{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:27:40Z","timestamp":1773480460175,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2001,6,13]],"date-time":"2001-06-13T00:00:00Z","timestamp":992390400000},"content-version":"vor","delay-in-days":1351,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1016\/s0092-8674(01)80011-8","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T15:51:15Z","timestamp":1027612275000},"page":"85-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":235,"title":["Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins"],"prefix":"10.1016","volume":"91","author":[{"given":"Traci M.Tanaka","family":"Hall","sequence":"first","affiliation":[]},{"given":"Jeffery A.","family":"Porter","sequence":"additional","affiliation":[]},{"given":"Keith E.","family":"Young","sequence":"additional","affiliation":[]},{"given":"Eugene V.","family":"Koonin","sequence":"additional","affiliation":[]},{"given":"Philip A.","family":"Beachy","sequence":"additional","affiliation":[]},{"given":"Daniel J.","family":"Leahy","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(01)80011-8_BIB1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0076-6879(96)66029-7","article-title":"Local alignment statistics","volume":"266","author":"Altschul","year":"1996","journal-title":"Meth. Enzymol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB2","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST\u2014 a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB3","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1002\/pro.5560041202","article-title":"3D domain swapping","volume":"4","author":"Bennett","year":"1995","journal-title":"Prot. Sci."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB4","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/378416a0","article-title":"A protein catalytic framework with an N-terminal nucleophile is capable of self-activation","volume":"378","author":"Brannigan","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB5","series-title":"X-PLOR, Version 3.1","author":"Br\u00fcnger","year":"1992"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB6","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/MCB.15.4.2294","article-title":"Proteolytic processing yields two secreted forms of sonic hedgehog","volume":"15","author":"Bumcrot","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB7","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0960-9822(02)70659-3","article-title":"Warthog and Groundhog, novel families related to Hedgehog","volume":"6","author":"Burglin","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB001","first-page":"760","article-title":"The CCP4 suite","volume":"D50","author":"Collaborative Computational Project Number 4","year":"1994","journal-title":"Acta Crystallogr."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/cmb.1997.4.193","article-title":"Statistical modeling, phylogenetic analysis and structure prediction of a protein splicing domain common to inteins and hedgehog proteins","volume":"4","author":"Dalgaard","year":"1997","journal-title":"J. Comput. Biol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0092-8674(00)80237-8","article-title":"Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity","volume":"89","author":"Duan","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB10","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1242\/dev.121.8.2337","article-title":"Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis","volume":"121","author":"Ekker","year":"1995","journal-title":"Development"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB11","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S0960-9822(95)00185-0","article-title":"Patterning activities of vertebrate hedgehog proteins in the developing eye and brain","volume":"5","author":"Ekker","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0092-8674(95)90398-4","article-title":"Long-range sclerotome induction by sonic hedgehog","volume":"81","author":"Fan","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB13","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0960-9822(95)00129-1","article-title":"Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signaling in Drosophila","volume":"5","author":"Fietz","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB14","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1074\/jbc.271.3.1732","article-title":"Activation of Glycosylasparaginase","volume":"271","author":"Guan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0168-9525(96)10051-2","article-title":"The world according to hedgehog","volume":"13","author":"Hammerschmidt","year":"1997","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0968-0004(00)89073-8","article-title":"Circular permutations of protein sequence","volume":"20","author":"Heinemann","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1126\/science.1925561","article-title":"Determination of macromolecular structures from anomalous diffraction of synchrotron radiation","volume":"254","author":"Hendrickson","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB18","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/j.1460-2075.1990.tb08287.x","article-title":"Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD)","volume":"9","author":"Hendrickson","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB19","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/pro.5560050204","article-title":"PROMOTIF\u2014a program to identify and analyze structural motifs in proteins","volume":"5","author":"Hutchinson","year":"1996","journal-title":"Prot. Sci."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0896-6273(95)90062-4","article-title":"Induction of midbrain dopaminergic neurons by Sonic hedgehog","volume":"15","author":"Hynes","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB21","first-page":"528","article-title":"Recombinant circle PCR and recombination PCR for site-specific mutagenesis without PCR product purification","volume":"12","author":"Jones","year":"1992","journal-title":"Biotechniques"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for the building of protein methods in electron density maps and the location of errors in these models","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr., A"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0968-0004(00)88989-6","article-title":"A protein splice-junction motif in hedgehog family