{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:06:05Z","timestamp":1770527165106,"version":"3.49.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[1998,2]]},"DOI":"10.1016\/s0306-4530(97)00076-0","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T19:41:21Z","timestamp":1027626081000},"page":"189-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"title":["Effect of nicotine on the immune system: Possible regulation of immune responses by central and peripheral mechanisms"],"prefix":"10.1016","volume":"23","author":[{"given":"Mohan L.","family":"Sopori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wieslaw","family":"Kozak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuemei","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Soszynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Kluger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth K.","family":"Perryman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Snow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0306-4530(97)00076-0_BIB1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1164\/ajrccm\/143.1.144","article-title":"Bronchiolar inflammation and fibrosis associated with smoking","volume":"143","author":"Adesina","year":"1991","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB2","first-page":"467","article-title":"Serum immunoglobulins in smokers and nonsmokers","volume":"47","author":"Andersen","year":"1982","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1001\/jama.1982.03330020025023","article-title":"Association between cigarette smoking and acute respiratory tract illness in young adults","volume":"248","author":"Aronson","year":"1982","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/path.1711330106","article-title":"Effects of tobacco smoke on splenic architecture and weight, during the primary immune response of BALB\/c mice","volume":"133","author":"Ayer","year":"1981","journal-title":"Journal of Pathology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB5","first-page":"8","article-title":"The immune system: our sixth sense","volume":"2","author":"Blalock","year":"1994","journal-title":"Immunologist"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB6","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1164\/ajrccm\/145.4_Pt_1.911","article-title":"Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry","volume":"145","author":"Bosken","year":"1992","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/00039896.1995.9935952","article-title":"Direct effects of nicotine on the brain: evidence for chemical addiction","volume":"50","author":"Braubar","year":"1995","journal-title":"Archives of Environmental Health"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB8","doi-asserted-by":"crossref","first-page":"C260","DOI":"10.1152\/ajpcell.1989.256.2.C260","article-title":"Cigarette smoking decreases interleukin-1 release by human alveolar macrophages","volume":"256","author":"Brown","year":"1989","journal-title":"American Journal of Physiology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB9","first-page":"76","article-title":"Cigarette smoking: a modifier of human immunodeficiency virus type 1 infection?","volume":"4","author":"Burns","year":"1991","journal-title":"Journal of AIDS"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB10","first-page":"718","article-title":"Cigarette smoking, premature rupture of membranes, and vertical transmission of HIV-1 among women with low CD4+ levels","volume":"7","author":"Burns","year":"1994","journal-title":"Journal of AIDS"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB11","first-page":"523","article-title":"The relationship of serum immunoglobulin E to cigarette smoking","volume":"124","author":"Burrows","year":"1981","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0091-6749(82)90042-2","article-title":"The relationship of serum immunoglobulin E, allergy skin test, and smoking to respiratory disorders","volume":"70","author":"Burrows","year":"1982","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB13","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/0090-1229(92)90035-M","article-title":"Inflammatory cytokines","volume":"62","author":"Cerami","year":"1992","journal-title":"Clinical Immunology and Immunopathology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB14","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/jnci\/55.5.1129","article-title":"Cell-mediated immune response to transplanted tumors in mice chronically exposed to fresh cigarette smoke","volume":"52","author":"Chalmer","year":"1975","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB15","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0140-6736(71)80071-5","article-title":"Smoking and leukocyte counts. Results of an epidemiological survey","volume":"2","author":"Corre","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1056\/NEJM197609092951101","article-title":"Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events","volume":"295","author":"Cryer","year":"1976","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/ijc.2910230504","article-title":"Low natural killer-cell activity and immunoglobulin levels associated with smoking human subjects","volume":"23","author":"Ferson","year":"1979","journal-title":"International Journal of Cancer"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB18","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/oxfordjournals.aje.a121084","article-title":"Cigarette smoking and epidemic influenza","volume":"90","author":"Finklea","year":"1969","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/10408449409049309","article-title":"The role of brain-immune interaction in immunotoxicology","volume":"24","author":"Fuchs","year":"1994","journal-title":"Critical Reviews in Toxicology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB20","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/taap.1995.1233","article-title":"Effects of nicotine on the immune response. I. Chronic exposure to nicotine impairs antigen receptor-mediated signal transduction in lymphocytes","volume":"135","author":"Geng","year":"1995","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB21","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.4049\/jimmunol.156.7.2384","article-title":"Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy","volume":"156","author":"Geng","year":"1996","journal-title":"Journal of Immunology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB22","first-page":"261","article-title":"Immunoglobulin