{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:07:28Z","timestamp":1784156848050,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5617,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Structure"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1016\/s0969-2126(98)00027-6","type":"journal-article","created":{"date-parts":[[2004,6,8]],"date-time":"2004-06-08T18:49:43Z","timestamp":1086720583000},"page":"249-254","source":"Crossref","is-referenced-by-count":282,"title":["Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2"],"prefix":"10.1016","volume":"6","author":[{"given":"David","family":"Barford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin G","family":"Neel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0969-2126(98)00027-6_BIB1","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1126\/science.278.5346.2075","article-title":"Signaling through scaffold, anchoring and adaptor proteins","volume":"278","author":"Pawson","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/373573a0","article-title":"Protein modules and signalling networks","volume":"373","author":"Pawson","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.biophys.26.1.259","article-title":"Modular peptide recognition domains in eukaryotic signalling","volume":"26","author":"Kuriyan","year":"1997","journal-title":"Annu. Rev. Biophys. Biomol. Struct"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/385595a0","article-title":"Three-dimensional structure of the tyrosine kinase c-Src","volume":"385","author":"Xu","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/385602a0","article-title":"Crystal structure of the Src family tyrosine kinase HCK","volume":"385","author":"Sicheri","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0092-8674(00)80938-1","article-title":"Crystal structure of the tyrosine phosphatase SHP-2","volume":"92","author":"Hof","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0955-0674(97)80063-4","article-title":"Protein tyrosine phosphatases in signal transduction","volume":"9","author":"Neel","year":"1997","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB8","doi-asserted-by":"crossref","first-page":"13434","DOI":"10.1016\/S0021-9258(19)38668-5","article-title":"Tyrosyl phosphorylation and growth factor receptor association of human corkscrew homologue, SH-PTP2","volume":"268","author":"Lechleider","year":"1993","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB9","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1016\/S0021-9258(17)36874-6","article-title":"Activation of the SH2-containing protein tyrosine phosphatase, SH-PTPs by phosphotyrosine-containing peptides derived from insulin receptor substrate-1","volume":"269","author":"Sugimoto","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0092-8674(95)90498-0","article-title":"The SH2-containing protein tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development","volume":"80","author":"Tang","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/MCB.18.1.161","article-title":"Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction","volume":"18","author":"O'Reilly","year":"1998","journal-title":"Mol. Cell Biol"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB12","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1093\/emboj\/16.9.2352","article-title":"Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase SHP-2","volume":"16","author":"Saxton","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(92)90098-W","article-title":"Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso","volume":"70","author":"Perkins","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB14","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1242\/dev.122.4.1137","article-title":"The SH2-domain containing protein tyrosine phosphatase corkscrew is required during signalling by sevenless, Ras1 and Raf","volume":"122","author":"Allard","year":"1996","journal-title":"Development"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/dbio.1996.0285","article-title":"The non receptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophilia","volume":"180","author":"Perkins","year":"1996","journal-title":"Dev. Biol"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB16","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1073\/pnas.90.3.1092","article-title":"Overexpression, purification, and characterization of SHPTP1, a Src homology 2-containing protein-tyrosine phosphatase","volume":"90","author":"Pei","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB17","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.1016\/S0021-9258(17)37504-X","article-title":"Characterisation of protein tyrosine phosphatase SH-PTP2","volume":"269","author":"Dechert","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB18","doi-asserted-by":"crossref","first-page":"21478","DOI":"10.1016\/S0021-9258(20)80562-6","article-title":"Activation of the SH2-containing phosphotyrosine phosphatase SH-PTPs by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor \u03b2","volume":"268","author":"Lechleider","year":"1993","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB19","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1074\/jbc.270.7.2897","article-title":"Potent stimulation of SHPTPs phosphatase activity by simultaneous occupancy of both SH2 domains","volume":"270","author":"Pluskey","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/379277a0","article-title":"Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2","volume":"379","author":"Eck","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB21","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1073\/pnas.93.3.1141","article-title":"Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1","volume":"93","author":"Pei","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB22","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/protein\/8.12.1309","article-title":"Regulation of protein tyrosine phosphatase 1C: opposing effects of two src homology domains","volume":"8","author":"Pregel","year":"1995","journal-title":"Protein Eng"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB23","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1126\/science.8128219","article-title":"Crystal structure of human protein tyrosine phosphatase 1B","volume":"263","author":"Barford","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/370571a0","article-title":"Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 \u00e5 and the complex with tungstate","volume":"370","author":"Stuckey","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/382555a0","article-title":"Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerisation","volume":"382","author":"Bilwes","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB26","doi-asserted-by":"crossref","first-page":"27505","DOI":"10.1074\/jbc.272.44.27505","article-title":"The crystal structure of domain 1 of receptor protein tyrosine phosphatase \u03bc","volume":"272","author":"Hoffmann","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB27","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1126\/science.7540771","article-title":"Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B","volume":"268","author":"Jia","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB28","first-page":"in press","article-title":"Visualisation of the cysteinyl-phosphate intermediate of a protein tyrosine phosphatase by X-ray crystallography","author":"Pannifer","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0092-8674(93)90141-C","article-title":"Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase","volume":"73","author":"Desai","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0969-2126(00)00044-7","article-title":"Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase","volume":"2","author":"Lee","year":"1994","journal-title":"Structure"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB31","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1074\/jbc.273.2.729","article-title":"Tandem SH2 domains confer high specificity in tyrosine kinase signalling","volume":"273","author":"Ottinger","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/385650a0","article-title":"Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement","volume":"385","author":"Moarefi","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0969-2126(98)00027-6_BIB33","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","article-title":"MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures","volume":"24","author":"Kraulis","year":"1991","journal-title":"J. Appl. Cryst"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212698000276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212698000276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T01:10:00Z","timestamp":1624410600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212698000276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["S0969212698000276"],"URL":"https:\/\/doi.org\/10.1016\/s0969-2126(98)00027-6","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}