{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:58:07Z","timestamp":1775858287470,"version":"3.50.1"},"reference-count":189,"publisher":"Elsevier","isbn-type":[{"value":"9780120329281","type":"print"}],"license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994]]},"DOI":"10.1016\/s1054-3589(08)60493-7","type":"book-chapter","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T18:51:28Z","timestamp":1207939888000},"page":"45-79","source":"Crossref","is-referenced-by-count":175,"title":["The Role of the l-arginine: Nitric Oxide Pathway in Circulatory Shock"],"prefix":"10.1016","author":[{"given":"Christoph","family":"Thiemermann","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S1054-3589(08)60493-7_bb0005","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1002\/eji.1830220911","article-title":"Immunosuppression induced by nitric oxide and its inhibition by interleukin-4","volume":"22","author":"Al-Ramadi","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0010","author":"Altura","year":"1983"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0015","first-page":"121","article-title":"Failure of microscopic metarterioles to elicit vasodilator responses to acetylcholine, bradykinin, histamine and substance P after ischemic shock, endotoxemia and trauma: Possible role of endothelial cells","volume":"2","author":"Altura","year":"1985","journal-title":"Microcirc. Endothelium Lymphatics"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0014-2999(91)90800-6","article-title":"An inhibitor of nitric oxide production, NG-nitro-l-arginine-methyl ester improves survival in anaphylactic shock","volume":"203","author":"Amir","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0025","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1476-5381.1993.tb12886.x","article-title":"Feedback inhibition of nitric oxide synthase activity by nitric oxide","volume":"108","author":"Assreuy","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0030","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/1043-4666(90)90012-I","article-title":"Hemorrhage induces the increase in serum TNF which is not associated with elevated levels of endotoxin","volume":"2","author":"Ayala","year":"1990","journal-title":"Cytokine"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0035","first-page":"R167","article-title":"Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage","volume":"260","author":"Ayala","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0040","first-page":"194P","article-title":"l-NG-nitro arginine p-nitroanilide (l-NAPNA): A selective inhibitor of nitric oxide synthase in the brain?","volume":"107","author":"Babbedge","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0045","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1073\/pnas.90.1.347","article-title":"Control of cardiac muscle cell function by an endogenous nitric oxide signaling system","volume":"90","author":"Balligrand","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0050","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1172\/JCI116461","article-title":"Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium","volume":"91","author":"Balligrand","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0055","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI115849","article-title":"Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage","volume":"90","author":"Baylis","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0060","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1177\/0310057X9202000303","article-title":"The cytokine network in the critically ill","volume":"20","author":"Bellomo","year":"1992","journal-title":"Anaesthiol. Intensive Care Med."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0065","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-2362.1991.tb01410.x","article-title":"Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock","volume":"21","author":"Billiau","year":"1991","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0070","first-page":"141P","article-title":"Selectivity of NG-nitro-l-arginine-p-anilide to preferentially inhibit neuronal NO synthase can be explained by differential hydrolysis to NG-nitro-l-arginine","volume":"109","author":"Bishop-Bailey","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0075","first-page":"281","article-title":"Vascular adrenergic interactions during hemorrhagic shock","volume":"44","author":"Bond","year":"1985","journal-title":"Fed. Proc."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0080","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1152\/ajplegacy.1967.212.2.488","article-title":"Cutaneous and skeletal muscle vascular responses to hemorrhagic and irreversible shock","volume":"212","author":"Bond","year":"1967","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0085","first-page":"286","article-title":"Hepatic and systemic hemodynamics and the neurohumoral systems in cirrhosis","author":"Bosch","year":"1988"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0090","first-page":"1","article-title":"Plasma Concentrations of endotoxin following jugular or portal injections of endotoxin and following gastrointestinal ischaemia due to hemorrhage","volume":"33","author":"Bottoms","year":"1991","journal-title":"Circ. Shock"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0095","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0014-2999(90)94185-Z","article-title":"Protective effect of s-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat","volume":"191","author":"Boughton-Smith","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0100","doi-asserted-by":"crossref","unstructured":"A.J.B. Brady P.A. Poole-Wilson S.E. Harding J.B. Warren Nitric oxide production within cardiac myocytes reduces their contractility in endotoxaemia. Am. J. Physiol. 263 H1963\u2013H1966","DOI":"10.1152\/ajpheart.1992.263.6.H1963"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0105","first-page":"75","article-title":"PAF\/cytokine auto-generated feedback networks in microvascular immune injury: Consequences in shock, ischemia and graft rejection","volume":"1","author":"Braquet","year":"1989","journal-title":"J. Lipid Med."