{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:01:19Z","timestamp":1757613679742,"version":"3.44.0"},"reference-count":561,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780128237618"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/b978-0-12-823761-8.00024-0","type":"book-chapter","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T21:06:06Z","timestamp":1663967166000},"page":"175-256","source":"Crossref","is-referenced-by-count":0,"title":["A metabolic and mitochondrial angle on aging"],"prefix":"10.1016","author":[{"given":"Ana I.","family":"Duarte","sequence":"first","affiliation":[]},{"given":"Izabela","family":"Sadowska-Bartosz","sequence":"additional","affiliation":[]},{"given":"Agnieszka","family":"Karkucinska-Wieckowska","sequence":"additional","affiliation":[]},{"given":"Magdalena","family":"Lebiedzinska-Arciszewska","sequence":"additional","affiliation":[]},{"given":"Carlos M.","family":"Palmeira","sequence":"additional","affiliation":[]},{"given":"Anabela P.","family":"Rolo","sequence":"additional","affiliation":[]},{"given":"Yaschar","family":"Kabiri","sequence":"additional","affiliation":[]},{"given":"Barbara","family":"Zavan","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Pinton","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[]},{"given":"Hans","family":"Zischka","sequence":"additional","affiliation":[]},{"given":"John G.","family":"Jones","sequence":"additional","affiliation":[]},{"given":"Grzegorz","family":"Bartosz","sequence":"additional","affiliation":[]},{"given":"Paulo J.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Mariusz R.","family":"Wieckowski","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1134\/S000629791712001X","article-title":"Programmed aging of mammals: proof of concept and prospects of biochemical approaches for anti-aging therapy","volume":"82","author":"Skulachev","year":"2017","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10522-008-9197-8","article-title":"Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging","volume":"10","author":"Brink","year":"2009","journal-title":"Biogerontology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1152\/physrev.00040.2015","article-title":"Neoteny, prolongation of youth: from naked mole rats to \u201cnaked apes\u201d (humans)","volume":"97","author":"Skulachev","year":"2017","journal-title":"Physiol Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib4","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ajhb.21225","article-title":"Human neoteny revisited: the case of synaptic plasticity","volume":"23","author":"Bufill","year":"2011","journal-title":"Am J Hum Biol: Off J Hum Biol Counc"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib5","doi-asserted-by":"crossref","first-page":"R791","DOI":"10.1016\/j.cub.2012.06.062","article-title":"Fetal brain development in chimpanzees vs humans","volume":"22","author":"Sakai","year":"2012","journal-title":"Curr Biol: CB"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1101\/gr.127324.111","article-title":"Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques","volume":"22","author":"Liu","year":"2012","journal-title":"Genome Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib7","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1073\/pnas.0900544106","article-title":"Transcriptional neoteny in the human brain","volume":"106","author":"Somel","year":"2009","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib8","doi-asserted-by":"crossref","first-page":"13281","DOI":"10.1073\/pnas.1105108108","article-title":"Extraordinary neoteny of synaptic spines in the human prefrontal cortex","volume":"108","author":"Petanjek","year":"2011","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1172\/JCI64125","article-title":"The role of mitochondria in aging","volume":"123","author":"Bratic","year":"2013","journal-title":"J Clin Investig"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib10","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain metabolism in health, aging, and neurodegeneration","volume":"36","author":"Camandola","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib11","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2337\/db11-1300","article-title":"The critical role of metabolic pathways in aging","volume":"61","author":"Barzilai","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1532-5415.1972.tb00787.x","article-title":"The biologic clock: the mitochondria?","volume":"20","author":"Harman","year":"1972","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0891-5849(98)00208-1","article-title":"Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle","volume":"26","author":"Mecocci","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: a theory based on free radical and radiation chemistry","volume":"11","author":"Harman","year":"1956","journal-title":"J Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib15","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/174689a0","article-title":"Free radicals in biological materials","volume":"174","author":"Commoner","year":"1954","journal-title":"Nature"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib16","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10522-009-9234-2","article-title":"Origin and evolution of the free radical theory of aging: a brief personal history, 1954\u20132009","volume":"10","author":"Harman","year":"2009","journal-title":"Biogerontology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1126\/science.273.5271.59","article-title":"Oxidative stress, caloric restriction, and aging","volume":"273","author":"Sohal","year":"1996","journal-title":"Science (N York, NY)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.bbagrm.2012.06.002","article-title":"Mitochondrial DNA damage and its consequences for mitochondrial gene expression","volume":"1819","author":"Cline","year":"2012","journal-title":"Biochim Biophy Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib19","first-page":"21","article-title":"Assessment of nuclear and mitochondrial DNA, expression of mitochondria-related genes in different brain regions in rats after whole-body X-ray irradiation","author":"Abdullaev","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1042\/CS20040148","article-title":"Mitochondrial DNA and aging","volume":"107","author":"Alexeyev","year":"2004","journal-title":"Clin Sci (London, England: 1979)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fgene.2019.00311","article-title":"Mitochondrial DNA damage does not determine C. elegans lifespan","volume":"10","author":"Ng","year":"2019","journal-title":"Front Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/ana.410340416","article-title":"Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain","volume":"34","author":"Mecocci","year":"1993","journal-title":"Ann Neurol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib23","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/ana.410360510","article-title":"Oxidative damage to mitochondrial DNA is increased in Alzheimer\u2019s disease","volume":"36","author":"Mecocci","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib24","doi-asserted-by":"crossref","first-page":"10469","DOI":"10.1073\/pnas.171202698","article-title":"Does oxidative damage to DNA increase with age?","volume":"98","author":"Hamilton","year":"2001","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib25","doi-asserted-by":"crossref","first-page":"12332","DOI":"10.1073\/pnas.91.25.12332","article-title":"DNA oxidative damage and life expectancy in houseflies","volume":"91","author":"Agarwal","year":"1994","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib26","doi-asserted-by":"crossref","first-page":"e80135","DOI":"10.1371\/journal.pone.0080135","article-title":"C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase\/cysteine synthase cysl-2","volume":"8","author":"Qabazard","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib27","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1089\/ars.2013.5448","article-title":"Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans","volume":"20","author":"Qabazard","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bcp.2018.01.030","article-title":"Is there a role of H(2)S in mediating health span benefits of caloric restriction?","volume":"149","author":"Ng","year":"2018","journal-title":"Biochemical Pharmacol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib29","doi-asserted-by":"crossref","first-page":"B240","DOI":"10.1093\/gerona\/53A.4.B240","article-title":"Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) lifespans","volume":"53","author":"Adachi","year":"1998","journal-title":"J Gerontol Ser A, Biol Sci Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5483\/BMBRep.2011.44.5.298","article-title":"Mitochondrial superoxide anion (O(2)(-)) inducible \u201cmev-1\u201d animal models for aging research","volume":"44","author":"Ishii","year":"2011","journal-title":"BMB Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib31","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1073\/pnas.87.12.4533","article-title":"Oxidative damage to DNA during aging: 8-hydroxy-2\u2032-deoxyguanosine in rat organ DNA and urine","volume":"87","author":"Fraga","year":"1990","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1152\/physiolgenomics.00122.2003","article-title":"Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging","volume":"16","author":"Van Remmen","year":"2003","journal-title":"Physiol Genomics"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3389\/fgene.2013.00111","article-title":"Telomere length and body temperature-independent determinants of mammalian longevity?","volume":"4","author":"Lehmann","year":"2013","journal-title":"Front Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1089\/rej.2008.0676","article-title":"Do mitochondrial DNA and metabolic rate complement each other in determination of the mammalian maximum longevity?","volume":"11","author":"Lehmann","year":"2008","journal-title":"Rejuvenat Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib35","doi-asserted-by":"crossref","first-page":"D1262","DOI":"10.1093\/nar\/gkv1187","article-title":"MitoAge: a database for comparative analysis of mitochondrial DNA, with a special focus on animal longevity","volume":"44","author":"Toren","year":"2016","journal-title":"Nucl Acids Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib36","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1007\/s00018-019-03024-5","article-title":"Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans","volume":"76","author":"Byrne","year":"2019","journal-title":"Cell Mol Life Sci: CMLS"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib37","doi-asserted-by":"crossref","first-page":"e1000022","DOI":"10.1371\/journal.pgen.1000022","article-title":"The C. elegans Opa1 homologue EAT-3 is essential for resistance to free radicals","volume":"4","author":"Kanazawa","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib38","doi-asserted-by":"crossref","first-page":"e0130940","DOI":"10.1371\/journal.pone.0130940","article-title":"Mitochondrial morphology and fundamental parameters of the mitochondrial respiratory chain are altered in caenorhabditis elegans strains deficient in mitochondrial dynamics and homeostasis processes","volume":"10","author":"Luz","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib39","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1083\/jcb.201110034","article-title":"Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage","volume":"197","author":"Kageyama","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib40","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S1097-2765(00)80391-3","article-title":"C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane","volume":"4","author":"Labrousse","year":"1999","journal-title":"Mol Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib41","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.cmet.2017.09.024","article-title":"Dietary restriction and AMPK increase lifespan via mitochondrial network and peroxisome remodeling","volume":"26","author":"Weir","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib42","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.201507035","article-title":"Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy","volume":"211","author":"Chen","year":"2015","journal-title":"J Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib43","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41467-017-00274-4","article-title":"Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways","volume":"8","author":"Chaudhari","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib44","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00335-016-9651-x","article-title":"Mitophagy plays a central role in mitochondrial ageing","volume":"27","author":"Diot","year":"2016","journal-title":"Mammalian Genome: Off J Int Mammalian Genome Soc"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in innate immune responses","volume":"11","author":"West","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib46","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.cmet.2019.01.022","article-title":"Mitochondrial dysfunction in C. elegans activates mitochondrial relocalization and nuclear hormone receptor-dependent detoxification genes","volume":"29","author":"Mao","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib47","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1038\/ncomms4837","article-title":"Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice","volume":"5","author":"Miwa","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib48","doi-asserted-by":"crossref","first-page":"51577","DOI":"10.1074\/jbc.M308489200","article-title":"Complex II defect via down-regulation of iron-sulfur subunit induces mitochondrial dysfunction and cell cycle delay in iron chelation-induced senescence-associated growth arrest","volume":"278","author":"Yoon","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib49","doi-asserted-by":"crossref","first-page":"e13321","DOI":"10.1111\/acel.13321","article-title":"Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon","volume":"20","author":"Stamp","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib50","doi-asserted-by":"crossref","first-page":"110924","DOI":"10.1016\/j.exger.2020.110924","article-title":"Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa","volume":"135","author":"\u00d6zsoy","year":"2020","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0921-8734(92)90016-I","article-title":"Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing\u2013a cytochemical-immunohistochemical study","volume":"275","author":"M\u00fcller-H\u00f6cker","year":"1992","journal-title":"Mutat Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib52","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0022-510X(90)90006-9","article-title":"Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration","volume":"100","author":"M\u00fcller-H\u00f6cker","year":"1990","journal-title":"J Neurol Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib53","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/0006-291X(89)92701-0","article-title":"Liver mitochondrial respiratory functions decline with age","volume":"165","author":"Yen","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib54","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1111\/jcmm.13855","article-title":"Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts","volume":"22","author":"Schuliga","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib55","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ddr.21242","article-title":"Antioxidant-mediated reversal of oxidative damage in mouse modeling of complex I inhibition","volume":"76","author":"Parameshwaran","year":"2015","journal-title":"Drug Dev Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib56","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1128\/MCB.01868-08","article-title":"Mitochondrial dysfunction contributes to oncogene-induced senescence","volume":"29","author":"Moiseeva","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib57","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.exger.2006.04.009","article-title":"Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts","volume":"41","author":"St\u00f6ckl","year":"2006","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib58","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.freeradbiomed.2004.11.034","article-title":"Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteine","volume":"38","author":"Cocco","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib59","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1371\/journal.pbio.0050110","article-title":"Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence","volume":"5","author":"Passos","year":"2007","journal-title":"PLoS Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib60","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/msb.2010.5","article-title":"Feedback between p21 and reactive oxygen production is necessary for cell senescence","volume":"6","author":"Passos","year":"2010","journal-title":"Mol Syst Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib61","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/1873-3468.13498","article-title":"Mitochondrial dysfunction and cell senescence: deciphering a complex relationship","volume":"593","author":"Chapman","year":"2019","journal-title":"FEBS Lett"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib62","doi-asserted-by":"crossref","first-page":"15691","DOI":"10.1038\/ncomms15691","article-title":"Cellular senescence drives age-dependent hepatic steatosis","volume":"8","author":"Ogrodnik","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib63","doi-asserted-by":"crossref","first-page":"7232614","DOI":"10.1155\/2020\/7232614","article-title":"Age- and organ-specific differences in mitochondrial bioenergetics in brown Norway rats","volume":"2020","author":"Pandya","year":"2020","journal-title":"J Aging Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib64","doi-asserted-by":"crossref","first-page":"C670","DOI":"10.1152\/ajpcell.00213.2006","article-title":"The mitochondrial energy transduction system and the aging process","volume":"292","author":"Navarro","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib65","doi-asserted-by":"crossref","first-page":"R501","DOI":"10.1152\/ajpregu.00492.2007","article-title":"Hippocampal mitochondrial dysfunction in rat aging","volume":"294","author":"Navarro","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib66","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1196\/annals.1395.030","article-title":"Proteome