{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:44:10Z","timestamp":1779345850212,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5556,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1016\/s0092-8674(00)81165-4","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T09:39:29Z","timestamp":1081589969000},"page":"361-372","source":"Crossref","is-referenced-by-count":849,"title":["Gene Dosage\u2013Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300"],"prefix":"10.1016","volume":"93","author":[{"given":"Tso-Pang","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk P","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-Dong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian-Ee","family":"Ch'ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Newsome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderick T","family":"Bronson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"En","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Eckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81165-4_BIB1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ng1097-211","article-title":"Drosophila CBP is required for dorsal-dependent twist gene expression","volume":"17","author":"Akimaru","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0092-8674(94)90127-9","article-title":"E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators","volume":"77","author":"Arany","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB3","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0092-8674(00)80304-9","article-title":"Recruitment of p300\/CBP in p53-dependent signal pathways","volume":"89","author":"Avantaggiati","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB4","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/384641a0","article-title":"The CBP co-activator is a histone acetyltransferase","volume":"384","author":"Bannister","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.279.5349.349","article-title":"Extension of life-span by introduction of telomerase into normal human cells","volume":"279","author":"Bodnar","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ng0996-33","article-title":"The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein","volume":"14","author":"Borrow","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/380435a0","article-title":"Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele","volume":"380","author":"Carmeliet","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB8","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1101\/gad.9.6.686","article-title":"twist is required in head mesenchyme for cranial neural tube morphogenesis","volume":"9","author":"Chen","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0092-8674(00)80516-4","article-title":"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P\/CAF and CBP\/p300","volume":"90","author":"Chen","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB10","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/365855a0","article-title":"Phosphorylated CREB binds specifically to the nuclear protein","volume":"365","author":"Chrivia","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB11","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/359328a0","article-title":"Requirement for a functional RB-1 gene in murine development","volume":"359","author":"Clarke","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0168-9525(93)90208-Y","article-title":"Transcriptional regulation of multigene loci","volume":"9","author":"Dillon","year":"1993","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB13","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1101\/gad.8.8.869","article-title":"Molecular cloning and functional analysis of the adenovirus E1A-associated 300-KD protein (p300) reveals a protein with properties of a transcriptional adaptor","volume":"7","author":"Eckner","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB14","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1101\/gad.10.19.2478","article-title":"Interaction and functional collaboration of p300\/CBP and bHLH proteins in muscle and B-cell differentiation","volume":"10","author":"Eckner","year":"1996","journal-title":"Genes Dev"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB15","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1128\/MCB.16.7.3454","article-title":"Association of p300 and CBP with simian virus 40 large T antigen","volume":"16","author":"Eckner","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0092-8674(91)90071-6","article-title":"splotch (Sp2H ), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3","volume":"67","author":"Epstein","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/380439a0","article-title":"Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene","volume":"380","author":"Ferrara","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0092-8674(95)90075-6","article-title":"Unique response pathways are established by allosteric interactions among nuclear hormone receptors","volume":"81","author":"Forman","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB19","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1073\/pnas.94.7.2927","article-title":"CREB-binding protein\/p300 are transcriptional coactivators of p65","volume":"94","author":"Gerritsen","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/38664","article-title":"Histone acetylation in chromatin structure and transcription","volume":"389","author":"Grunstein","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0092-8674(00)80521-8","article-title":"Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain","volume":"90","author":"Gu","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/42972","article-title":"Synergistic activation of transcription by CBP and p53","volume":"387","author":"Gu","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB23","doi-asserted-by":"crossref","first-page":"11540","DOI":"10.1073\/pnas.93.21.11540","article-title":"p300 is a component of an estrogen receptor coactivator complex","volume":"93","author":"Hanstein","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB24","doi-asserted-by":"crossref","first-page":"20049","DOI":"10.1074\/jbc.272.32.20049","article-title":"Transcriptional coactivator p300 stimulates cell type\u2013specific gene expression in cardiac myocytes","volume":"272","author":"Hasegawa","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB25","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1073\/pnas.87.15.5883","article-title":"Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis","volume":"87","author":"Howe","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB26","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1182\/blood.V90.12.4699","article-title":"Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)","volume":"90","author":"Ida","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0092-8674(00)81118-6","article-title":"A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors","volume":"85","author":"Kamei","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","article-title":"Targeted mutation of the DNA methyltransferase