{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T23:42:43Z","timestamp":1768866163104,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Food Microbiology"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1016\/s0168-1605(98)00045-2","type":"journal-article","created":{"date-parts":[[2002,10,14]],"date-time":"2002-10-14T13:55:20Z","timestamp":1034603720000},"page":"127-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Protection against gastrointestinal diseases\u2014Present facts and future developments"],"prefix":"10.1016","volume":"41","author":[{"given":"Heinrich","family":"Kasper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0168-1605(98)00045-2_BIB1","first-page":"131","article-title":"The effect of acidophilus milk in the treatment of constipation in hospitalised geriatric patients","volume":"15","author":"Alm","year":"1983","journal-title":"Symp. Swd. Nutr. Found."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB2","first-page":"245","article-title":"Chronic constipation reversed by restoration of bowel flora. A case and a hypothesis","volume":"4","author":"Andrews","year":"1992","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB3","first-page":"389","article-title":"Antagonistic effects of deoxycholic acid and butyrate on epithelial cell proliferation in the proximal and distal human colon","volume":"32","author":"Bartram","year":"1994","journal-title":"Z. Gastroenterol."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB4","first-page":"3283","article-title":"Proliferation of human colonic mucosa as an intermediate biomarker of carcinogenesis: Effects of butyrate, deoxycholate, calcium, ammonia, and pH","volume":"53","author":"Bartram","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB5","first-page":"A38","article-title":"In vivo Helicobacter pylori clearance failure with Lactobacillus acidophilus","volume":"102","author":"Bazoli","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/S0168-1605(98)00045-2_BIB6","first-page":"142","article-title":"Effect of Lactobacillus acidophilus and Bifidobacterium bifidum on rectal cell kinetics and fecal pH","volume":"23","author":"Biasco","year":"1991","journal-title":"Ital. J. Gastroenterol."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB7","first-page":"224","article-title":"Treatment of recurrent Clostridium difficile colitis with Lactobacillus GG","volume":"21","author":"Biller","year":"1995","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB8","first-page":"509","article-title":"Effect of feeding yogurt versus milk in children with persistent diarrhea","volume":"11","author":"Boudraa","year":"1990","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0140-6736(87)93078-9","article-title":"Joghurt with Bifidobacterium longum reduces erythromycin-induced gastrointestinal effects","volume":"2","author":"Colombel","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/S0168-1605(98)00045-2_BIB10","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1051\/rnd:19800603","article-title":"Comparative effects of a diet enriched in live or heated yogurt on the immune system of the mouse","volume":"20","author":"Conge","year":"1980","journal-title":"Reprod. Nutr. Dev."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3109\/08923978809041429","article-title":"Enhancement of host resistance against Salmonella typhimurium infection by a diet supplemented with yogurt","volume":"10","author":"De Simone","year":"1988","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/00365529309096063","article-title":"The effect of exogenous administration of Lactobacillus reuteri R2LC and oat fiber on acetic acid-induced colitis in the rat","volume":"28","author":"Fabia","year":"1993","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/ajcn\/39.5.756","article-title":"The effect of milk and lactobacillus feeding on human intestinal bacterial enzyme activity","volume":"39","author":"Goldin","year":"1984","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01308354","article-title":"Survival of Lactobacillus species (strain GG) in human gastrointestinal tract","volume":"37","author":"Goldin","year":"1992","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/jnci\/64.2.255","article-title":"Effect of diet and Lactobacillus acidophilus supplements on human fecal bacterial enzymes","volume":"64","author":"Goldin","year":"1980","journal-title":"JNCI"},{"key":"10.1016\/S0168-1605(98)00045-2_BIB16","doi-asserted-by":"crossref","unstructured":"Gorbach, S.L., Chang, T.W., Goldin, B., 1987. Successful treatment of relapsing Clostridium difficile colitis with Lactobacillus GG. Lancet II, 1519.","DOI":"10.1016\/S0140-6736(87)92646-8"},{"key":"10.1016\/S0168-1605(98)00045-2_BIB17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1753-4887.1992.tb02485.x","article-title":"Nutrition and the gastrointestinal microflora","volume":"50","author":"Gorbach","year":"1992","journal-title":"Nutr. Rev."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1708-8305.1997.tb00772.x","article-title":"Efficacy of Lactobacillus GG as a diarrheal preventive in travellers","volume":"4","author":"Hilton","year":"1997","journal-title":"J. Travel Med."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB19","first-page":"90","article-title":"A human Lactobacillus strain (Lactobacillus casei strain GG) promotes recovery from acute diarrhea in children","volume":"88","author":"Isolauri","year":"1991","journal-title":"Pediatrics"},{"key":"10.1016\/S0168-1605(98)00045-2_BIB20","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1007\/BF02087695","article-title":"Oral bacteriotherapy for viral gastroenteritis","volume":"39","author":"Isolauri","year":"1994","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB21","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1056\/NEJM199511163332016","article-title":"Lactobacilli to prevent traveler's diarrhea?","volume":"333","author":"Katelaris","year":"1995","journal-title":"New Engl. J. Med."