{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:17:47Z","timestamp":1777439867317,"version":"3.51.4"},"reference-count":73,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Cell Biology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.ceb.2012.05.010","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T20:16:05Z","timestamp":1343679365000},"page":"460-466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"title":["Finding the will and the way of ERAD substrate retrotranslocation"],"prefix":"10.1016","volume":"24","author":[{"given":"Randolph Y","family":"Hampton","sequence":"first","affiliation":[]},{"given":"Thomas","family":"Sommer","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.ceb.2012.05.010_bib0005","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1126\/science.1209235","article-title":"Road to ruin: targeting proteins for degradation in the endoplasmic reticulum","volume":"334","author":"Smith","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ceb.2012.05.010_bib0010","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/bies.201000046","article-title":"ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum","volume":"32","author":"Mehnert","year":"2010","journal-title":"Bioessays"},{"key":"10.1016\/j.ceb.2012.05.010_bib0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/35050524","article-title":"Hrd1p\/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation","volume":"3","author":"Bays","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0020","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1101\/gad.933301","article-title":"A conserved ubiquitin ligase of the nuclear envelope\/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation","volume":"15","author":"Swanson","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.ceb.2012.05.010_bib0025","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1073\/pnas.0506618103","article-title":"The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site","volume":"103","author":"Chen","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ceb.2012.05.010_bib0030_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1091\/mbc.e10-09-0760","article-title":"The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508","volume":"22","author":"Grove","year":"2011","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0035_1","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1126\/science.273.5282.1725","article-title":"ER degradation of a misfolded luminal protein by the cytosolic ubiquitin\u2013proteasome pathway","volume":"273","author":"Hiller","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ceb.2012.05.010_bib0040","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0014-5793(98)01724-4","article-title":"Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species","volume":"443","author":"Plemper","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ceb.2012.05.010_bib0045","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1074\/jbc.274.6.3453","article-title":"The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct","volume":"274","author":"Brodsky","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0050","doi-asserted-by":"crossref","first-page":"9871","DOI":"10.1074\/jbc.274.14.9871","article-title":"Identification and characterization of a protein destruction signal in the encephalomyocarditis virus 3C protease","volume":"274","author":"Lawson","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0055","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/genetics\/144.4.1355","article-title":"Yeast mutants deficient in ER-associated degradation of the Z variant of alpha-1-protease inhibitor","volume":"144","author":"McCracken","year":"1996","journal-title":"Genetics"},{"key":"10.1016\/j.ceb.2012.05.010_bib0060","doi-asserted-by":"crossref","first-page":"13797","DOI":"10.1073\/pnas.93.24.13797","article-title":"Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate","volume":"93","author":"Werner","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ceb.2012.05.010_bib0065","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1096\/fasebj.14.5.769","article-title":"Degradation of unassembled soluble Ig subunits by cytosolic proteasomes: evidence that retrotranslocation and degradation are coupled events","volume":"14","author":"Mancini","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.ceb.2012.05.010_bib0070_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0092-8674(95)90240-6","article-title":"Degradation of CFTR by the ubiquitin\u2013proteasome pathway","volume":"83","author":"Ward","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0075","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1021\/cr800544v","article-title":"Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway","volume":"109","author":"Hampton","year":"2009","journal-title":"Chem Rev"},{"key":"10.1016\/j.ceb.2012.05.010_bib0080","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/10409238.2010.485605","article-title":"Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase","volume":"45","author":"Jo","year":"2010","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0085","doi-asserted-by":"crossref","first-page":"20800","DOI":"10.1074\/jbc.272.33.20800","article-title":"Cytosolic degradation of T-cell receptor alpha chains by the proteasome","volume":"272","author":"Yu","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0090","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(00)81054-5","article-title":"The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol","volume":"84","author":"Wiertz","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0095","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1002\/j.1460-2075.1996.tb00560.x","article-title":"Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin proteasome pathway","volume":"15","author":"Biederer","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2012.05.010_bib0100","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1126\/science.278.5344.1806","article-title":"Role of Cue1p in ubiquitination and degradation at the ER surface","volume":"278","author":"Biederer","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.ceb.2012.05.010_bib0105_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/414652a","article-title":"The AAA ATPase Cdc48\/p97 and its partners transport proteins from the ER into the cytosol","volume":"414","author":"Ye","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2012.05.010_bib0110","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cell.2007.11.023","article-title":"Dissecting the ER-associated degradation of a misfolded polytopic membrane