alterations in rat mitochondria caused by aging","volume":"1100","author":"Dencher","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib67","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S2213-8587(14)70034-8","article-title":"Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases","volume":"2","author":"Kalyani","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib68","doi-asserted-by":"crossref","first-page":"15364","DOI":"10.1073\/pnas.93.26.15364","article-title":"Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle","volume":"93","author":"Rooyackers","year":"1996","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib69","first-page":"8","article-title":"Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria","author":"Ubaida-Mohien","year":"2019","journal-title":"eLife"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib70","doi-asserted-by":"crossref","first-page":"320","DOI":"10.18632\/aging.100657","article-title":"Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function","volume":"6","author":"Stauch","year":"2014","journal-title":"Aging"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib71","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/pmic.201400277","article-title":"Proteomic analysis and functional characterization of mouse brain mitochondria during aging reveal alterations in energy metabolism","volume":"15","author":"Stauch","year":"2015","journal-title":"Proteomics"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib72","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ng1291","article-title":"Comparing genomic expression patterns across species identifies shared transcriptional profile in aging","volume":"36","author":"McCarroll","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib73","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/gerona\/glx160","article-title":"Effect of aging on mitochondrial energetics in the human atria","volume":"73","author":"Emelyanova","year":"2018","journal-title":"J Gerontol Ser A, Biol Sci Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib74","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.mad.2008.02.010","article-title":"Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart","volume":"129","author":"Preston","year":"2008","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib75","doi-asserted-by":"crossref","first-page":"4898217","DOI":"10.1155\/2020\/4898217","article-title":"Age-related deterioration of mitochondrial function in the intestine","volume":"2020","author":"Schneider","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib76","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1073\/pnas.0505903103","article-title":"Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission","volume":"103","author":"Greaves","year":"2006","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib77","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1474-9726.2009.00531.x","article-title":"Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts","volume":"9","author":"Nooteboom","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib78","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.exger.2010.01.013","article-title":"Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts","volume":"45","author":"Greaves","year":"2010","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib79","doi-asserted-by":"crossref","first-page":"e1003082","DOI":"10.1371\/journal.pgen.1003082","article-title":"Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations","volume":"8","author":"Greaves","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib80","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1038\/sj.onc.1209605","article-title":"The many shapes of mitochondrial death","volume":"25","author":"Cereghetti","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib81","first-page":"6","article-title":"Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila","author":"Brandt","year":"2017","journal-title":"eLife"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib82","first-page":"1199","article-title":"Aging of the liver: age-associated mitochondrial damage in intact hepatocytes","volume":"24","author":"Sastre","year":"1996","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib83","doi-asserted-by":"crossref","first-page":"e48395","DOI":"10.15252\/embr.201948395","article-title":"Causal roles of mitochondrial dynamics in longevity and healthy aging","volume":"20","author":"Sharma","year":"2019","journal-title":"EMBO Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib84","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.cub.2014.08.060","article-title":"Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles","volume":"24","author":"Udagawa","year":"2014","journal-title":"Curr Biol: CB"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib85","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1242\/jcs.059246","article-title":"Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1","volume":"123","author":"Mai","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib86","doi-asserted-by":"crossref","first-page":"22977","DOI":"10.1074\/jbc.M700679200","article-title":"Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence","volume":"282","author":"Lee","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib87","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbabio.2015.05.017","article-title":"Mitochondria: are they causal players in cellular senescence?","volume":"1847","author":"Correia-Melo","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib88","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/jcp.20753","article-title":"Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1","volume":"209","author":"Yoon","year":"2006","journal-title":"J Cell Physiol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib89","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/ncb1524","article-title":"Reducing mitochondrial fission results in increased lifespan and fitness of two fungal ageing models","volume":"9","author":"Scheckhuber","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib90","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41467-017-00525-4","article-title":"Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster","volume":"8","author":"Rana","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib91","doi-asserted-by":"crossref","first-page":"8638","DOI":"10.1073\/pnas.1216197110","article-title":"Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan","volume":"110","author":"Rana","year":"2013","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib92","doi-asserted-by":"crossref","first-page":"e13191","DOI":"10.1111\/acel.13191","article-title":"Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss","volume":"19","author":"Amartuvshin","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib93","doi-asserted-by":"crossref","first-page":"17923","DOI":"10.18632\/oncotarget.4235","article-title":"Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice","volume":"6","author":"Leduc-Gaudet","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib94","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.molcel.2018.11.034","article-title":"The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging","volume":"73","author":"D'Amico","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib95","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/j.1600-0854.2007.00644.x","article-title":"Moving mitochondria: establishing distribution of an essential organelle","volume":"8","author":"Frederick","year":"2007","journal-title":"Traffic (Copenhagen, Den)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib96","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1523\/JNEUROSCI.2799-15.2016","article-title":"Age-related phasic patterns of mitochondrial maintenance in adult caenorhabditis elegans neurons","volume":"36","author":"Morsci","year":"2016","journal-title":"J Neurosci: Off J Soc Neurosci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib97","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","article-title":"The mitochondrial basis of aging","volume":"61","author":"Sun","year":"2016","journal-title":"Mol Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib98","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/bs.ircmb.2018.05.006","article-title":"Mitochondria and reactive oxygen species in aging and age-related diseases","volume":"340","author":"Giorgi","year":"2018","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib99","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.redox.2018.09.025","article-title":"New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis","volume":"20","author":"Yuan","year":"2019","journal-title":"Redox Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib100","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cell.2006.01.002","article-title":"Methylglyoxal comes of AGE","volume":"124","author":"Ramasamy","year":"2006","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib101","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1074\/jbc.M116.759084","article-title":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation causes mitochondrial dysfunction during oxidative stress-induced cell death","volume":"292","author":"Nakajima","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib102","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.plipres.2012.10.004","article-title":"Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease","volume":"52","author":"Leamy","year":"2013","journal-title":"Prog Lipid Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib103","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of Insulin Action and Insulin Resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib104","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/acel.12073","article-title":"Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione","volume":"12","author":"Nguyen","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/joim.12071","article-title":"Ectopic lipid storage and insulin resistance: a harmful relationship","volume":"274","author":"Boren","year":"2013","journal-title":"J Intern Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib106","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41556-018-0205-1","article-title":"mTOR as a central hub of nutrient signalling and cell growth","volume":"21","author":"Kim","year":"2019","journal-title":"Nat Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib107","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1073\/pnas.1716173114","article-title":"Twenty-five years of mTOR: uncovering the link from nutrients to growth","volume":"114","author":"Sabatini","year":"2017","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib108","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/BOR.0b013e328358d59b","article-title":"Sarcopenia in older adults","volume":"24","author":"Walston","year":"2012","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib109","first-page":"100","article-title":"Cachexia and sarcopenia: mechanisms and potential targets for intervention","volume":"22","author":"Argil\u00e9s","year":"2015","journal-title":"Curr Oppharmacol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib110","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1096\/fj.05-4607fje","article-title":"Insulin resistance of muscle protein metabolism in aging","volume":"20","author":"Rasmussen","year":"2006","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib111","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2018.02.019","article-title":"Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging","volume":"27","author":"Redman","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib112","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.cell.2016.07.031","article-title":"Metabolic control of longevity","volume":"166","author":"L\u00f3pez-Ot\u00edn","year":"2016","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib113","doi-asserted-by":"crossref","first-page":"24441","DOI":"10.18632\/aging.103987","article-title":"Caloric restriction: implications for sarcopenia and potential mechanisms","volume":"12","author":"Xie","year":"2020","journal-title":"Aging"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib114","first-page":"709","article-title":"Nutritional modulation of nonalcoholic fatty liver disease and insulin resistance: human data","volume":"13","author":"Yki-J\u00e4rvinen","year":"2010","journal-title":"Curr OpClNutr Metab Care"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11684-013-0262-6","article-title":"Mechanisms of insulin resistance in obesity","volume":"7","author":"Ye","year":"2013","journal-title":"Front Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib116","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2016.04.001","article-title":"Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling","volume":"100","author":"Brand","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib117","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.sbi.2019.03.001","article-title":"Structure and mechanisms of ROS generation by NADPH oxidases","volume":"59","author":"Magnani","year":"2019","journal-title":"Curr OpStruct Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib118","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.exger.2010.01.003","article-title":"The sites and topology of mitochondrial superoxide production","volume":"45","author":"Brand","year":"2010","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem J"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib120","doi-asserted-by":"crossref","first-page":"47129","DOI":"10.1074\/jbc.M208262200","article-title":"Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants","volume":"277","author":"Echtay","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib121","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201102095","article-title":"Signal transduction by reactive oxygen species","volume":"194","author":"Finkel","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib122","doi-asserted-by":"crossref","first-page":"4350965","DOI":"10.1155\/2016\/4350965","article-title":"ROS and ROS-mediated cellular signaling","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib123","article-title":"Oxidative stress: concept and some practical aspects","volume":"9","author":"Sies","year":"2020","journal-title":"Antioxid (Basel, Switz)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib124","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib125","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib126","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr Biol: CB"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib127","doi-asserted-by":"crossref","first-page":"pe1","DOI":"10.1126\/stke.2000.53.pe1","article-title":"Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation","volume":"2000","author":"Rhee","year":"2000","journal-title":"Sci STKE: Signal Transduct Knowl Environ"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib128","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cell.2005.05.016","article-title":"Redox redux: revisiting PTPs and the control of cell signaling","volume":"121","author":"Tonks","year":"2005","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib129","first-page":"343","article-title":"Selected methodologies to assess oxidative\/antioxidant status in vivo: a critical review","volume":"12","author":"Del Rio","year":"2002","journal-title":"Nutr Metabol Cardiovas Dis: NMCD"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal Biochem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib131","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bbalip.2014.10.007","article-title":"The isoprostanes\u201325 years later","volume":"1851","author":"Milne","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib132","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0047-6374(95)01655-4","article-title":"Differential oxidative damage to mitochondrial proteins during aging","volume":"85","author":"Agarwal","year":"1995","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib133","doi-asserted-by":"crossref","first-page":"868","DOI":"10.18632\/aging.101450","article-title":"Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging","volume":"10","author":"Gonos","year":"2018","journal-title":"Aging"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib134","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/glycob\/cwq171","article-title":"Oxidative depolymerization of polysaccharides by reactive oxygen\/nitrogen species","volume":"21","author":"Duan","year":"2011","journal-title":"Glycobiology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.abb.2015.10.021","article-title":"Oxidative stress, free radicals and protein peroxides","volume":"595","author":"Gebicki","year":"2016","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib136","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0891-5849(02)00765-7","article-title":"Carbonyl modified proteins in cellular regulation, aging, and disease","volume":"32","author":"Levine","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib137","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00726-003-0012-1","article-title":"Recent advances in the analysis of oxidized proteins","volume":"25","author":"Requena","year":"2003","journal-title":"Amino Acids"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib138","doi-asserted-by":"crossref","first-page":"19683","DOI":"10.1074\/jbc.REV119.006217","article-title":"Detection, identification, and quantification of oxidative protein modifications","volume":"294","author":"Hawkins","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib139","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1046\/j.1523-1755.63.s84.47.x","article-title":"Are advanced oxidation protein products potential uremic toxins?","author":"Witko-Sarsat","year":"2003","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib140","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.2174\/0929867323666160902154748","article-title":"Circulating advanced oxidation protein products as oxidative stress biomarkers and progression mediators in pathological conditions related to inflammation and immune dysregulation","volume":"23","author":"Cristani","year":"2016","journal-title":"Curr Med Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib141","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1096\/fj.02-0752rev","article-title":"Oxidative