{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:14:49Z","timestamp":1762928089449,"version":"build-2065373602"},"reference-count":85,"publisher":"Elsevier BV","issue":"17-18","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.drudis.2010.07.003","type":"journal-article","created":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T04:36:33Z","timestamp":1281155793000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Cancer therapy via modulation of micro RNA levels: a promising future"],"prefix":"10.1016","volume":"15","author":[{"given":"Satya K.","family":"Kota","sequence":"first","affiliation":[]},{"given":"Savithri","family":"Balasubramanian","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2010.07.003_bib0005","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1242\/dev.005629","article-title":"The growing catalog of small RNAs and their association with distinct Argonaute\/Piwi family members","volume":"135","author":"Farazi","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.drudis.2010.07.003_bib0010","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0015","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","article-title":"Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA","volume":"408","author":"Pasquinelli","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0020","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0025","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0030","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1006\/dbio.1999.9523","article-title":"The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation","volume":"216","author":"Olsen","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.drudis.2010.07.003_bib0035","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","article-title":"Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs","volume":"433","author":"Lim","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0040","doi-asserted-by":"crossref","first-page":"16230","DOI":"10.1073\/pnas.0808830105","article-title":"MicroRNA-directed transcriptional gene silencing in mammalian cells","volume":"105","author":"Kim","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drudis.2010.07.003_bib0045","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.drudis.2010.07.003_bib0050","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1261\/rna.5167604","article-title":"Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs","volume":"10","author":"Bohnsack","year":"2004","journal-title":"RNA"},{"key":"10.1016\/j.drudis.2010.07.003_bib0060","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/35053110","article-title":"Role for a bidentate ribonuclease in the initiation step of RNA interference","volume":"409","author":"Bernstein","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0065","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nature03868","article-title":"TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing","volume":"436","author":"Chendrimada","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0070","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1126\/science.1102755","article-title":"A protein sensor for siRNA asymmetry","volume":"306","author":"Tomari","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.drudis.2010.07.003_bib0075","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","article-title":"Origins and mechanisms of miRNAs and siRNAs","volume":"136","author":"Carthew","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0080","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1101\/gad.5.10.1813","article-title":"Negative regulatory sequences in the lin-14 3\u2032-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development","volume":"5","author":"Wightman","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.drudis.2010.07.003_bib0085","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nature07299","article-title":"MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation","volume":"455","author":"Tay","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0090","doi-asserted-by":"crossref","first-page":"14879","DOI":"10.1073\/pnas.0803230105","article-title":"A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence","volume":"105","author":"Forman","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drudis.2010.07.003_bib0095","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of mammalian microRNA targets","volume":"115","author":"Lewis","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nsmb.1762","article-title":"MicroRNA assassins: factors that regulate the disappearance of miRNAs","volume":"17","author":"Kai","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.drudis.2010.07.003_bib0105","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nature04138","article-title":"The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development","volume":"438","author":"Hornstein","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0110","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0092-8674(03)00231-9","article-title":"bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila","volume":"113","author":"Brennecke","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0115","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(03)00428-8","article-title":"MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing","volume":"113","author":"Ambros","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0120","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A mammalian microRNA expression atlas based on small RNA library sequencing","volume":"129","author":"Landgraf","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0125","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0130","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12094-007-0029-0","article-title":"microRNAs and cancer: role in tumorigenesis, patient classification and therapy","volume":"9","author":"Hernando","year":"2007","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.drudis.2010.07.003_bib0135","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1089\/scd.2009.0113","article-title":"Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs","volume":"18","author":"Kashyap","year":"2009","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.drudis.2010.07.003_bib0140","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs\u2014microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.drudis.2010.07.003_bib0145","first-page":"pe41","article-title":"Slowing down the Ras lane: miRNAs as tumor suppressors?","volume":"297","author":"Morris","year":"2005","journal-title":"Sci. STKE"},{"key":"10.1016\/j.drudis.2010.07.003_bib0150","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/nature05939","article-title":"A microRNA component of the p53 tumour suppressor network","volume":"447","author":"He","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0155","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.gde.2005.12.005","article-title":"MicroRNAs as oncogenes","volume":"16","author":"Hammond","year":"2006","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.drudis.2010.07.003_bib0160","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature03552","article-title":"A microRNA polycistron