{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:39:57Z","timestamp":1776742797099,"version":"3.51.2"},"reference-count":55,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1016\/s0143-4160(98)90028-8","type":"journal-article","created":{"date-parts":[[2004,4,23]],"date-time":"2004-04-23T05:53:05Z","timestamp":1082699585000},"page":"323-338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALMS"],"prefix":"10.1016","volume":"23","author":[{"given":"Sonja L.","family":"Toutenhoofd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Foletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Wicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes A.","family":"Rhyner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Tolon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel E.","family":"Strehler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0143-4160(98)90028-8_BIB1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.bi.56.070187.002143","article-title":"Intracellular calcium homeostasis","volume":"56","author":"Carafoli","year":"1987","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB2","series-title":"Calmodulin","volume":"Vol. 5","year":"1988"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB3","first-page":"34","article-title":"Calmodulin","author":"Rogers","year":"1996"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/geno.1993.1211","article-title":"Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14824-q31, 2p21.1-p21.3, and 19813.2-813.3","volume":"16","author":"Berchtold","year":"1993","journal-title":"Genomics"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB5","doi-asserted-by":"crossref","first-page":"17055","DOI":"10.1016\/S0021-9258(18)37497-0","article-title":"Multiple divergent mRNAs code for a single human calmodulin","volume":"263","author":"Fischer","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB6","first-page":"1873","article-title":"Multiple calmodulin mRNA species are derived from two distinct genes","volume":"7","author":"Nojima","year":"1987","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0022-2836(89)90388-4","article-title":"Structural organization of multiple rat calmodulin genes","volume":"208","author":"Nojima","year":"1989","journal-title":"J Mol Biol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0169-328X(92)90039-E","article-title":"Molecular cloning of calmodulin mRNA species which are preferentially expressed in neurons in the rat brain","volume":"13","author":"Ni","year":"1992","journal-title":"Mol Brain Res"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1432-1033.1994.00071.x","article-title":"Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM 1P1 and CALM1P2","volume":"225","author":"Rhyner","year":"1994","journal-title":"Eur J Biochem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/jcb.240580407","article-title":"Multiple mRNA species are generated by alternate polyadenylation from the human calmodulin-I gene","volume":"58","author":"Senterre-Lesenfants","year":"1995","journal-title":"J Cell Biochem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0022-2836(87)90258-0","article-title":"The structure of a gene for rat calmodulin","volume":"193","author":"Nojima","year":"1987","journal-title":"J Mol Biol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB12","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0167-4781(90)90203-E","article-title":"Structural organization of the human CaMIII calmodulin gene","volume":"1087","author":"Koller","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0169-328X(94)90046-9","article-title":"Distribution and regulation of calmodulin mRNAs in rat brain","volume":"22","author":"Gannon","year":"1994","journal-title":"Mol Brain Res"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB14","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1091\/mbc.2.10.819","article-title":"Developmental regulation of calmodulin gene expression in rat brain and skeletal muscle","volume":"2","author":"Weinman","year":"1991","journal-title":"Cell Regul"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jnr.490360112","article-title":"Expression of three nonallelic genes coding calmodulin exhibits similar localization on the central nervous system of adult rats","volume":"36","author":"Ikeshima","year":"1993","journal-title":"J Neurosci Res"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB16","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1210\/mend-3-10-1569","article-title":"Analysis of expression of multiple genes encoding calmodulin during spermatogenesis","volume":"3","author":"Slaughter","year":"1989","journal-title":"Mol Endocrinol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB17","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0006-291X(89)92434-0","article-title":"Differential calmodulin gene expression in fetal, adult, and neoplastic tissues of rodents","volume":"159","author":"MacManus","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB18","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0143-4160(93)90061-A","article-title":"Calmodulin expression during proliferative activation of human T lymphocytes","volume":"14","author":"Colomer","year":"1993","journal-title":"Cell Calcium"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB19","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/hep.1840200432","article-title":"Calmodulin expression during rat liver regeneration","volume":"20","author":"Agell","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jcp.1041540218","article-title":"Coordinate regulation of mRNAs from multiple calmodulin genes during myoblast differentiation in vitro","volume":"154","author":"Christenson","year":"1993","journal-title":"J Cell Physiol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB21","author":"Sambrook","year":"1989"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0003-2697(83)90418-9","article-title":"A technique for labeling DNA endonuclease restriction fragments to high specific activity","volume":"132","author":"Feinberg","year":"1983","journal-title":"Anal Biochem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00291357","article-title":"Unusual scarcity of restriction site polymorphism in the human thyroglobulin gene. A linkage study suggesting autosomal dominance of a defective thyroglobulin allele","volume":"67","author":"Baas","year":"1984","journal-title":"Hum Genet"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB24","series-title":"Current Protocols in Molecular Biology","author":"Ausubel","year":"1996"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single step method of RNA extraction by acid-guanidium-thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB26","doi-asserted-by":"crossref","first-page":"16663","DOI":"10.1016\/S0021-9258(18)49306-4","article-title":"Molecular analysis of human and rat calmodulin complementary DNA clones","volume":"262","author":"SenGupta","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0306-4522(96)00214-X","article-title":"Comparative study of the pattern of expression of calmodulin messenger RNAs in the mouse brain","volume":"75","author":"Sola","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0143-4160(91)90038-G","article-title":"Neural regulation of calmodulin in adult Xenopus leg muscle","volume":"12","author":"Nishikawa","year":"1991","journal-title":"Cell Calcium"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB29","first-page":"8842","article-title":"A calcium responsive element that regulates expression of two calcium binding proteins in Purkinje cells","volume":"94","author":"Arnold","year":"1997"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0092-8674(89)90176-1","article-title":"The \u2018initiator\u2019 as a transcription control element","volume":"57","author":"Smale","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-4838(93)90271-R","article-title":"Fucctional analysis of the promoters of the human CaMIII calmodulin gene and of the intronless gene coding for a calmodulin-like protein","volume":"1163","author":"Koller","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/321209a0","article-title":"CpGrich islands and the function of DNA methylation","volume":"321","author":"Bird","year":"1986","journal-title":"Nature"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB33","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/jcp.1041490309","article-title":"The increase of calmodulin in PC 12 cells induced by NGF is caused by differential expression of multiple mRNAs for calmodulin","volume":"149","author":"Bai","year":"1991","journal-title":"J Cell Physiol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB34","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/jcp.1041590318","article-title":"Expression of calmodulin and calmodulin binding proteins in lymphoblastoid cells","volume":"159","author":"Colomer","year":"1994","journal-title":"J Cell Physiol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB35","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/jnr.490420503","article-title":"Developmental expression of calmodulin mRNA and protein in regions of the postnatal rat brain","volume":"42","author":"Berry","year":"1995","journal-title":"J Neurosci Res"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1210\/mend-3-1-193","article-title":"Chicken calmodulin promoter activity in proliferating and differentiated cells","volume":"3","author":"Epstein","year":"1989","journal-title":"Mol Endocrinol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0169-328X(93)90106-Y","article-title":"Expression of the rat calmodulin gene II in the central nervous system: a 294-base promoter and 68-base leader segment mediates neuron-specific gene expression in transgenic mice","volume":"20","author":"Matsuo","year":"1993","journal-title":"Mol Brain Res"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0303-7207(94)90145-7","article-title":"Spermatocyte-specific transcription by calmodulin gene I1 promoter in transgenic mice","volume":"99","author":"Ikeshima","year":"1994","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0169-328X(95)00032-N","article-title":"Spatial and temporal regulation of the rat calmodulin gene III directed by a 877-base promoter and 103-base leader segment in the mature and embryonal central nervous system of transgenic mice","volume":"31","author":"Shimoda","year":"1995","journal-title":"Mol Brain Res"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB40","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0092-8674(86)90599-4","article-title":"Isolation of the yeast calmodulin gene: calmodulin is an essential protein","volume":"47","author":"Davis","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0306-4522(96)00532-5","article-title":"Differential response of calmodulin genes in the mouse brain after systemic kainate administration","volume":"78","author":"Sola","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB42","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0169-328X(95)00015-K","article-title":"Effect of hexachlorocyclohexane isomers on calmodulin mRNA expression in the central nervous system","volume":"30","author":"Barron","year":"1995","journal-title":"Mol Brain Res"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB43","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0959-437X(95)80044-1","article-title":"CpG islands and genes","volume":"5","author":"Cross","year":"1995","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB44","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1074\/jbc.271.8.4417","article-title":"The serotonin la receptor gene contains a TATA-less promoter that responds to MAZ and Sp 1","volume":"271","author":"Parks","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB45","doi-asserted-by":"crossref","first-page":"16308","DOI":"10.1074\/jbc.270.27.16308","article-title":"The human medium chain acyl-CoA dehydrogenase gene promoter consists of a complex arrangement of nuclear receptor response elements and Sp1 binding sites","volume":"270","author":"Leone","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB46","doi-asserted-by":"crossref","first-page":"30039","DOI":"10.1016\/S0021-9258(18)43985-3","article-title":"Insulin-dependent phosphorylation of calmodulin in rat hepatocytes","volume":"269","author":"Joyal","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB47","doi-asserted-by":"crossref","first-page":"16116","DOI":"10.1016\/S0021-9258(17)33980-7","article-title":"Isolation of phosphorylated calmodulin from rat liver and identification of the in vivo phosphorylation site","volume":"269","author":"Quadroni","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB48","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1021\/bi9600198","article-title":"Identification of insulin-stimulated phosphorylation sites on calmodulin","volume":"35","author":"Joyal","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB49","first-page":"3580","article-title":"Analysis and in vivo disruption of the gene encoding for calmodulin in Schizosaccharomyces pombe","volume":"84","author":"Takeda","year":"1987"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB50","first-page":"365","article-title":"Cooperative regulation of cell proliferation by calcium and calmodulin in Aspergillus nidulans","volume":"6","author":"Lu","year":"1992","journal-title":"Mol. Endocrinol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0092-8674(90)90250-I","article-title":"Mutations in Paramecium calmodulin indicate functional differences between the C-terminal and N-terminal lobes in vivo","volume":"62","author":"Kink","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB52","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1083\/jcb.119.6.1625","article-title":"Mutations in yeast calmodulin cause defects in spindle pole body functions and nuclear integrity","volume":"119","author":"Sun","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB53","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0143-4160(92)90057-Y","article-title":"Yeast calmodulin: structural and functional elements essential for the cell cycle","volume":"13","author":"Ohya","year":"1992","journal-title":"Cell Calcium"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB54","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.8310294","article-title":"Diverse essential functions revealed by complementing yeast calmodulin mutants","volume":"263","author":"Ohya","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0143-4160(98)90028-8_BIB55","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1432-1033.1994.tb18882.x","article-title":"New nonlethal calmodulin mutations in Paramecium. A structural and functional bipartition hypothesis","volume":"222","author":"Ling","year":"1994","journal-title":"Eur J Biochem"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416098900288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416098900288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:00:35Z","timestamp":1758916835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416098900288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["S0143416098900288"],"URL":"https:\/\/doi.org\/10.1016\/s0143-4160(98)90028-8","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALMS","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0143-4160(98)90028-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}