{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:29:54Z","timestamp":1769858994724,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":11728,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1988,9]]},"DOI":"10.1016\/s0021-9258(18)37702-0","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:41:26Z","timestamp":1609807286000},"page":"13282-13290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":231,"title":["Mutational analysis of the ligand binding domain of the low density lipoprotein receptor."],"prefix":"10.1016","volume":"263","author":[{"given":"V","family":"Esser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L E","family":"Limbird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D W","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0021-9258(18)37702-0_bib1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/279679a0","volume":"279","author":"Goldstein","year":"1979","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)37702-0_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0968-0004(83)90350-X","volume":"8","author":"Helenius","year":"1983","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0021-9258(18)37702-0_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.cb.01.110185.000245","volume":"1","author":"Goldstein","year":"1985","journal-title":"Annu. Rev. Cell. Biol."},{"key":"10.1016\/S0021-9258(18)37702-0_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0304-4157(83)90001-1","volume":"737","author":"Mahley","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0021-9258(18)37702-0_bib5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jss.400080302","volume":"8","author":"Brown","year":"1978","journal-title":"J. Supramol. Struct."},{"key":"10.1016\/S0021-9258(18)37702-0_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0092-8674(84)90188-0","volume":"39","author":"Yamamoto","year":"1984","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)37702-0_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1083\/jcb.74.1.119","volume":"74","author":"Basu","year":"1977","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0021-9258(18)37702-0_bib8","doi-asserted-by":"crossref","first-page":"9053","DOI":"10.1016\/S0021-9258(17)34284-9","volume":"253","author":"Weisgraber","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib9","doi-asserted-by":"crossref","first-page":"7279","DOI":"10.1016\/S0021-9258(19)66966-8","volume":"252","author":"Mahley","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib10","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1016\/S0021-9258(17)39866-6","volume":"259","author":"Innerarity","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib11","first-page":"155","volume":"53","author":"Scott","year":"1987","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/S0021-9258(18)37702-0_bib12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/323738a0","volume":"323","author":"Yang","year":"1986","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)37702-0_bib13","doi-asserted-by":"crossref","first-page":"13114","DOI":"10.1016\/S0021-9258(18)69278-6","volume":"261","author":"Hobbs","year":"1896","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.3873704","volume":"228","author":"S\u00fcdhof","year":"1985","journal-title":"Science"},{"key":"10.1016\/S0021-9258(18)37702-0_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0968-0004(85)90140-9","volume":"10","author":"Doolittle","year":"1985","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0021-9258(18)37702-0_bib16","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1073\/pnas.80.7.1802","volume":"80","author":"Drakenberg","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)37702-0_bib17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0014-5793(84)80023-X","volume":"165","author":"Sugo","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1016\/S0021-9258(18)37702-0_bib18","doi-asserted-by":"crossref","first-page":"7856","DOI":"10.1073\/pnas.84.22.7856","volume":"84","author":"Przysiecki","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)37702-0_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0021-9258(19)57350-1","volume":"263","author":"Stenflo","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib20","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/326760a0","volume":"326","author":"Davis","year":"1987","journal-title":"Nature"},{"key":"10.1016\/S0021-9258(18)37702-0_bib21","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1016\/S0021-9258(17)35862-3","volume":"261","author":"Davis","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib22","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0092-8674(83)90079-X","volume":"32","author":"Tolleshaug","year":"1983","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)37702-0_bib23","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1126\/science.3010466","volume":"232","author":"Yamamoto","year":"1986","journal-title":"Science"},{"key":"10.1016\/S0021-9258(18)37702-0_bib24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0021-9258(19)75941-9","volume":"262","author":"Lehrman","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib25","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1083\/jcb.106.6.1831","volume":"106","author":"Pathak","year":"1988","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0021-9258(18)37702-0_bib26","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0092-8674(86)90076-0","volume":"46","author":"Gething","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)37702-0_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0076-6879(83)98152-1","volume":"98","author":"Goldstein","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0021-9258(18)37702-0_bib28","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1073\/pnas.78.3.1396","volume":"78","author":"Kovanen","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0021-9258(18)37702-0_bib29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0092-8674(84)90388-X","volume":"37","author":"Russell","year":"1984","journal-title":"Cell"},{"key":"10.1016\/S0021-9258(18)37702-0_bib30","doi-asserted-by":"crossref","first-page":"11923","DOI":"10.1016\/S0021-9258(19)68494-2","volume":"256","author":"Beisiegel","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib31","doi-asserted-by":"crossref","first-page":"17443","DOI":"10.1016\/S0021-9258(18)45399-9","volume":"262","author":"van Driel","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib32","doi-asserted-by":"crossref","first-page":"16127","DOI":"10.1016\/S0021-9258(18)47706-X","volume":"262","author":"van Driel","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-9258(18)37702-0_bib33","series-title":"Molecular Cloning: A Laboratory Manual","author":"Maniatis","year":"1982"},{"key":"10.1016\/S0021-9258(18)37702-0_bib34","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1089\/dna.1.1984.3.479","volume":"3","author":"Zoller","year":"1984","journal-title":"DNA (NY)"},{"key":"10.1016\/S0021-9258(18)37702-0_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0076-6879(83)01005-8","volume":"101","author":"Messing","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0021-9258(18)37702-0_bib36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-2836(80)90196-5","volume":"143","author":"Sanger","year":"1980","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0021-9258(18)37702-0_bib37","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/0076-6879(83)00074-9","volume":"100","author":"Zoller","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0021-9258(18)37702-0_bib38","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.2990046","volume":"229","author":"Myers","year":"1985","journal-title":"Science"},{"key":"10.1016\/S0021-9258(18)37702-0_bib39","series-title":"DNA Cloning II. A Practical Approach.","first-page":"143","author":"Gorman","year":"1985"},{"key":"10.1016\/S0021-9258(18)37702-0_bib40","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.2988123","volume":"228","author":"S\u00fcdhof","year":"1985","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818377020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818377020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T04:52:12Z","timestamp":1758171132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818377020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":40,"journal-issue":{"issue":"26","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["S0021925818377020"],"URL":"https:\/\/doi.org\/10.1016\/s0021-9258(18)37702-0","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1988,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutational analysis of the ligand binding domain of the low density lipoprotein receptor.","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0021-9258(18)37702-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 1988 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}