as a potential human oncogene","volume":"435","author":"He","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0165","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1158\/0008-5472.CAN-05-2352","article-title":"A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation","volume":"65","author":"Hayashita","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.drudis.2010.07.003_bib0170","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drudis.2010.07.003_bib0175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ccr.2007.12.008","article-title":"MicroRNA signature predicts survival and relapse in lung cancer","volume":"13","author":"Yu","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0180","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2141.2008.07077.x","article-title":"Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma","volume":"141","author":"Lawrie","year":"2008","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.drudis.2010.07.003_bib0185","unstructured":"Hanke, M. et al.: A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol. Oncol. (in press)."},{"key":"10.1016\/j.drudis.2010.07.003_bib0190","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/carcin\/bgp219","article-title":"miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer","volume":"30","author":"Gallardo","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.drudis.2010.07.003_bib0195","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJMoa0901282","article-title":"MicroRNA expression, survival, and response to interferon in liver cancer","volume":"361","author":"Ji","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.drudis.2010.07.003_bib0200","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1056\/NEJMoa0803785","article-title":"Dicer, Drosha, and outcomes in patients with ovarian cancer","volume":"359","author":"Merritt","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.drudis.2010.07.003_bib0205","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1349-7006.2005.00015.x","article-title":"Reduced expression of Dicer associated with poor prognosis in lung cancer patients","volume":"96","author":"Karube","year":"2005","journal-title":"Cancer Sci."},{"key":"10.1016\/j.drudis.2010.07.003_bib0210","doi-asserted-by":"crossref","first-page":"19075","DOI":"10.1073\/pnas.0509603102","article-title":"The role of microRNA genes in papillary thyroid carcinoma","volume":"102","author":"He","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drudis.2010.07.003_bib0215","doi-asserted-by":"crossref","first-page":"8535","DOI":"10.1158\/0008-5472.CAN-08-2129","article-title":"A SNP in a let-7 microRNA complementary site in the KRAS 3\u2032 untranslated region increases non-small cell lung cancer risk","volume":"68","author":"Chin","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.drudis.2010.07.003_bib0220","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10549-009-0633-5","article-title":"A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk","volume":"121","author":"Yang","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.drudis.2010.07.003_bib0225","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/humu.20837","article-title":"Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women","volume":"30","author":"Hu","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.drudis.2010.07.003_bib0230","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.1038\/sj.onc.1210425","article-title":"Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92","volume":"26","author":"Matsubara","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.drudis.2010.07.003_bib0235","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1074\/jbc.M608939200","article-title":"An E2F\/miR-20a autoregulatory feedback loop","volume":"282","author":"Sylvestre","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drudis.2010.07.003_bib0240","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1038\/sj.onc.1210083","article-title":"miR-21-mediated tumor growth","volume":"26","author":"Si","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.drudis.2010.07.003_bib0245","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1073\/pnas.0808263106","article-title":"Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor","volume":"106","author":"Segura","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drudis.2010.07.003_bib0250","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nmeth1079","article-title":"MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells","volume":"4","author":"Ebert","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.drudis.2010.07.003_bib0255","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ncb2024","article-title":"miR-9, a MYC\/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis","volume":"12","author":"Ma","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.drudis.2010.07.003_bib0260","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/onc.2009.445","article-title":"Regression of murine lung tumors by the let-7 microRNA","volume":"29","author":"Trang","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.drudis.2010.07.003_bib0265","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1073\/pnas.0712321105","article-title":"Suppression of non-small cell lung tumor development by the let-7 microRNA family","volume":"105","author":"Kumar","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.drudis.2010.07.003_bib0270","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1158\/0008-5472.CAN-09-0529","article-title":"MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes","volume":"69","author":"Li","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.drudis.2010.07.003_bib0275","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/1471-2407-8-266","article-title":"Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumor spheres","volume":"8","author":"Ji","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.drudis.2010.07.003_bib0280","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cell.2009.04.021","article-title":"Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model","volume":"137","author":"Kota","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0285","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/mt.2009.207","article-title":"Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes","volume":"18","author":"Takeshita","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.drudis.2010.07.003_bib0290","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1038\/mt.2008.159","article-title":"miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy","volume":"16","author":"Suzuki","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.drudis.2010.07.003_bib0295","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/nm.1776","article-title":"Engineering microRNA responsiveness to decrease virus pathogenicity","volume":"14","author":"Kelly","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2010.07.003_bib0300","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1158\/1078-0432.CCR-09-0051","article-title":"MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells","volume":"15","author":"Lee","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.drudis.2010.07.003_bib0305","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature04303","article-title":"Silencing