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0110","first-page":"97","article-title":"Perspectives in platelet-activating factor research","volume":"39","author":"Braquet","year":"1987","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0021-9258(19)49862-1","article-title":"Nitric oxide synthase regulatory phosphorylation sites: Phosphorylation by cyclic AMP dependent protein kinase, protein kinase C, and calcium\/calmodulin protein kinase: Identification of flavin and calmodulin binding sites","volume":"267","author":"Bredt","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0120","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/01.RES.72.2.387","article-title":"NG-nitro-l-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists","volume":"72","author":"Buxton","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0120","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/eji.1830230508","article-title":"Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans","volume":"23","author":"Cenci","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0130","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00003246-198206000-00019","article-title":"Endogenous and exogenous catecholamines in critical care medicine","volume":"10","author":"Chernow","year":"1982","journal-title":"Crit. Care Med."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0135","first-page":"68","article-title":"Endothelium-dependent relaxant action of platelet-activating factor in the rat mesentery","volume":"341","author":"Chiba","year":"1990","journal-title":"Naunyn-Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0140","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2337\/diab.41.8.897","article-title":"Does nitric oxide mediate autoimmune destruction of beta cells: Possible therapeutic interventions in IDDM","volume":"41","author":"Corbett","year":"1992","journal-title":"Diabetes"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0145","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1476-5381.1993.tb13552.x","article-title":"Support of renal blood flow after ischemic-reperfusion injury by endogenous formation of nitric oxide and of vasodilator cyclo-oxygenase metabolites","volume":"109","author":"Cristol","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0150","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/0024-3205(91)90596-4","article-title":"Activated neutrophils inhibit cerebrovascular endothelium-dependent relaxations in vitro","volume":"49","author":"Csaki","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0155","first-page":"57","article-title":"Clinical disorders involving adrenocortical insufficiency and overreactivity","volume":"3","author":"Cullen","year":"1980"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0160","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/0006-291X(92)91852-H","article-title":"Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-\u03b3 in murine macrophages","volume":"182","author":"Cunha","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0165","first-page":"563","article-title":"Induction of macrophage parasiticidal activity by Staphylococcus aureus and exotoxins through the nitric oxide synthase pathway","volume":"78","author":"Cunha","year":"1993","journal-title":"Immunology"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0170","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/00000658-199010000-00009","article-title":"Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis","volume":"212","author":"Curran","year":"1990","journal-title":"Ann. Surg."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0175","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1126\/science.8456300","article-title":"Multiple defects of immune cell function in mice with disrupted interferon-\u03b3 genes","volume":"259","author":"Dalton","year":"1993","journal-title":"Science"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V77.8.1627.1627","article-title":"Interleukin-1 and interleukin-1 antagonism","volume":"77","author":"Dinarello","year":"1991","journal-title":"Blood"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0185","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0167-5699(91)90142-G","article-title":"Blocking IL-1: Interleukin-1 receptor antagonists in vivo and in vitro","volume":"12","author":"Dinarello","year":"1991","journal-title":"Immunol. Today"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0190","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1161\/01.RES.73.2.217","article-title":"Molecular mechanisms of nitric oxide regulation: Potential relevance to cardiovascular disease","volume":"73","author":"Dinerman","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0195","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/0006-291X(90)91583-E","article-title":"Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages","volume":"172","author":"Di Rosa","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0200","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0006-291X(05)80832-0","article-title":"Nitric oxide mediates tumour necrosis factor-a cytoxicity in endothelial cells","volume":"186","author":"Estrada","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0205","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1073\/pnas.89.12.5361","article-title":"Purification of a distinctive form of endotoxin-induced nitric oxide synthase from rat liver","volume":"89","author":"Evans","year":"1992","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0210","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1128\/IAI.60.10.4133-4139.1992","article-title":"Differential effects of monoclonal antibodies to tumor necrosis factor \u03b1 and \u03b3 interferon on induction of hepatic nitric oxide synthase in experimental gram-negative synthesis","volume":"60","author":"Evans","year":"1992","journal-title":"Infect. Immunol."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0210","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1476-5381.1993.tb12803.x","article-title":"Nitric oxide modulates vascular permeability in the rat coronary circulation","volume":"108","author":"Filep","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0220","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0022-4804(85)90046-0","article-title":"Diminished pressor responses to exogenous norepinephrine and angiotensin II in septic, unanaesthetized rats: Evidence for a prostaglandin-mediated effect","volume":"38","author":"Fink","year":"1985","journal-title":"J. Surg. Res."