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Med. 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Rev. Cell Dev. Biol."},{"issue":"Suppl 3","key":"10.1016\/j.cell.2011.01.032_bib157","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/humrep\/13.suppl_3.237","article-title":"The role of leukemia inhibitory factor and interleukin-6 in human reproduction","volume":"13","author":"Smith","year":"1998","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cell.2011.01.032_bib158","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/0014-4827(83)90025-3","article-title":"Medium conditioned by feeder cells inhibits the differentiation of embryonal carcinoma cultures","volume":"145","author":"Smith","year":"1983","journal-title":"Exp. 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