DNA damage: mechanisms, mutation, and disease","volume":"17","author":"Cooke","year":"2003","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib142","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/10590500902885684","article-title":"8-hydroxy-2\u2032 -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. Journal of environmental science and health Part C","volume":"27","author":"Valavanidis","year":"2009","journal-title":"Environ Carcinogenesis Ecotoxicol Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib143","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1179\/135100001101535996","article-title":"Garbage catastrophe theory of aging: imperfect removal of oxidative damage?","volume":"6","author":"Terman","year":"2001","journal-title":"Redox Rep: Commun Free Radic Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib144","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.1074\/jbc.R116.751164","article-title":"Non-enzymatic molecular damage as a prototypic driver of aging","volume":"292","author":"Golubev","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib145","first-page":"2018","article-title":"[The other side of metabolism]","volume":"61","author":"Golubev","year":"1996","journal-title":"Biokhimiia (Moscow, Russia)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtbi.2009.01.009","article-title":"How could the Gompertz-Makeham law evolve","volume":"258","author":"Golubev","year":"2009","journal-title":"J Theor Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib147","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.mad.2004.07.009","article-title":"The role of oxidative damage and stress in aging","volume":"125","author":"Bokov","year":"2004","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib148","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0891-5849(02)00857-2","article-title":"Protein oxidation during aging of the nematode Caenorhabditis elegans","volume":"33","author":"Ishii","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib149","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/534","article-title":"Extension of drosophila lifespan by overexpression of human SOD1 in motorneurons","volume":"19","author":"Parkes","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib150","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.4161\/cc.8.11.8595","article-title":"Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?","volume":"8","author":"Gems","year":"2009","journal-title":"Cell Cycle (Georgetown, Tex)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib151","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/jama.297.8.842","article-title":"Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis","volume":"297","author":"Bjelakovic","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib152","first-page":"f10","article-title":"Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials","volume":"346","author":"Myung","year":"2013","journal-title":"BMJ (Clin Res ed)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib153","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib154","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/S0891-5849(02)01040-7","article-title":"Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses","volume":"33","author":"Jones","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib155","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0531-5565(02)00175-4","article-title":"Aging-related changes in the thiol\/disulfide redox state: implications for the use of thiol antioxidants","volume":"37","author":"Dr\u00f6ge","year":"2002","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib156","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/10715760600592962","article-title":"Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes","volume":"40","author":"Gil","year":"2006","journal-title":"Free Radic Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib157","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/cbf.937","article-title":"Age-related changes in the glutathione redox system","volume":"20","author":"Erden-Inal","year":"2002","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib158","first-page":"783","article-title":"[Lipid peroxide and antioxidants in the elderly]","volume":"46","author":"Tokunaga","year":"1998","journal-title":"Rinsho Byori Jpn J Clin Pathol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib159","first-page":"449","article-title":"Age-related changes of glutathione content, glutathione reductase and glutathione peroxidase activity of human erythrocytes","volume":"24","author":"Matsubara","year":"1991","journal-title":"Braz J Med Biol Res=Rev Brasileira de Pesqui medicas e biologicas"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib160","first-page":"613","article-title":"Redox parameters as markers of the rate of aging and predictors of lifespan","volume":"75","author":"Mart\u00ednez de Toda","year":"2020","journal-title":"J Gerontol Ser A, Biol Sci Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib161","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.freeradbiomed.2016.01.029","article-title":"Do glutathione levels decline in aging human brain?","volume":"93","author":"Tong","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib162","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0891-5849(96)00591-6","article-title":"Age-related changes in the peroxyl radical scavenging capacity of human plasma","volume":"23","author":"Aejmelaeus","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib163","doi-asserted-by":"crossref","first-page":"M660","DOI":"10.1093\/gerona\/57.10.M660","article-title":"Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group","volume":"57","author":"Kuzuya","year":"2002","journal-title":"J Gerontol Ser A, Biol Sci Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib164","first-page":"221","article-title":"Altered oxidative stress in healthy old subjects","volume":"9","author":"Rondanelli","year":"1997","journal-title":"Aging (Milan, Italy)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib165","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000085119","article-title":"Age-dependent change of uric acid level in the dermis using cutaneous microdialysis","volume":"51","author":"Lee","year":"2005","journal-title":"Gerontology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib166","first-page":"16","article-title":"Assessment of total antioxidant capacity in human plasma","volume":"46","author":"Goraca","year":"2004","journal-title":"Folia medica"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib167","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1024\/0300-9831.71.6.332","article-title":"Plasma protein oxidation and antioxidant defense during aging","volume":"71","author":"Garibaldi","year":"2001","journal-title":"Int J Vitam Nutr Res Internationale Z fur Vitamin- und Ernahrungsforschung J Int de vitaminologie et de Nutr"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib168","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0531-5565(03)00188-8","article-title":"Anti malondialdehyde-adduct immunological response as a possible marker of successful aging","volume":"38","author":"Traverso","year":"2003","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib169","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/ageing\/20.6.413","article-title":"Influence of sex and age on vitamin A and E status","volume":"20","author":"Succari","year":"1991","journal-title":"Age Ageing"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0009-8981(00)00422-8","article-title":"Antioxidant enzyme activities and malondialdehyde levels related to aging","volume":"305","author":"Inal","year":"2001","journal-title":"Clin Chim Acta; Int J Clin Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib171","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0531-5565(00)00198-4","article-title":"Alterations of antioxidant enzymes and oxidative stress markers in aging","volume":"36","author":"Kasapoglu","year":"2001","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib172","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/clinchem\/38.1.66","article-title":"Age-correlated modifications of copper-zinc superoxide dismutase and glutathione-related enzyme activities in human erythrocytes","volume":"38","author":"Ceballos-Picot","year":"1992","journal-title":"Clin Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib173","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0921-8734(95)00017-Z","article-title":"An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans","volume":"338","author":"Barnett","year":"1995","journal-title":"Mutat Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib174","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3349\/ymj.2003.44.1.9","article-title":"Influence of sex and age on the activity of antioxidant enzymes of polymorphonuclear leukocytes in healthy subjects","volume":"44","author":"Saraymen","year":"2003","journal-title":"Yonsei Med J"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib175","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1620\/tjem.197.119","article-title":"Lipid peroxidation and antioxidant enzymes in Turkish population: relation to age, gender, exercise, and smoking","volume":"197","author":"Ozbay","year":"2002","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib176","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.exger.2004.06.002","article-title":"Oxidative stress and the mitochondrial theory of aging in human skeletal muscle","volume":"39","author":"Gianni","year":"2004","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib177","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1196\/annals.1297.059","article-title":"Glutathione metabolism during aging and in Alzheimer disease","volume":"1019","author":"Liu","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib178","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.18632\/aging.101881","article-title":"Sex differences in the aging human heart: decreased sirtuins, pro-inflammatory shift and reduced anti-oxidative defense","volume":"11","author":"Barcena de Arellano","year":"2019","journal-title":"Aging"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib179","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-4165(91)90061-K","article-title":"Sex-dependent differences in the effects of aging on antioxidant defense mechanisms of rat liver","volume":"1074","author":"Rikans","year":"1991","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib180","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/ars.2017.7249","article-title":"Comparison of whole body SOD1 knockout with muscle-specific SOD1 knockout mice reveals a role for nerve redox signaling in regulation of degenerative pathways in skeletal muscle","volume":"28","author":"Sakellariou","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib181","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.freeradbiomed.2011.07.020","article-title":"Increased lifespan from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage","volume":"51","author":"Cabreiro","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib182","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1073\/pnas.87.11.4270","article-title":"Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span","volume":"87","author":"Seto","year":"1990","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib183","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1128\/MCB.19.1.216","article-title":"FLP recombinase-mediated induction of Cu\/Zn-superoxide dismutase transgene expression can extend the lifespan of adult Drosophila melanogaster flies","volume":"19","author":"Sun","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib184","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.onc.1208207","article-title":"CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life","volume":"24","author":"Elchuri","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib185","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1474-9726.2008.00449.x","article-title":"The overexpression of major antioxidant enzymes does not extend the lifespan of mice","volume":"8","author":"P\u00e9rez","year":"2009","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib186","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bbagen.2009.06.003","article-title":"Is the oxidative stress theory of aging dead?","volume":"1790","author":"P\u00e9rez","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib187","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/gerona\/glp100","article-title":"Overexpression of Mn superoxide dismutase does not increase lifespan in mice","volume":"64","author":"Jang","year":"2009","journal-title":"J Gerontol Ser A, Biol Sci Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib188","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1096\/fj.08-127415","article-title":"Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish lifespan","volume":"23","author":"Salmon","year":"2009","journal-title":"FASEB J: Off Publ Feder Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib189","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1128\/MCB.23.3.916-922.2003","article-title":"The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice","volume":"23","author":"Nonn","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib190","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.freeradbiomed.2007.11.018","article-title":"Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress","volume":"44","author":"P\u00e9rez","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib191","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1089\/ars.2012.5111","article-title":"The free radical theory of aging revisited: the cell signaling disruption theory of aging","volume":"19","author":"Vi\u00f1a","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib192","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.freeradbiomed.2019.01.045","article-title":"The free radical theory of frailty: mechanisms and opportunities for interventions to promote successful aging","volume":"134","author":"Vi\u00f1a","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib193","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2046-2395-3-6","article-title":"Mitochondrial oxidative stress in aging and healthspan","volume":"3","author":"Dai","year":"2014","journal-title":"Longev Healthspan"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib194","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1093\/nar\/29.10.2117","article-title":"A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA","volume":"29","author":"Hamilton","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib195","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.aac7516","article-title":"Mutations causing mitochondrial disease: what is new and what challenges remain?","volume":"349","author":"Lightowlers","year":"2015","journal-title":"Science (N York, NY)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib196","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0891-5849(93)90165-Q","article-title":"Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species","volume":"15","author":"Ku","year":"1993","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib197","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2174\/1874609810801010010","article-title":"The mitochondrial free radical theory of aging: a critical view","volume":"1","author":"Sanz","year":"2008","journal-title":"Curr Aging Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib198","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0047-6374(89)90096-1","article-title":"Superoxide anion radical production in different animal species","volume":"49","author":"Sohal","year":"1989","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib199","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1474-9726.2007.00312.x","article-title":"Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms","volume":"6","author":"Lambert","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib200","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.mad.2005.06.009","article-title":"Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat","volume":"126","author":"Andziak","year":"2005","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib201","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1474-9726.2006.00237.x","article-title":"High oxidative damage levels in the longest-living rodent, the naked mole-rat","volume":"5","author":"Andziak","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib202","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1126\/science.1106653","article-title":"Extension of murine lifespan by overexpression of catalase targeted to mitochondria","volume":"308","author":"Schriner","year":"2005","journal-title":"Science (N York, NY)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib203","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ng.95","article-title":"DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice","volume":"40","author":"Vermulst","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib204","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/ng1988","article-title":"Mitochondrial point mutations do not limit the natural lifespan of mice","volume":"39","author":"Vermulst","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib205","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.18632\/aging.100404","article-title":"Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents","volume":"3","author":"Anisimov","year":"2011","journal-title":"Aging"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib206","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/46311","article-title":"The p66shc adaptor protein controls oxidative stress response and lifespan in mammals","volume":"402","author":"Migliaccio","year":"1999","journal-title":"Nature"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib207","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cell.2005.05.011","article-title":"Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis","volume":"122","author":"Giorgio","year":"2005","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib208","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1126\/science.1135380","article-title":"Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc","volume":"315","author":"Pinton","year":"2007","journal-title":"Science (N York, NY)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib209","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.mad.2005.03.004","article-title":"p66(shc) is