{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:59:38Z","timestamp":1771999178778,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2005,7,22]],"date-time":"2005-07-22T00:00:00Z","timestamp":1121990400000},"content-version":"vor","delay-in-days":2639,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1016\/s0960-9822(98)70225-8","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T15:10:35Z","timestamp":1090595435000},"page":"563-573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":308,"title":["Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction"],"prefix":"10.1016","volume":"8","author":[{"given":"L.J.","family":"Holsinger","sequence":"first","affiliation":[]},{"given":"I.A.","family":"Graef","sequence":"additional","affiliation":[]},{"given":"W.","family":"Swat","sequence":"additional","affiliation":[]},{"given":"T.","family":"Chi","sequence":"additional","affiliation":[]},{"given":"D.M.","family":"Bautista","sequence":"additional","affiliation":[]},{"given":"L.","family":"Davidson","sequence":"additional","affiliation":[]},{"given":"R.S.","family":"Lewis","sequence":"additional","affiliation":[]},{"given":"F.W.","family":"Alt","sequence":"additional","affiliation":[]},{"given":"G.R.","family":"Crabtree","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0960-9822(98)70225-8_BIB1","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/j.1460-2075.1989.tb08354.x","article-title":"vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells","volume":"8","author":"Katzav","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0960-9822(92)90396-R","article-title":"Vagaries of Vav","volume":"2","author":"Puil","year":"1992","journal-title":"Curr Biol"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/374470a0","article-title":"Defective signalling through T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene","volume":"374","author":"Zhang","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/374467a0","article-title":"Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav","volume":"374","author":"Tarakhovsky","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB5","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/374474a0","article-title":"Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes","volume":"374","author":"Fischer","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB6","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1128\/MCB.15.8.4337","article-title":"A functional T-cell receptor signaling pathway is required for p95vav activity","volume":"15","author":"Wu","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S1074-7613(00)80485-9","article-title":"Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation","volume":"4","author":"Wu","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB8","doi-asserted-by":"crossref","first-page":"9810","DOI":"10.1073\/pnas.92.21.9810","article-title":"Signal transduction in T lymphocytes using a conditional allele of Sos","volume":"92","author":"Holsinger","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/385169a0","article-title":"Phosphotyrosine-dependent activation of Rac-1 GDP\/GTP exchange by the vav proto-oncogene product","volume":"385","author":"Crespo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0092-8674(92)90163-7","article-title":"The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(92)90164-8","article-title":"The small GTP-binding protein rac regulates growth factor-induced membrane ruffling","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0092-8674(95)90370-4","article-title":"Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia","volume":"81","author":"Nobes","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0092-8674(94)90259-3","article-title":"The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells","volume":"79","author":"Chong","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB14","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0092-8674(95)90036-5","article-title":"Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets","volume":"82","author":"Hartwig","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB15","doi-asserted-by":"crossref","first-page":"17656","DOI":"10.1074\/jbc.270.30.17656","article-title":"Rho family GTPases bind to phosphoinositide kinases","volume":"270","author":"Tolias","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB16","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0092-8674(05)80019-4","article-title":"Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs","volume":"81","author":"Minden","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB17","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0092-8674(05)80018-2","article-title":"The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK\/SAPK signaling pathway","volume":"81","author":"Coso","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0092-8674(00)81371-9","article-title":"Rac and Ccd42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK\/SAPK MAP kinase kinase","volume":"87","author":"Lamarche","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB19","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.274.5291.1374","article-title":"Rac regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase","volume":"274","author":"Joneson","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB20","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0960-9822(02)70786-0","article-title":"Faciogenital dysplasia protein (FDG1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases","volume":"6","author":"Olson","year":"1996","journal-title":"Curr Biol"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB21","first-page":"455","article-title":"Rac-1 dependent stimulation of the JNK\/SAPK signaling pathway by vav","volume":"13","author":"Crespo","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB22","first-page":"2405","article-title":"Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP\/GTP exchange factor","volume":"9","author":"Bustelo","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/newbio241257a0","article-title":"Normal distribution, patching and capping of lymphocyte surface immunoglobulin studied by electron microscopy","volume":"241","author":"de Petris","year":"1973","journal-title":"Nature New Biol"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/250054a0","article-title":"Inhibition and reversal of capping by cytochalasin B, vinblastine and colchicine","volume":"250","author":"de Petris","year":"1974","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1084\/jem.136.4.885","article-title":"Ligand-induced movement of lymphocyte membrane macromolecules. I. Analysis by immunofluorescence and