{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T13:10:10Z","timestamp":1748783410733,"version":"3.41.0"},"reference-count":116,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780128021477"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1016\/b978-0-12-802147-7.00028-0","type":"book-chapter","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T20:34:24Z","timestamp":1455914064000},"page":"387-400","source":"Crossref","is-referenced-by-count":3,"title":["Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals"],"prefix":"10.1016","author":[{"given":"Jo\u00e3o S.","family":"Teodoro","sequence":"first","affiliation":[]},{"given":"Filipe V.","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"Anabela P.","family":"Rolo","sequence":"additional","affiliation":[]},{"given":"Carlos M.","family":"Palmeira","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/B978-0-12-802147-7.00028-0_bib1","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.bbagen.2014.03.006","article-title":"Kolaviron, a natural flavonoid from the seeds of Garcinia kola, reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion, and inflammatory transcription factors, ERK1\/2, NF-\u03baB, p38, Akt, p-c-JUN and JNK","volume":"1840","author":"Abarikwu","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/B978-0-12-802147-7.00028-0_bib2","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1161\/01.ATV.0000181761.16341.2b","article-title":"Extracellular signal-regulated kinase\u2013dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine","volume":"25","author":"Abidi","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1211\/jpp.58.1.0015","article-title":"Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia kola in streptozotocin-induced diabetes mellitus rats","volume":"58","author":"Adaramoye","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1515\/jbcpp-2013-0139","article-title":"Kolaviron, a biflavonoid fraction from Garcinia kola, protects against isoproterenol-induced injury by mitigating cardiac dysfunction and oxidative stress in rats","volume":"26","author":"Adaramoye","year":"2015","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1515\/jbcpp-2012-0078","article-title":"Nevirapine induces testicular toxicity in Wistar rats: reversal effect of kolaviron (biflavonoid from Garcinia kola seeds)","volume":"24","author":"Adaramoye","year":"2013","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib6","first-page":"1","article-title":"Garcinia kola seed ameliorates renal, hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats","volume":"22","author":"Adedara","year":"2014","journal-title":"Pharm. Biol."},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3109\/0886022X.2015.1006085","article-title":"Renoprotection of Kolaviron against benzo (A) pyrene-induced renal toxicity in rats","volume":"37","author":"Adedara","year":"2015","journal-title":"Ren. Fail."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1749-6632.2010.05850.x","article-title":"Resveratrol and life extension","volume":"1215","author":"Agarwal","year":"2011","journal-title":"Ann. N.Y. Acad. Sci."},{"issue":"5A","key":"10.1016\/B978-0-12-802147-7.00028-0_bib9","first-page":"2783","article-title":"Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies","volume":"24","author":"Aggarwal","year":"2004","journal-title":"Anticancer Res."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib10","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s11064-015-1527-z","article-title":"Kolaviron, a Garcinia kola biflavonoid complex, protects against ischemia\/reperfusion injury: pertinent mechanistic insights from biochemical and physical evaluations in rat brain","volume":"40","author":"Akinmoladun","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxrep.2014.11.006","article-title":"Dietary administration of Nexrutine inhibits rat liver tumorigenesis and induces apoptotic cell death in human hepatocellular carcinoma cells","volume":"2","author":"Alam","year":"2015","journal-title":"Toxicol. Rep."},{"issue":"5","key":"10.1016\/B978-0-12-802147-7.00028-0_bib12","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1111\/j.1471-4159.2009.06228.x","article-title":"The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide","volume":"110","author":"Albani","year":"2009","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/B978-0-12-802147-7.00028-0_bib13","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/biof.118","article-title":"Neuroprotective properties of resveratrol in different neurodegenerative disorders","volume":"36","author":"Albani","year":"2010","journal-title":"Biofactors"},{"issue":"5","key":"10.1016\/B978-0-12-802147-7.00028-0_bib14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1080\/14756360802610761","article-title":"Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine","volume":"24","author":"Al-Masri","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"10","key":"10.1016\/B978-0-12-802147-7.00028-0_bib15","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.3390\/molecules15106688","article-title":"Hypericum perforatum L. hypericaceae\/guttiferae sunflower, olive and palm oil extracts attenuate cold restraint stress-induced gastric lesions","volume":"15","author":"Arsic","year":"2010","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bbrc.2006.11.043","article-title":"Berberine alters the processing of Alzheimer\u2019s amyloid precursor protein to decrease Abeta secretion","volume":"352","author":"Asai","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib17","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: the