{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:40:01Z","timestamp":1758044401505,"version":"3.44.0"},"reference-count":58,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780128177808"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/b978-0-12-817780-8.00009-8","type":"book-chapter","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T05:39:53Z","timestamp":1594359593000},"page":"125-141","source":"Crossref","is-referenced-by-count":8,"title":["Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants"],"prefix":"10.1016","author":[{"given":"Miguel","family":"Pinto","sequence":"first","affiliation":[]},{"given":"Sofia","family":"Benfeito","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0010","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The blood-brain barrier: bottleneck in brain drug development","volume":"2","author":"Pardridge","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0025","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1602\/neurorx.2.4.541","article-title":"Medicinal chemical properties of successful central nervous system drugs","volume":"2","author":"Pajouhesh","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem J"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0035","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"The role of oxidative stress in neurodegenerative diseases","volume":"24","author":"Kim","year":"2015","journal-title":"Exp Neurobiol"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0040","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.tins.2004.06.005","article-title":"Energetic basis of brain activity: implications for neuroimaging","volume":"27","author":"Shulman","year":"2004","journal-title":"Trends Neurosci"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0045","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 Reasons why the brain is susceptible to oxidative stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0050","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.bbadis.2011.12.009","article-title":"Oxidative stress and cerebral endothelial cells: regulation of the blood-brain-barrier and antioxidant based interventions","volume":"1822","author":"Freeman","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0060","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1517\/17460441.2015.974545","article-title":"Blood-brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics","volume":"10","author":"Stanimirovic","year":"2015","journal-title":"Expert Opin Drug Discovery"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0065","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1177\/0271678X16630991","article-title":"In vitro models of the blood-brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use","volume":"36","author":"Helms","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.nu.16.070196.000341","article-title":"Antioxidants in human health and disease","volume":"16","author":"Halliwell","year":"1996","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0075","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mito.2012.12.002","article-title":"Antioxidant therapy: still in search of the \u2018magic bullet\u2019","volume":"13","author":"Benfeito","year":"2013","journal-title":"Mitochondrion"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0080","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/aps.2012.128","article-title":"New insights into huperzine A for the treatment of Alzheimer's disease","volume":"33","author":"Zhang","year":"2012","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1745-7254.2006.00255.x","article-title":"Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine","volume":"27","author":"Wang","year":"2006","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0090","series-title":"Neuroprotective natural products","article-title":"Lipid peroxidation and mitochondrial dysfunction in Alzheimer's and Parkinson's diseases: role of natural products as cytoprotective agents","author":"Fern\u00e1ndez-Moriano","year":"2017"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0095","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jnr.490240220","article-title":"Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat","volume":"24","author":"Tang","year":"1989","journal-title":"J Neurosci Res"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0100","series-title":"Nutrition and lifestyle in neurological autoimmune diseases","article-title":"Chapter 25\u2014The role of natural products in the prevention and treatment of multiple sclerosis","author":"Shamsizadeh","year":"2017"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0105","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1758-5996-6-80","article-title":"Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases","volume":"6","author":"Gomes","year":"2014","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0110","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0891-5849(96)00269-9","article-title":"Neuroprotection by the metabolic antioxidant \u03b1-lipoic acid","volume":"22","author":"Packer","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0115","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1471-4159.2007.04773.x","article-title":"Vitamin transport and homeostasis in mammalian brain: focus on vitamins B and E","volume":"103","author":"Spector","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neuint.2004.07.008","article-title":"Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders","volume":"46","author":"Poon","year":"2005","journal-title":"Neurochem Int"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0125","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainres.2013.01.054","article-title":"Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism","volume":"1505","author":"Jalali-Nadoushan","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0130","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1097\/NEN.0b013e31818f8f51","article-title":"The role of dietary antioxidant insufficiency on the permeability of the blood-brain barrier","volume":"67","author":"Mohammed","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0135","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1212\/WNL.47.4.1037","article-title":"Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients: dose-response study and correlations with plasma levels","volume":"47","author":"Pappert","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0140","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0197-4580(03)00031-9","article-title":"Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease","volume":"24","author":"Rinaldi","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0145","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3390\/ijms18071583","article-title":"Dietary modulation of oxidative stress in Alzheimer's disease","volume":"18","author":"Thapa","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0150","doi-asserted-by":"crossref","first-page":"1322S","DOI":"10.1093\/ajcn\/62.6.1322S","article-title":"Interaction among vitamin C, vitamin E, and beta-carotene","volume":"62","author":"Niki","year":"1995","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0155","doi-asserted-by":"crossref","first-page":"11720","DOI":"10.1073\/pnas.171325998","article-title":"Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke","volume":"98","author":"Huang","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0160","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1172\/JCI119832","article-title":"Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters","volume":"100","author":"Agus","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0165","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4315\/0362-028X-64.3.379","article-title":"Antioxidant activity of resveratrol compared with common food additives","volume":"64","author":"Murcia","year":"2001","journal-title":"J Food