{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:10:10Z","timestamp":1764688210413},"reference-count":40,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gene"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1016\/s0378-1119(97)00628-8","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T15:20:46Z","timestamp":1027610446000},"page":"23-30","source":"Crossref","is-referenced-by-count":54,"title":["Quantitation of age-related mitochondrial DNA deletions in rat tissues shows that their pattern of accumulation differs from that of humans"],"prefix":"10.1016","volume":"209","author":[{"given":"David L","family":"Yowe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce N","family":"Ames","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0378-1119(97)00628-8_BIB1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.cb.04.110188.001445","article-title":"Biogenesis of mitochondria","volume":"4","author":"Attardi","year":"1988","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB2","first-page":"618","article-title":"Age-related human mtDNA deletions: A heterogeneous set of deletions arising at a single pair of directly repeated sequences","volume":"54","author":"Baumer","year":"1994","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB3","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1073\/pnas.76.4.1967","article-title":"Rapid evolution of animal mitochondrial DNA","volume":"76","author":"Brown","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB4","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/nar\/21.4.1047","article-title":"A rapid and versatile method to synthesize internal standards for competitive PCR","volume":"21","author":"Celi","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02434081","article-title":"Analysis of age-associated mitochondrial DNA deletion breakpoint regions from mice suggests a novel model of deletion formation","volume":"19","author":"Chung","year":"1996","journal-title":"Age"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.cb.07.110191.002321","article-title":"Replication and transcription of vertebrate mitochondrial DNA","volume":"7","author":"Clayton","year":"1991","journal-title":"Annu. Rev. Cell. Biol."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0921-8734(92)90021-G","article-title":"Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease","volume":"275","author":"Corral-Debrinski","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/geno.1994.1525","article-title":"Marked changes in mitochondrial DNA deletion levels in Alzheimer brains","volume":"23","author":"Corral-Debrinski","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB9","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1093\/nar\/18.23.6927","article-title":"Detection of a specific mitochondrial DNA deletion in tissues of older humans","volume":"18","author":"Cortopassi","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB10","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1073\/pnas.89.16.7370","article-title":"A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues","volume":"89","author":"Cortopassi","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0921-8734(95)00020-7","article-title":"Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology","volume":"338","author":"Cortopassi","year":"1995","journal-title":"Mutat. Res."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0921-8734(94)90009-4","article-title":"Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA","volume":"316","author":"Edris","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0047-6374(96)01696-X","article-title":"Mitochondrial electron transport chain activities and DNA deletions in regions of the rat brain","volume":"87","author":"Filburn","year":"1996","journal-title":"Mechan. Ageing Dev."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/bbrc.1997.6409","article-title":"Quantification of wild-type mitochondrial DNA and its 4.8kb deletion in rat organs","volume":"233","author":"Filser","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF02602930","article-title":"The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates","volume":"28","author":"Gadaleta","year":"1989","journal-title":"J. Mol. Evol."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0921-8734(92)90022-H","article-title":"Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats","volume":"275","author":"Gadaleta","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB17","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1073\/pnas.87.7.2725","article-title":"Analysis of cytokine mRNA and DNA: Detection and quantitation by competitive polymerase chain reaction","volume":"87","author":"Gilliland","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB18","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/bies.950181208","article-title":"Mitochondrial genetics and human disease","volume":"18","author":"Grossman","year":"1996","journal-title":"Bioessays"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB19","first-page":"99","article-title":"Mitochondrial DNA and disease","volume":"28","author":"Hammans","year":"1994","journal-title":"Essays Biochem."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB20","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1212\/WNL.45.10.1879","article-title":"Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients","volume":"45","author":"Horton","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.ge.29.120195.001055","article-title":"Molecular genetic aspects of human mitochondrial disorders","volume":"29","author":"Larsson","year":"1995","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0925-4439(94)90056-6","article-title":"Differential accumulations of 4,977bp deletion in mitochondrial DNA of various tissues in human ageing","volume":"1226","author":"Lee","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB23","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0891-5849(96)00546-1","article-title":"Age-associated alterations of the mitochondrial genome","volume":"22","author":"Lee","year":"1997","journal-title":"Free Rad. Biol. Med."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB24","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1093\/nar\/23.20.4122","article-title":"Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle","volume":"23","author":"Melov","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB25","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1073\/pnas.85.17.6465","article-title":"Normal oxidative damage to mitochondrial and nuclear DNA is extensive","volume":"85","author":"Richter","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0921-8734(92)90029-O","article-title":"Reactive oxygen and DNA damage in mitochondria","volume":"275","author":"Richter","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB27","unstructured":"Sambrook, J., Fritsch, E.F., Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB28","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.2711184","article-title":"A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA","volume":"244","author":"Schon","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB29","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF00762733","article-title":"Mitochondrial free Ca2+ concentration in living cells","volume":"26","author":"Sheu","year":"1994","journal-title":"J. Bioener. Biomembr."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB30","doi-asserted-by":"crossref","first-page":"10771","DOI":"10.1073\/pnas.91.23.10771","article-title":"Oxidative damage and mitochondrial decay in aging","volume":"91","author":"Shigenaga","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0925-4439(92)90059-V","article-title":"Accumulation of deletions in human mitochondrial DNA during normal aging: Analysis by quantitative PCR","volume":"1180","author":"Simonetti","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng1292-318","article-title":"Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain","volume":"2","author":"Soong","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB33","doi-asserted-by":"crossref","first-page":"24769","DOI":"10.1074\/jbc.270.42.24769","article-title":"Multiple deletions are detectable in mitochondrial DNA of aging mice","volume":"270","author":"Tanhauser","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB34","doi-asserted-by":"crossref","first-page":"27536","DOI":"10.1074\/jbc.271.44.27536","article-title":"Mammalian mitochondria possess homologous DNA recombination activity","volume":"271","author":"Thyagarajan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB35","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1212\/WNL.43.2.280","article-title":"Mitochondrial DNA alterations as a source of human disorders","volume":"43","author":"Tritschler","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0027-5107(95)00165-4","article-title":"Multiple, large deletions in rat mitochondrial DNA: evidence for a major hot spot","volume":"349","author":"Van Tuyle","year":"1996","journal-title":"Mutat. Res."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB37","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1146\/annurev.bi.61.070192.005523","article-title":"Diseases of the mitochondrial DNA","volume":"61","author":"Wallace","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB38","unstructured":"Wallace, D.C., Bohr, V.A., Cortopassi, G., Kadenbach, B., Linn, S., Linnane, A.W., Richter, C., Shay, J.W., 1995. Group report: The role of bioenergetics and mitochondrial DNA mutations in aging and age-related diseases. In: Esser, K., Martin, G.M. (Eds.), Molecular Aspects of Aging. Wiley, New York, pp. 199\u2013225."},{"key":"10.1016\/S0378-1119(97)00628-8_BIB39","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1073\/pnas.94.2.514","article-title":"Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress","volume":"94","author":"Yakes","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0378-1119(97)00628-8_BIB40","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.275.5303.1129","article-title":"Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked","volume":"275","author":"Yang","year":"1997","journal-title":"Science"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111997006288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111997006288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T15:53:28Z","timestamp":1555948408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111997006288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":40,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["S0378111997006288"],"URL":"https:\/\/doi.org\/10.1016\/s0378-1119(97)00628-8","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}