in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"7117","key":"10.1016\/B978-0-12-802147-7.00028-0_bib18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature05354","article-title":"Resveratrol improves health and survival of mice on a high-calorie diet","volume":"444","author":"Baur","year":"2006","journal-title":"Nature"},{"issue":"15","key":"10.1016\/B978-0-12-802147-7.00028-0_bib19","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1523\/JNEUROSCI.5831-09.2010","article-title":"Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans","volume":"30","author":"Bizat","year":"2010","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0031-6997(25)00027-4","article-title":"Pharmacology of cyclosporine (sandimmune). I. Introduction","volume":"41","author":"Borel","year":"1990","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ab.2005.05.027","article-title":"LED fluorescence spectroscopy for direct determination of monoamine oxidase B inactivation","volume":"343","author":"Castillo","year":"2005","journal-title":"Anal. Biochem."},{"issue":"12","key":"10.1016\/B978-0-12-802147-7.00028-0_bib22","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.cgh.2014.02.024","article-title":"Resveratrol does not benefit patients with nonalcoholic fatty liver disease","volume":"12","author":"Chachay","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"11","key":"10.1016\/B978-0-12-802147-7.00028-0_bib23","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/nm.2049","article-title":"Foxo1 integrates insulin signaling with mitochondrial function in the liver","volume":"15","author":"Cheng","year":"2009","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib24","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.neuroscience.2009.01.017","article-title":"Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway","volume":"159","author":"Della-Morte","year":"2009","journal-title":"Neuroscience"},{"issue":"8","key":"10.1016\/B978-0-12-802147-7.00028-0_bib25","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1517\/14712598.2012.704014","article-title":"Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials","volume":"12","author":"Derosa","year":"2012","journal-title":"Expert Opin. Biol. Ther."},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib26","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2174\/138945011795528930","article-title":"Berberine as a promising safe anti-cancer agent\u2014is there a role for mitochondria?","volume":"12","author":"Diogo","year":"2011","journal-title":"Curr. Drug Targets"},{"issue":"10","key":"10.1016\/B978-0-12-802147-7.00028-0_bib27","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.bbadis.2013.05.018","article-title":"Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice","volume":"1832","author":"Dolinsky","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"1\u20132","key":"10.1016\/B978-0-12-802147-7.00028-0_bib28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tox.2010.11.005","article-title":"Hepatoprotective activity of berberine is mediated by inhibition of TNF-\u03b1, COX-2, and iNOS expression in CCl(4)-intoxicated mice","volume":"280","author":"Domitrovi\u0107","year":"2011","journal-title":"Toxicology"},{"issue":"41","key":"10.1016\/B978-0-12-802147-7.00028-0_bib29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4103\/0973-1296.149708","article-title":"The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes","volume":"11","author":"Eid","year":"2015","journal-title":"Pharmacogn. Mag."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1358\/dof.2009.034.04.1360696","article-title":"Resveratrol\/SRT-501","volume":"34","author":"Elliott","year":"2009","journal-title":"Drugs Fut."},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.atherosclerosissup.2004.08.033","article-title":"The origin of the statins. 2004","volume":"5","author":"Endo","year":"2004","journal-title":"Atheroscler. Suppl."},{"issue":"10","key":"10.1016\/B978-0-12-802147-7.00028-0_bib32","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.nutres.2014.09.005","article-title":"Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease","volume":"34","author":"Faghihzadeh","year":"2014","journal-title":"Nutr. Res."},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00008469-200506000-00003","article-title":"Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural bioflavonoid of Garcinia kola seeds","volume":"14","author":"Farombi","year":"2005","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1749-8546-5-33","article-title":"Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats","volume":"5","author":"Feng","year":"2010","journal-title":"Chin. Med."},{"issue":"8","key":"10.1016\/B978-0-12-802147-7.00028-0_bib35","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0024-3205(99)00410-5","article-title":"Biological effects of resveratrol","volume":"66","author":"Fr\u00e9mont","year":"2000","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib36","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.antiviral.2012.03.005","article-title":"Quercetin inhibits rhinovirus replication in vitro and in vivo","volume":"94","author":"Ganesan","year":"2012","journal-title":"Antiviral Res."