levels in smokers and nonsmokers","volume":"44","author":"Gerrard","year":"1980","journal-title":"Annals of Allergy"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB23","first-page":"4966","article-title":"Interleukin 1 receptor blockade attenuates the host inflammatory response","volume":"87","author":"Gershenwald","year":"1990"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF01974009","article-title":"Effects of cigarette smoke on the antibody response to thymic independent antigens from different lymphoid tissues of mice","volume":"66","author":"Goud","year":"1992","journal-title":"Archives of Toxicology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB25","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1001\/jama.1992.03480150068039","article-title":"Sexual behavior, smoking, and HIV-1 infection in Haitain women","volume":"267","author":"Halsey","year":"1992","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB26","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1056\/NEJM199509283331305","article-title":"Bacterial pneumonia in persons infected with the human immunodeficiency virus. Pulmonary complication of HIV infection study group","volume":"333","author":"Hirschtick","year":"1995","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB27","first-page":"145","article-title":"Chemical constituents and bioactivity of tobacco smoke","volume":"74","author":"Hoffmann","year":"1986","journal-title":"IARC Science Publisher"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB28","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/00039896.1976.10667230","article-title":"Low-tar high-tar cigarettes: comparison of effects in mice","volume":"31","author":"Holt","year":"1976","journal-title":"Archives of Environmental Health"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1128\/br.41.1.205-216.1977","article-title":"Environmentally induced changes in immunological function: acute and chronic effects of inhalation of tobacco smoke and other atmospheric contaminants in man and experimental animals","volume":"41","author":"Holt","year":"1977","journal-title":"Bacteriology Review"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB30","first-page":"459","article-title":"Numerical and functional alteration in circulatory lymphocytes in cigarette smokers","volume":"61","author":"Hughes","year":"1985","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB31","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/10408449009089870","article-title":"Effects of mainstream and environmental tobacco smoke on the immune system in animals and humans: a review","volume":"20","author":"Johnson","year":"1990","journal-title":"Critical Reviews in Toxicology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB32","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM198210213071702","article-title":"Cigarette smoke as a risk factor for epidemic A (H1N1) influenza in young men","volume":"307","author":"Kark","year":"1982","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0092-8674(94)90333-6","article-title":"Cytokine signal transduction","volume":"76","author":"Kishimoto","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB34","first-page":"R480","article-title":"Systemic but not central administration of tumor necrosis factor-\u03b1 attenuates LPS-induced fever in rats","volume":"268","author":"Klir","year":"1995","journal-title":"American Journal of Physiology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/physrev.1991.71.1.93","article-title":"Fever: role of pyrogens and cryogens","volume":"71","author":"Kluger","year":"1991","journal-title":"Physiology Review"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB36","series-title":"Fever: Basic Mechanisms and Management","first-page":"255","article-title":"The adaptive value of fever","author":"Kluger","year":"1997"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000097199","article-title":"Cytokines and fever","volume":"2","author":"Kluger","year":"1995","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB38","first-page":"R621","article-title":"Sickness behavior in mice deficient in interleukin-6 during turpentine and influenza pneumonitis","volume":"272","author":"Kozak","year":"1997","journal-title":"American Journal of Physiology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB39","first-page":"R969","article-title":"Thermal and behavioral effects of lipopolysaccharide and influenza in interleukin-1\u03b2-deficient mice","volume":"269","author":"Kozak","year":"1995","journal-title":"American Journal of Physiology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1749-6632.1982.tb22124.x","article-title":"The phenomenon of the acute phase response","volume":"389","author":"Kushner","year":"1982","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0304-3940(85)90182-X","article-title":"Autoradiographic localization of [3H]-nicotine binding sites in the rat brain","volume":"53","author":"London","year":"1985","journal-title":"Neuroscience Letters"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0024-3205(76)90046-1","article-title":"The effects of cigarette smoke on influenza virus: a murine model system","volume":"19","author":"Mackenzie","year":"1976","journal-title":"Life Sciences"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB43","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1210\/endo.132.5.8386611","article-title":"Nicotine stimulates the expression of c-fos protein in the parvocellular paraventricular nucleus and brainstem catecholaminergic regions","volume":"132","author":"Matta","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0165-5728(94)90213-5","article-title":"Immunological effects of acute and chronic nicotine administration in rats","volume":"50","author":"McAllister","year":"1994","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB45","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1164\/ajrccm.150.3.8087340","article-title":"Altered cytokine regulation in the lungs of cigarette smokers","volume":"150","author":"McCrea","year":"1994","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB46","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1365-2230.1993.tb00986.x","article-title":"Does smoking influence acne?","volume":"18","author":"Mills","year":"1993","journal-title":"Clinical and Experimental Dermatology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0091-7435(85)90023-4","article-title":"Risk factor analysis among