{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:46:36Z","timestamp":1762159596925},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[1997,8]]},"DOI":"10.1016\/s0006-8993(97)00561-1","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T22:02:28Z","timestamp":1027634548000},"page":"259-266","source":"Crossref","is-referenced-by-count":54,"title":["Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)"],"prefix":"10.1016","volume":"765","author":[{"given":"Alok C","family":"Pant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Veeranna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish C","family":"Pant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niranjana","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0006-8993(97)00561-1_BIB1","doi-asserted-by":"crossref","first-page":"20825","DOI":"10.1016\/S0021-9258(19)36859-0","article-title":"Substrate specificity characterization of a cdc2-like protein kinase purified from Bovine brain","volume":"268","author":"Beaudette","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB2","doi-asserted-by":"crossref","first-page":"9805","DOI":"10.1016\/S0021-9258(17)39307-9","article-title":"The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state","volume":"260","author":"Carden","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB3","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1523\/JNEUROSCI.07-11-03489.1987","article-title":"Two stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns","volume":"7","author":"Carden","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB4","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1523\/JNEUROSCI.10-11-03714.1990","article-title":"Transfected rat high-molecular-weight neurofilament (NF-H) co-assembles with vimentin in a predominantly non-dephosphorylated form","volume":"10","author":"Chin","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/375061a0","article-title":"Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"375","author":"Collard","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0092-8674(93)90158-M","article-title":"Progressive neuropathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis","volume":"73","author":"Cote","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0092-8674(92)90183-D","article-title":"Local modulation of neurofilament phosphorylation axonal caliber and slow axonal transport by myelinating Schwann cells","volume":"68","author":"deWaegh","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB8","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1046\/j.1471-4159.1994.63062324.x","article-title":"Identification of endogenously phosphorylkated KSP sites in the high molecular weight rat neurofilament protein","volume":"63","author":"Elhanany","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB9","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1046\/j.1471-4159.1996.66041698.x","article-title":"Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin dependent kinase-5","volume":"66","author":"Guidato","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB10","unstructured":"N. Hirokawa, Molecular architecture and dynamics of neuronal cytoskeleton, in: R.D. Burgoyne (Ed.), The Neuronal Cytoskeleton, John Wiley and Sons, New York, 1991, pp. 5\u201374."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1083\/jcb.66.2.351","article-title":"The slow component of axonal transport: identification of the major structural polypeptides of the axon and their generality among mammalian neurons","volume":"66","author":"Hoffman","year":"1975","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB12","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1073\/pnas.84.10.3472","article-title":"Neurofilament gene expression a major determinant of axon caliber","volume":"84","author":"Hoffman","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000132421","article-title":"The human neurofilament gene (NEFL) is located on the short arm of chromosome 8","volume":"45","author":"Hurst","year":"1987","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-5793(94)80501-6","article-title":"Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain","volume":"342","author":"Ishiguro","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB15","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/j.1460-2075.1988.tb03032.x","article-title":"The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it","volume":"7","author":"Lees","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB16","doi-asserted-by":"crossref","first-page":"25922","DOI":"10.1016\/S0021-9258(18)35696-5","article-title":"Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34 cdc2","volume":"267","author":"Lew","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/371423a0","article-title":"A brain-specific activator of cyclin dependent kinase 5","volume":"371","author":"Lew","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB18","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1073\/pnas.86.7.2463","article-title":"Cloning of a cDNA encoding the rat high molecular weight neurofilament peptide (NF-H): developmental and tissue expression in the rat, and mapping of its human homologue to chromosome 1 and 22","volume":"86","author":"Lieberburg","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0955-0674(05)80003-1","article-title":"Molecular biology of neuronal intermediate filaments","volume":"5","author":"Liem","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB20","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/1044-7431(92)90067-C","article-title":"Casein kinase I and II from squid brain exhibit selective neurofilament phosphorylation","volume":"3","author":"Link","year":"1992","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB21","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/j.1460-2075.1987.tb02409.x","article-title":"The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family","volume":"6","author":"Meyers","year":"1987","journal-title":"EMBO J."