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib37","first-page":"282","article-title":"Experimental study on the insulin-sensitivity-increasing effect of berberine in insulin resistant rat models","volume":"3","author":"Gao","year":"1997","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/bip.22572","article-title":"Interaction of A\u03b2(25-35) fibrillation products with mitochondria: effect of small-molecule natural products","volume":"102","author":"Ghobeh","year":"2014","journal-title":"Biopolymers"},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbadis.2011.10.008","article-title":"Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis","volume":"1822","author":"Gomes","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib40","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.talanta.2010.01.015","article-title":"Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics","volume":"81","author":"Gu","year":"2010","journal-title":"Talanta"},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib41","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1101\/sqb.2007.72.024","article-title":"Sirtuins in aging and disease","volume":"72","author":"Guarente","year":"2007","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib42","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12263-014-0451-1","article-title":"In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity","volume":"10","author":"Henagan","year":"2015","journal-title":"Genes Nutr."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2015.02.007","article-title":"Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo","volume":"754","author":"Hu","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/B978-0-12-802147-7.00028-0_bib44","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s00204-002-0351-9","article-title":"Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver","volume":"76","author":"Hwang","year":"2002","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5214\/ans.0972.7531.200203","article-title":"Kolaviron, isolated from Garcinia kola, inhibits acetylcholinesterase activities in the hippocampus and striatum of wistar rats","volume":"20","author":"Ijomone","year":"2013","journal-title":"Ann. Neurosci."},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mc.20690","article-title":"Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis","volume":"50","author":"James","year":"2011","journal-title":"Mol. Carcinog."},{"issue":"8","key":"10.1016\/B978-0-12-802147-7.00028-0_bib47","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.3390\/molecules16086732","article-title":"Berberine: a potential multipotent natural product to combat Alzheimer\u2019s disease","volume":"16","author":"Ji","year":"2011","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib48","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cmet.2013.09.004","article-title":"Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet","volume":"18","author":"Jimenez-Gomez","year":"2013","journal-title":"Cell Metabolism."},{"issue":"8","key":"10.1016\/B978-0-12-802147-7.00028-0_bib49","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1248\/bpb.32.1433","article-title":"Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids","volume":"32","author":"Jung","year":"2009","journal-title":"Biol. Pharm. Bull."},{"issue":"1\u20132","key":"10.1016\/B978-0-12-802147-7.00028-0_bib50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mrfmmm.2009.11.001","article-title":"Berberine and a Berberis lycium extract inactivate Cdc25A and induce \u03b1-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis","volume":"683","author":"Khan","year":"2010","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib51","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3177\/jnsv.50.61","article-title":"Resveratrol inhibits N-nitrosodiethylamine-induced ornithine decarboxylase and cyclooxygenase in mice","volume":"50","author":"Khanduja","year":"2004","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"issue":"13","key":"10.1016\/B978-0-12-802147-7.00028-0_bib52","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1038\/sj.emboj.7601758","article-title":"SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer\u2019s disease and amyotrophic lateral sclerosis","volume":"26","author":"Kim","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virusres.2015.01.018","article-title":"Role of dietary antioxidants in human metapneumovirus infection","volume":"200C","author":"Komaravelli","year":"2015","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib54","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-2001-10874","article-title":"Monoamine oxidase inhibitors from rhizoma of Coptis chinensis","volume":"67","author":"Kong","year":"2001","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.metabol.2008.08.013","article-title":"Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression","volume":"58","author":"Kong","year":"2009","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib56","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4103\/0253-7613.129312","article-title":"Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxy dopamine induced Parkinsonism","volume":"46","author":"Kosaraju","year":"2014","journal-title":"Indian J. Pharmacol."},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib57","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1517\/13543780902880850","article-title":"Current investigational drugs for major depression","volume":"18","author":"Kulkarni","year":"2009","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib58","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ptr.2968","article-title":"Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders","volume":"24","author":"Kulkarni","year":"2010","journal-title":"Phytother. Res."