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0225","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1126\/science.1631560","article-title":"Negative inotropic effects of cytokines on the heart mediated by nitric oxide","volume":"257","author":"Finkel","year":"1992","journal-title":"Science"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0230","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/0006-291X(90)91183-S","article-title":"Incubation with endotoxin activates the l-arginine pathway in vascular tissue","volume":"171","author":"Fleming","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl.12","key":"10.1016\/S1054-3589(08)60493-7_bb0235","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1097\/00005344-199204002-00038","article-title":"Endothelium-derived kinins account for the immediate response of endothelial cells to bacterial lipopolysaccharide","volume":"20","author":"Fleming","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0240","first-page":"349","article-title":"RP 55778, a PAF receptor antagonist, prevents and reverses hemoconcentration and TNF release","volume":"1","author":"Floch","year":"1989","journal-title":"J. Lipid Med."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0245","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/278456a0","article-title":"Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation","volume":"278","author":"Flower","year":"1979","journal-title":"Nature (London)"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0250","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/0006-2952(91)90581-O","article-title":"Isoforms of nitric oxide synthase: Characterization and purification from different cell types","volume":"42","author":"Forstermann","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0255","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1476-5381.1992.tb14439.x","article-title":"The cardiodepressant and vasodepressant effects of tumour necrosis factor in rat isolated atrial and aortic tissues","volume":"106","author":"Foulkes","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0260","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0021-9258(17)44821-6","article-title":"The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes","volume":"265","author":"Fu","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0265","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature (London)"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0270","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1161\/01.RES.71.5.1268","article-title":"Interferon-\u03b3 and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells","volume":"71","author":"Geng","year":"1992","journal-title":"Circ. Res."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0275","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1084\/jem.177.2.547","article-title":"Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia","volume":"177","author":"Gerard","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0280","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00917870","article-title":"Influence of corticosteroids on human polymorphonuclear leukocyte function in vitro: Reduction of lysosomal enzyme release and superoxide production","volume":"1","author":"Goldstein","year":"1976","journal-title":"Inflammation"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0285","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0014-2999(90)94099-J","article-title":"An l-arginine-derived factor mediates endotoxin-induced vascular hyposensitivity to calcium","volume":"191","author":"Gray","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0290","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/j.1476-5381.1991.tb12327.x","article-title":"The effect of inhibitors of the l-arginine\/nitric oxide pathway on endotoxin-induced loss of vascular responsiveness in anaesthetized rats","volume":"103","author":"Gray","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0290","first-page":"6","article-title":"The role of plasma arginine in nitric oxide synthesis: Studies with arginase-treated guinea-pigs and rats","volume":"1","author":"Griffith","year":"1992"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0300","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0021-9258(18)35667-9","article-title":"Tetrahydrobiopterin synthesis: An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle","volume":"267","author":"Gross","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0305","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0006-291X(90)91245-N","article-title":"Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine","volume":"170","author":"Gross","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0310","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0006-291X(91)90965-A","article-title":"Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent. calmodulin-independent and inhibited by arginine analogues with a rank order of potency characteristic of activated macrophages","volume":"178","author":"Gross","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0315","article-title":"LPS induces GTP cyclohydrolase in vascular smooth muscle: Role in NO biosynthesis and LPS-mediated vascular dysfunction in vivo","author":"Gross","year":"1993","journal-title":"FASEB J."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0320","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1172\/JCI109365","article-title":"Corticosteroids inhibit complement-induced granulocyte aggregation","volume":"63","author":"Hammerschmidt","year":"1979","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0325","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/jlb.52.4.390","article-title":"Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury","volume":"52","author":"Harbrecht","year":"1992","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0330","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1152\/ajplegacy.1964.206.6.1262","article-title":"Effect of hemorrhagic shock on release of norepininephine by tyramine","volume":"206","author":"Harrison","year":"1964","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0335","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/bj2880255","article-title":"Induction of nitric oxide synthase in L929 cells by tumour-necrosis factor \u03b1 is prevented by inhibitors of poly(ADP-ribose) polymerase","volume":"288","author":"Hauschildt","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0340","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1172\/JCI115666","article-title":"Evidence for cytokine-inducible nitric oxide synthesis from l-arginine in patients receiving interleukin-2 therapy","volume":"89","author":"Hibbs","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0345","first-page":"H660","article-title":"Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats","volume":"264","author":"Hollenberg","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0350","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0300-9572(89)90023-3","article-title":"Platelet-activating