{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:18:10Z","timestamp":1775503090218,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[1982,6,1]],"date-time":"1982-06-01T00:00:00Z","timestamp":391737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1982,6,1]],"date-time":"1982-06-01T00:00:00Z","timestamp":391737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":14024,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1982,6]]},"DOI":"10.1016\/s0021-9258(18)34504-6","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T23:06:05Z","timestamp":1609801565000},"page":"6825-6835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Gene conversion of two functional goat alpha-globin genes preserves only minimal flanking sequences."],"prefix":"10.1016","volume":"257","author":[{"given":"E A","family":"Schon","sequence":"first","affiliation":[]},{"given":"S M","family":"Wernke","sequence":"additional","affiliation":[]},{"given":"J B","family":"Lingrel","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0021-9258(18)34504-6_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0003-9861(69)90356-7","volume":"132","author":"Adams","year":"1969","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/S0021-9258(18)34504-6_bib2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1172\/JCI110289","volume":"68","author":"Baird","year":"1981","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0021-9258(18)34504-6_bib3","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/290304a0","volume":"290","author":"Benoist","year":"1981","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)34504-6_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.847462","volume":"196","author":"Blattner","year":"1977","journal-title":"Science"},{"key":"10.1016\/S0021-9258(18)34504-6_bib5","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1016\/S0021-9258(19)42568-4","volume":"249","author":"Brown","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)34504-6_bib6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/290677a0","volume":"290","author":"Brown","year":"1981","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)34504-6_bib7","series-title":"Hemoglobinopathies","author":"Bunn","year":"1977"},{"key":"10.1016\/S0021-9258(18)34504-6_bib8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0092-8674(80)90305-0","volume":"20","author":"Calos","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib9","series-title":"Atlas of Protein Sequence and Structure","volume":"Vol. 5","year":"1972"},{"key":"10.1016\/S0021-9258(18)34504-6_bib10","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1073\/pnas.78.3.1411","volume":"78","author":"Dierks","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)34504-6_bib11","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1073\/pnas.78.10.5998","volume":"78","author":"Dodgson","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)34504-6_bib12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0092-8674(80)90429-8","volume":"21","author":"Efstratiadis","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib13","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1172\/JCI109426","volume":"63","author":"Embury","year":"1979","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0021-9258(18)34504-6_bib14","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1073\/pnas.77.5.2596","volume":"77","author":"Engel","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)34504-6_bib15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0005-2795(68)90197-9","volume":"168","author":"Garrick","year":"1968","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0021-9258(18)34504-6_bib16","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1073\/pnas.77.1.518","volume":"77","author":"Goossens","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)34504-6_bib17","doi-asserted-by":"crossref","first-page":"7102","DOI":"10.1073\/pnas.77.12.7102","volume":"77","author":"Grosschedl","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)34504-6_bib18","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/0092-8674(79)90239-3","volume":"18","author":"Hardison","year":"1979","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib19","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1016\/S0021-9258(18)43745-3","volume":"255","author":"Haynes","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)34504-6_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0092-8674(78)90081-8","volume":"15","author":"Heindell","year":"1978","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib21","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/284632a0","volume":"284","author":"Higgs","year":"1980","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)34504-6_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01659159","volume":"1","author":"Holmquist","year":"1972","journal-title":"J. Mol. Evol."},{"key":"10.1016\/S0021-9258(18)34504-6_bib23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/0003-9861(67)90111-7","volume":"121","author":"Huisman","year":"1967","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/S0021-9258(18)34504-6_bib24","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1016\/S0021-9258(18)95996-X","volume":"242","author":"Huisman","year":"1967","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)34504-6_bib25","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1016\/S0021-9258(19)34192-4","volume":"243","author":"Huisman","year":"1968","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)34504-6_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01653945","volume":"2","author":"Kimura","year":"1972","journal-title":"J. Mol. Evol."},{"key":"10.1016\/S0021-9258(18)34504-6_bib27","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0092-8674(79)90138-7","volume":"18","author":"Konkel","year":"1979","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0092-8674(80)90492-4","volume":"21","author":"Lacy","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0092-8674(80)90240-8","volume":"20","author":"Lauer","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0092-8674(80)90428-6","volume":"21","author":"Lawn","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib31","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/293196a0","volume":"293","author":"Leder","year":"1981","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)34504-6_bib32","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1073\/pnas.77.12.7054","volume":"77","author":"Liebhaber","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)34504-6_bib33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/290026a0","volume":"290","author":"Liebhaber","year":"1981","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)34504-6_bib34","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1093\/nar\/9.15.3707","volume":"9","author":"Lie-Injo","year":"1981","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0021-9258(18)34504-6_bib35","