{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:45:49Z","timestamp":1784810749579,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5617,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1016\/s0092-8674(00)81410-5","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T05:39:29Z","timestamp":1081575569000},"page":"829-839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3277,"title":["A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis"],"prefix":"10.1016","volume":"92","author":[{"given":"Pere","family":"Puigserver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reed","family":"Graves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M","family":"Spiegelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81410-5_BIB1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1126\/science.277.5328.965","article-title":"AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer","volume":"277","author":"Anzick","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/384641a0","article-title":"The CBP co-activator is a histone acetyltransferase","volume":"384","author":"Bannister","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-5793(97)00384-0","article-title":"Uncoupling protein-3","volume":"408","author":"Boss","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB4","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/S0021-9258(17)35962-8","article-title":"Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein","volume":"5","author":"Bouillaud","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB5","first-page":"R1291","article-title":"Increase in cytochrome oxidase capacity of BAT and other tissues in cold-acclimated gerbils","volume":"258","author":"Bourhim","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1042\/bst0240407","article-title":"Adrenergic regulation of brown adipocyte differentiation","volume":"24","author":"Cannon","year":"1996","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB7","doi-asserted-by":"crossref","first-page":"24335","DOI":"10.1016\/S0021-9258(19)51087-0","article-title":"In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor, and a CACCC box-binding protein","volume":"269","author":"Cassard-Doulcier","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB8","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1002\/j.1460-2075.1995.tb00044.x","article-title":"Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor","volume":"14","author":"Cavailles","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/383099a0","article-title":"Role of CBP\/P300 in nuclear receptor signaling","volume":"383","author":"Chakravarti","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB10","doi-asserted-by":"crossref","first-page":"10774","DOI":"10.1073\/pnas.88.23.10774","article-title":"Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs","volume":"88","author":"Champigny","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0092-8674(00)80516-4","article-title":"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex","volume":"90","author":"Chen","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng0397-269","article-title":"Uncoupling protein-2","volume":"15","author":"Fleury","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ng0397-223","article-title":"Obesity research springs a proton leak","volume":"15","author":"Flier","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0006-2952(96)00345-0","article-title":"Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent","volume":"52","author":"Foellmi-Adams","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB15","first-page":"383","article-title":"Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans","volume":"16","author":"Garruti","year":"1992","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB16","doi-asserted-by":"crossref","first-page":"900","DOI":"10.2337\/diab.46.5.900","article-title":"Cloning and characterization of an uncoupling protein homolog","volume":"46","author":"Gimeno","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB17","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0955-0674(97)80066-X","article-title":"Nuclear receptor coactivators","volume":"9","author":"Glass","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB18","doi-asserted-by":"crossref","first-page":"24129","DOI":"10.1074\/jbc.272.39.24129","article-title":"Uncoupling protein-3","volume":"270","author":"Gong","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0092-8674(01)80010-6","article-title":"Transcription properties of a cell type\u2013specific TATA-binding protein, TRF","volume":"91","author":"Hansen","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB20","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/42750","article-title":"A signature motif in transcriptional co-activators mediates binding to nuclear receptors","volume":"387","author":"Heery","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB21","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1139\/y89-063","article-title":"Role of thermogenesis in the regulation of energy balance in relation to obesity","volume":"67","author":"Himms-Hagen","year":"1989","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3181\/00379727-208-43847A","article-title":"Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats","volume":"208","author":"Himms-Hagen","year":"1995","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/377397a0","article-title":"Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor","volume":"377","author":"Horlein","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB24","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1126\/science.274.5295.2100","article-title":"Inhibition of adipogenesis through MAP kinase mediates phosphorylation of PPAR\u03b3","volume":"274","author":"Hu","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB25","doi-asserted-by":"crossref","first-page":"16250","DOI":"10.1016\/S0021-9258(17)36228-2","article-title":"Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression","volume":"260","author":"Jacobsson","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0092-8674(00)81118-6","article-title":"A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors","volume":"85","author":"Kamei","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB27","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1101\/gad.10.9.1096","article-title":"ADD1\/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism","volume":"10","author":"Kim","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/bj3160607","article-title":"Biogenesis of thermogenic mitochondria in brown adipose tissue of Djungarian hamsters during cold adaptation","volume":"316","author":"Klingenspor","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB29","first-page":"59","article-title":"An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene","volume":"14","author":"Kozak","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0092-8674(91)90620-E","article-title":"Functional activity of