factor and cytokine interactions in shock","volume":"18","author":"Hosford","year":"1989","journal-title":"Resuscitation"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0355","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1126\/science.8456301","article-title":"Immune response in mice that lack the interferon-gamma receptor","volume":"259","author":"Huang","year":"1993","journal-title":"Science"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0360","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1476-5381.1990.tb14163.x","article-title":"Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat","volume":"101","author":"Hutcheson","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0365","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0006-2952(91)90618-F","article-title":"Signal transduction mechanisms involving nitric oxide","volume":"41","author":"Ignarro","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0370","first-page":"H1038","article-title":"Loss of vascular responsiveness induced by endotoxin involves l-arginine pathway","volume":"259","author":"Julou-Schaeffer","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0370","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1111\/j.1476-5381.1989.tb12688.x","article-title":"Evidence for the involvement of a plasma kallikrein-kinin system in the immediate hypotension produced by endotoxin in anaesthetized rats","volume":"98","author":"Katori","year":"1989","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0380","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/jnci\/84.11.827","article-title":"Overproduction of nitric oxide in cytokine-mediated and septic shock","volume":"84","author":"Kilbourn","year":"1992","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0385","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/0006-291X(90)91565-A","article-title":"Reversal of endotoxin-mediated shock by NG-monomethyl-l-arginine, an inhibitor of nitric oxide synthesis","volume":"172","author":"Kilbourn","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0390","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1073\/pnas.87.9.3629","article-title":"NG-Methyl-l-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide","volume":"87","author":"Kilbourn","year":"1990","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0395","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/0006-291X(91)91010-A","article-title":"NG-Monomethyl-l-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock","volume":"178","author":"Klabunde","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0400","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0014-2999(91)90636-5","article-title":"Cardiovascular actions of inhibitors of endothelium-derived relaxing factor (nitric oxide) formation\/release in anaesthetized dogs","volume":"199","author":"Klabunde","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0405","first-page":"47","article-title":"NG-Methyl-l-arginine restores arterial pressure in hemorrhaged rats","volume":"40","author":"Klabunde","year":"1993","journal-title":"Circ. Shock"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0410","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1042\/bj2700833","article-title":"Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat","volume":"270","author":"Knowles","year":"1990","journal-title":"Biochem. J."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0415","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0006-291X(90)91551-3","article-title":"Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver, and aorta of the rat","volume":"172","author":"Knowles","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0420","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/0006-291X(92)90708-S","article-title":"Detection of nitric oxide production in lipopolysaccharide-treated rats by ESR using carbon monoxide hemoglobin","volume":"184","author":"Kosaka","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0425","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0006-291X(92)91571-7","article-title":"Synergistic stimulation of nitric oxide hemoglobin production in rats by recombinant interleukin 1 and tumor necrosis factor","volume":"189","author":"Kosaka","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl.3","key":"10.1016\/S1054-3589(08)60493-7_bb0430","doi-asserted-by":"crossref","first-page":"S198","DOI":"10.1097\/00005344-199117003-00037","article-title":"Changes of contractile and endothelium-dependent relaxant responses following a haemorrhagic hypotension in cats: Regional differences","volume":"17","author":"Kovach","year":"1991","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0435","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/01.STR.22.12.1541","article-title":"Effect of hemorrhagic hypotension on cerebrovascular reactivity and ultrastructure in the cat","volume":"22","author":"Kovach","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0440","first-page":"H611","article-title":"Nitric oxide modulates microvascular permeability","volume":"31","author":"Kubes","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0445","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1073\/pnas.88.11.4651","article-title":"Nitric oxide: An endogenous modulator of leukocyte adhesion","volume":"88","author":"Kubes","year":"1991","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0450","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/01.RES.73.1.164","article-title":"Inhibition of nitric oxide production: Mechanisms of vascular albumin leakage","volume":"73","author":"Kurose","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0455","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-2999(92)90221-O","article-title":"Characterization of cell selectivity of two novel inhibitors of nitric oxide synthesis","volume":"216","author":"Lambert","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0460","first-page":"1220","article-title":"Constitutive and inducible nitric oxide synthases in human megakaryoblastic cells","volume":"262","author":"Lelchuk","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0460","first-page":"959","article-title":"Regional differences in the effects of septic shock on vascular reactivity in the rabbit","volume":"261","author":"Li","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0470","first-page":"868","article-title":"Nitric oxide inhibition in rats improves blood pressure and renal function during hypovolemic shock","volume":"261","author":"Lieberthal","year":"1991","journal-title":"Am. J. Physiol."