{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:08:08Z","timestamp":1770703688268,"version":"3.49.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[1991,1]]},"DOI":"10.1016\/0898-6568(91)90027-r","type":"journal-article","created":{"date-parts":[[2003,2,11]],"date-time":"2003-02-11T19:09:49Z","timestamp":1044990589000},"page":"501-513","source":"Crossref","is-referenced-by-count":131,"title":["Phosphoinositide 3-kinase: A new effector in signal transduction?"],"prefix":"10.1016","volume":"3","author":[{"given":"C.Peter","family":"Downes","sequence":"first","affiliation":[]},{"given":"A.Nigel","family":"Carter","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/0898-6568(91)90027-R_BIB1","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/S0021-9258(19)73933-7","volume":"237","author":"Brockerhoff","year":"1962","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB2","doi-asserted-by":"crossref","first-page":"11,147","DOI":"10.1021\/bi00503a001","volume":"29","author":"Carpenter","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/0898-6568(91)90027-R_BIB3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1990.tb19297.x","volume":"193","author":"Downes","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/351033a0","volume":"351","author":"Stephens","year":"1991","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB5","doi-asserted-by":"crossref","first-page":"21,676","DOI":"10.1016\/S0021-9258(18)45793-6","volume":"265","author":"Cunningham","year":"1990","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB6","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/0006-291X(91)91603-A","volume":"175","author":"Cunningham","year":"1991","journal-title":"Biochem. biophys. Res. Commun."},{"key":"10.1016\/0898-6568(91)90027-R_BIB7","first-page":"1411","volume":"87","author":"Ruderman","year":"1990"},{"key":"10.1016\/0898-6568(91)90027-R_BIB8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0021-9258(19)40243-3","volume":"165","author":"Endermann","year":"1990","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0092-8674(91)90639-G","volume":"64","author":"Cantley","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/334353a0","volume":"334","author":"Traynor-Kaplan","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB11","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.1016\/S0021-9258(19)39361-5","volume":"265","author":"Kucera","year":"1990","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB12","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/S0021-9258(19)39818-7","volume":"265","author":"Nolan","year":"1990","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB13","first-page":"2117","volume":"81","author":"Sugimoto","year":"1984"},{"key":"10.1016\/0898-6568(91)90027-R_BIB14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/bj2470165","volume":"247","author":"Whitman","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/0898-6568(91)90027-R_BIB15","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/332644a0","volume":"332","author":"Whitman","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB16","doi-asserted-by":"crossref","first-page":"8068","DOI":"10.1016\/S0021-9258(18)92941-8","volume":"266","author":"Choudhury","year":"1991","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB17","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1128\/MCB.10.6.2909","volume":"10","author":"Cohen","year":"1990","journal-title":"Molec. Cell. Biol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0092-8674(91)90409-R","volume":"65","author":"Escobedo","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0092-8674(91)90411-Q","volume":"65","author":"Otsu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0092-8674(91)90410-Z","volume":"65","author":"Solnik","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB21","doi-asserted-by":"crossref","first-page":"19,704","DOI":"10.1016\/S0021-9258(17)45429-9","volume":"265","author":"Carpenter","year":"1990","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB22","doi-asserted-by":"crossref","first-page":"8108","DOI":"10.1016\/S0021-9258(18)92948-0","volume":"266","author":"Shibasaki","year":"1991","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/312315a0","volume":"312","author":"Berridge","year":"1984","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/341197a0","volume":"341","author":"Berridge","year":"1989","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB25","series-title":"Molecular Mechanisms odf Transmembrane Signalling","first-page":"3","author":"Downes","year":"1985"},{"key":"10.1016\/0898-6568(91)90027-R_BIB26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0092-8674(89)90182-7","volume":"57","author":"Auger","year":"1989","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB27","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1128\/JVI.64.10.4718-4725.1990","volume":"64","author":"Serunian","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/bj2590267","volume":"259","author":"Stephens","year":"1989","journal-title":"Biochem. J."