highly expressed in fibroblasts from centenarians","volume":"126","author":"Pandolfi","year":"2005","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.abb.2009.03.007","article-title":"Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues","volume":"486","author":"Lebiedzinska","year":"2009","journal-title":"Arch Biochem Biophy"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib211","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/gerona\/61.8.781","article-title":"Calorie restriction in mice: effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition","volume":"61","author":"Faulks","year":"2006","journal-title":"J Gerontol Ser A, Biol Sci Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib212","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature02517","article-title":"Premature ageing in mice expressing defective mitochondrial DNA polymerase","volume":"429","author":"Trifunovic","year":"2004","journal-title":"Nature"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib213","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science (N York, NY)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib214","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/acel.12212","article-title":"In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice","volume":"13","author":"Logan","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib215","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1474-9726.2006.00209.x","article-title":"Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?","volume":"5","author":"Khrapko","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib216","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1073\/pnas.96.3.846","article-title":"Mitochondrial disease in superoxide dismutase 2 mutant mice","volume":"96","author":"Melov","year":"1999","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib217","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng1295-376","article-title":"Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase","volume":"11","author":"Li","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib218","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.mad.2005.11.004","article-title":"Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging","volume":"127","author":"Mansouri","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib219","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1073\/pnas.0903485106","article-title":"Antioxidants prevent health-promoting effects of physical exercise in humans","volume":"106","author":"Ristow","year":"2009","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib220","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.exger.2010.03.014","article-title":"How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis)","volume":"45","author":"Ristow","year":"2010","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib221","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.cub.2010.10.057","article-title":"Inhibition of respiration extends C. elegans lifespan via reactive oxygen species that increase HIF-1 activity","volume":"20","author":"Lee","year":"2010","journal-title":"Curr Biol: CB"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib222","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2009.07.034","article-title":"4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila","volume":"139","author":"Zid","year":"2009","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib223","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cmet.2007.08.011","article-title":"Glucose restriction extends Caenorhabditis elegans lifespan by inducing mitochondrial respiration and increasing oxidative stress","volume":"6","author":"Schulz","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib224","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/gerona\/60.7.847","article-title":"Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels","volume":"60","author":"Ward","year":"2005","journal-title":"J Gerontol Ser A, Biol Sci Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib225","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/bbrc.2001.5583","article-title":"Measurement of F(2)-isoprostanes unveils profound oxidative stress in aged rats","volume":"287","author":"Roberts","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib226","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0891-5849(03)00187-4","article-title":"Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men","volume":"34","author":"Sacheck","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib227","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.mam.2004.02.003","article-title":"Aging and oxidative stress","volume":"25","author":"Junqueira","year":"2004","journal-title":"Mol Asp Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib228","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0009-9120(03)00035-3","article-title":"Age-related increases in plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in elderly subjects","volume":"36","author":"Mutlu-T\u00fcrko\u011flu","year":"2003","journal-title":"Clin Biochem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib229","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0024-3205(00)00722-0","article-title":"Changes in the intracellular homocysteine and glutathione content associated with aging","volume":"67","author":"Hernanz","year":"2000","journal-title":"Life Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib230","first-page":"329","article-title":"Free radicals and brain aging","volume":"20","author":"Poon","year":"2004","journal-title":"Clgeriatric Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib231","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0197-4580(02)00019-2","article-title":"Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases","volume":"23","author":"Floyd","year":"2002","journal-title":"Neurobiol Aging"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib232","doi-asserted-by":"crossref","first-page":"B459","DOI":"10.1093\/gerona\/56.11.B459","article-title":"Age-related changes in protein oxidation and proteolysis in mammalian cells","volume":"56","author":"Grune","year":"2001","journal-title":"J Gerontol Ser A, Biol Sci Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib233","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1749-6632.2001.tb05632.x","article-title":"Protein oxidation in aging and age-related diseases","volume":"928","author":"Stadtman","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib234","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2174\/0929867043365341","article-title":"Role of oxidant species in aging","volume":"11","author":"Stadtman","year":"2004","journal-title":"Curr Med Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib235","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/med.20073","article-title":"Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls","volume":"27","author":"Aldini","year":"2007","journal-title":"Med Res Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib236","doi-asserted-by":"crossref","DOI":"10.3390\/proteomes4020018","article-title":"Role of protein carbonylation in skeletal muscle mass loss associated with chronic conditions","volume":"4","author":"Barreiro","year":"2016","journal-title":"Proteomes"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib237","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac4765","article-title":"Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men","volume":"7","author":"Boden","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib238","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0891-5849(02)00780-3","article-title":"Oxidatively modified proteins in aging and disease","volume":"32","author":"Beal","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib239","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/j.1471-4159.2006.04334.x","article-title":"Proteomic analysis of protein nitration in rat cerebellum: effect of biological aging","volume":"100","author":"Gokulrangan","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib240","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2174\/1874609810666170315112634","article-title":"Protein tyrosine nitration: role in aging","volume":"10","author":"Chakravarti","year":"2017","journal-title":"Curr aging Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib241","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.biocel.2003.08.009","article-title":"Lipofuscin","volume":"36","author":"Terman","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib242","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1080\/10715760600953859","article-title":"Clinical oxidation parameters of aging","volume":"40","author":"Voss","year":"2006","journal-title":"Free Radic Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib243","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0891-5849(02)00959-0","article-title":"Lipofuscin: mechanisms of age-related accumulation and influence on cell function","volume":"33","author":"Brunk","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib244","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.redox.2017.01.017","article-title":"Mitochondrial contribution to lipofuscin formation","volume":"11","author":"K\u00f6nig","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib245","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/15287399309531806","article-title":"8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage","volume":"40","author":"Loft","year":"1993","journal-title":"J Toxicol Environ Health"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib246","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1096\/fj.04-1767fje","article-title":"Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study","volume":"19","author":"Gedik","year":"2005","journal-title":"FASEB J: Off Publ Feder Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib247","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1073\/pnas.85.17.6465","article-title":"Normal oxidative damage to mitochondrial and nuclear DNA is extensive","volume":"85","author":"Richter","year":"1988","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib248","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.tins.2004.07.005","article-title":"Free radicals and aging","volume":"27","author":"Barja","year":"2004","journal-title":"Trends Neurosci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib249","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0197-4580(96)00165-0","article-title":"8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer\u2019s disease","volume":"17","author":"Te Koppele","year":"1996","journal-title":"Neurobiol Aging"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib250","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1749-6632.2002.tb02912.x","article-title":"Wine, diet, antioxidant defenses, and oxidative damage","volume":"957","author":"P\u00e9rez","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib251","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1080\/15287390500182818","article-title":"Age-related changes in oxidative DNA damage and benzo(a)pyrene diolepoxide-I (BPDE-I)-DNA adduct levels in human stomach","volume":"68","author":"Lee","year":"2005","journal-title":"J Toxicol Environ Health Part A"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib252","first-page":"520","article-title":"[Age-associated increase in amount of DNA adducts in rat and human organs and its application to age estimation]","volume":"68","author":"Tomaru","year":"1993","journal-title":"[Hokkaido igaku zasshi] Hokkaido J Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib253","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0921-8734(93)90007-P","article-title":"Age-dependent increases of DNA adducts (I-compounds) in human and rat brain DNA","volume":"295","author":"Randerath","year":"1993","journal-title":"Mutat Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib254","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/carcin\/23.2.307","article-title":"The in vivo levels of DNA alkylation products in human lymphocytes are not age dependent: an assay of 7-methyl- and 7-(2-hydroxyethyl)-guanine DNA adducts","volume":"23","author":"Zhao","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib255","first-page":"217","article-title":"Implications of results of molecular epidemiology on DNA adducts, their repair and mutations for mechanisms of human cancer","author":"Hemminki","year":"2004","journal-title":"IARC Sci Publ"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib256","first-page":"3011","article-title":"Telomere attrition as ageing biomarker","volume":"25","author":"Bekaert","year":"2005","journal-title":"Anticancer Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib257","doi-asserted-by":"crossref","DOI":"10.1098\/rsbl.2017.0463","article-title":"Does oxidative stress shorten telomeres in vivo? A review","volume":"13","author":"Reichert","year":"2017","journal-title":"Biol Lett"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib258","doi-asserted-by":"crossref","first-page":"10771","DOI":"10.1073\/pnas.91.23.10771","article-title":"Oxidative damage and mitochondrial decay in aging","volume":"91","author":"Shigenaga","year":"1994","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib259","doi-asserted-by":"crossref","DOI":"10.3390\/genes9010022","article-title":"The aging mitochondria","volume":"9","author":"Theurey","year":"2018","journal-title":"Genes"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib260","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12725","article-title":"Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore longitudinal study of aging","volume":"17","author":"Gonzalez-Freire","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib261","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1126\/science.1082889","article-title":"Mitochondrial dysfunction in the elderly: possible role in insulin resistance","volume":"300","author":"Petersen","year":"2003","journal-title":"Science (N York, NY)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib262","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1073\/pnas.89.16.7370","article-title":"A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues","volume":"89","author":"Cortopassi","year":"1992","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib263","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0047-6374(88)90037-1","article-title":"Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions\/additions with aging","volume":"43","author":"Pik\u00f3","year":"1988","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib264","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng1292-318","article-title":"Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain","volume":"2","author":"Soong","year":"1992","journal-title":"Nat Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib265","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0140-6736(89)92145-4","article-title":"Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases","volume":"1","author":"Linnane","year":"1989","journal-title":"Lancet (London, Engl)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib266","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tig.2008.11.007","article-title":"Mitochondrial DNA mutations and aging: devils in the details?","volume":"25","author":"Khrapko","year":"2009","journal-title":"Trends Genetics: TIG"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib267","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1042\/bj20021594","article-title":"Mitochondrial threshold effects","volume":"370","author":"Rossignol","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib268","doi-asserted-by":"crossref","first-page":"337","DOI":"10.14336\/AD.2013.0400337","article-title":"Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice","volume":"4","author":"Kazachkova","year":"2013","journal-title":"Aging Dis"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib269","doi-asserted-by":"crossref","first-page":"16158","DOI":"10.3390\/ijms160716158","article-title":"Thyroid hormone mediated modulation of energy expenditure","volume":"16","author":"Vaitkus","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib270","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1113\/JP270211","article-title":"Skeletal muscle mitochondrial H2 O2 emission increases with immobilization and decreases after aerobic training in young and older men","volume":"593","author":"Gram","year":"2015","journal-title":"J Physiol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib271","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1474-9726.2008.00394.x","article-title":"Age-related increase of superoxide generation in the brains of mammals and birds","volume":"7","author":"Sasaki","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib272","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0047-6374(94)90104-X","article-title":"Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse","volume":"74","author":"Sohal","year":"1994","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib273","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1038\/sj.emboj.7600354","article-title":"Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase","volume":"23","author":"Brieba","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib274","doi-asserted-by":"crossref","first-page":"28942","DOI":"10.1038\/srep28942","article-title":"Oxidative DNA damage stalls the human mitochondrial replisome","volume":"6","author":"Stojkovi\u010d","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib275","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1093\/nar\/gkf392","article-title":"The mitochondrial DNA polymerase as a target of oxidative damage","volume":"30","author":"Graziewicz","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib276","doi-asserted-by":"crossref","first-page":"14659","DOI":"10.1074\/jbc.270.24.14659","article-title":"Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria","volume":"270","author":"Kang","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib277","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nrm3439","article-title":"Minimizing the damage: repair pathways keep mitochondrial DNA