{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:25:48Z","timestamp":1772817948562,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1016\/s1471-4914(01)02161-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T10:02:01Z","timestamp":1027591321000},"page":"482-484","source":"Crossref","is-referenced-by-count":103,"title":["PI 3-kinase, mTOR, protein synthesis and cancer"],"prefix":"10.1016","volume":"7","author":[{"given":"Peter K","family":"Vogt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S1471-4914(01)02161-X_BIB1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/35077225","article-title":"Oncogenic kinase signalling","volume":"411","author":"Blume-Jensen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S1471-4914(01)02161-X_BIB2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)00117-3","article-title":"TOR, a central controller of cell growth","volume":"103","author":"Schmelzle","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S1471-4914(01)02161-X_BIB3","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1093\/emboj\/16.12.3693","article-title":"Rapamycin suppresses 5\u2032TOP mRNA translation through inhibition of p70s6k","volume":"16","author":"Jefferies","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.biochem.68.1.913","article-title":"eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation","volume":"68","author":"Gingras","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/5042","article-title":"PIK3CA is implicated as an oncogene in ovarian cancer","volume":"21","author":"Shayesteh","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB6","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1073\/pnas.96.8.4240","article-title":"New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase\/AKT pathway","volume":"96","author":"Cantley","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S. A."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB7","first-page":"3504","article-title":"A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells","volume":"60","author":"Sekulic","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB8","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1006\/bbrc.1996.1280","article-title":"Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer","volume":"225","author":"Miwa","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB9","doi-asserted-by":"crossref","first-page":"21528","DOI":"10.1074\/jbc.274.31.21528","article-title":"Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines","volume":"274","author":"Nakatani","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/(SICI)1098-2744(199802)21:2<81::AID-MC1>3.0.CO;2-R","article-title":"Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas","volume":"21","author":"Ruggeri","year":"1998","journal-title":"Mol. Carcinog."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB11","doi-asserted-by":"crossref","first-page":"9267","DOI":"10.1073\/pnas.89.19.9267","article-title":"AKT2, a putative oncogene encoding a member of a subfamily of protein-serine\/threonine kinases, is amplified in human ovarian carcinomas","volume":"89","author":"Cheng","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB12","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1073\/pnas.93.8.3636","article-title":"Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA","volume":"93","author":"Cheng","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/ijc.2910640412","article-title":"Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas","volume":"64","author":"Bellacosa","year":"1995","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S1471-4914(01)02161-X_BIB14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1357-2725(98)00132-0","article-title":"eIF4E expression in tumors: its possible role in progression of malignancies","volume":"31","author":"De Benedetti","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB15","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1038\/sj.onc.1204091","article-title":"The rapamycin-sensitive signal transduction pathway as a target for cancer therapy","volume":"19","author":"Hidalgo","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S1471-4914(01)02161-X_BIB16","doi-asserted-by":"crossref","first-page":"10320","DOI":"10.1073\/pnas.171060098","article-title":"An inhibitor of mTOR reduces neoplasia and normalizes p70\/S6 kinase activity in Pten+\/\u2212 mice","volume":"98","author":"Podsypanina","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB17","doi-asserted-by":"crossref","first-page":"10314","DOI":"10.1073\/pnas.171076798","article-title":"Enhanced sensitivity of PTEN\u2013deficient tumors to inhibition of FRAP\/mTOR","volume":"98","author":"Neshat","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1073\/pnas.011528498","article-title":"A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt","volume":"98","author":"Aoki","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S1471-4914(01)02161-X_BIB19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/345544a0","article-title":"Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5\u2032 cap","volume":"345","author":"Lazaris-Karatzas","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S1471-4914(01)02161-X_BIB20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1128\/MCB.16.1.405","article-title":"Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains","volume":"16","author":"Mahalingam","year":"1996","journal-title":"Mol. Cell. Biol."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149140102161X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149140102161X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T16:23:04Z","timestamp":1556468584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147149140102161X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S147149140102161X"],"URL":"https:\/\/doi.org\/10.1016\/s1471-4914(01)02161-x","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}