},{"key":"10.1016\/0898-6568(91)90027-R_BIB29","doi-asserted-by":"crossref","first-page":"15,668","DOI":"10.1016\/S0021-9258(19)84884-6","volume":"264","author":"Traynor-Kaplan","year":"1989","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB30","doi-asserted-by":"crossref","first-page":"20,181","DOI":"10.1016\/S0021-9258(19)47043-9","volume":"264","author":"Auger","year":"1989","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB31","doi-asserted-by":"crossref","first-page":"22,086","DOI":"10.1016\/S0021-9258(18)45672-4","volume":"265","author":"Yamamoto","year":"1990","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB32","doi-asserted-by":"crossref","first-page":"17,809","DOI":"10.1016\/S0021-9258(19)84645-8","volume":"264","author":"Serunian","year":"1989","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB33","doi-asserted-by":"crossref","first-page":"8759","DOI":"10.1016\/S0021-9258(18)81858-0","volume":"264","author":"Lips","year":"1989","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB34","doi-asserted-by":"crossref","first-page":"19,911","DOI":"10.1016\/S0021-9258(19)47197-4","volume":"264","author":"Lips","year":"1990","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB35","series-title":"Methods in Inositide Research","first-page":"159","author":"Auger","year":"1990"},{"key":"10.1016\/0898-6568(91)90027-R_BIB36","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1708916","volume":"252","author":"Koch","year":"1991","journal-title":"Science"},{"key":"10.1016\/0898-6568(91)90027-R_BIB37","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0092-8674(87)90168-1","volume":"50","author":"Kaplan","year":"1987","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0092-8674(90)90220-9","volume":"61","author":"Kaplan","year":"1990","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB39","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1126\/science.2157284","volume":"247","author":"Kazlauskas","year":"1990","journal-title":"Science"},{"key":"10.1016\/0898-6568(91)90027-R_BIB40","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0092-8674(90)90013-5","volume":"62","author":"Kypta","year":"1990","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB41","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1128\/MCB.10.5.2359","volume":"10","author":"Morrison","year":"1990","journal-title":"Molec. Cell. Biol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB42","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1002\/j.1460-2075.1990.tb07527.x","volume":"9","author":"Kazlauskas","year":"1990","journal-title":"Eur. molec. Biol. Org. J."},{"key":"10.1016\/0898-6568(91)90027-R_BIB43","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1128\/MCB.10.2.435","volume":"10","author":"Margolis","year":"1990","journal-title":"Molec. Cell. Biol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB44","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/0092-8674(89)90510-2","volume":"58","author":"Kazlauskas","year":"1989","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB45","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.2466336","volume":"243","author":"Coughlin","year":"1989","journal-title":"Science"},{"key":"10.1016\/0898-6568(91)90027-R_BIB46","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1128\/MCB.11.2.1125","volume":"11","author":"Escobedo","year":"1991","journal-title":"Molec. Cell. Biol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/318183a0","volume":"318","author":"White","year":"1985","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/352073a0","volume":"352","author":"Sun","year":"1991","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB49","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1128\/MCB.11.2.1107","volume":"11","author":"Vartikovski","year":"1991","journal-title":"Molec. Cell. Biol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB50","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1128\/MCB.11.4.1972","volume":"11","author":"Fukui","year":"1991","journal-title":"Molec. Cell. Biol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB51","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/332272a0","volume":"332","author":"Mayer","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB52","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/342699a0","volume":"342","author":"Varticovski","year":"1989","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB53","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1128\/MCB.10.11.5601","volume":"10","author":"Reedijk","year":"1990","journal-title":"Molec. Cell. Ciol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB54","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1002\/j.1460-2075.1990.tb07417.x","volume":"9","author":"Shurtleff","year":"1990","journal-title":"Eur. molec. Biol. Org. J."},{"key":"10.1016\/0898-6568(91)90027-R_BIB55","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/j.1460-2075.1991.tb07993.x","volume":"10","author":"Lev","year":"1991","journal-title":"Eur. molec. Biol. Org. J."