intact","volume":"13","author":"Kazak","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib278","doi-asserted-by":"crossref","first-page":"40544","DOI":"10.1074\/jbc.M508772200","article-title":"Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes","volume":"280","author":"Hu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib279","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nature09773","article-title":"DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair","volume":"471","author":"Gao","year":"2011","journal-title":"Nature"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib280","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1093\/nar\/27.18.3638","article-title":"Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase","volume":"27","author":"Takao","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib281","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1073\/pnas.072670199","article-title":"Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues","volume":"99","author":"Nekhaeva","year":"2002","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib282","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1196\/annals.1354.022","article-title":"Mitochondria damage checkpoint, aging, and cancer","volume":"1067","author":"Singh","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib283","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.dnarep.2011.12.001","article-title":"Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis","volume":"11","author":"Halsne","year":"2012","journal-title":"DNA Repair"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib284","doi-asserted-by":"crossref","first-page":"e1003794","DOI":"10.1371\/journal.pgen.1003794","article-title":"Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage","volume":"9","author":"Kennedy","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib285","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrfmmm.2005.12.012","article-title":"Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors","volume":"599","author":"Zheng","year":"2006","journal-title":"Mutat Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib286","doi-asserted-by":"crossref","first-page":"e1002028","DOI":"10.1371\/journal.pgen.1002028","article-title":"Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins","volume":"7","author":"Ameur","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib287","doi-asserted-by":"crossref","first-page":"e1005333","DOI":"10.1371\/journal.pgen.1005333","article-title":"Simultaneous DNA and RNA mapping of somatic mitochondrial mutations across diverse human cancers","volume":"11","author":"Stewart","year":"2015","journal-title":"PLoS Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib288","doi-asserted-by":"crossref","first-page":"e1003974","DOI":"10.1371\/journal.pgen.1003974","article-title":"Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations","volume":"10","author":"Itsara","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib289","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1165\/ajrcmb\/6.1.88","article-title":"Age-related decrease in respiratory muscle mitochondrial function in rats","volume":"6","author":"Torii","year":"1992","journal-title":"Am J Respirat Cell Mol Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib290","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1165\/ajrcmb\/6.5.543","article-title":"Aging-associated deletions of human diaphragmatic mitochondrial DNA","volume":"6","author":"Torii","year":"1992","journal-title":"Am J Respirat Cell Mol Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib291","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0925-4439(94)90056-6","article-title":"Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing","volume":"1226","author":"Lee","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib292","doi-asserted-by":"crossref","first-page":"e1004620","DOI":"10.1371\/journal.pgen.1004620","article-title":"Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing","volume":"10","author":"Greaves","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib293","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0047-6374(95)01611-3","article-title":"High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys","volume":"83","author":"Schwarze","year":"1995","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib294","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0027-5107(03)00010-1","article-title":"Accumulation of point mutations in mitochondrial DNA of aging mice","volume":"526","author":"Khaidakov","year":"2003","journal-title":"Mutat Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib295","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev-biochem-060408-093701","article-title":"Somatic mitochondrial DNA mutations in mammalian aging","volume":"79","author":"Larsson","year":"2010","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib296","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0014-5793(94)01063-3","article-title":"Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle","volume":"354","author":"Lee","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib297","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1749-6632.1996.tb39054.x","article-title":"Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process","volume":"786","author":"Wei","year":"1996","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib298","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-5793(93)81484-H","article-title":"The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages","volume":"317","author":"M\u00fcnscher","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib299","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1006\/bbrc.1993.2158","article-title":"Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans","volume":"195","author":"Zhang","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib300","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1126\/science.286.5440.774","article-title":"Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication","volume":"286","author":"Michikawa","year":"1999","journal-title":"Science (N York, NY)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib301","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1073\/pnas.061013598","article-title":"Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication","volume":"98","author":"Wang","year":"2001","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib302","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0006-291X(91)91788-E","article-title":"Ageing-associated 5 kb deletion in human liver mitochondrial DNA","volume":"178","author":"Yen","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib303","first-page":"1009","article-title":"Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria","volume":"32","author":"Hsieh","year":"1994","journal-title":"Biochem Mol Biol Int"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib304","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1006\/bbrc.1994.2732","article-title":"Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles","volume":"205","author":"Lezza","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib305","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1177\/153537020222700901","article-title":"Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging","volume":"227","author":"Wei","year":"2002","journal-title":"Exp Biol Med (Maywood, NJ)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib306","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1093\/nar\/gnf067","article-title":"Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR","volume":"30","author":"He","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib307","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0891-5849(01)00517-2","article-title":"Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle","volume":"30","author":"Pesce","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib308","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1093\/nar\/29.21.4502","article-title":"Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection","volume":"29","author":"Cao","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib309","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1096\/fj.00-0320com","article-title":"Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia","volume":"15","author":"Wanagat","year":"2001","journal-title":"FASEB J: Off Publ Feder Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib310","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1186\/1471-2164-15-677","article-title":"Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints","volume":"15","author":"Dong","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib311","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.tig.2004.07.003","article-title":"Two direct repeats cause most human mtDNA deletions","volume":"20","author":"Samuels","year":"2004","journal-title":"Trends Genet: TIG"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib312","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1093\/nar\/gks500","article-title":"Mitochondrial DNA deletions are associated with non-B DNA conformations","volume":"40","author":"Damas","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib313","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1086\/507132","article-title":"Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers","volume":"79","author":"Bua","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib314","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/gerona\/62.3.235","article-title":"Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss","volume":"62","author":"Herbst","year":"2007","journal-title":"J Gerontol Ser A, Biol Sci Med Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib315","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng1769","article-title":"High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease","volume":"38","author":"Bender","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib316","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/ng1778","article-title":"Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons","volume":"38","author":"Kraytsberg","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib317","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ajhg.2007.09.018","article-title":"Nature of mitochondrial DNA deletions in substantia nigra neurons","volume":"82","author":"Reeve","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib318","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/acel.12146","article-title":"Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain","volume":"13","author":"Taylor","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib319","first-page":"384","article-title":"Accumulation of mitochondrial DNA deletions in human retina during aging","volume":"37","author":"Barreau","year":"1996","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib320","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/molehr\/4.7.657","article-title":"Multiple deletions of mitochondrial DNA are associated with the decline of motility and fertility of human spermatozoa","volume":"4","author":"Kao","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib321","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1095\/biolreprod49.4.730","article-title":"Rapid accumulation of deleted mitochondrial deoxyribonucleic acid in postmenopausal ovaries","volume":"49","author":"Kitagawa","year":"1993","journal-title":"Biol Reprod"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib322","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0925-4439(92)90059-V","article-title":"Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR","volume":"1180","author":"Simonetti","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib323","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s00415-008-0892-9","article-title":"Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions","volume":"255","author":"Bender","year":"2008","journal-title":"J Neurol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib324","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/acel.12231","article-title":"When man got his mtDNA deletions?","volume":"13","author":"Popadin","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib325","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1093\/hmg\/ddu176","article-title":"Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle","volume":"23","author":"Campbell","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib326","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cmet.2015.04.005","article-title":"Mosaic deficiency in mitochondrial oxidative metabolism promotes cardiac arrhythmia during aging","volume":"21","author":"Baris","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib327","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/hmg\/ddn437","article-title":"Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons","volume":"18","author":"Fukui","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib328","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0921-8734(92)90028-N","article-title":"Lipid peroxidation and mtDNA degeneration. A hypothesis","volume":"275","author":"Hruszkewycz","year":"1992","journal-title":"Mutat Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib329","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/0016-5085(93)90959-G","article-title":"Hepatic mitochondrial energy production in rats with chronic iron overload","volume":"105","author":"Bacon","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib330","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0014-5793(00)01082-6","article-title":"The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles","volume":"466","author":"Paradies","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib331","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0014-5793(01)03206-9","article-title":"Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis","volume":"509","author":"Petrosillo","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib332","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0891-5849(02)00856-0","article-title":"Role of oxidative stress and protein oxidation in the aging process","volume":"33","author":"Sohal","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib333","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1073\/pnas.0510346103","article-title":"Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis","volume":"103","author":"Miyoshi","year":"2006","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib334","doi-asserted-by":"crossref","first-page":"11168","DOI":"10.1073\/pnas.94.21.11168","article-title":"Oxidative damage during aging targets mitochondrial aconitase","volume":"94","author":"Yan","year":"1997","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib335","doi-asserted-by":"crossref","first-page":"12896","DOI":"10.1073\/pnas.95.22.12896","article-title":"Mitochondrial adenine nucleotide translocase is modified oxidatively during aging","volume":"95","author":"Yan","year":"1998","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib336","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.mad.2010.07.003","article-title":"Signaling pathways in mitochondrial dysfunction and aging","volume":"131","author":"Mammucari","year":"2010","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib337","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2796.2007.01905.x","article-title":"Mitochondrial dysfunction as a cause of ageing","volume":"263","author":"Trifunovic","year":"2008","journal-title":"J Intern Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib338","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/9780470725207.ch14","article-title":"Mitochondrial dysfunction in mammalian ageing","volume":"287","author":"Terzioglu","year":"2007","journal-title":"Novartis Found Sympos"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib339","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1096\/fj.04-2622fje","article-title":"Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging","volume":"19","author":"Judge","year":"2005","journal-title":"FASEB J: Off Publ Feder Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib340","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1474-9726.2010.00581.x","article-title":"Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria","volume":"9","author":"Dai","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib341","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.freeradbiomed.2010.12.009","article-title":"Exercise-induced oxidative stress in humans: cause and consequences","volume":"51","author":"Powers","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib342","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/acel.12102","article-title":"Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice","volume":"12","author":"Siegel","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib343","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1113\/jphysiol.2005.097782","article-title":"Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle","volume":"569","author":"Marcinek","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib344","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1073\/pnas.0610131104","article-title":"Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo","volume":"104","author":"Amara","year":"2007","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib345","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cmet.2010.11.004","article-title":"Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance","volume":"12","author":"Lee","year":"2010","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib346","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1096\/fj.09-146308","article-title":"Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration","volume":"24","author":"Jang","year":"2010","journal-title":"FASEB J: Off Publ Feder Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib347","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1096\/fj.13-228130","article-title":"CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice","volume":"27","author":"Zhang","year":"2013","journal-title":"FASEB J: Off Publ Feder Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib348","doi-asserted-by":"crossref","first-page":"19432","DOI":"10.1073\/pnas.0908786106","article-title":"Age-related hearing loss in C57BL\/6J mice is mediated by Bak-dependent mitochondrial apoptosis","volume":"106","author":"Someya","year":"2009","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib349","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/acel.12650","article-title":"The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore","volume":"16","author":"Rottenberg","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib350","doi-asserted-by":"crossref","first-page":"927","DOI":"10.14336\/AD.2019.0820","article-title":"Sirtuins