gene results in embryonic lethality","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/42981","article-title":"Binding and modulation of p53 by p300\/CBP coactivators","volume":"387","author":"Lill","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB30","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1126\/science.276.5317.1404","article-title":"Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C","volume":"276","author":"Lin","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB31","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0092-8674(00)80538-3","article-title":"hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization","volume":"90","author":"Meyerson","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB32","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(93)90573-9","article-title":"High affinity VEGF binding and developmental expression suggest FLK-1 as a major regulator of vasculogenesis and angiogenesis","volume":"72","author":"Millauer","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/0092-8674(95)90139-6","article-title":"Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins","volume":"83","author":"Molkentin","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0959-437X(05)80342-9","article-title":"DNA tumor virus transforming proteins and the cell cycle","volume":"3","author":"Moran","year":"1993","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB35","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0092-8674(00)80376-1","article-title":"RNA helicase A mediates association of CBP with RNA polymerase II","volume":"90","author":"Nakajima","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB36","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1101\/gad.11.6.738","article-title":"Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors","volume":"11","author":"Nakajima","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB37","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.277.5328.955","article-title":"Telomerase catalytic subunit homologs from fission yeast and human [see comments]","volume":"277","author":"Nakamura","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB38","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1126\/science.1411535","article-title":"E2F","volume":"258","author":"Nevins","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB39","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1002\/j.1460-2075.1996.tb00637.x","article-title":"Interaction of the co-activator CBP with Myb proteins","volume":"15","author":"Oelgeschlager","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB40","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0092-8674(00)82001-2","article-title":"The transcriptional coactivators p300 and CBP are histone acetyltransferases","volume":"87","author":"Ogryzko","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB41","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1128\/MCB.16.2.694","article-title":"Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism","volume":"16","author":"Parker","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB42","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1126\/science.275.5299.523","article-title":"Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator","volume":"275","author":"Perkins","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB43","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/376348a0","article-title":"Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP","volume":"376","author":"Petrij","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/emboj\/16.2.369","article-title":"p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription","volume":"16","author":"Puri","year":"1997","journal-title":"Embo J"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB45","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1128\/MCB.17.2.1010","article-title":"Molecular mechanisms of myogenic coactivation by p300","volume":"17","author":"Sartorelli","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/381235a0","article-title":"Transcription factor AP-2 essential for cranial closure and craniofacial development","volume":"381","author":"Schorle","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB47","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0168-9525(91)90215-C","article-title":"Cross-coupling of signal transduction pathways","volume":"7","author":"Schule","year":"1991","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB48","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0962-8924(97)01048-9","article-title":"The p300\/CBP family","volume":"7","author":"Shikama","year":"1997","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB49","doi-asserted-by":"crossref","first-page":"8884","DOI":"10.1073\/pnas.93.17.8884","article-title":"CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor\u2013dependent transcription","volume":"93","author":"Smith","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB50","doi-asserted-by":"crossref","first-page":"8732","DOI":"10.1073\/pnas.94.16.8732","article-title":"MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)","volume":"94","author":"Sobulo","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB51","doi-asserted-by":"crossref","first-page":"10215","DOI":"10.1073\/pnas.94.19.10215","article-title":"Abnormal skeletal patterning in embryos lacking a single Cbp allele","volume":"94","author":"Tanaka","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB52","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/42652","article-title":"The transcriptional co-activator p\/CIP binds CBP and mediates nuclear-receptor function","volume":"387","author":"Torchia","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB53","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0968-0004(97)01016-5","article-title":"Histone acetylation","volume":"22","author":"Wade","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(00)81165-4_BIB54","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0092-8674(89)90984-7","article-title":"Cellular targets for transformation by the adenovirus E1A","volume":"56","author":"Whyte","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB55","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/382319a0","article-title":"A p300\/CBP-associated factor that competes with the adenoviral oncoprotein E1A","volume":"382","author":"Yang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81165-4_BIB56","doi-asserted-by":"crossref","first-page":"10626","DOI":"10.1073\/pnas.93.20.10626","article-title":"The nuclear hormone receptor coactivator SRC-1 is a specific target of p300","volume":"93","author":"Yao","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400811654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400811654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T23:08:31Z","timestamp":1585696111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400811654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["S0092867400811654"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81165-4","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}