},{"issue":"Suppl. 12","key":"10.1016\/S1054-3589(08)60493-7_bb0475","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1097\/00005344-199204002-00041","article-title":"Lipoteichoic acid: A new inducer of nitric oxide synthase","volume":"20","author":"Lonchampt","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0480","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/hep.1840080207","article-title":"Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral blood in patients with cirrhosis","volume":"8","author":"Lumsden","year":"1988","journal-title":"Hepatology"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0485","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1476-5381.1993.tb13613.x","article-title":"Prevention of nitric oxide synthase induction in vascular smooth muscle cells by microtubule depolymerizing agents","volume":"109","author":"Marczin","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0490","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0021-9258(18)31375-9","article-title":"Nitric oxide synthase structure and mechanism","volume":"268","author":"Marletta","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0495","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1476-5381.1992.tb14499.x","article-title":"Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774","volume":"107","author":"Marotta","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0500","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1073\/pnas.89.9.3917","article-title":"Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme","volume":"89","author":"Masferrer","year":"1992","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0505","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0006-2952(93)90072-5","article-title":"Inhibition of nitric oxide synthesis by methylene blue","volume":"45","author":"Mayer","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0510","first-page":"23","article-title":"Reduced myocardial responses to calcium during endotoxic shock in the rat","volume":"7","author":"McCaig","year":"1980","journal-title":"Circ. Shock"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0515","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1476-5381.1991.tb12159.x","article-title":"Identification of N-iminoethyl-l-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells","volume":"102","author":"McCall","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0520","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1002\/eji.1830211032","article-title":"Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone","volume":"21","author":"McCall","year":"1991","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0525","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/0006-291X(92)90800-Z","article-title":"Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils","volume":"186","author":"McCall","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0530","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1172\/JCI114679","article-title":"Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility: Association with vascular cytokine release","volume":"86","author":"McKenna","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0535","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1152\/jappl.1992.73.1.324","article-title":"Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis","volume":"73","author":"Meyer","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0540","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1152\/ajplegacy.1944.141.1.132","article-title":"The effect of renin and angiotensin during hemorrhagic hypotension and shock","volume":"141","author":"Middleton","year":"1944","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0545","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-2999(93)90357-N","article-title":"Selective inhibition of the inducible nitric oxide synthase by aminoguanidiene","volume":"233","author":"Misko","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0550","first-page":"117P","article-title":"Relationship between endothelial cell activation and subsequent NO synthase activity: Inhibition by oxygen derived free radicals","volume":"104","author":"Mitchell","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0550","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1476-5381.1993.tb13563.x","article-title":"Induction by endotoxin of nitric oxide synthase in the rat mesentery: Lack of effect on action of vasoconstrictors","volume":"109","author":"Mitchell","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0560","first-page":"18","article-title":"A role of interleukin-1 in septic shock","author":"Moldawer","year":"1993"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0565","first-page":"109","article-title":"Nitric oxide: Physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0570","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1476-5381.1990.tb14717.x","article-title":"NG-nitroarginine (l-NOARG), a novel l-arginine reversible inhibitor of endothelium-dependent vasodilatation in vitro","volume":"99","author":"Moore","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0575","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1476-5381.1992.tb14486.x","article-title":"Involvement of nitric oxide in the PAF-induced relaxation of rat thoracic aorta","volume":"107","author":"Moritoki","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0580","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0014-5793(90)81445-T","article-title":"Induction of nitric oxide by cytokines in vascular smooth muscle cells","volume":"275","author":"M\u00fclsch","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0585","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1096\/fasebj.6.12.1381691","article-title":"Nitric oxide as a secretory product of mammalian cells","volume":"6","author":"Nathan","year":"1992","journal-title":"FASEB J."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0590","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0952-7915(91)90079-G","article-title":"Role of nitric oxide synthesis in macrophage antimicrobial activity","volume":"3","author":"Nathan","year":"1991","journal-title":"Current Opinion Immunol."},{"issue":"Suppl. 