and their biological relevance in aging and age-related diseases","volume":"11","author":"Zhao","year":"2020","journal-title":"Aging Dis"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib351","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.mad.2005.03.012","article-title":"Overview of caloric restriction and ageing","volume":"126","author":"Masoro","year":"2005","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib352","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.arr.2014.11.005","article-title":"Calorie restriction mimetics: can you have your cake and eat it, too?","volume":"20","author":"Ingram","year":"2015","journal-title":"Ageing Res Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib353","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1173635","article-title":"Caloric restriction delays disease onset and mortality in rhesus monkeys","volume":"325","author":"Colman","year":"2009","journal-title":"Science (N York, NY)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib354","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1474-9726.2005.00152.x","article-title":"Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance","volume":"4","author":"Miller","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib355","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1096\/fj.05-5568com","article-title":"Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins","volume":"20","author":"Sanz","year":"2006","journal-title":"FASEB J: Off Publ Feder Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib356","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10522-008-9200-4","article-title":"Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver","volume":"10","author":"Caro","year":"2009","journal-title":"Biogerontology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib357","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10522-012-9384-5","article-title":"Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria","volume":"13","author":"Sanchez-Roman","year":"2012","journal-title":"Biogerontology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib358","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nrg2188","article-title":"Genetic links between diet and lifespan: shared mechanisms from yeast to humans","volume":"8","author":"Bishop","year":"2007","journal-title":"Nat Rev Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib359","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.cmet.2017.09.020","article-title":"System-wide benefits of intermeal fasting by autophagy","volume":"26","author":"Martinez-Lopez","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib360","doi-asserted-by":"crossref","DOI":"10.3390\/nu11061234","article-title":"Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans","volume":"11","author":"Jamshed","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib361","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-079X.2011.00856.x","article-title":"A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases","volume":"51","author":"Stehle","year":"2011","journal-title":"J Pineal Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib362","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1600-079X.1986.tb00760.x","article-title":"Human melatonin production decreases with age","volume":"3","author":"Sack","year":"1986","journal-title":"J Pineal Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib363","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1210\/jcem.86.7.7655","article-title":"Dietary caloric restriction prevents the age-related decline in plasma melatonin levels of rhesus monkeys","volume":"86","author":"Roth","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib364","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cell.2017.07.035","article-title":"Aged stem cells reprogram their daily rhythmic functions to adapt to stress","volume":"170","author":"Solanas","year":"2017","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib365","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.cell.2017.07.042","article-title":"Circadian reprogramming in the liver identifies metabolic pathways of aging","volume":"170","author":"Sato","year":"2017","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib366","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature10533","article-title":"Genome sequencing reveals insights into physiology and longevity of the naked mole rat","volume":"479","author":"Kim","year":"2011","journal-title":"Nature"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib367","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF01253102","article-title":"Pineal atrophy and other neuroendocrine and circumventricular features of the naked mole-rat, Heterocephalus glaber (R\u00fcppell), a fossorial, equatorial rodent","volume":"52","author":"Quay","year":"1981","journal-title":"J Neural Transm"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib368","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1074\/jbc.R116.771915","article-title":"Key proteins and pathways that regulate lifespan","volume":"292","author":"Pan","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib369","doi-asserted-by":"crossref","first-page":"110796","DOI":"10.1016\/j.exger.2019.110796","article-title":"Mitochondrial uncoupling and longevity\u2014a role for mitokines?","volume":"130","author":"Klaus","year":"2020","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib370","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tips.2010.02.003","article-title":"Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases","volume":"31","author":"Imai","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib371","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib372","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cmet.2013.07.013","article-title":"Sirt1 extends lifespan and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH","volume":"18","author":"Satoh","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib373","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.freeradbiomed.2019.07.017","article-title":"Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins","volume":"141","author":"Palmeira","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib374","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5483\/BMBRep.2019.52.1.290","article-title":"Sirtuin signaling in cellular senescence and aging","volume":"52","author":"Lee","year":"2019","journal-title":"BMB Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib375","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib376","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib377","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice","volume":"14","author":"Yoshino","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib378","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.exger.2008.06.013","article-title":"Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart","volume":"43","author":"Barger","year":"2008","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib379","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cmet.2008.06.011","article-title":"Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan","volume":"8","author":"Pearson","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib380","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: the in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat Rev Drug Dis"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib381","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib382","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1093\/carcin\/bgm144","article-title":"Resveratrol suppresses prostate cancer progression in transgenic mice","volume":"28","author":"Harper","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib383","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.intimp.2007.05.008","article-title":"Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo","volume":"7","author":"Li","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib384","doi-asserted-by":"crossref","first-page":"32695","DOI":"10.1074\/jbc.M110.133892","article-title":"SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator","volume":"285","author":"Dai","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib385","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tips.2013.12.004","article-title":"Small molecule SIRT1 activators for the treatment of aging and age-related diseases","volume":"35","author":"Hubbard","year":"2014","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib386","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature06261","article-title":"Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib387","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/ATVBAHA.108.164368","article-title":"Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells","volume":"28","author":"Ota","year":"2008","journal-title":"Arteriosclerosis Thrombosis Vasc Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib388","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jep.2014.04.025","article-title":"Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway","volume":"154","author":"Jamal","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib389","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1161\/ATVBAHA.110.210500","article-title":"Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway","volume":"30","author":"Ota","year":"2010","journal-title":"Arteriosclerosis Thrombosis Vasc Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib390","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.3892\/mmr.2013.1417","article-title":"Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation","volume":"7","author":"Suo","year":"2013","journal-title":"Mol Med Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib391","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11010-014-2046-y","article-title":"Hydrogen sulfide delays nicotinamide-induced premature senescence via upregulation of SIRT1 in human umbilical vein endothelial cells","volume":"393","author":"Zheng","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib392","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1248\/bpb.31.1265","article-title":"Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence","volume":"31","author":"Lee","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib393","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.arr.2013.06.003","article-title":"The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer\u2019s disease","volume":"12","author":"Jayasena","year":"2013","journal-title":"Ageing Res Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib394","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.07.040","article-title":"P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage","volume":"158","author":"Wang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib395","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2337\/db12-1139","article-title":"Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome","volume":"62","author":"Escande","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib396","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10522-013-9489-5","article-title":"Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence","volume":"15","author":"Braidy","year":"2014","journal-title":"Biogerontology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib397","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.cell.2013.05.027","article-title":"SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib398","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.neurobiolaging.2012.12.005","article-title":"Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-\u03b3 coactivator 1\u03b1 regulated \u03b2-secretase 1 degradation and mitochondrial gene expression in Alzheimer\u2019s mouse models","volume":"34","author":"Gong","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib399","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1126\/science.aaf2693","article-title":"NAD+ repletion improves mitochondrial and stem cell function and enhances lifespan in mice","volume":"352","author":"Zhang","year":"2016","journal-title":"Science (N York, NY)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib400","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature01578","article-title":"Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae","volume":"423","author":"Anderson","year":"2003","journal-title":"Nature"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib401","doi-asserted-by":"crossref","first-page":"18881","DOI":"10.1074\/jbc.M111773200","article-title":"Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels","volume":"277","author":"Anderson","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib402","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1021\/jm502009h","article-title":"Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors","volume":"58","author":"Haffner","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib403","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10522-004-2566-z","article-title":"Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging","volume":"5","author":"Ferrari","year":"2004","journal-title":"Biogerontology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib404","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbrc.2009.08.121","article-title":"Uncoupling of oxidative phosphorylation by curcumin: implication of its cellular mechanism of action","volume":"389","author":"Lim","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib405","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051239","article-title":"The role of curcumin in the modulation of ageing","volume":"20","author":"Bielak-Zmijewska","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib406","doi-asserted-by":"crossref","first-page":"19201","DOI":"10.18632\/oncotarget.8450","article-title":"Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature","volume":"7","author":"Grabowska","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib407","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3390\/nu7020905","article-title":"Effect of curcumin supplementation on physiological fatigue and physical performance in mice","volume":"7","author":"Huang","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib408","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.metabol.2015.07.010","article-title":"Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels","volume":"64","author":"Ray Hamidie","year":"2015","journal-title":"Metabol: Clin Exp"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib409","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.tips.2017.01.009","article-title":"Sirtuin inhibition: strategies, inhibitors, and therapeutic potential","volume":"38","author":"Jiang","year":"2017","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib410","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1107\/S2053230X15019986","article-title":"Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking","volume":"71","author":"Rumpf","year":"2015","journal-title":"Acta Crystallogr Sect F, Struct Biol Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib411","doi-asserted-by":"crossref","first-page":"8340","DOI":"10.1021\/jm500777s","article-title":"Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach","volume":"57","author":"Cui","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib412","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ccr.2011.12.020","article-title":"Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib","volume":"21","author":"Li","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib413","doi-asserted-by":"crossref","first-page":"8193","DOI":"10.1021\/jm301115r","article-title":"Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells","volume":"55","author":"Rotili","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib414","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.str.2007.02.002","article-title":"Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin","volume":"15","author":"Schuetz","year":"2007","journal-title":"Structure (London, Engl: 1993)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib415","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.celrep.2012.11.001","article-title":"The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington\u2019s disease mouse models","volume":"2","author":"Chopra","year":"2012","journal-title":"Cell Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib416","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0531-5565(00)00135-2","article-title":"Uncoupling to survive? The role of mitochondrial inefficiency in ageing","volume":"35","author":"Brand","year":"2000","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib417","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biochi.2016.11.013","article-title":"Targeted mitochondrial uncoupling beyond UCP1 - The fine line between death and metabolic health","volume":"134","author":"Ost","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib418","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.1997.77.3.731","article-title":"Cellular energy utilization and molecular origin of standard metabolic rate in mammals","volume":"77","author":"Rolfe","year":"1997","journal-title":"Physiol Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib419","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41586-019-1400-3","article-title":"H(+) transport is an integral function of the mitochondrial ADP\/ATP carrier","volume":"571","author":"Bertholet","year":"2019","journal-title":"Nature"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib420","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.bbamcr.2016.04.013","article-title":"UCPs, at the interface between bioenergetics and metabolism","volume":"1863","author":"Bouillaud","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib421","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrm1592","article-title":"The mitochondrial uncoupling-protein homologues","volume":"6","author":"Krauss","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib422","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2174\/1566524018666180308110822","article-title":"Uncoupling protein overexpression in metabolic disease and the risk of uncontrolled cell proliferation and tumorigenesis","volume":"17","author":"Ruiz-Ramirez","year":"2017","journal-title":"Curr