ultrastructural radioautography","volume":"136","author":"Unanue","year":"1972","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB26","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.181.2.577","article-title":"Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton","volume":"181","author":"Valitutti","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/385083a0","article-title":"Selective modulation of protein kinase C-theta during T-cell activation","volume":"385","author":"Monks","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB28","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1073\/pnas.88.20.9166","article-title":"The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein","volume":"88","author":"Chan","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB29","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/347396a0","article-title":"Co-capping of ras proteins with surface immunoglobulins in B lymphocytes","volume":"347","author":"Graziadei","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB30","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0960-9822(98)70224-6","article-title":"Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor","volume":"8","author":"Fischer","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/357695a0","article-title":"Identification of calcineurin as a key signalling enzyme in T cell activation","volume":"357","author":"Clipstone","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB32","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB33","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/352803a0","article-title":"Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A","volume":"352","author":"Flanagan","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1074-7613(00)80367-2","article-title":"A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes","volume":"7","author":"Turner","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB35","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/346719a0","article-title":"Stimulation of p21ras upon T-cell activation","volume":"346","author":"Downward","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB36","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/j.1460-2075.1995.tb07001.x","article-title":"Involvement of p21ras distinguishes positive and negative selection in thymocytes","volume":"14","author":"Swan","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB37","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1073\/pnas.93.10.4683","article-title":"Activated Ras signals differentiation and expansion of CD4+8+ thymocytes","volume":"93","author":"Swat","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB38","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/385172a0","article-title":"Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc","volume":"385","author":"Wolfe","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1126\/science.2783497","article-title":"Contigent genetic regulatory events in T lymphocyte activation","volume":"243","author":"Crabtree","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB40","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1002\/j.1460-2075.1996.tb00766.x","article-title":"Multiple p21ras effector pathways regulate nuclear factor of activated T cells","volume":"15","author":"Genot","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB41","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.79.2.409","article-title":"Two distinct mechanisms for redistribution of lymphocyte surface macromolecules. I. Relationship to cytoplasmic myosin","volume":"79","author":"Braun","year":"1978","journal-title":"J Cell Biol"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB42","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0092-8674(00)81050-8","article-title":"Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization","volume":"84","author":"Symons","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB43","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1073\/pnas.93.11.5615","article-title":"Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42","volume":"93","author":"Kolluri","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB44","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.4049\/jimmunol.151.8.4383","article-title":"T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses","volume":"151","author":"Molina","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB45","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1073\/pnas.92.11.5027","article-title":"Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42","volume":"92","author":"Stowers","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB46","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0092-8674(00)80353-0","article-title":"Role of a new Rho family member in cell migration and axon guidance in C. elegans","volume":"90","author":"Zipkin","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB47","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/383837a0","article-title":"Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression","volume":"383","author":"Timmerman","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB48","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.273.5271.104","article-title":"T cell activation determined by T cell receptor number and tunable thresholds","volume":"273","author":"Viola","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/1074-7613(95)90093-4","article-title":"Isolation of mutant T lymphocytes with defects in capacitative calcium entry","volume":"3","author":"Serafini","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB50","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1093\/nar\/12.18.7035","article-title":"Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter","volume":"12","author":"Melton","year":"1984","journal-title":"Nucl Acids Res"},{"key":"10.1016\/S0960-9822(98)70225-8_BIB51","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1101\/gad.4.10.1823","article-title":"Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor","volume":"4","author":"Fiering","year":"1990","journal-title":"Genes Dev"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982298702258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982298702258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:58:54Z","timestamp":1760777934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982298702258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["S0960982298702258"],"URL":"https:\/\/doi.org\/10.1016\/s0960-9822(98)70225-8","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0960-9822(98)70225-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}