},{"issue":"9","key":"10.1016\/B978-0-12-802147-7.00028-0_bib59","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1158\/1078-0432.CCR-06-2974","article-title":"Akt\/cAMP-responsive element binding protein\/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract","volume":"13","author":"Kumar","year":"2007","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/B978-0-12-802147-7.00028-0_bib60","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/carcin\/bgs219","article-title":"Nexrutine(R) inhibits tumorigenesis in mouse skin and induces apoptotic cell death in human squamous carcinoma A431 and human melanoma A375 cells","volume":"33","author":"Kumar","year":"2012","journal-title":"Carcinogenesis"},{"issue":"9","key":"10.1016\/B978-0-12-802147-7.00028-0_bib61","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/j.1745-7254.2007.00694.x","article-title":"Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models","volume":"28","author":"Kwon","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib62","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"issue":"10","key":"10.1016\/B978-0-12-802147-7.00028-0_bib63","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1007\/s11356-014-3885-5","article-title":"Oxidative stress and brain mitochondria swelling induced by endosulfan and protective role of quercetin in rat","volume":"22","author":"Lakroun","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"42","key":"10.1016\/B978-0-12-802147-7.00028-0_bib64","doi-asserted-by":"crossref","first-page":"28885","DOI":"10.1074\/jbc.M109.052407","article-title":"Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine","volume":"284","author":"Li","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib65","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1089\/jmf.2013.2905","article-title":"Contribution of phenolics and essential oils to the antioxidant and antimicrobial properties of Disporopsis pernyi (Hua) Diels","volume":"17","author":"Lin","year":"2014","journal-title":"J. Med. Food."},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib66","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0026-895X(24)05644-X","article-title":"Berberine inhibits HIF-1alpha expression via enhanced proteolysis","volume":"66","author":"Lin","year":"2004","journal-title":"Mol. Pharmacol."},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib67","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3945\/ajcn.113.082024","article-title":"Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials","volume":"99","author":"Liu","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib68","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00210-010-0502-0","article-title":"Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study","volume":"381","author":"Liu","year":"2010","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/B978-0-12-802147-7.00028-0_bib69","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mce.2009.12.027","article-title":"Berberine modulates insulin signaling transduction in insulin-resistant cells","volume":"317","author":"Liu","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"issue":"10","key":"10.1016\/B978-0-12-802147-7.00028-0_bib70","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1507\/endocrj.K10E-043","article-title":"Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXR\u03b1 and PPAR\u03b1 transcriptional programs","volume":"57","author":"Liu","year":"2010","journal-title":"Endocr. J."},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib71","first-page":"143","article-title":"Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1\u03b1 pathway","volume":"33","author":"Liu","year":"2015","journal-title":"Restor. Neurol. Neurosci."},{"issue":"16","key":"10.1016\/B978-0-12-802147-7.00028-0_bib72","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/j.ejca.2008.07.040","article-title":"Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer","volume":"44","author":"Liu","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib73","doi-asserted-by":"crossref","first-page":"308134","DOI":"10.1155\/2013\/308134","article-title":"Update on berberine in nonalcoholic fatty liver disease","volume":"2013","author":"Liu","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"9","key":"10.1016\/B978-0-12-802147-7.00028-0_bib74","doi-asserted-by":"crossref","first-page":"e75628","DOI":"10.1371\/journal.pone.0075628","article-title":"MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth","volume":"8","author":"Lo","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib75","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1677\/JOE-08-0419","article-title":"Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats","volume":"200","author":"Lu","year":"2009","journal-title":"J. Endocrinol."},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib76","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-2184.2006.00377.x","article-title":"The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential","volume":"39","author":"Mahdi","year":"2006","journal-title":"Cell Prolif."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib77","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jinorgbio.2015.01.001","article-title":"Quercetin encapsulation in modified silica nanoparticles: potential use against Cu(II)-induced oxidative stress in neurodegeneration","volume":"145C","author":"Nday","year":"2015","journal-title":"J. Inorg. Biochem."