protein","volume":"132","author":"Nakatsukasa","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0115_1","doi-asserted-by":"crossref","first-page":"14710","DOI":"10.1074\/jbc.M809607200","article-title":"In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase","volume":"284","author":"Garza","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0120","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1074\/jbc.M210158200","article-title":"Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation","volume":"278","author":"Tirosh","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0125","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.molcel.2005.07.027","article-title":"Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen","volume":"19","author":"Bhamidipati","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0130","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1091\/mbc.12.12.4114","article-title":"HRD4\/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins","volume":"12","author":"Bays","year":"2001","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0135","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/emboj\/21.4.615","article-title":"Role of the ubiquitin-selective CDC48(UFD1\/NPL4)chaperone (segregase) in ERAD of OLE1 and other substrates","volume":"21","author":"Braun","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2012.05.010_bib0140","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1091\/mbc.12.10.3226","article-title":"The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation","volume":"12","author":"Hitchcock","year":"2001","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0145","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ncb746","article-title":"Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48","volume":"4","author":"Jarosch","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0150_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1128\/MCB.22.2.626-634.2002","article-title":"AAA-ATPase p97\/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation","volume":"22","author":"Rabinovich","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0155","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tibs.2011.06.001","article-title":"Cdc48: a power machine in protein degradation","volume":"36","author":"Stolz","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.ceb.2012.05.010_bib0160","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ncb2407","article-title":"Emerging functions of the VCP\/p97 AAA-ATPase in the ubiquitin system","volume":"14","author":"Meyer","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0165","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/ncb1997","article-title":"A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor-promoter DNA complex","volume":"11","author":"Wilcox","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0170","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/nature06388","article-title":"Cdc48\/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin","volume":"450","author":"Ramadan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2012.05.010_bib0175","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.molcel.2006.03.036","article-title":"Central pore residues mediate the p97\/VCP activity required for ERAD","volume":"22","author":"DeLaBarre","year":"2006","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0180","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jmb.2005.01.060","article-title":"Nucleotide dependent motion and mechanism of action of p97\/VCP","volume":"347","author":"DeLaBarre","year":"2005","journal-title":"J Mol Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0185","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nsb972","article-title":"Complete structure of p97\/valosin-containing protein reveals communication between nucleotide domains","volume":"10","author":"DeLaBarre","year":"2003","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0190","doi-asserted-by":"crossref","first-page":"7166","DOI":"10.1074\/jbc.M705893200","article-title":"A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates","volume":"283","author":"Lipson","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0195_1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2007.03.046","article-title":"Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system","volume":"129","author":"Wahlman","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0200","doi-asserted-by":"crossref","first-page":"28127","DOI":"10.1074\/jbc.M503138200","article-title":"Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate","volume":"280","author":"Kothe","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0205","doi-asserted-by":"crossref","first-page":"35903","DOI":"10.1074\/jbc.M301080200","article-title":"Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD","volume":"278","author":"Taxis","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0210","doi-asserted-by":"crossref","first-page":"32665","DOI":"10.1074\/jbc.M705216200","article-title":"The Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD)","volume":"282","author":"Hrizo","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0215","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1073\/pnas.090083497","article-title":"The protein translocation channel mediates glycopeptide export across the endoplasmic reticulum membrane","volume":"97","author":"Gillece","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ceb.2012.05.010_bib0220","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/384432a0","article-title":"Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction","volume":"384","author":"Wiertz","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2012.05.010_bib0225","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1242\/jcs.03351","article-title":"Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum","volume":"120","author":"Ng","year":"2007","journal-title":"J Cell Sci"},{"issue":"Pt 22","key":"10.1016\/j.ceb.2012.05.010_bib0230","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1242\/jcs.112.22.4123","article-title":"Genetic interactions of Hrd3p and Der3p\/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation","volume":"112","author":"Plemper","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ceb.2012.05.010_bib0235","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1038\/emboj.2009.231","article-title":"Sec61p is part of the endoplasmic reticulum-associated degradation