{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:40:05Z","timestamp":1773535205942,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1994,10,1]],"date-time":"1994-10-01T00:00:00Z","timestamp":780969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology: Molecular Pharmacology"],"published-print":{"date-parts":[[1994,10]]},"DOI":"10.1016\/0922-4106(94)90092-2","type":"journal-article","created":{"date-parts":[[2002,12,14]],"date-time":"2002-12-14T09:03:24Z","timestamp":1039856604000},"page":"243-248","source":"Crossref","is-referenced-by-count":46,"title":["Changes in brain microvessel endothelial cell monolayer permeability induced by adrenergic drugs"],"prefix":"10.1016","volume":"269","author":[{"given":"Nuno","family":"Borges","sequence":"first","affiliation":[]},{"given":"Fenglin","family":"Shi","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Kenneth L.","family":"Audus","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/0922-4106(94)90092-2_BIB1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1471-4159.1986.tb04527.x","article-title":"Characteristics of the large neutral amino acid transport system of bovine brain microvessel endothelial cell monolayers","volume":"47","author":"Audus","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/0922-4106(94)90092-2_BIB2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1016337202335","article-title":"Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism","volume":"32","author":"Audus","year":"1986","journal-title":"Pharm. Res."},{"key":"10.1016\/0922-4106(94)90092-2_BIB3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1749-6632.1987.tb45787.x","article-title":"Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrier","volume":"507","author":"Audus","year":"1987","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/0922-4106(94)90092-2_BIB4","first-page":"1","article-title":"Brain uptake of drugs: the influence of chemical and biological factors","volume":"23","author":"Audus","year":"1992","journal-title":"Adv, Drug Res."},{"key":"10.1016\/0922-4106(94)90092-2_BIB5","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/j.1471-4159.1986.tb08519.x","article-title":"Catecholamine-metabolizing enzymes of bovine brain microvessel endothelial cell monolayers","volume":"46","author":"Baranczyk-Kuzma","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/0922-4106(94)90092-2_BIB6","first-page":"13","article-title":"Adrenergic influences in brain edema formation and resolution","volume":"14","author":"Borges","year":"1994","journal-title":"J. Auton. Pharmacol."},{"key":"10.1016\/0922-4106(94)90092-2_BIB7","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/0006-8993(73)90131-5","article-title":"Are brain vessels innervated by central (non-sympathetic) adrenergic neurons?","volume":"63","author":"Edvinsson","year":"1973","journal-title":"Brain Res."},{"key":"10.1016\/0922-4106(94)90092-2_BIB8","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/00005344-199108000-00006","article-title":"Angiotensin peptide regulation of bovine brain microvessel endothelial cell permeability","volume":"18","author":"Guillot","year":"1991","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/0922-4106(94)90092-2_BIB9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0026-2862(90)90055-V","article-title":"Fluid-phase endocytosis by primary cultures of bovine brain microvessel endothelial cell monolayers","volume":"39","author":"Guillot","year":"1990","journal-title":"Microvasc. Res."},{"key":"10.1016\/0922-4106(94)90092-2_BIB10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-2999(80)90168-5","article-title":"Adrenergic receptors of cerebral microvessels","volume":"61","author":"Harik","year":"1980","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/0922-4106(94)90092-2_BIB11","series-title":"Frontiers in Catecholamine Research","first-page":"91","article-title":"The innervation of cerebral blood vessels by central noradrenergic neurons","author":"Hartman","year":"1973"},{"key":"10.1016\/0922-4106(94)90092-2_BIB12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0197-0186(93)90098-P","article-title":"The blood-brain barrier in vitro: the second decade","volume":"23","author":"Joo","year":"1993","journal-title":"Neurochem. Int."},{"key":"10.1016\/0922-4106(94)90092-2_BIB13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0006-8993(82)90324-9","article-title":"Ontogenesis of alpha and beta receptors located on cerebral microvessels","volume":"242","author":"Kobayashi","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/0922-4106(94)90092-2_BIB14","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0006-8993(81)90225-0","article-title":"Subtypes of \u03b2-adrenergic receptors in rat cerebral microvessels","volume":"220","author":"Kobayashi","year":"1981","journal-title":"Brain Res."},{"issue":"Suppl. 80","key":"10.1016\/0922-4106(94)90092-2_BIB15","first-page":"72","article-title":"Evidence for involvement of microtubules in the enhanced transendothelial pinocytosis in the blood-brain barrier induced by high intravascular pressure","volume":"60","author":"Larsson","year":"1979","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/0922-4106(94)90092-2_BIB16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01409014","article-title":"Application of cultured endothelial cells of the brain microvasculature in the study of the blood-brain barrier","volume":"14","author":"Miller","year":"1992","journal-title":"J. Tissue Cult. Methods"},{"key":"10.1016\/0922-4106(94)90092-2_BIB17","first-page":"313","article-title":"The effect of dibenzazepines (tricyclic antidepressants) on cerebral capillary permeability in the rat in vivo","volume":"213","author":"Preskhorn","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/0922-4106(94)90092-2_BIB18","first-page":"3726","article-title":"Central noradrenergic regulation of cerebral blood flow and vascular permeability","volume":"72","author":"Raichle","year":"1975"},{"key":"10.1016\/0922-4106(94)90092-2_BIB19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/aja.1001440208","article-title":"Capillary innervation in mammalian central nervous system: an electron microscopic demonstration","volume":"144","author":"Rennels","year":"1975","journal-title":"Am. J. Anat."},{"key":"10.1016\/0922-4106(94)90092-2_BIB20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0014-2999(90)90133-Q","article-title":"Amitriptyline induced morphological alterations of the rat blood-brain barrier","volume":"176","author":"Sarmento","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/0922-4106(94)90092-2_BIB21","first-page":"838","article-title":"Increase in blood-brain barrier permeability due to amitriptyline is accompanied by augmented pinocytosis in cerebral capillaries","volume":"96","author":"Sarmento","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/0922-4106(94)90092-2_BIB22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/BF00184295","article-title":"Adrenergic influences on the control of blood-brain barrier permeability","volume":"343","author":"Sarmento","year":"1991","journal-title":"Naunyn-Schmied. Arch. Pharmacol."},{"key":"10.1016\/0922-4106(94)90092-2_BIB23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF01808769","article-title":"Influence of electrical stimulation of locus coeruleus on the rat blood-brain barrier permeability to sodium fluorescein","volume":"127","author":"Sarmento","year":"1994","journal-title":"Acta Neurochir."},{"key":"10.1016\/0922-4106(94)90092-2_BIB24","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1023\/A:1018903330985","article-title":"Biotin uptake and transport across bovine brain microvessel endothelial cell monolayers","volume":"10","author":"Shi","year":"1993","journal-title":"Pharm. Res."}],"container-title":["European Journal of Pharmacology: Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0922410694900922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0922410694900922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T14:22:45Z","timestamp":1554128565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0922410694900922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["0922410694900922"],"URL":"https:\/\/doi.org\/10.1016\/0922-4106(94)90092-2","relation":{},"ISSN":["0922-4106"],"issn-type":[{"value":"0922-4106","type":"print"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}