proteins","volume":"20","author":"Koonin","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB24","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","article-title":"MOLSCRIPT","volume":"24","author":"Kraulis","year":"1991","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB25","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1242\/dev.121.8.2349","article-title":"Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage","volume":"121","author":"Lai","year":"1995","journal-title":"Development"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/prot.340190107","article-title":"Crystallization of a fragment of human fibronectin","volume":"19","author":"Leahy","year":"1994","journal-title":"Proteins"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB27","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.7985023","article-title":"Auto-proteolysis in hedgehog protein biogenesis","volume":"266","author":"Lee","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB28","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1126\/science.271.5253.1247","article-title":"Crystal structure of the lactose operon repressor and its complexes with DNA and inducer","volume":"271","author":"Lewis","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB29","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0960-9822(95)00156-4","article-title":"Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage","volume":"5","author":"Lopez-Martinez","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/protein\/1.1.37","article-title":"The crystal structure of alpha-bungarotoxin at 2.5 \u00c5 resolution","volume":"1","author":"Love","year":"1986","journal-title":"Prot. Eng."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/375322a0","article-title":"Requirement of 19K form of sonic hedgehog for induction of distinct ventral cell types in CNS explants","volume":"375","author":"Marti","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB32","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0959-440X(96)80059-5","article-title":"Structural classification of proteins","volume":"6","author":"Murzin","year":"1996","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Meth. Enzymol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB34","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1093\/nar\/22.7.1125","article-title":"Protein splicing elements","volume":"22","author":"Perler","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB35","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/nar\/25.6.1087","article-title":"Compilation and analysis of intein sequences","volume":"25","author":"Perler","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB36","article-title":"Modular organization of inteins and C-terminal autocatalytic domains","volume":"in press","author":"Pietrokovski","year":"1997","journal-title":"Prot. Sci."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB37","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1002\/pro.5560031218","article-title":"Conserved sequence features of inteins (protein introns) and their use in identifying new inteins and related proteins","volume":"3","author":"Pietrokovski","year":"1994","journal-title":"Prot. Sci."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0968-0004(00)89003-9","article-title":"Swaposins","volume":"20","author":"Ponting","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB39","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/374363a0","article-title":"The product of hedgehog autoproteolytic cleavage active in local and long-range signaling","volume":"374","author":"Porter","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0092-8674(00)80074-4","article-title":"Hedgehog patterning activity","volume":"86","author":"Porter","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.274.5285.255","article-title":"Cholesterol modification of Hedgehog signaling proteins in animal development","volume":"274","author":"Porter","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB42","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0076-6879(97)76077-4","article-title":"Treatment of multiwavelength anomalous diffraction data as a special case of multiple isomorphous replacement","volume":"276","author":"Ramakrishnan","year":"1997","journal-title":"Meth. Enzymol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0022-2836(90)90161-E","article-title":"Cardiotoxin VII4 from Naja mossambica mossambica","volume":"214","author":"Rees","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0092-8674(95)90397-6","article-title":"Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis","volume":"81","author":"Roelink","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB45","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/prot.340090304","article-title":"A workbench for multiple alignment construction and analysis","volume":"9","author":"Schuler","year":"1991","journal-title":"Proteins"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB46","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1126\/science.7973627","article-title":"Crystal structure of LacI member, PurR, bound to DNA","volume":"266","author":"Schumacher","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB002","first-page":"18","article-title":"The application of direct methods and Patterson interpretation to high-resolution native protein structure","volume":"D49","author":"Sheldrick","year":"1993","journal-title":"Acta Crystallogr."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB47","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0092-8674(01)80011-8_BIB48","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1073\/pnas.72.3.777","article-title":"Crystallization of nerve growth factor from mouse submaxillary glands","volume":"72","author":"Wlodawer","year":"1975","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(01)80011-8_BIB49","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1002\/j.1460-2075.1996.tb00898.x","article-title":"The mechanism of protein splicing and its modulation by mutation","volume":"15","author":"Xu","year":"1996","journal-title":"EMBO J."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867401800118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867401800118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:45:43Z","timestamp":1758797143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867401800118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["S0092867401800118"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(01)80011-8","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1997,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(01)80011-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 Cell Press.  All rights reserved.","name":"copyright","label":"Copyright"}]}}