{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:43:04Z","timestamp":1786999384727,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Respiratory Medicine"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/s2213-2600(19)30059-1","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T18:43:27Z","timestamp":1554144207000},"page":"487-496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":154,"title":["Use of a molecular classifier to identify usual interstitial pneumonia in conventional transbronchial lung biopsy samples: a prospective validation study"],"prefix":"10.1016","volume":"7","author":[{"given":"Ganesh","family":"Raghu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R","family":"Flaherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Lederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V","family":"Colby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve D","family":"Groshong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon T","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Benzaquen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Calero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy H","family":"Case","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J","family":"Criner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navdeep S","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Ramaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hagmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Russell","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair A","family":"Gauhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G","family":"Pankratz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonha","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Sean","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Neville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori R","family":"Lofaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia C","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin K","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando J","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S2213-2600(19)30059-1_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1164\/ajrccm.165.2.ats01","volume":"165","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib2","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra1705751","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"Lederer","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias","volume":"188","author":"Travis","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1378\/chest.09-1002","article-title":"Incidence, prevalence, and clinical course of idiopathic pulmonary fibrosis: a population-based study","volume":"137","author":"Fern\u00e1ndez P\u00e9rez","year":"2010","journal-title":"Chest"},{"key":"10.1016\/S2213-2600(19)30059-1_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1164\/rccm.201006-0894CI","article-title":"Clinical course and prediction of survival in idiopathic pulmonary fibrosis","volume":"183","author":"Ley","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib6","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib7","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","article-title":"Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline","volume":"198","author":"Raghu","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12890-017-0560-x","article-title":"Barriers to timely diagnosis of interstitial lung disease in the real world: the INTENSITY survey","volume":"18","author":"Cosgrove","year":"2018","journal-title":"BMC Pulm Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib9","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1164\/rccm.201506-1063ST","article-title":"An official ATS\/ERS\/JRS\/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline","volume":"192","author":"Raghu","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib10","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1056\/NEJMoa1113354","article-title":"Prednisone, azathioprine, and n-acetylcysteine for pulmonary fibrosis","volume":"366","author":"Raghu","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib11","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1378\/chest.116.5.1168","article-title":"The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary fibrosis and other interstitial lung disease: a prospective study","volume":"116","author":"Raghu","year":"1999","journal-title":"Chest"},{"key":"10.1016\/S2213-2600(19)30059-1_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1164\/ajrccm.164.2.2101090","article-title":"Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis","volume":"164","author":"Hunninghake","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1164\/rccm.200611-1696OC","article-title":"Computed tomography findings in pathological usual interstitial pneumonia","volume":"177","author":"Sumikawa","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1378\/chest.14-0976","article-title":"CT scan findings of probable usual interstitial pneumonitis have a high predictive value for histologic usual interstitial pneumonitis","volume":"147","author":"Chung","year":"2015","journal-title":"Chest"},{"key":"10.1016\/S2213-2600(19)30059-1_bib15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/thoraxjnl-2016-209671","article-title":"The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia","volume":"72","author":"Brownell","year":"2017","journal-title":"Thorax"},{"key":"10.1016\/S2213-2600(19)30059-1_bib16","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1164\/rccm.200606-833OC","article-title":"Idiopathic interstitial pneumonia: do community and academic physicians agree on diagnosis?","volume":"175","author":"Flaherty","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib17","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1183\/13993003.00378-2016","article-title":"Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997\u20132008","volume":"48","author":"Hutchinson","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/S2213-2600(19)30059-1_bib18","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1164\/rccm.201508-1632OC","article-title":"In-hospital mortality after surgical lung biopsy for interstitial lung disease in the United States. 2000 to 2011","volume":"193","author":"Hutchinson","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib19","first-page":"1828","article-title":"Diagnostic yield and complications of transbronchial lung cryobiopsy for interstitial lung disease. A systematic review and metaanalysis","volume":"13","author":"Johannson","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/S2213-2600(19)30059-1_bib20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1164\/rccm.201504-0711OC","article-title":"Bronchoscopic lung cryobiopsy increases diagnostic confidence in the multidisciplinary diagnosis of idiopathic pulmonary fibrosis","volume":"193","author":"Tomassetti","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib21","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.21037\/jtd.2017.06.96","article-title":"Transbronchial cryobiopsy for diffuse parenchymal lung disease: a state-of-the-art review of procedural techniques, current evidence, and future challenges","volume":"9","author":"Lentz","year":"2017","journal-title":"J Thorac Dis"},{"key":"10.1016\/S2213-2600(19)30059-1_bib22","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2013.09.034","article-title":"The somatic genomic landscape of glioblastoma","volume":"155","author":"Brennan","year":"2013","journal-title":"Cell"},{"key":"10.1016\/S2213-2600(19)30059-1_bib23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S2213-2600(15)00140-X","article-title":"Classification of usual interstitial pneumonia in patients with interstitial lung disease: assessment of a machine learning approach using high-dimensional transcriptional data","volume":"3","author":"Kim","year":"2015","journal-title":"Lancet Respir Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib24","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1513\/AnnalsATS.201612-947OC","article-title":"Usual interstital pneumonia can be detected in transbronchial biopsies using machine learning","volume":"14","author":"Pankratz","year":"2017","journal-title":"Ann Am Thorac Soc"},{"issue":"suppl 2","key":"10.1016\/S2213-2600(19)30059-1_bib25","first-page":"147","article-title":"Identification of usual interstitial pneumonia pattern using RNA-seq and machine learning: challenges and solutions","volume":"19","author":"Choi","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/S2213-2600(19)30059-1_bib26","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1164\/ajrccm.164.9.2103074","article-title":"Histopathologic variability in usual and nonspecific interstitial pneumonias","volume":"164","author":"Flaherty","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib27","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1164\/rccm.201702-0400PP","article-title":"A standardized diagnostic ontology for fibrotic interstitial lung disease: an international working group perspective","volume":"196","author":"Ryerson","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S2213-2600(17)30433-2","article-title":"Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society white paper","volume":"6","author":"Lynch","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib29","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1136\/thoraxjnl-2012-202943","article-title":"Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis","volume":"68","author":"Yang","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/S2213-2600(19)30059-1_bib30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1164\/rccm.200504-644OC","article-title":"Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis","volume":"173","author":"Selman","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S2213-2600(19)30059-1_bib31","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.chest.2016.09.028","article-title":"Utility of transbronchial versus surgical lung biopsy in the diagnosis of suspected fibrotic interstitial lung disease","volume":"151","author":"Sheth","year":"2017","journal-title":"Chest"}],"container-title":["The Lancet Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213260019300591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213260019300591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:37:46Z","timestamp":1761979066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213260019300591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S2213260019300591"],"URL":"https:\/\/doi.org\/10.1016\/s2213-2600(19)30059-1","relation":{},"ISSN":["2213-2600"],"issn-type":[{"value":"2213-2600","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of a molecular classifier to identify usual interstitial pneumonia in conventional transbronchial lung biopsy samples: a prospective validation study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S2213-2600(19)30059-1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/S2213-2600(19)30058-X","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}