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB22","unstructured":"E.J. Nestler, P. Greengard (Eds.), Applications of protein phosphorylation systems to other areas of Neuroscience, in: Protein Phosphorylation in the Nervous System, John Wiley and Sons, New York, 1984, pp. 215\u2013242."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1750-3639.1993.tb00723.x","article-title":"The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathology","volume":"3","author":"Nixon","year":"1993","journal-title":"Brain Pathol."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/cm.970220202","article-title":"Dynamics of neuronal intermediate filaments: a developmental perspective","volume":"22","author":"Nixon","year":"1992","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB25","doi-asserted-by":"crossref","first-page":"11173","DOI":"10.1073\/pnas.93.20.11173","article-title":"Targeted disruption of the cyclin dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death","volume":"93","author":"Oshima","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB26","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/bj2560665","article-title":"Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain","volume":"256","author":"Pant","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB27","doi-asserted-by":"crossref","first-page":"23512","DOI":"10.1016\/S0021-9258(19)49492-1","article-title":"Brain proline directed kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimers paired helical filaments","volume":"268","author":"Paudel","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB28","unstructured":"J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning; A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB29","unstructured":"J. Shaw, Neurofilament proteins, in: R.D. Burgoyne (Ed.), The Neuronal Cytoskeleton, John Wiley and Sons, New York, 1991, pp. 185\u2013214."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB30","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1046\/j.1471-4159.1995.64051988.x","article-title":"Molecular characterization of a neuronal-specific protein that stimulates the activity of cdk5","volume":"64","author":"Shetty","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB31","doi-asserted-by":"crossref","first-page":"6844","DOI":"10.1073\/pnas.90.14.6844","article-title":"Cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization","volume":"90","author":"Shetty","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.bi.57.070188.003113","article-title":"Molecular and cellular biology of intermediate filaments","volume":"57","author":"Steinert","year":"1988","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB33","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1073\/pnas.80.19.6126","article-title":"Monoclonal antibodies distinguishing phosphorylated and nonphosphorylated forms of neurofilaments in situ","volume":"80","author":"Sternberger","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB34","doi-asserted-by":"crossref","first-page":"14245","DOI":"10.1074\/jbc.271.24.14245","article-title":"Phosphorylation of high molecular weight neurofilament protein (NF-H) by cdk5 and p35","volume":"271","author":"Sun","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB35","doi-asserted-by":"crossref","first-page":"26897","DOI":"10.1074\/jbc.270.45.26897","article-title":"An isoform of the neuronal cyclin-dependent kinase 5 (cdk5) activator","volume":"270","author":"Tang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/371419a0","article-title":"p35 is a neural specific regulatory subunit of cyclin dependent kinase 5","volume":"371","author":"Tsai","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/BF02527763","article-title":"Inhibition of neuronal cyclin dependent kinase-5 by staurosporine and purine analogs is dependent of activation by Munc-18","volume":"21","author":"Veeranna","year":"1996","journal-title":"Neurochem. Res."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB38","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1046\/j.1471-4159.1995.64062681.x","article-title":"Neuronal cyclin-dependent kinase 5 phosphorylation sites in neurofilament protein (NF-H) are dephosphosphorylated by protein phosphatase 2A","volume":"64","author":"Veeranna","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/S0006-8993(97)00561-1_BIB39","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(92)90518-H","article-title":"D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA","volume":"71","author":"Xiong","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0092-8674(93)90157-L","article-title":"Increased expression of neurofilament NF-L produces morphological alterations that resembles pathology of human motor neuron disease","volume":"73","author":"Xu","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0006-8993(97)00561-1_BIB41","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0959-4388(94)90006-X","article-title":"Neuronal intermediate filaments: new progress on an old subject","volume":"4","author":"Xu","year":"1994","journal-title":"Curr. Opin. Neurobiol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899397005611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899397005611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T08:37:25Z","timestamp":1620808645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899397005611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["S0006899397005611"],"URL":"https:\/\/doi.org\/10.1016\/s0006-8993(97)00561-1","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}