{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:29:21Z","timestamp":1773656961881,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Medicine Today"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1016\/s1357-4310(98)01344-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T22:51:50Z","timestamp":1027637510000},"page":"431-437","source":"Crossref","is-referenced-by-count":42,"title":["Targeted gene correction: a new strategy for molecular medicine"],"prefix":"10.1016","volume":"4","author":[{"given":"Shanzhang","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allyson","family":"Cole-Strauss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric B","family":"Kmiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1357-4310(98)01344-6_BIB1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/317230a0","article-title":"Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination","volume":"317","author":"Smithies","year":"1985","journal-title":"Nature"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB2","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1126\/science.2660260","article-title":"Altering the genome by homologous recombination","volume":"244","author":"Capecchi","year":"1989","journal-title":"Science"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.gt.3300556","article-title":"The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro","volume":"5","author":"Stern","year":"1998","journal-title":"Gene Ther."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ng0498-325","article-title":"Human gene targeting by viral vectors","volume":"18","author":"Russell","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/373084a0","article-title":"DNA structure-dependent requirements for yeast RAD genes in gene conversion","volume":"373","author":"Sugawara","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0092-8674(95)90434-4","article-title":"DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA","volume":"82","author":"Sung","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0092-8674(00)81394-X","article-title":"Human RAD51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro","volume":"87","author":"Baumann","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB8","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1073\/pnas.85.2.524","article-title":"Transformation of yeast with synthetic oligonucleotides","volume":"85","author":"Moerschell","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB9","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1126\/science.271.5250.802","article-title":"Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair","volume":"271","author":"Wang","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB10","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1128\/MCB.14.9.6097","article-title":"A role for RNA synthesis in homologous pairing events","volume":"14","author":"Kotani","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB11","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1128\/MCB.14.3.1949","article-title":"Transcription activates RecA-promoted homologous pairing of nucleosomal DNA","volume":"14","author":"Kotani","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB12","unstructured":"Roth, D. and Wilson, J. (1988) Genetic Recombination (Kucherlapati, R. and Smith, G.R.), pp. 621\u2013653, American Society of Microbiology, Washington"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s004380050771","article-title":"RecA-mediated joint molecule formation between O-methylated RNA\/DNA hairpins and single- or double-stranded targets","volume":"258","author":"Havre","year":"1998","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB14","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1074\/jbc.273.13.7507","article-title":"Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells","volume":"273","author":"Pollard","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB15","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nbt0597-462","article-title":"In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer","volume":"15","author":"Goldman","year":"1997","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB16","doi-asserted-by":"crossref","first-page":"9682","DOI":"10.1073\/pnas.93.18.9682","article-title":"Guanidinium-cholesterol cationic lipids: efficient vectors for the transfection of eukaryotic cells","volume":"93","author":"Vigneron","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB17","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","article-title":"A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine","volume":"92","author":"Boussif","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB18","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1073\/pnas.93.5.2071","article-title":"Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA\u2013DNA oligonucleotide","volume":"93","author":"Yoon","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB19","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/hep.510250626","article-title":"Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA\/DNA oligonucleotide","volume":"25","author":"Kren","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB20","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1126\/science.273.5280.1386","article-title":"Correction of the mutation responsible for sickle cell anemia by an RNA\/DNA oligonucleotide","volume":"273","author":"Cole-Strauss","year":"1996","journal-title":"Science"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nm0398-285","article-title":"In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA\/DNA oligonucleotides","volume":"4","author":"Kren","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0168-9525(97)01232-8","article-title":"Transgenic plants: environmentally safe factories of the future","volume":"13","author":"Palmgren","year":"1997","journal-title":"Trends Genet."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB23","unstructured":"Kipp, P.B. et al. Gene targeting in plants via Q site-directed mutagenesis, in Gene Targeting Protocols (Kmiec, E. and Gruenert, D.), Humana Press (in press)"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB24","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1016\/S0021-9258(19)67858-0","article-title":"Heteroduplex repair in extracts of human HeLa cells","volume":"266","author":"Thomas","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0092-8674(87)90646-5","article-title":"Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells","volume":"51","author":"Thomas","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB26","unstructured":"Bartlett, R.J. et al. (1998) Targeted revision of the mdx point mutation in Nature Biology Short Reports (Vol. 9), pp. 163\u2013164, Nature Publishing Co."},{"key":"10.1016\/S1357-4310(98)01344-6_BIB27","unstructured":"Lai, L.W. et al. (1998) Correction of carbonic anhydrase II mutation in renal tubular cells by chimeric RNA\/DNA oligonucleotide, Conference Proceedings: 1st Annual Meeting of the American Society of Gene Therapy, p. 183, American Society of Gene Therapy"},{"key":"10.1016\/S1357-4310(98)01344-6_BIB28","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nm0398-274","article-title":"The site-specific correction of genetic defects","volume":"4","author":"Strauss","year":"1998","journal-title":"Nat. Med."}],"container-title":["Molecular Medicine Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357431098013446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357431098013446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T19:58:04Z","timestamp":1620849484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357431098013446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["S1357431098013446"],"URL":"https:\/\/doi.org\/10.1016\/s1357-4310(98)01344-6","relation":{},"ISSN":["1357-4310"],"issn-type":[{"value":"1357-4310","type":"print"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}