of microRNAs in vivo with \u2018antagomirs\u2019","volume":"438","author":"Krutzfeldt","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0310","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nature06783","article-title":"LNA-mediated microRNA silencing in non-human primates","volume":"452","author":"Elmen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0315","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/clpt.2008.174","article-title":"Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides","volume":"84","author":"Sepp-Lorenzino","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.drudis.2010.07.003_bib0320","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s11095-006-9180-5","article-title":"Lipid-based nanoparticles for nucleic acid delivery","volume":"24","author":"Li","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.drudis.2010.07.003_bib0325","first-page":"1317","article-title":"Targeted delivery of siRNA by nonviral vectors: lessons learned from recent advances","volume":"9","author":"Li","year":"2008","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"10.1016\/j.drudis.2010.07.003_bib0330","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/mt.2009.306","article-title":"Novel RNA-based strategies for therapeutic gene silencing","volume":"18","author":"Sibley","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.drudis.2010.07.003_bib0335","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ccr.2009.10.014","article-title":"miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation","volume":"16","author":"Garofalo","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0340","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2007.05.022","article-title":"MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer","volume":"133","author":"Meng","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.drudis.2010.07.003_bib0345","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1158\/0008-5472.CAN-06-4607","article-title":"Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma","volume":"67","author":"Gramantieri","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.drudis.2010.07.003_bib0350","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1101\/gad.1777409","article-title":"The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo","volume":"23","author":"Huse","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.drudis.2010.07.003_bib0355","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.1158\/0008-5472.CAN-05-0137","article-title":"MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells","volume":"65","author":"Chan","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.drudis.2010.07.003_bib0360","first-page":"1653","article-title":"Co-suppression of miR-221\/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo","volume":"34","author":"Zhang","year":"2009","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.drudis.2010.07.003_bib0365","doi-asserted-by":"crossref","first-page":"15161","DOI":"10.1523\/JNEUROSCI.4966-09.2009","article-title":"The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors","volume":"29","author":"Kefas","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.drudis.2010.07.003_bib0370","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1128\/MCB.00332-09","article-title":"Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt\/beta-catenin signaling pathway","volume":"29","author":"Saydam","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.drudis.2010.07.003_bib0375","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2007.10.054","article-title":"let-7 regulates self renewal and tumorigenicity of breast cancer cells","volume":"131","author":"Yu","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.07.003_bib0380","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncb1722","article-title":"The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1","volume":"10","author":"Gregory","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.drudis.2010.07.003_bib0385","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nature06487","article-title":"Endogenous human microRNAs that suppress breast cancer metastasis","volume":"451","author":"Tavazoie","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.07.003_bib0390","doi-asserted-by":"crossref","first-page":"923","DOI":"10.4161\/cc.9.5.10930","article-title":"The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer","volume":"9","author":"Ribas","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.drudis.2010.07.003_bib0395","unstructured":"Hagman, Z. et al., miR-34c is down regulated in prostate cancer and exerts tumor suppressive functions. Int. J. Cancer. (in press)."},{"key":"10.1016\/j.drudis.2010.07.003_bib0400","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1158\/0008-5472.CAN-08-2894","article-title":"miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon","volume":"69","author":"Gandellini","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.drudis.2010.07.003_bib0405","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1073\/pnas.0500613102","article-title":"Accumulation of miR-155 and BIC RNA in human B cell lymphomas","volume":"102","author":"Eis","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drudis.2010.07.003_bib0410","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/ncb2037","article-title":"Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia","volume":"12","author":"Mavrakis","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.drudis.2010.07.003_bib0415","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1101\/gad.1872909","article-title":"Genetic dissection of the miR-17\u223c92 cluster of microRNAs in Myc-induced B-cell lymphomas","volume":"23","author":"Mu","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.drudis.2010.07.003_bib0420","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1073\/pnas.242606799","article-title":"Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia","volume":"99","author":"Calin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.drudis.2010.07.003_bib0425","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1182\/blood-2009-03-211938","article-title":"MicroRNA 29b functions in acute myeloid leukemia","volume":"114","author":"Garzon","year":"2009","journal-title":"Blood"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644610002527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644610002527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:06:38Z","timestamp":1761221198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644610002527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":85,"journal-issue":{"issue":"17-18","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S1359644610002527"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2010.07.003","relation":{},"ISSN":["1359-6446"],"issn-type":[{"type":"print","value":"1359-6446"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cancer therapy via modulation of micro RNA levels: a promising future","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2010.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}