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib78","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s12010-014-1129-2","article-title":"Apigenin and quercetin ameliorate mitochondrial alterations by tunicamycin-induced ER stress in 3T3-L1 adipocytes","volume":"174","author":"Nisha","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2015.01.002","article-title":"Resveratrol supplementation: where are we now and where should we go?","volume":"21C","author":"Novelle","year":"2015","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib80","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1995-7645(14)60003-1","article-title":"Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice","volume":"7","author":"Oluwatosin","year":"2014","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"8","key":"10.1016\/B978-0-12-802147-7.00028-0_bib81","doi-asserted-by":"crossref","first-page":"12349","DOI":"10.3390\/molecules190812349","article-title":"Berberine, an epiphany against cancer","volume":"19","author":"Ortiz","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib82","series-title":"Biomarkers in Toxicology","first-page":"847","article-title":"Biomarkers of mitochondrial dysfunction and toxicity","author":"Palmeira","year":"2014"},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib83","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/ng1534","article-title":"Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons","volume":"37","author":"Parker","year":"2005","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib84","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cmet.2008.06.011","article-title":"Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span","volume":"8","author":"Pearson","year":"2008","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib85","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1124\/jpet.107.128017","article-title":"Mitochondrially targeted effects of berberine [Natural Yellow 18, 5, 6-dihydro-9, 10-dimethoxybenzo (g)-1, 3-benzodioxolo (5, 6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions","volume":"323","author":"Pereira","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib86","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3844\/ajassp.2010.480.485","article-title":"Neuroprotective effect of quercetin encapsulated liposomes: a novel therapeutic strategy against Alzheimer\u2019s disease","volume":"7","author":"Phachonpai","year":"2010","journal-title":"Am. J. Appl. Sci."},{"issue":"5","key":"10.1016\/B978-0-12-802147-7.00028-0_bib87","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cmet.2012.04.003","article-title":"SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function","volume":"15","author":"Price","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib88","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.brainres.2014.01.035","article-title":"Quercetin improves hypoxia-ischemia induced cognitive deficits via promoting remyelination in neonatal rat","volume":"1553","author":"Qu","year":"2014","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/B978-0-12-802147-7.00028-0_bib89","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.etp.2009.06.006","article-title":"Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats","volume":"62","author":"Renugadevi","year":"2010","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/B978-0-12-802147-7.00028-0_bib90","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.arr.2013.11.002","article-title":"What are the roles of calorie restriction and diet quality in promoting healthy longevity?","volume":"13","author":"Rizza","year":"2014","journal-title":"Ageing Res. Rev."},{"issue":"5","key":"10.1016\/B978-0-12-802147-7.00028-0_bib91","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/carcin\/bgi286","article-title":"Chemopreventive effect of trans-resveratrol\u2014a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis","volume":"27","author":"Sengottuvelan","year":"2006","journal-title":"Carcinogenesis"},{"issue":"5","key":"10.1016\/B978-0-12-802147-7.00028-0_bib92","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1089\/jmf.2014.3242","article-title":"Protective effects of quercetin against HgCl2-induced nephrotoxicity in Sprague-Dawley rats","volume":"18","author":"Shin","year":"2015","journal-title":"J. Med. Food"},{"issue":"9","key":"10.1016\/B978-0-12-802147-7.00028-0_bib93","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/aps.2010.139","article-title":"AMPK in cardiovascular health and disease","volume":"31","author":"Shirwany","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib94","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1212\/WNL.57.6.1089","article-title":"Cholesterol and Alzheimer\u2019s disease is there a link?","volume":"57","author":"Simons","year":"2001","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/B978-0-12-802147-7.00028-0_bib95","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/CAD.0b013e328330d95b","article-title":"A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs","volume":"20","author":"Sun","year":"2009","journal-title":"Anticancer Drugs"},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib96","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.mito.2013.09.002","article-title":"Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation","volume":"13","author":"Teodoro","year":"2013","journal-title":"Mitochondrion"},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib97","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1158\/1078-0432.CCR-03-0105","article-title":"Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats","volume":"10","author":"Tseng","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/B978-0-12-802147-7.00028-0_bib98","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/db07-1552","article-title":"Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action","volume":"57","author":"Turner","year":"2008","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/B978-0-12-802147-7.00028-0_bib99","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.3390\/molecules16032032","article-title":"Antioxidant therapy as a potential approach to severe influenza-associated complications","volume":"16","author":"Uchide","year":"2011","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/B978-0-12-802147-7.00028-0_bib100","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.freeradbiomed.2011.01.005","article-title":"Quercetin-iron chelates are transported via glucose transporters","volume":"50","author":"Vlachodimitropoulou","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib101","first-page":"258","article-title":"Protective effects of quercetin on cadmium-induced cytotoxicity in primary cultures of rat proximal tubular cells","volume":"26","author":"Wang","year":"2013","journal-title":"Biomed. Environ. Sci."