machinery","volume":"28","author":"Schafer","year":"2009","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2012.05.010_bib0240","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/42276","article-title":"Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation","volume":"388","author":"Plemper","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2012.05.010_bib0245","doi-asserted-by":"crossref","first-page":"33883","DOI":"10.1074\/jbc.M803054200","article-title":"Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY","volume":"283","author":"Willer","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0250","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1083\/jcb.200804053","article-title":"Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins","volume":"181","author":"Scott","year":"2008","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0360","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.201203061","article-title":"Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase","volume":"197","author":"Rubenstein","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0255","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/yea.1407","article-title":"Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis","volume":"23","author":"Sato","year":"2006","journal-title":"Yeast"},{"key":"10.1016\/j.ceb.2012.05.010_bib0260","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature02592","article-title":"A membrane protein required for dislocation of misfolded proteins from the ER","volume":"429","author":"Lilley","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2012.05.010_bib0265_1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02656","article-title":"A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol","volume":"429","author":"Ye","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2012.05.010_bib0270","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/j.1460-2075.1996.tb00411.x","article-title":"Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast","volume":"15","author":"Knop","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2012.05.010_bib0275","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1074\/jbc.M008608200","article-title":"Membrane topology and function of Der3\/Hrd1p as a ubiquitin\u2013protein ligase (E3) involved in endoplasmic reticulum degradation","volume":"276","author":"Deak","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0280","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1074\/jbc.M512215200","article-title":"Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)","volume":"281","author":"Kreft","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0285_1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.molcel.2009.03.010","article-title":"Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase","volume":"34","author":"Sato","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0290","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/ncb1298","article-title":"Ubx2 links the Cdc48 complex to ER-associated protein degradation","volume":"7","author":"Neuber","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0295","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/ncb1299","article-title":"Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation","volume":"7","author":"Schuberth","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0300","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1083\/jcb.151.1.69","article-title":"Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p","volume":"151","author":"Gardner","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0305_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cell.2010.10.028","article-title":"Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p","volume":"143","author":"Carvalho","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0310_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.molcel.2009.10.015","article-title":"Usa1 functions as a scaffold of the HRD-ubiquitin ligase","volume":"36","author":"Horn","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0315","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.febslet.2011.04.009","article-title":"Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking","volume":"585","author":"Stanley","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ceb.2012.05.010_bib0320","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1091\/mbc.e09-07-0586","article-title":"The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation","volume":"21","author":"Bernardi","year":"2010","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0325","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1091\/mbc.e09-08-0743","article-title":"Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum","volume":"21","author":"Li","year":"2010","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2012.05.010_bib0330","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature06004","article-title":"A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum","volume":"448","author":"Ploegh","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2012.05.010_bib0335","doi-asserted-by":"crossref","first-page":"27872","DOI":"10.1074\/jbc.C111.266452","article-title":"Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation","volume":"286","author":"Olzmann","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0365","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1194\/jlr.R024117","article-title":"The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans","volume":"53","author":"Yang","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ceb.2012.05.010_bib0345","doi-asserted-by":"crossref","first-page":"19288","DOI":"10.1074\/jbc.M110.134213","article-title":"Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets","volume":"285","author":"Hartman","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2012.05.010_bib0350","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ncb2383","article-title":"Defining human ERAD networks through an integrative mapping strategy","volume":"14","author":"Christianson","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0355_1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nsmb.2111","article-title":"Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant alpha-1 antitrypsin from the endoplasmic reticulum","volume":"18","author":"Greenblatt","year":"2011","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.ceb.2012.05.010_bib0370_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2012.06.008","article-title":"Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins","author":"Fleig","year":"2012","journal-title":"Mol Cell"}],"container-title":["Current Opinion in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067412000816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067412000816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:17:50Z","timestamp":1760620670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955067412000816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0955067412000816"],"URL":"https:\/\/doi.org\/10.1016\/j.ceb.2012.05.010","relation":{},"ISSN":["0955-0674"],"issn-type":[{"value":"0955-0674","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Finding the will and the way of ERAD substrate retrotranslocation","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceb.2012.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}