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/jn\/124.1.18","article-title":"Lactobacillus stain GG supplementation decreases colonic hydrolytic and reductive enzyme activities in healthy female adults","volume":"124","author":"Ling","year":"1994","journal-title":"J. Nutr."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1574-695X.1994.tb00011.x","article-title":"Modulation of a specific humoral response and changes in intestinal flora mediated through fermented milk intake","volume":"10","author":"Link-Amster","year":"1994","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000177907","article-title":"Promotion of IgA immune response in patients with Crohn's disease by oral bacteriotherapy with Lactobacillus GG","volume":"40","author":"Malin","year":"1996","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1574-6976.1993.tb00019.x","article-title":"Potential of using lactic acid bacteria for therapy and immunomodulation in man","volume":"12","author":"Marteau","year":"1993","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB26","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/ajcn\/52.4.685","article-title":"Effect of chronic ingestion of a fermented diary product containing Lactobacillus acidophilus and Bifidobacterium bifidum on metabolic activities of the colonic flora in humans","volume":"52","author":"Marteau","year":"1990","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB27","doi-asserted-by":"crossref","first-page":"A166","DOI":"10.1016\/0016-5085(95)23326-1","article-title":"L. acidophilus supernatant as an adjuvant in the therapy of H. pylori in humans","volume":"108","author":"Michetti","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/S0168-1605(98)00045-2_BIB28","first-page":"1085","article-title":"Clinical experience with the use of the high-concentration lactic acid bacteria preparation LP-201 to treat habitual costipation","volume":"8","author":"Ogawa","year":"1974","journal-title":"Clin. Rep."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0027-5107(94)90182-1","article-title":"Binding of mutagenic heterocyclic amines by intestinal and lactic acid bacteria","volume":"311","author":"Orrhage","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/food.19840280619","article-title":"Some studies of the bacterial flora associated with the mucosa of the human gastrointestinal tract","volume":"28","author":"Peach","year":"1994","journal-title":"Die Nahrung"},{"key":"10.1016\/S0168-1605(98)00045-2_BIB31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1017\/S002202990002687X","article-title":"Prevention of gastrointestinal infection using immunobiological methods with milk fermented with Lactobacillus casei and Lactobacillus acidophilus","volume":"57","author":"Perdigon","year":"1990","journal-title":"J. Dairy Res."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB32","first-page":"17","article-title":"Systemic augmentation of the immune response in mice by feeding fermented milks with Lactobacillus casei and Lactobacillus acidophilus","volume":"63","author":"Perdigon","year":"1988","journal-title":"Immunology"},{"key":"10.1016\/S0168-1605(98)00045-2_BIB33","first-page":"3914","article-title":"Inhibitory effect of Bifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen","volume":"53","author":"Reddy","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1128\/am.29.1.7-12.1975","article-title":"Degradation of N-nitrosamines by intestinal bacteria","volume":"29","author":"Rowland","year":"1975","journal-title":"Appl. Microbiol."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB35","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(94)91708-6","article-title":"Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus","volume":"344","author":"Saavedra","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/S0168-1605(98)00045-2_BIB36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1043-4526(08)60116-3","article-title":"Effect of consumption of lactic cultures on human health","volume":"37","author":"Sanders","year":"1993","journal-title":"Adv. Food Nutr. Res."},{"key":"10.1016\/S0168-1605(98)00045-2_BIB37","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0959-8049(95)00165-F","article-title":"Role of short-chain fatty acids in the prevention of colorectal cancer","volume":"31","author":"Scheppach","year":"1995","journal-title":"Eur. J. Cancer"}],"container-title":["International Journal of Food Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168160598000452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168160598000452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:11:04Z","timestamp":1759144264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168160598000452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["S0168160598000452"],"URL":"https:\/\/doi.org\/10.1016\/s0168-1605(98)00045-2","relation":{},"ISSN":["0168-1605"],"issn-type":[{"value":"0168-1605","type":"print"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection against gastrointestinal diseases\u2014Present facts and future developments","name":"articletitle","label":"Article Title"},{"value":"International Journal of Food Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0168-1605(98)00045-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Elsevier Science B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}