Prot"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0170","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.niox.2003.09.005","article-title":"Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells","volume":"9","author":"Lorenz","year":"2003","journal-title":"Nitric Oxide"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0175","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/foods6100092","article-title":"Curcumin: a review of its' effects on human health","volume":"6","author":"Hewlings","year":"2017","journal-title":"Foods"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0180","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bbadis.2011.10.006","article-title":"Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease","volume":"1822","author":"Mecocci","year":"2012","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0185","doi-asserted-by":"crossref","first-page":"10062","DOI":"10.1038\/s41598-017-10672-9","article-title":"Nanocurcumin is superior to native curcumin in preventing degenerative changes in experimental cerebral malaria","volume":"7","author":"Dende","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0190","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.3390\/ijms12095592","article-title":"Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises?","volume":"12","author":"Mereles","year":"2011","journal-title":"Int J Mol Sci"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0195","doi-asserted-by":"crossref","first-page":"21589","DOI":"10.1021\/acsami.5b07045","article-title":"Choline derivate-modified doxorubicin loaded micelle for glioma therapy","volume":"7","author":"Li","year":"2015","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0200","first-page":"180","article-title":"Blood brain barrier permeability of (\u2212)-epigallocatechin gallate, its proliferation-enhancing activity of human neuroblastoma SH-SY5Y cells, and its preventive effect on age-related cognitive dysfunction in mice","volume":"9","author":"Pervin","year":"2017","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0205","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1040-8428(01)00212-8","article-title":"The role of oxidative stress in mechanisms of metal-induced carcinogenesis","volume":"42","author":"Galaris","year":"2002","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0210","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.apsb.2014.12.003","article-title":"Quercetin protects human brain microvascular endothelial cells from fibrillar beta-amyloid1-40-induced toxicity","volume":"5","author":"Li","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0215","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1021\/jf0208132","article-title":"Effects of phenolic acids on human phenolsulfotransferases in relation to their antioxidant activity","volume":"51","author":"Yeh","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0220","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1248\/bpb.30.1052","article-title":"Antimelanogenic and antioxidant properties of gallic acid","volume":"30","author":"Kim","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0225","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1038\/s41598-017-07272-y","article-title":"Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria","volume":"7","author":"Teixeira","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0230","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1111\/jphp.12126","article-title":"Impact of caffeic acid on aluminium chloride-induced dementia in rats","volume":"65","author":"Khan","year":"2013","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0235","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s11064-012-0935-6","article-title":"Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer's disease and some pro-oxidant induced oxidative stress in rats' brain-in vitro","volume":"38","author":"Oboh","year":"2013","journal-title":"Neurochem Res"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0240","first-page":"5499","article-title":"Neuroprotective potential of ferulic acid in the rotenone model of Parkinson's disease","volume":"9","author":"Ojha","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0245","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jpba.2012.12.016","article-title":"Phenolic acid metabolites derived from coffee consumption are unlikely to cross the blood-brain barrier","volume":"76","author":"Lardeau","year":"2013","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0250","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.nbd.2009.07.028","article-title":"Approaches to transport therapeutic drugs across the blood\u2013brain barrier to treat brain diseases","volume":"37","author":"Gabathuler","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0255","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.2174\/1381612822666151221150733","article-title":"Evolving drug delivery strategies to overcome the blood brain barrier","volume":"22","author":"Hersh","year":"2016","journal-title":"Curr Pharm Des"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0260","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1021\/cn300191b","article-title":"Noninvasive and targeted drug delivery to the brain using focused ultrasound","volume":"4","author":"Burgess","year":"2013","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0265","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1039\/C4CC08798D","article-title":"Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry","volume":"51","author":"Cagide","year":"2015","journal-title":"Chem Commun"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0270","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ejmech.2019.01.055","article-title":"Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction","volume":"167","author":"Benfeito","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0275","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1021\/acs.bioconjchem.8b00151","article-title":"Development of a PEGylated-based platform for efficient delivery of dietary antioxidants across the blood-brain barrier","volume":"29","author":"Fernandes","year":"2018","journal-title":"Bioconjug Chem"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0280","doi-asserted-by":"crossref","first-page":"39557","DOI":"10.1021\/acsami.8b17224","article-title":"PEGylated PLGA nanoparticles as a smart carrier to increase the cellular uptake of a coumarin-based monoamine oxidase B inhibitor","volume":"10","author":"Fernandes","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0285","doi-asserted-by":"crossref","first-page":"e57735","DOI":"10.1371\/journal.pone.0057735","article-title":"Neuroprotective role of nanoencapsulated quercetin in combating ischemia-reperfusion induced neuronal damage in young and aged rats","volume":"8","author":"Ghosh","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0290","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/10717544.2018.1461955","article-title":"Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease","volume":"25","author":"Fan","year":"2018","journal-title":"Drug Deliv"},{"key":"10.1016\/B978-0-12-817780-8.00009-8_bb0295","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3109\/08982104.2014.899369","article-title":"Multifunctional liposomes for nasal delivery of the anti-Alzheimer drug tacrine hydrochloride","volume":"24","author":"Corace","year":"2014","journal-title":"J Liposome Res"}],"container-title":["Oxidative Stress and Dietary Antioxidants in Neurological Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128177808000098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128177808000098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T12:31:57Z","timestamp":1757680317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780128177808000098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9780128177808"],"references-count":58,"URL":"https:\/\/doi.org\/10.1016\/b978-0-12-817780-8.00009-8","relation":{},"subject":[],"published":{"date-parts":[[2020]]}}}