1623919608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/089662739190262X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,8]]}},"alternative-id":["089662739190262X"],"URL":"https:\/\/doi.org\/10.1016\/0896-6273(91)90262-x","relation":{},"ISSN":["0896-6273"],"issn-type":[{"value":"0896-6273","type":"print"}],"subject":[],"published":{"date-parts":[[1991,8]]}}}