12","key":"10.1016\/S1054-3589(08)60493-7_bb0595","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1097\/00005344-199204002-00037","article-title":"The role of nitric oxide in endotoxic shock: Effects of NG-monomethyl-l-arginine","volume":"20","author":"Nava","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0600","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00000658-199111000-00013","article-title":"Nitrogen oxide levels in patients after trauma and during sepsis","volume":"214","author":"Ochoa","year":"1991","journal-title":"Ann. Surg."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0605","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/jnci\/84.11.864","article-title":"Increased circulating nitrogen oxides after human tumor immunotherapy: Correlation with toxic hemodynamic changes","volume":"84","author":"Ochoa","year":"1992","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0610","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0006-291X(91)91864-9","article-title":"Inactivation of macrophage nitric oxide synthase activity by NG-monomethyl-l-arginine","volume":"177","author":"Olken","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0615","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/327524a0","article-title":"Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor","volume":"327","author":"Palmer","year":"1987","journal-title":"Nature (London)"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0620","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1476-5381.1992.tb14202.x","article-title":"The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids","volume":"105","author":"Palmer","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0625","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/01.RES.72.3.539","article-title":"Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia","volume":"72","author":"Parker","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0630","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/00003246-198710000-00006","article-title":"Serial hemodynamic patterns in survivors and non-survivors of septic shock in humans","volume":"15","author":"Parker","year":"1987","journal-title":"Crit. Care Med."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0635","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1476-5381.1973.tb08154.x","article-title":"Myocardial and circulatory effects of E. coli endotoxin: Modification of the response to catecholamines","volume":"47","author":"Parratt","year":"1973","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0640","article-title":"Effect of dexamethasone on the onset and persistence of vascular hyporeactivity induced by E. coli lipopolysaccharide in rats","author":"Paya","year":"1993","journal-title":"Circ. Shock"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0645","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/0140-6736(91)92376-D","article-title":"Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock","volume":"338","author":"Petros","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/S1054-3589(08)60493-7_rf0645","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0006-291X(05)81003-4","article-title":"Endotoxin and TNF\u03b1 directly stimulate nitric oxide formation in cultured rat hepatocytes from chronically endotoxemic rats","volume":"185","author":"Pittner","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0655","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1476-5381.1992.tb14233.x","article-title":"Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension","volume":"105","author":"Pizcueta","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0660","first-page":"256","article-title":"Platelet-activating factor (PAF) and tumor necrosis factor-\u03b1 (TNF\u03b1) interactions in endotoxemic shock: Studies with BN 50739, a novel PAF antagonist","volume":"255","author":"Rabinovici","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0665","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1073\/pnas.87.24.10043","article-title":"Glucocorticoids inhibit the expression of an inducible, but not the constitutive nitric oxide synthase in vascular endothelial cells","volume":"87","author":"Radomski","year":"1990","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0670","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1476-5381.1990.tb12709.x","article-title":"Characterization of the l-arginine: nitric oxide pathway in human platelets","volume":"101","author":"Radomski","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0675","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.86.9.3375","article-title":"Role of endothelium-derived nitric oxide in the regulation of blood pressure","volume":"86","author":"Rees","year":"1989","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0680","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0006-291X(05)80068-3","article-title":"Dexmethasone prevents the induction of a nitric oxide synthase and the associated effects on the vascular tone: An insight into endotoxic shock","volume":"173","author":"Rees","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0685","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1476-5381.1990.tb14151.x","article-title":"Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo","volume":"101","author":"Rees","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0690","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0006-291X(92)91550-A","article-title":"Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from l-arginine","volume":"189","author":"Rogers","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0695","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0014-5793(91)81123-P","article-title":"Widespread tissue distribution, species distribution and changes in activity of calcium-dependent and calcium-independent nitric oxide synthases","volume":"291","author":"Salter","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0700","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.1073\/pnas.86.16.6328","article-title":"Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitrix oxide-like factor","volume":"86","author":"Saivemini","year":"1989","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0705","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1073\/pnas.87.7.2593","article-title":"Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Eschericia coli lipopolysaccharide","volume":"87","author":"Salvemini","year":"1990","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0710","first-page":"H1086","article-title":"Angiotensin II, vasopressin, and sympathetic activity in conscious rat with endotoxaemia","volume":"249","author":"Schaller","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0715","first-page":"H611","article-title":"Thrombin inhibits induction of nitric