men referred for possible acquired immune deficiency syndrome","volume":"14","author":"Newell","year":"1985","journal-title":"Preventive Medicine"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB48","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00002030-199305000-00015","article-title":"The effect of cigarette smoking on the development of AIDS in HIV-1 seropositive individuals","volume":"7","author":"Nieman","year":"1993","journal-title":"AIDS"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB49","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1126\/science.1700866","article-title":"The phosphorylation of PLC-\u03b31 results in increase of its catalytic activity","volume":"250","author":"Nishibe","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB50","series-title":"A Stereotaxic Atlas of the Rat Brain","author":"Pellegrino","year":"1979"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/mpat.1995.0056","article-title":"Tumor necrosis factor as a mediator of inflammation in influenza A viral pneumonia","volume":"19","author":"Peper","year":"1995","journal-title":"Microbial Pathogen"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB52","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/0140-6736(92)91600-D","article-title":"Mortality from tobacco in developed countries: indirect estimation from national vital statistics","volume":"339","author":"Peto","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB53","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/08923979209005405","article-title":"Nicotine enhances interleukin production of rat splenic T lymphocytes","volume":"14","author":"Petro","year":"1992","journal-title":"Immunopharmacology and Immunotoxicology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB54","first-page":"393","article-title":"The pulmonary macrophage population of human smokers","volume":"25","author":"Plowman","year":"1982","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB55","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0143-4160(94)90076-0","article-title":"Intracellular calcium signaling induced by thapsigargin in excitable and inexcitable cell","volume":"16","author":"Razani-Boroujerdi","year":"1994","journal-title":"Cell Calcium"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0091-3057(86)90062-6","article-title":"Pituitary hormone response to cigarette smoking","volume":"24","author":"Seyler","year":"1986","journal-title":"Pharmacology and Biochemical Behavior"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB57","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0041-008X(89)90254-8","article-title":"Cigarette smoke causes inhibition of the immune response to intratracheally administered antigens","volume":"97","author":"Sopori","year":"1989","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB58","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0090-1229(85)90054-6","article-title":"Immune responsiveness of monkeys exposed chronically to cigarette smoke","volume":"36","author":"Sopori","year":"1985","journal-title":"Clinical Immunology and Immunopathology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB59","series-title":"Immunotoxicology and Immunopharmacology","first-page":"413","article-title":"Effects of tobacco smoke on the immune system","author":"Sopori","year":"1994"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB60","first-page":"663","article-title":"Cigarette smoke and the immune response: mechanism of nicotine-induced immunosuppression","volume":"86","author":"Sopori","year":"1993","journal-title":"Advanced Biosciences"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB61","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/infdis\/133.1.91","article-title":"Influenza virus infection in nude mice","volume":"133","author":"Sullivan","year":"1976","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02123572","article-title":"Plaque assay and primary isolation of influenza A viruses in an established line of canine kidney cells (MDCK) in the presence of trypsin","volume":"162","author":"Tobita","year":"1975","journal-title":"Medical Microbiology and Immunology"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB63","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1164\/ajrccm\/144.3_Pt_1.612","article-title":"T cell subsets in healthy black smokers and nonsmokers. Evidence for ethnic group as an important response modifier","volume":"144","author":"Tollerud","year":"1991","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB64","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1164\/ajrccm\/139.1.194","article-title":"Association of cigarette smoking with decreased numbers of circulating natural killer cells","volume":"139","author":"Tollerud","year":"1989","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB65","series-title":"Tobacco Smoking and Nicotine: A Neurobiological Approach","first-page":"263","article-title":"Nicotinic regulation of sympathoadrenal catecholamine secretion: cross tolerance to stress","author":"Van Loon","year":"1987"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB66","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(94)90334-4","article-title":"Signal transduction by lymphocyte antigen receptors","volume":"76","author":"Weiss","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0306-4530(97)00076-0_BIB67","first-page":"469","volume":"Vol. 43","author":"US Department of Health and Human Services","year":"1994","journal-title":"CDC Morbidity and Mortality Weekly Report"}],"container-title":["Psychoneuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453097000760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306453097000760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:23:23Z","timestamp":1759681403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306453097000760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,2]]}},"alternative-id":["S0306453097000760"],"URL":"https:\/\/doi.org\/10.1016\/s0306-4530(97)00076-0","relation":{},"ISSN":["0306-4530"],"issn-type":[{"value":"0306-4530","type":"print"}],"subject":[],"published":{"date-parts":[[1998,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of nicotine on the immune system: Possible regulation of immune responses by central and peripheral mechanisms","name":"articletitle","label":"Article Title"},{"value":"Psychoneuroendocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0306-4530(97)00076-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}