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The co\u2010immunoprecipitation with PS1 in transfected COS\u20107 cells indicates that PS1 directly interacts with endogenous \u03b2\u2010catenin, and the interaction requires residues 322\u2013450 of PS1 and 445\u2013676 of \u03b2\u2010catenin. Both proteins are co\u2010localized in the endoplasmic reticulum. Over\u2010expression of PS1 reduces the level of cytoplasmic \u03b2\u2010catenin, and inhibits \u03b2\u2010catenin\u2010T cell factor\u2010regulated transcription. 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