},{"key":"10.1016\/0898-6568(91)90027-R_BIB56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0092-8674(90)90801-K","volume":"61","author":"Ullrich","year":"1990","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB57","doi-asserted-by":"crossref","first-page":"20,061","DOI":"10.1016\/S0021-9258(17)30465-9","volume":"265","author":"Thomas","year":"1990","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB58","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/0092-8674(91)90261-V","volume":"64","author":"Vu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB59","doi-asserted-by":"crossref","first-page":"21,470","DOI":"10.1016\/S0021-9258(20)88206-4","volume":"264","author":"Gierschik","year":"1989","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB60","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/bj2780475","volume":"278","author":"King","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/0898-6568(91)90027-R_BIB61","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0006-291X(90)92344-Y","volume":"168","author":"Yamamoto","year":"1990","journal-title":"Biochem. biophys. Res. Commun."},{"key":"10.1016\/0898-6568(91)90027-R_BIB62","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1128\/MCB.8.9.3603","volume":"8","author":"Ferrell","year":"1988","journal-title":"Molec. Cell. Biol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB63","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1016\/S0021-9258(18)83201-X","volume":"264","author":"Nakamura","year":"1989","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB64","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/0006-291X(91)91506-8","volume":"174","author":"Takayama","year":"1991","journal-title":"Biochem. biophys. Res. Commun."},{"key":"10.1016\/0898-6568(91)90027-R_BIB65","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1128\/MCB.10.7.3806","volume":"10","author":"Gutkind","year":"1990","journal-title":"Molec. Cell. Biol."},{"key":"10.1016\/0898-6568(91)90027-R_BIB66","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/314472a0","volume":"314","author":"Lassing","year":"1985","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB67","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/325362a0","volume":"325","author":"janmey","year":"1987","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB68","doi-asserted-by":"crossref","first-page":"16,725","DOI":"10.1016\/S0021-9258(17)44818-6","volume":"265","author":"Eberle","year":"1990","journal-title":"J. biol. Chem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB69","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/350678a0","volume":"350","author":"Hempstead","year":"1991","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB70","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0092-8674(91)90419-Y","volume":"65","author":"Klein","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0898-6568(91)90027-R_BIB71","first-page":"2424","volume":"73","author":"Green","year":"1976"},{"key":"10.1016\/0898-6568(91)90027-R_BIB72","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/268501a0","volume":"268","author":"Dichter","year":"1977","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB73","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1432-1033.1990.tb19384.x","volume":"193","author":"Gotoh","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/0898-6568(91)90027-R_BIB74","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-5793(90)80386-W","volume":"271","author":"Gomez","year":"1990","journal-title":"Fedn Eur. biochem. Socs Letts"},{"key":"10.1016\/0898-6568(91)90027-R_BIB75","first-page":"6940","volume":"86","author":"Anderson","year":"1989"},{"key":"10.1016\/0898-6568(91)90027-R_BIB76","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/353170a0","volume":"353","author":"Gomez","year":"1991","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB77","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/334715a0","volume":"334","author":"Sturgill","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0898-6568(91)90027-R_BIB78","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/bj2770231","volume":"277","author":"Burns","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/0898-6568(91)90027-R_BIB79","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/bj2770239","volume":"277","author":"Burns","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/0898-6568(91)90027-R_BIB80","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/bj2770245","volume":"277","author":"Symmons","year":"1991","journal-title":"Biochem. J."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:089865689190027R?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:089865689190027R?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T02:55:31Z","timestamp":1622775331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/089865689190027R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":80,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["089865689190027R"],"URL":"https:\/\/doi.org\/10.1016\/0898-6568(91)90027-r","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}