{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:46:33Z","timestamp":1776843993954,"version":"3.51.2"},"reference-count":29,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[1982,11,1]],"date-time":"1982-11-01T00:00:00Z","timestamp":404956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1982,11,1]],"date-time":"1982-11-01T00:00:00Z","timestamp":404956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":13874,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1982,11]]},"DOI":"10.1016\/s0021-9258(18)33504-x","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T22:38:31Z","timestamp":1609799911000},"page":"13704-13712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":570,"title":["Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis."],"prefix":"10.1016","volume":"257","author":[{"given":"O W","family":"Griffith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0021-9258(18)33504-X_bib1","first-page":"234","volume":"27","author":"Misani","year":"1950","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/S0021-9258(18)33504-X_bib2","series-title":"Enzyme-activated Irreversible Inhibitors","first-page":"187","author":"Meister","year":"1978"},{"key":"10.1016\/S0021-9258(18)33504-X_bib3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1021\/bi00757a001","volume":"11","author":"Rao","year":"1972","journal-title":"Biochemistry"},{"key":"10.1016\/S0021-9258(18)33504-X_bib4","doi-asserted-by":"crossref","first-page":"6674","DOI":"10.1016\/S0021-9258(17)32998-8","volume":"251","author":"Cooper","year":"1976","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib5","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0021-9258(17)34188-1","volume":"254","author":"Griffith","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib6","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1016\/S0021-9258(18)35980-5","volume":"254","author":"Griffith","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib7","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/S0021-9258(17)38077-8","volume":"253","author":"Griffith","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0076-6879(81)77011-3","volume":"77","author":"Griffith","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0021-9258(18)33504-X_bib9","doi-asserted-by":"crossref","first-page":"12263","DOI":"10.1016\/S0021-9258(18)43264-4","volume":"256","author":"Griffith","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib10","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.76.11.5606","volume":"76","author":"Griffith","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)33504-X_bib11","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1016\/S0021-9258(19)69341-5","volume":"256","author":"Griffith","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib12","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1073\/pnas.78.12.7492","volume":"78","author":"Dethmers","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)33504-X_bib13","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/S0021-9258(19)68139-1","volume":"257","author":"Rouzer","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib14","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1073\/pnas.78.4.2532","volume":"78","author":"Rouzer","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)33504-X_bib15","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1073\/pnas.79.5.1621","volume":"79","author":"Rouzer","year":"1982","journal-title":"Proc. Natl. Acad. Sei U. S. A."},{"key":"10.1016\/S0021-9258(18)33504-X_bib16","volume":"41","author":"Arrick","year":"1982","journal-title":"Fed. Proc."},{"key":"10.1016\/S0021-9258(18)33504-X_bib17","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0021-9258(19)68180-9","volume":"257","author":"Arrick","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib18","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1084\/jem.153.3.720","volume":"153","author":"Arrick","year":"1981","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0021-9258(18)33504-X_bib19","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1016\/S0021-9258(19)43407-8","volume":"248","author":"Richman","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib20","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1021\/bi00831a038","volume":"8","author":"Ronzio","year":"1969","journal-title":"Biochemistry"},{"key":"10.1016\/S0021-9258(18)33504-X_bib21","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1016\/S0021-9258(17)40500-X","volume":"252","author":"Sekura","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib22","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0006-291X(77)91198-6","volume":"79","author":"Griffith","year":"1977","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0021-9258(18)33504-X_bib23","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1016\/S0021-9258(17)40865-9","volume":"253","author":"Lebo","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib24","doi-asserted-by":"crossref","first-page":"11732","DOI":"10.1016\/S0021-9258(19)70195-1","volume":"255","author":"Beamer","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib25","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1016\/S0021-9258(18)34639-8","volume":"257","author":"Seelig","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)33504-X_bib26","series-title":"Enzyme-activated Irreversible Inhibitors","first-page":"1","author":"Abeles","year":"1978"},{"key":"10.1016\/S0021-9258(18)33504-X_bib27","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1073\/pnas.76.12.6319","volume":"76","author":"Griffith","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)33504-X_bib28","volume":"41","author":"Anderson","year":"1982","journal-title":"Fed. Proc."},{"key":"10.1016\/S0021-9258(18)33504-X_bib29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/jm00297a029","volume":"13","author":"Baker","year":"1970","journal-title":"J. Med. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192581833504X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192581833504X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T04:39:25Z","timestamp":1758170365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192581833504X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,11]]},"references-count":29,"journal-issue":{"issue":"22","published-print":{"date-parts":[[1982,11]]}},"alternative-id":["S002192581833504X"],"URL":"https:\/\/doi.org\/10.1016\/s0021-9258(18)33504-x","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1982,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0021-9258(18)33504-X","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 1982 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}