{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:06:10Z","timestamp":1789088770567,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"10559","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/s0140-6736(26)01295-x","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:01:56Z","timestamp":1788476516000},"page":"1029-1040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Porcine kidney xenotransplantation as a bridge to allotransplantation: a first-in-human study"],"prefix":"10.1016","volume":"408","author":[{"given":"Leonardo V","family":"Riella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago J","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy A","family":"Rosales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire T","family":"Avillach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnar","family":"Palsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hullekes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchama","family":"Verhoeff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pomahac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Santagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Giarraputo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Neal","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen N","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay A","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Getchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Perrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kolev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Bercovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme T","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha K","family":"Tanguturi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneesh C","family":"Bapat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Pattanayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Longchamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"El-Khoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Duggan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimul","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Pierson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joren C","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay A","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahel","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Colvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(26)01295-X_bib1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.2215\/CJN.01280209","article-title":"Half of kidney transplant candidates who are older than 60 years now placed on the waiting list will die before receiving a deceased-donor transplant","volume":"4","author":"Schold","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/S0140-6736(26)01295-X_bib2","doi-asserted-by":"crossref","first-page":"e1691","DOI":"10.1016\/S2214-109X(25)00222-0","article-title":"The potential of kidney transplantation to reduce mortality from chronic kidney disease: a global, cross-sectional, modelling study","volume":"13","author":"Zambeli-Ljepovi\u0107","year":"2025","journal-title":"Lancet Glob Health"},{"key":"10.1016\/S0140-6736(26)01295-X_bib3","doi-asserted-by":"crossref","DOI":"10.1097\/TP.0000000000005652","article-title":"Advancing hope through science: The Inaugural Richard Slayman International Workshop on Xenotransplantation","author":"Riella","year":"2026","journal-title":"Transplantation"},{"key":"10.1016\/S0140-6736(26)01295-X_bib4","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/ajt.16930","article-title":"First clinical-grade porcine kidney xenotransplant using a human decedent model","volume":"22","author":"Porrett","year":"2022","journal-title":"Am J Transplant"},{"key":"10.1016\/S0140-6736(26)01295-X_bib5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/SLA.0000000000004996","article-title":"Anti-C5 antibody tesidolumab reduces early antibody-mediated rejection and prolongs survival in renal xenotransplantation","volume":"274","author":"Adams","year":"2021","journal-title":"Ann Surg"},{"key":"10.1016\/S0140-6736(26)01295-X_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJMoa2201422","article-title":"Genetically modified porcine-to-human cardiac xenotransplantation","volume":"387","author":"Griffith","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(26)01295-X_bib7","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1056\/NEJMoa2412747","article-title":"Xenotransplantation of a porcine kidney for end-stage kidney disease","volume":"392","author":"Kawai","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(26)01295-X_bib8","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1056\/NEJMoa2120238","article-title":"Results of two cases of pig-to-human kidney xenotransplantation","volume":"386","author":"Montgomery","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(26)01295-X_bib9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41591-025-04053-3","article-title":"Immune profiling in a living human recipient of a gene-edited pig kidney","volume":"32","author":"Ribas","year":"2026","journal-title":"Nat Med"},{"key":"10.1016\/S0140-6736(26)01295-X_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nm1172","article-title":"Marked prolongation of porcine renal xenograft survival in baboons through the use of \u03b11,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue","volume":"11","author":"Yamada","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/S0140-6736(26)01295-X_bib11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41586-023-06594-4","article-title":"Design and testing of a humanized porcine donor for xenotransplantation","volume":"622","author":"Anand","year":"2023","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(26)01295-X_bib12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41586-025-09847-6","article-title":"Physiology and immunology of a pig-to-human decedent kidney xenotransplant","volume":"650","author":"Montgomery","year":"2025","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(26)01295-X_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12880","article-title":"Iscalimab combined with transient tesidolumab prolongs