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After pre\u2010loading the ANT\u2010containing proteoliposomes with ATP, malate or AMP, a gradual release of the trapped compounds by increasing the external Ca<jats:sup>2+<\/jats:sup>concentrations could be demonstrated.<jats:italic>N<\/jats:italic>\u2010Methyl\u2010Val\u20104\u2010cyclosporin did not inhibit the Ca<jats:sup>2+<\/jats:sup>dependent release of internal substances from ANT liposomes. This inhibitor was found to be specific for the mitochondrial permeability transition pore (MTP) in intact mitochondria or reconstituted MTP\u2010like protein complexes (e.g. hexokinase, porin, ANT complex). However, ADP in concentrations &gt;20 \u03bcM inhibited the liberation of internal compounds, while in contrast, atractyloside (30 \u03bcM) and HgCl<jats:sub>2<\/jats:sub>(5 \u03bcM) both induced permeability of the ANT\u2010containing liposomes resulting in a release of trapped substances. 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