myogenic HLH proteins requires heter-oligomerization with E12\/E47-like proteins in vivo","volume":"66","author":"Lassar","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB31","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/366740a0","article-title":"Development of obesity in transgenic mice following the genetic ablation of brown adipose tissue","volume":"366","author":"Lowell","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0092-8674(92)90352-D","article-title":"A novel B cell\u2013derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors","volume":"71","author":"Luo","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB33","series-title":"Molecular Cloning","author":"Maniatis","year":"1989"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB34","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1042\/bj3080749","article-title":"Co-ordinate decrease in the expression of mitochondrial genome and nuclear genes for mitochondrial proteins in the lactation-induced mitochondrial hypotrophy of rat brown fat","volume":"308","author":"Martin","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0092-8674(00)80218-4","article-title":"Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase","volume":"89","author":"Nagy","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/bst0140223","article-title":"Mechanisms of thermogenesis in brown adipose tissue","volume":"14","author":"Nicholls","year":"1986","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB37","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.270.5240.1354","article-title":"Sequence and characterization of a coactivator for the steroid hormone receptor superfamily","volume":"270","author":"Onate","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)80211-1","article-title":"What is up and down with histone aceylation and transcription","volume":"89","author":"Pazin","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB39","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1073\/pnas.90.18.8392","article-title":"Production of high titre, helper-free retroviruses by transient transfection","volume":"90","author":"Pear","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1530\/eje.0.1360231","article-title":"Thyroid hormone and gene expression in the regulation of mitochondrial respiratory function","volume":"136","author":"Pillar","year":"1997","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB41","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1042\/bj3170827","article-title":"In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid","volume":"317","author":"Puigserver","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB42","doi-asserted-by":"crossref","first-page":"16464","DOI":"10.1016\/S0021-9258(17)46245-4","article-title":"Alpha- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture","volume":"25","author":"Rehnmark","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB43","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1128\/MCB.16.7.3410","article-title":"Differentiation-dependent expression of the brown adipocyte uncoupling protein gene","volume":"16","author":"Sears","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB44","first-page":"141","article-title":"Role of co-activators and co-repressors in the mechanism of steroid\/thyroid receptor action","volume":"52","author":"Shibata","year":"1997","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB45","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/thy.1995.5.481","article-title":"Thyroid hormone control of thermogenesis and energy balance","volume":"5","author":"Silva","year":"1995","journal-title":"Thyroid"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1530\/eje.0.1360251","article-title":"Regulation of the uncoupling protein gene expression","volume":"136","author":"Silva","year":"1997","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB47","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/38304","article-title":"Steroid receptor coactivator-1 is a histone acetyltransferase","volume":"389","author":"Spencer","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB48","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0092-8674(00)81359-8","article-title":"Adipogenesis and obesity","volume":"87","author":"Spiegelman","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB49","doi-asserted-by":"crossref","first-page":"29909","DOI":"10.1074\/jbc.271.47.29909","article-title":"Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation","volume":"271","author":"Tai","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB50","first-page":"1271","article-title":"Stimulation of adipogenesis in fibroblasts by PPAR\u03b32, a lipid-activated transcription factor","volume":"43","author":"Tontonoz","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB51","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1101\/gad.8.10.1224","article-title":"mPPAR\u03b32","volume":"8","author":"Tontonoz","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB52","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/42652","article-title":"The transcriptional co-activator p\/CIP binds CBP and mediates nuclear-receptor function","volume":"387","author":"Torchia","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.1997.6740","article-title":"UCP3","volume":"235","author":"Vidal-Puig","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB54","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1002\/j.1460-2075.1996.tb00736.x","article-title":"TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors","volume":"15","author":"Voegel","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB55","doi-asserted-by":"crossref","first-page":"16347","DOI":"10.1074\/jbc.270.27.16347","volume":"270","author":"Wrutniak","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81410-5_BIB56","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1073\/pnas.93.14.6975","article-title":"The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine\/arginine-rich proteins","volume":"93","author":"Yuryev","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81410-5_BIB57","doi-asserted-by":"crossref","first-page":"25500","DOI":"10.1074\/jbc.272.41.25500","article-title":"Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor","volume":"272","author":"Zhu","year":"1997","journal-title":"J. Biol. Chem."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400814105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400814105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:43:30Z","timestamp":1758797010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400814105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["S0092867400814105"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81410-5","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1998,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(00)81410-5","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Cell Press.  All rights reserved.","name":"copyright","label":"Copyright"}]}}