survival in pig-to-rhesus monkey renal xenografts","volume":"31","author":"Adams","year":"2024","journal-title":"Xenotransplantation"},{"key":"10.1016\/S0140-6736(26)01295-X_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-47679-6","article-title":"Consistent survival in consecutive cases of life-supporting porcine kidney xenotransplantation using 10GE source pigs","volume":"15","author":"Eisenson","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/S0140-6736(26)01295-X_bib15","article-title":"Physiologic homeostasis in a living human after pig kidney xenotransplantation","volume":"16","author":"Lee","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/S0140-6736(26)01295-X_bib16","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/ndt\/gfw099","article-title":"The mode of sensitization and its influence on allograft outcomes in highly sensitized kidney transplant recipients","volume":"31","author":"Redfield","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/S0140-6736(26)01295-X_bib17","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1097\/TP.0000000000004197","article-title":"Expert opinion special feature: patient selection for initial clinical trials of pig organ transplantation","volume":"106","author":"Pierson","year":"2022","journal-title":"Transplantation"},{"key":"10.1016\/S0140-6736(26)01295-X_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ajt.2025.10.005","article-title":"Beyond theory and into practice: a qualitative study of the experiences of xenotransplant recipients","volume":"26","author":"Levan","year":"2025","journal-title":"Am J Transplant"},{"key":"10.1016\/S0140-6736(26)01295-X_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-38465-x","article-title":"Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation","volume":"14","author":"Firl","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/S0140-6736(26)01295-X_bib20","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1034\/j.1600-6143.2003.00179.x","article-title":"Accommodation in ABO-incompatible kidney allografts, a novel mechanism of self-protection against antibody-mediated injury","volume":"3","author":"Park","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1016\/S0140-6736(26)01295-X_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1681\/ASN.2008030279","article-title":"C4d deposition without rejection correlates with reduced early scarring in ABO-incompatible renal allografts","volume":"20","author":"Haas","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/S0140-6736(26)01295-X_bib22","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/ki.2011.497","article-title":"Pros and cons for C4d as a biomarker","volume":"81","author":"Cohen","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/S0140-6736(26)01295-X_bib23","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/cas.14692","article-title":"Programmed cell death 1-expressing CD56-negative natural killer (NK) cell expansion is a hallmark of chronic NK cell activation during dasatinib treatment","volume":"112","author":"Ishiyama","year":"2021","journal-title":"Cancer Sci"},{"key":"10.1016\/S0140-6736(26)01295-X_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/JCI175996","article-title":"C5 inhibition with eculizumab prevents thrombotic microangiopathy in a case series of pig-to-human kidney xenotransplantation","volume":"134","author":"Jones-Carr","year":"2024","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(26)01295-X_bib25","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/S0140-6736(23)01349-1","article-title":"Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study","volume":"402","author":"Loupy","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(26)01295-X_bib26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41586-025-09846-7","article-title":"Multi-omics analysis of a pig-to-human decedent kidney xenotransplant","volume":"650","author":"Schmauch","year":"2025","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(26)01295-X_bib27","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.kint.2025.11.018","article-title":"Mechanistic insights from transcript analysis of long-term pig to non-human primate kidney xenografts","volume":"109","author":"Rosales","year":"2026","journal-title":"Kidney Int"},{"key":"10.1016\/S0140-6736(26)01295-X_bib28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(23)00775-4","article-title":"Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report","volume":"402","author":"Mohiuddin","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(26)01295-X_bib29","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.ajt.2025.06.030","article-title":"Sensitization in transplantation assessment of risk 2025 innate working group: the potential role of innate allorecognition in kidney allograft damage","volume":"25","author":"Thaunat","year":"2025","journal-title":"Am J Transplant"},{"key":"10.1016\/S0140-6736(26)01295-X_bib30","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.ajt.2025.06.016","article-title":"Infectious disease surveillance and management in clinical xenotransplantation: experience with the first human porcine kidney transplant","volume":"25","author":"Fishman","year":"2025","journal-title":"Am J Transplant"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014067362601295X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014067362601295X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:07:33Z","timestamp":1789085253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014067362601295X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"journal-issue":{"issue":"10559","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S014067362601295X"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(26)01295-x","relation":{},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porcine kidney xenotransplantation as a bridge to allotransplantation: a first-in-human study","name":"articletitle","label":"Article Title"},{"value":"The Lancet","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0140-6736(26)01295-X","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/S0140-6736(26)01479-0","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}