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1021\/bi00688a010","volume":"14","author":"Maniatis","year":"1975","journal-title":"Biochemistry"},{"key":"10.1016\/S0021-9258(18)34504-6_bib36","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0092-8674(78)90036-3","volume":"15","author":"Maniatis","year":"1978","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib37","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0076-6879(80)65059-9","volume":"65","author":"Maxam","year":"1980","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0021-9258(18)34504-6_bib38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0092-8674(81)90057-X","volume":"25","author":"McKnight","year":"1981","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib39","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0092-8674(80)90347-5","volume":"22","author":"Michelson","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/277108a0","volume":"277","author":"Mulligan","year":"1979","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)34504-6_bib41","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(79)90139-9","volume":"18","author":"Nishioka","year":"1979","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib42","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1073\/pnas.77.5.2806","volume":"77","author":"Nishioka","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)34504-6_bib43","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1073\/pnas.75.12.5950","volume":"75","author":"Orkin","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)34504-6_bib44","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0092-8674(81)90324-X","volume":"24","author":"Orkin","year":"1981","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib45","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0092-8674(80)90641-8","volume":"20","author":"Perler","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib46","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1073\/pnas.78.10.6362","volume":"78","author":"Popp","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)34504-6_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/263211a0","volume":"263","author":"Proudfoot","year":"1976","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)34504-6_bib48","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0092-8674(80)90491-2","volume":"21","author":"Proudfoot","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib49","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0076-6879(80)65062-9","volume":"65","author":"Queen","year":"1980","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0021-9258(18)34504-6_bib50","doi-asserted-by":"crossref","first-page":"9306","DOI":"10.1016\/S0021-9258(19)70562-6","volume":"255","author":"Richards","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)34504-6_bib51","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/nar\/7.5.1137","volume":"5","author":"Richards","year":"1979","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0021-9258(18)34504-6_bib52","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.1016\/S0021-9258(18)50536-6","volume":"254","author":"Robbins","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)34504-6_bib53","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0378-1119(77)90047-6","volume":"1","author":"Rougeon","year":"1977","journal-title":"Gene"},{"key":"10.1016\/S0021-9258(18)34504-6_bib54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-5793(78)80145-8","volume":"87","author":"Sanger","year":"1978","journal-title":"FEBS Lett"},{"key":"10.1016\/S0021-9258(18)34504-6_bib55","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0092-8674(81)90419-0","volume":"27","author":"Schon","year":"1981","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib56","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0092-8674(81)90302-0","volume":"26","author":"Shen","year":"1981","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib57","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0092-8674(80)90426-2","volume":"21","author":"Slightom","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib58","series-title":"Handbook of Biochemistry","year":"1968"},{"key":"10.1016\/S0021-9258(18)34504-6_bib59","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-2836(75)80083-0","volume":"99","author":"Southern","year":"1975","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0021-9258(18)34504-6_bib60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(81)90028-3","volume":"26","author":"Van Arsdell","year":"1981","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib61","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/286222a0","volume":"286","author":"Vanin","year":"1980","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)34504-6_bib62","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0005-2795(80)90297-4","volume":"625","author":"Vestri","year":"1980","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0021-9258(18)34504-6_bib63","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1093\/nar\/9.15.3731","volume":"9","author":"Villeponteau","year":"1981","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0021-9258(18)34504-6_bib64","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0092-8674(81)90330-5","volume":"24","author":"Weaver","year":"1981","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib65","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0092-8674(74)90045-2","volume":"3","author":"Wensink","year":"1974","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)34504-6_bib66","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1016\/S0021-9258(19)34193-6","volume":"243","author":"Wilson","year":"1968","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)34504-6_bib67","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/226354a0","volume":"226","author":"Wilson","year":"1970","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)34504-6_bib68","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1073\/pnas.77.4.2158","volume":"77","author":"Zimmer","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818345046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818345046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T04:41:09Z","timestamp":1758170469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818345046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,6]]},"references-count":68,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1982,6]]}},"alternative-id":["S0021925818345046"],"URL":"https:\/\/doi.org\/10.1016\/s0021-9258(18)34504-6","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1982,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene conversion of two functional goat alpha-globin genes preserves only minimal flanking sequences.","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0021-9258(18)34504-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 1982 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}