oxide synthase in vascular smooth muscle cells","volume":"264","author":"Schini","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0720","first-page":"265","article-title":"Hemodynamic and hormonal alterations in hepatic cirrhosis","author":"Schrier","year":"1988"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0725","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1172\/JCI110228","article-title":"Corticosteroids block binding of chemotactic peptide to its receptor on granulocyte aggregates in vitro","volume":"68","author":"Schubitz","year":"1981","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0730","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1476-5381.1992.tb09021.x","article-title":"Induction and potential biological relevance of a Ca2+-independent nitric oxide synthase in the myocardium","volume":"105","author":"Schulz","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0730","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/0006-291X(92)91330-S","article-title":"The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages","volume":"188","author":"Severn","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0740","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1006\/bbrc.1993.1359","article-title":"Pyrrolidine dithocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages","volume":"191","author":"Sherman","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0745","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1172\/JCI116045","article-title":"Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis","volume":"90","author":"Shultz","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0750","first-page":"G996","article-title":"vitro hyporeactivity to methoxamine in portal hypertensive rats: Reversal by nitric oxide blockade","volume":"262","author":"Sieber","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0755","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0014-2999(92)90326-Y","article-title":"Splanchnic vascular endothelial dysfunction in rat endotoxemia: Role of superoxide radicals","volume":"212","author":"Siegfried","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0760","doi-asserted-by":"crossref","unstructured":"R. Simatov. Glucocorticoids inhibit endorphin synthesis by pituitary cells. Nature (London)280, 684","DOI":"10.1038\/280684a0"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0765","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1476-5381.1993.tb13512.x","article-title":"Porcine endocardial cells in culture express the inducible form of nitric oxide synthase","volume":"108","author":"Smith","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0770","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1476-5381.1991.tb12375.x","article-title":"Coronary vasodilatation induced by endotoxin in the rabbit isolated perfused heart is nitric oxide-dependent and inhibited by dexamethasone","volume":"104","author":"Smith","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0775","first-page":"9P","article-title":"Amides and esters of NG-nitro-l-arginine (e.g. l-NAME) must be hydrolyzed to become active NO synthase inhibitors","volume":"109","author":"Southan","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0780","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1073\/pnas.89.18.8711","article-title":"Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anaesthetized rabbits","volume":"89","author":"Sprague","year":"1992","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0785","doi-asserted-by":"crossref","first-page":"C910","DOI":"10.1152\/ajpcell.1991.260.5.C910","article-title":"Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes","volume":"260","author":"Stadler","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0790","first-page":"789","article-title":"Protective actions of S-nitroso-N-penicillamine (SNAP) in a rat model of hemorrhagic shock","volume":"14","author":"Symington","year":"1992","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0795","first-page":"307","article-title":"Role of the l-arginine-nitric oxide pathway in the changes in cerebrovascular reactivity following hemorrhagic hypotension and retransfusion","volume":"37","author":"Szabo","year":"1992","journal-title":"Circ. Shock"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0800","first-page":"238","article-title":"Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat","volume":"36","author":"Szabo","year":"1992","journal-title":"Circ. Shock"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0805","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1476-5381.1993.tb12879.x","article-title":"Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock","volume":"108","author":"Szabo","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0810","first-page":"31P","article-title":"Role of constitutive and inducible nitric oxide synthases in the cardiovascular response in systemic anaphylaxis","volume":"110","author":"Szabo","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0815","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1098\/rspb.1993.0108","article-title":"Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuate the cardiovascular response to bacterial endotoxin in adrenalectomized rats","volume":"253","author":"Szabo","year":"1993","journal-title":"Proc. R. Soc. B"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0820","first-page":"11P","article-title":"An antagonist of platelet-activating factor (WEB 2086) inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide","volume":"109","author":"Szabo","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0815","first-page":"674","article-title":"Nifedipine inhibits endotoxin-mediated nitric oxide synthase induction","volume":"256","author":"Szabo","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0830","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/0024-3205(92)90262-N","article-title":"Tumor necrosis factor-\u03b1 induces vascular hyporesponsiveness in Sprague-Dawley rats","volume":"50","author":"Takahashi","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0835","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/jac\/30.6.839","article-title":"Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone","volume":"30","author":"Teale","year":"1992","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0840","first-page":"187","article-title":"Biosynthesis and interaction of endothelium-derived vasoactive