},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib102","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.metabol.2010.02.005","article-title":"Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats","volume":"60","author":"Wang","year":"2011","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib103","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.atherosclerosis.2009.08.050","article-title":"Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters","volume":"209","author":"Wang","year":"2010","journal-title":"Atherosclerosis"},{"issue":"39","key":"10.1016\/B978-0-12-802147-7.00028-0_bib104","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.3748\/wjg.14.6004","article-title":"Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity","volume":"14","author":"Wang","year":"2008","journal-title":"World J. Gastroenterol."},{"issue":"8","key":"10.1016\/B978-0-12-802147-7.00028-0_bib105","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s11064-009-9920-0","article-title":"Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats","volume":"34","author":"Wu","year":"2009","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib106","doi-asserted-by":"crossref","first-page":"530","DOI":"10.4314\/ajtcam.v9i4.9","article-title":"Garcinia kola seeds: is the aqueous extract a true aphrodisiac in male Wistar rats?","volume":"9","author":"Yakubu","year":"2012","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"issue":"9","key":"10.1016\/B978-0-12-802147-7.00028-0_bib107","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s12272-011-0915-4","article-title":"The effect of quercetin-3-O-\u03b2-d-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression","volume":"34","author":"Yan","year":"2011","journal-title":"Arch. Pharm. Res."},{"issue":"11","key":"10.1016\/B978-0-12-802147-7.00028-0_bib108","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1053\/meta.2002.34715","article-title":"Effects of berberine on glucose metabolism in vitro","volume":"51","author":"Yin","year":"2002","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib109","doi-asserted-by":"crossref","first-page":"E148","DOI":"10.1152\/ajpendo.00211.2007","article-title":"Berberine improves glucose metabolism through induction of glycolysis","volume":"294","author":"Yin","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/B978-0-12-802147-7.00028-0_bib110","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.apsb.2012.06.003","article-title":"Effects and mechanisms of berberine in diabetes treatment","volume":"2","author":"Yin","year":"2012","journal-title":"Acta Pharm. Sin. B"},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib111","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0002-9149(03)00533-2","article-title":"Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy","volume":"92","author":"Zeng","year":"2003","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/B978-0-12-802147-7.00028-0_bib112","first-page":"760","article-title":"Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease","volume":"30","author":"Zhang","year":"2009","journal-title":"Saudi Med. J."},{"issue":"2","key":"10.1016\/B978-0-12-802147-7.00028-0_bib113","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.metabol.2009.07.029","article-title":"Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression","volume":"59","author":"Zhang","year":"2010","journal-title":"Metabolism"},{"issue":"23","key":"10.1016\/B978-0-12-802147-7.00028-0_bib114","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1158\/0008-5472.CAN-10-1546","article-title":"Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells","volume":"70","author":"Zhang","year":"2010","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/B978-0-12-802147-7.00028-0_bib115","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1210\/jc.2007-2404","article-title":"Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine","volume":"93","author":"Zhang","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/B978-0-12-802147-7.00028-0_bib116","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neulet.2008.09.064","article-title":"Neuroprotective effects of berberine on stroke models in vitro and in vivo","volume":"447","author":"Zhou","year":"2008","journal-title":"Neurosci. Lett."}],"container-title":["Nutraceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128021477000280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128021477000280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T12:53:16Z","timestamp":1748782396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780128021477000280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9780128021477"],"references-count":116,"URL":"https:\/\/doi.org\/10.1016\/b978-0-12-802147-7.00028-0","relation":{},"subject":[],"published":{"date-parts":[[2016]]}}}