mediators","volume":"4","author":"Thiemermann","year":"1991","journal-title":"Eicosanoids"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0845","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0014-2999(90)90062-B","article-title":"Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo","volume":"182","author":"Thiemermann","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0850","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1073\/pnas.90.1.267","article-title":"Nitric oxide mediates hyporeactivity to noradrenaline and vascular decompensation in hemorrhagic shock","volume":"90","author":"Thiemermann","year":"1993","journal-title":"Proc Natl Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0855","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1476-5381.1993.tb13789.x","article-title":"Tumour necrosis factor is an endogenous mediator of the induction of nitric oxide synthase in endotoxin shock in the rat","volume":"110","author":"Thiemermann","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0860","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/0140-6736(91)91384-7","article-title":"Hyperdynamic circulation in cirrhosis: A role for nitric oxide?","volume":"337","author":"Vallance","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0865","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1476-5381.1992.tb14356.x","article-title":"The role of induction of nitric oxide synthesis in the altered responses of jugular veins from endotoxaemic rabbits","volume":"106","author":"Vallance","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0870","first-page":"216","article-title":"Nitric oxide and tumour necrosis factor in terminal arterioles of rat skeletal muscle","volume":"1","author":"Vicaut","year":"1992"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0875","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0090-1229(87)90087-0","article-title":"Production and clearance of tumor necrosis factor exposed to endotoxin and dexamethasone","volume":"45","author":"Waage","year":"1987","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0880","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0014-2999(87)90417-1","article-title":"Diminution of contractile response of the aorta from endotoxin-injected rats","volume":"141","author":"Wakabayashi","year":"1987","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0885","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1476-5381.1991.tb12285.x","article-title":"Endothelium-derived relaxing factor plays an important role in the regulation of renal cortical blood flow in the rat","volume":"102","author":"Walder","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0890","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1006\/jsre.1993.1077","article-title":"Endothelial cell dysfunction occurs after hemorrhage in nonheparinized, but not in preheparinized models","volume":"54","author":"Wang","year":"1993","journal-title":"J. Surg. Res."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0895","article-title":"Endothelial cell dysfunction occurs very early following trauma-hemorrhage and persists despite fluid resuscitation","author":"Wang","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0900","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0024-3205(91)90251-6","article-title":"Nitric oxide hemoglobin in mice and rats in endotoxic shock","volume":"49","author":"Wang","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0905","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0014-2999(93)90352-I","article-title":"Nitric oxide inhalation attenuates pulmonary hypertension and improves gas exchange in endotoxin shock","volume":"233","author":"Weitzberg","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0910","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/cvr\/26.1.48","article-title":"Protective and pathological roles of nitric oxide in endotoxin shock","volume":"26","author":"Wright","year":"1992","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/S1054-3589(08)60493-7_rf0905","first-page":"156P","article-title":"Role of endogenous tumour necrosis factor, interleukin-1 and platelet-activating factor in the vascular hyporeactivity in rats treated with endotoxin","volume":"110","author":"Wu","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0920","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1164\/ajrccm\/142.6_Pt_1.1263","article-title":"Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro","volume":"142","author":"Wylam","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0925","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0165-022X(89)90071-7","article-title":"A simple turbidometric time assay of the endotoxin in plasma","volume":"18","author":"Yomota","year":"1989","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10.1016\/S1054-3589(08)60493-7_bb0930","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/01.RES.73.1.205","article-title":"Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life","volume":"73","author":"Yoshizumi","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0935","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1073\/pnas.89.6.2051","article-title":"Induction of nitric oxide synthase activity by toxic shock syndrome toxin 1 in a macrophage-monocyte cell line","volume":"89","author":"Zembowicz","year":"1992","journal-title":"Proc Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0940","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1097\/00005344-199206000-00021","article-title":"Evidence for a role of nitric oxide in hypovolemic hemorrhagic shock","volume":"19","author":"Zingarelli","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/S1054-3589(08)60493-7_bb0945","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/eji.1830190213","article-title":"Differential regulation of lipopolysaccharide-induced interleukin-1 and tumor necrosis factor synthesis: Effects of endogenous and exogenous glucocorticoids and the role of the pituitary-adrenal axis","volume":"19","author":"Zuckerman","year":"1989","journal-title":"Eur. J. Immunol."}],"container-title":["Advances in Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358908604937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358908604937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T22:47:37Z","timestamp":1631054857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054358908604937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994]]},"ISBN":["9780120329281"],"references-count":189,"URL":"https:\/\/doi.org\/10.1016\/s1054-3589(08)60493-7","relation":{},"ISSN":["1054-3589"],"issn-type":[{"value":"1054-3589","type":"print"}],"subject":[],"published":{"date-parts":[[1994]]}}}