Mol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib423","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1474-9728.2004.00097.x","article-title":"Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer","volume":"3","author":"Speakman","year":"2004","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib424","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1432-1033.1978.tb12045.x","article-title":"Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation","volume":"82","author":"Heaton","year":"1978","journal-title":"Eur J Biochem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib425","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0006-291X(76)90849-4","article-title":"Mitochondrial protein alteration in active brown fat: a soidum dodecyl sulfate-polyacrylamide gel electrophoretic study","volume":"73","author":"Ricquier","year":"1976","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib426","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0020-711X(91)90062-R","article-title":"The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue","volume":"23","author":"Klaus","year":"1991","journal-title":"Int J Biochem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib427","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1984.64.1.1","article-title":"Thermogenic mechanisms in brown fat","volume":"64","author":"Nicholls","year":"1984","journal-title":"Physiol Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib428","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00424-009-0729-0","article-title":"The role of mitochondrial uncoupling proteins in lifespan","volume":"459","author":"Dietrich","year":"2010","journal-title":"Pflug Arch: Eur J Physiol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib429","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.exger.2008.09.011","article-title":"Characterization of survival and phenotype throughout the lifespan in UCP2\/UCP3 genetically altered mice","volume":"43","author":"McDonald","year":"2008","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib430","doi-asserted-by":"crossref","first-page":"E621","DOI":"10.1152\/ajpendo.90903.2008","article-title":"Uncoupling protein-2 regulates lifespan in mice","volume":"296","author":"Andrews","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib431","doi-asserted-by":"crossref","first-page":"37391","DOI":"10.1074\/jbc.M605552200","article-title":"Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells","volume":"281","author":"Chan","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib432","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/164_2018_138","article-title":"The mechanism FA-dependent H(+) transport by UCP1","volume":"251","author":"Bertholet","year":"2019","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib433","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080795","article-title":"Mitochondrial uncoupling: a key controller of biological processes in physiology and diseases","volume":"8","author":"Demine","year":"2019","journal-title":"Cells"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib434","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030280","article-title":"2,4 Dinitrophenol as Medicine","volume":"8","author":"Geisler","year":"2019","journal-title":"Cells"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib435","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1474-9726.2008.00407.x","article-title":"Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity","volume":"7","author":"Caldeira da Silva","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib436","doi-asserted-by":"crossref","first-page":"19341","DOI":"10.1074\/jbc.M114.568204","article-title":"The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality","volume":"289","author":"Goldgof","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib437","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.brainres.2017.03.018","article-title":"Neuroprotective effects of 2,4-dinitrophenol in an acute model of Parkinson\u2019s disease","volume":"1663","author":"Lee","year":"2017","journal-title":"Brain Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib438","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neurobiolaging.2019.09.011","article-title":"A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson\u2019s disease","volume":"85","author":"Kishimoto","year":"2020","journal-title":"Neurobiol Aging"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib439","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1134\/S0006297920060024","article-title":"Manipulating cellular energetics to slow aging of tissues and organs","volume":"85","author":"Sokolov","year":"2020","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib440","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/emermed-2013-203335","article-title":"Increasing frequency of severe clinical toxicity after use of 2,4-dinitrophenol in the UK: a report from the National Poisons Information Service","volume":"32","author":"Kamour","year":"2015","journal-title":"Emerg Med J: EMJ"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib441","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1083\/jcb.201702058","article-title":"Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals","volume":"216","author":"Quir\u00f3s","year":"2017","journal-title":"J Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib442","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1038\/sj.emboj.7601184","article-title":"Regulation of mitochondrial morphology through proteolytic cleavage of OPA1","volume":"25","author":"Ishihara","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib443","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41598-017-18582-6","article-title":"Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner","volume":"8","author":"Miyazono","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib444","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cmet.2007.10.010","article-title":"Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease","volume":"6","author":"Gates","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib445","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1474-9726.2010.00648.x","article-title":"Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice","volume":"10","author":"Keipert","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib446","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1038\/s41467-018-05805-1","article-title":"Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers","volume":"9","author":"Kumar","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib447","doi-asserted-by":"crossref","first-page":"43079","DOI":"10.1074\/jbc.M206726200","article-title":"High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content","volume":"277","author":"Couplan","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib448","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/physiolgenomics.00299.2004","article-title":"Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation","volume":"21","author":"Klaus","year":"2005","journal-title":"Physiol Genomics"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib449","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/80450","article-title":"Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice","volume":"6","author":"Li","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib450","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1152\/physiolgenomics.00194.2007","article-title":"Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1","volume":"32","author":"Katterle","year":"2008","journal-title":"Physiol Genomics"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib451","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbabio.2009.11.008","article-title":"UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production","volume":"1797","author":"Keipert","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib452","doi-asserted-by":"crossref","first-page":"E495","DOI":"10.1152\/ajpendo.00518.2012","article-title":"Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system","volume":"304","author":"Keipert","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib453","doi-asserted-by":"crossref","first-page":"e94689","DOI":"10.1371\/journal.pone.0094689","article-title":"Activation of AMPK\u03b12 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity","volume":"9","author":"Ost","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib454","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12263-015-0507-x","article-title":"Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity","volume":"10","author":"Voigt","year":"2015","journal-title":"Genes Nutr"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib455","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nm.3624","article-title":"Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefits","volume":"20","author":"Ristow","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib456","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","article-title":"Physiological roles of mitochondrial reactive oxygen species","volume":"48","author":"Sena","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib457","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cmet.2014.01.011","article-title":"Mitohormesis","volume":"19","author":"Yun","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib458","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.15252\/embr.201642195","article-title":"The integrated stress response","volume":"17","author":"Pakos-Zebrucka","year":"2016","journal-title":"EMBO Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib459","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1096\/fj.14-261503","article-title":"Muscle mitohormesis promotes cellular survival via serine\/glycine pathway flux","volume":"29","author":"Ost","year":"2015","journal-title":"FASEB J: Off Publ Feder Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib460","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1134\/S0006297916120051","article-title":"Uncouplers of oxidation and phosphorylation as antiaging compounds","volume":"81","author":"Knorre","year":"2016","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib461","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1242\/jcs.197269","article-title":"Mitochondrial depolarization in yeast zygotes inhibits clonal expansion of selfish mtDNA","volume":"130","author":"Karavaeva","year":"2017","journal-title":"J Cell Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib462","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.arr.2011.11.005","article-title":"Of mice and men: the benefits of caloric restriction, exercise, and mimetics","volume":"11","author":"Mercken","year":"2012","journal-title":"Ageing Res Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib463","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0047-6374(97)00140-1","article-title":"Longevity of exercising male rats: effect of an antioxidant supplemented diet","volume":"100","author":"Holloszy","year":"1998","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib464","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1080\/07853890.2018.1511918","article-title":"Implications of low muscle mass across the continuum of care: a narrative review","volume":"50","author":"Prado","year":"2018","journal-title":"Ann Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib465","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a029785","article-title":"Effects of exercise and aging on skeletal muscle","volume":"8","author":"Distefano","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib466","doi-asserted-by":"crossref","first-page":"3428543","DOI":"10.1155\/2019\/3428543","article-title":"Long-term moderate exercise combined with metformin treatment induces an hormetic response that prevents strength and muscle mass loss in old female wistar rats","volume":"2019","author":"Hern\u00e1ndez-\u00c1lvarez","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib467","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.exger.2018.10.006","article-title":"Beneficial alterations in body composition, physical performance, oxidative stress, inflammatory markers, and adipocytokines induced by long-term high-intensity interval training in an aged rat model","volume":"113","author":"Li","year":"2018","journal-title":"Exp Gerontol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib468","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.2174\/0929867325666171129215251","article-title":"Anti-aging drugs\u2014prospect of longer life?","volume":"25","author":"Klimova","year":"2018","journal-title":"Curr medicinal Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib469","first-page":"7","article-title":"Biology of healthy aging and longevity","volume":"68","author":"Carmona","year":"2016","journal-title":"Rev de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib470","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1753-4887.2009.00185.x","article-title":"Exercise: it\u2019s the real thing!","volume":"67","author":"Hawley","year":"2009","journal-title":"Nutr Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib471","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1017\/S0033583500005795","article-title":"Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants","volume":"29","author":"Skulachev","year":"1996","journal-title":"Q Rev Biophys"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib472","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-5793(97)01159-9","article-title":"High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria","volume":"416","author":"Korshunov","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib473","first-page":"1191","article-title":"Aging is a specific biological function rather than the result of a disorder in complex living systems: biochemical evidence in support of Weismann\u2019s hypothesis","volume":"62","author":"Skulachev","year":"1997","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib474","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0306-4522(02)00763-7","article-title":"Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons","volume":"118","author":"Bickler","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib475","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1152\/jn.1989.62.4.882","article-title":"Anoxia produces smaller changes in synaptic transmission, membrane potential, and input resistance in immature rat hippocampus","volume":"62","author":"Cherubini","year":"1989","journal-title":"J Neurophysiol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib476","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cell.2014.02.055","article-title":"The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans","volume":"157","author":"Yee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib477","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1134\/S0006297914100010","article-title":"New data on programmed aging\u2014slow phenoptosis","volume":"79","author":"Skulachev","year":"2014","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib478","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1134\/S000629791612004X","article-title":"Study of age-dependent structural and functional changes of mitochondria in skeletal muscles and heart of naked mole rats (Heterocephalus glaber)","volume":"81","author":"Holtze","year":"2016","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib479","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/0003-9861(80)90546-9","article-title":"Postnatal development of rat liver mitochondria: state 3 respiration, adenine nucleotide translocase activity, and the net accumulation of adenine nucleotides","volume":"201","author":"Aprille","year":"1980","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib480","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3945\/an.112.002998","article-title":"Fructose: it\u2019s \u201calcohol without the buzz\u201d","volume":"4","author":"Lustig","year":"2013","journal-title":"Adv Nutr (Bethesda, Md)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib481","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1242\/jeb.085381","article-title":"No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates","volume":"217","author":"Larson","year":"2014","journal-title":"J Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib482","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1097\/WNR.0b013e32833370cf","article-title":"Extreme hypoxia tolerance of naked mole-rat brain","volume":"20","author":"Larson","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib483","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainresbull.2013.07.008","article-title":"Metabolic regulatory clues from the naked mole rat: toward brain regulatory functions during stroke","volume":"98","author":"Nathaniel","year":"2013","journal-title":"Brain Res Bull"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib484","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/jnc.13149","article-title":"Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat","volume":"134","author":"Triplett","year":"2015","journal-title":"J Neurochem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib485","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.celrep.2015.07.008","article-title":"Metabolic damage and premature thymus aging caused by stromal catalase deficiency","volume":"12","author":"Griffith","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib486","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nm.3212","article-title":"Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I","volume":"19","author":"Chouchani","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib487","doi-asserted-by":"crossref","first-page":"8837893","DOI":"10.1155\/2020\/8837893","article-title":"Mitochondria-targeted antioxidants: a step towards disease treatment","volume":"2020","author":"Jiang","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib488","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.2174\/1389203720666190830163735","article-title":"A mitochondrial approach to cardiovascular risk and disease","volume":"25","author":"Veloso","year":"2019","journal-title":"Curr Pharm Des"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib489","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2174\/1874467212666181127151059","article-title":"Mitochondria-targeted drugs","volume":"12","author":"Zinovkin","year":"2019","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib490","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biocel.2018.02.007","article-title":"Mitochondria: targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants","volume":"97","author":"Teixeira","year":"2018","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib491","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nrd.2018.174","article-title":"Mitochondria as a therapeutic target for common pathologies","volume":"17","author":"Murphy","year":"2018","journal-title":"Nat Rev Drug Dis"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib492","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd2796","article-title":"The influence of lead discovery strategies on the properties of drug candidates","volume":"8","author":"Keser\u00fc","year":"2009","journal-title":"Nat Rev Drug Dis"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib493","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nrd1523","article-title":"The role of the medicinal chemist in drug discovery\u2013then and now","volume":"3","author":"Lombardino","year":"2004","journal-title":"Nat Rev Drug Dis"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib494","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-3-319-08927-0_21","article-title":"The impact of physicochemical and molecular properties in drug design: navigation in the \u201cdrug-like\u201d chemical space","volume":"822","author":"Vallianatou","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib495","doi-asserted-by":"crossref","first-page":"9128","DOI":"10.1002\/anie.201404761","article-title":"Advancing the drug discovery and development process","volume":"53","author":"Nicolaou","year":"2014","journal-title":"Angew Chem (Int ed Engl)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib496","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.drudis.2019.06.014","article-title":"Drug repurposing: a promising tool to accelerate the drug discovery process","volume":"24","author":"Parvathaneni","year":"2019","journal-title":"Drug Dis Today"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib497","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrd3499","article-title":"Bio-inspired, bioengineered and biomimetic drug delivery carriers","volume":"10","author":"Yoo","year":"2011","journal-title":"Nat Rev Drug Dis"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib498","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1074\/jbc.M009093200","article-title":"Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties","volume":"276","author":"Kelso","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib499","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10522-020-09883-x","article-title":"Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function","volume":"21","author":"Thoma","year":"2020","journal-title":"Biogerontology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib500","first-page":"31372","article-title":"Mitochondrial oxidative damage in aging and Alzheimer\u2019s disease: implications for mitochondrially targeted antioxidant therapeutics","volume":"2006","author":"Reddy","year":"2006","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib501","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.bbadis.2013.09.005","article-title":"MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis","volume":"1832","author":"Mao","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib502","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.pharmtox.47.120505.105110","article-title":"Targeting antioxidants to mitochondria by conjugation to lipophilic cations","volume":"47","author":"Murphy","year":"2007","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib503","first-page":"399","article-title":"MitoQ\u2013a mitochondria-targeted antioxidant","volume":"10","author":"Tauskela","year":"2007","journal-title":"IDrugs: Investig Drugs J"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib504","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.tips.2012.03.010","article-title":"Mitochondrial pharmacology","volume":"33","author":"Smith","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib505","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib506","doi-asserted-by":"crossref","first-page":"21295","DOI":"10.1074\/jbc.M501527200","article-title":"Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools","volume":"280","author":"James","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib507","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10522-018-9756-6","article-title":"Mitigating peroxynitrite mediated mitochondrial dysfunction in aged rat brain by mitochondria-targeted antioxidant MitoQ","volume":"19","author":"Maiti","year":"2018","journal-title":"Biogerontology"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib508","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.freeradbiomed.2016.07.005","article-title":"Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ","volume":"97","author":"Stucki","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib509","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2014.02.019","article-title":"Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis","volume":"70","author":"Miquel","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib510","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.freeradbiomed.2010.08.028","article-title":"Neuroprotection by a mitochondria-targeted drug in a Parkinson\u2019s disease model","volume":"49","author":"Ghosh","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib511","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1152\/japplphysiol.00670.2017","article-title":"Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice","volume":"124","author":"Gioscia-Ryan","year":"2018","journal-title":"J Appl Physiol (Bethesda, Md: 1985)"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib512","doi-asserted-by":"crossref","first-page":"15703","DOI":"10.1523\/JNEUROSCI.0552-11.2011","article-title":"The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer\u2019s disease","volume":"31","author":"McManus","year":"2011","journal-title":"J Neurosci: Off J Soc Neurosci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib513","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.freeradbiomed.2014.03.003","article-title":"The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease","volume":"71","author":"Ng","year":"2014","journal-title":"Free Radic Biol Med"},{"issue":"Suppl 2","key":"10.1016\/B978-0-12-823761-8.00024-0_bib514","doi-asserted-by":"crossref","first-page":"S609","DOI":"10.3233\/JAD-2010-100564","article-title":"Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer\u2019s disease neurons","volume":"20","author":"Manczak","year":"2010","journal-title":"J Alzheimer\u2019s Dis: JAD"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib515","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/hmg\/ddw045","article-title":"Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington\u2019s disease","volume":"25","author":"Yin","year":"2016","journal-title":"Hum Mol Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib516","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.freeradbiomed.2019.11.021","article-title":"The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington\u2019s disease mice","volume":"146","author":"Pinho","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib517","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1038\/s41418-018-0165-9","article-title":"Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy","volume":"25","author":"Kim","year":"2018","journal-title":"Cell Death Differ"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib518","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12017-008-8044-z","article-title":"Mitochondrial medicine for aging and neurodegenerative diseases","volume":"10","author":"Reddy","year":"2008","journal-title":"Neuromol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib519","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/jcsm.12223","article-title":"Redox homeostasis and age-related deficits in neuromuscular integrity and function","volume":"8","author":"Sakellariou","year":"2017","journal-title":"J Cachexia, Sarcopenia Muscle"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib520","doi-asserted-by":"crossref","first-page":"8575263","DOI":"10.1155\/2018\/8575263","article-title":"The effect of MitoQ on aging-related biomarkers: a systematic review and meta-analysis","volume":"2018","author":"Braakhuis","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib521","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1134\/S0006297908120018","article-title":"Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: synthesis and in vitro studies","volume":"73","author":"Antonenko","year":"2008","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib522","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbabio.2008.12.008","article-title":"An attempt to prevent senescence: a mitochondrial approach","volume":"1787","author":"Skulachev","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib523","doi-asserted-by":"crossref","first-page":"800","DOI":"10.2174\/138945011795528859","article-title":"Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies","volume":"12","author":"Skulachev","year":"2011","journal-title":"Curr Drug Targets"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib524","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1134\/S0006297908120055","article-title":"Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence","volume":"73","author":"Anisimov","year":"2008","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib525","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/sj.ki.5002568","article-title":"The role of mitochondria in oxidative and nitrosative stress during ischemia\/reperfusion in the rat kidney","volume":"72","author":"Plotnikov","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib526","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1134\/S000629790812002X","article-title":"Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke)","volume":"73","author":"Bakeeva","year":"2008","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib527","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbadis.2010.09.008","article-title":"Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia\/reperfusion","volume":"1812","author":"Plotnikov","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib528","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1134\/S0006297912070073","article-title":"The phenoptosis problem: what is causing the death of an organism? Lessons from acute kidney injury","volume":"77","author":"Zorov","year":"2012","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib529","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1134\/S0006297912090106","article-title":"Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family","volume":"77","author":"Plotnikov","year":"2012","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib530","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1134\/S0006297912060144","article-title":"Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss","volume":"77","author":"Jankauskas","year":"2012","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib531","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1134\/S0006297910020045","article-title":"New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties","volume":"75","author":"Plotnikov","year":"2010","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib532","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1134\/S0006297911120108","article-title":"In vivo injected mitochondria-targeted plastoquinone antioxidant SkQR1 prevents \u03b2-amyloid-induced decay of long-term potentiation in rat hippocampal slices","volume":"76","author":"Kapay","year":"2011","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib533","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1073\/pnas.0910216107","article-title":"Penetrating cation\/fatty acid anion pair as a mitochondria-targeted protonophore","volume":"107","author":"Severin","year":"2010","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib534","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1038\/sj.onc.1205513","article-title":"A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis","volume":"21","author":"Trinei","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib535","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1073\/pnas.0336359100","article-title":"Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet","volume":"100","author":"Napoli","year":"2003","journal-title":"Proc Natl Acad Sci U S Am"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib536","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/s10541-005-0213-1","article-title":"Uncoupler of oxidative phosphorylation prolongs the lifespan of Drosophila","volume":"70","author":"Padalko","year":"2005","journal-title":"Biochem Biokhimiia"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib537","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3233\/JAD-122428","article-title":"Mitochondria-targeted plastoquinone antioxidant SkQ1 prevents amyloid-\u03b2-induced impairment of long-term potentiation in rat hippocampal slices","volume":"36","author":"Kapay","year":"2013","journal-title":"J Alzheimer\u2019s Dis: JAD"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib538","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3233\/JAD-2011-111391","article-title":"Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases","volume":"28","author":"Skulachev","year":"2012","journal-title":"J Alzheimer\u2019s Dis: JAD"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib539","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nm.1868","article-title":"Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer\u2019s disease","volume":"14","author":"Du","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib540","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1038\/s41598-017-07272-y","article-title":"Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria","volume":"7","author":"Teixeira","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib541","doi-asserted-by":"crossref","first-page":"7084","DOI":"10.1021\/acs.jmedchem.7b00741","article-title":"Development of a mitochondriotropic antioxidant based on caffeic acid: proof of concept on cellular and mitochondrial oxidative stress models","volume":"60","author":"Teixeira","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib542","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3109\/10715762.2012.662593","article-title":"Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold","volume":"46","author":"Teixeira","year":"2012","journal-title":"Free Radic Res"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib543","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.freeradbiomed.2020.12.023","article-title":"Mitochondria-targeted phenolic antioxidants induce ROS-protective pathways in primary human skin fibroblasts","volume":"163","author":"Teixeira","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib544","doi-asserted-by":"crossref","first-page":"5828120","DOI":"10.1155\/2018\/5828120","article-title":"Mito-TEMPO alleviates renal fibrosis by reducing inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress","volume":"2018","author":"Liu","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib545","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1096\/fj.13-237008","article-title":"Comparing the effects of mitochondrial targeted and localized antioxidants with cellular antioxidants in human skin cells exposed to UVA and hydrogen peroxide","volume":"28","author":"Oyewole","year":"2014","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib546","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.redox.2015.08.007","article-title":"SS-31 attenuates TNF-\u03b1 induced cytokine release from C2C12 myotubes","volume":"6","author":"Lightfoot","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib547","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/clpt.2014.174","article-title":"Serendipity and the discovery of novel compounds that restore mitochondrial plasticity","volume":"96","author":"Szeto","year":"2014","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib548","doi-asserted-by":"crossref","first-page":"34682","DOI":"10.1074\/jbc.M402999200","article-title":"Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury","volume":"279","author":"Zhao","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib549","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.bbabio.2015.06.006","article-title":"Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia","volume":"1847","author":"Birk","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib550","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mcn.2019.03.001","article-title":"Small molecules as therapeutic drugs for Alzheimer\u2019s disease","volume":"96","author":"Oliver","year":"2019","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib551","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/bph.12461","article-title":"First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics","volume":"171","author":"Szeto","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib552","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1093\/hmg\/ddr381","article-title":"Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer\u2019s disease","volume":"20","author":"Calkins","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib553","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3233\/JAD-170988","article-title":"Synergistic protective effects of mitochondrial division inhibitor 1 and mitochondria-targeted small peptide SS31 in Alzheimer\u2019s disease","volume":"62","author":"Reddy","year":"2018","journal-title":"J Alzheimer\u2019s Dis: JAD"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib554","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1093\/hmg\/ddr139","article-title":"Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer\u2019s disease: implications for neuronal damage","volume":"20","author":"Manczak","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib555","doi-asserted-by":"crossref","first-page":"33944","DOI":"10.1038\/srep33944","article-title":"Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy","volume":"6","author":"Sakellariou","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib556","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1096\/fj.201600450R","article-title":"Long-term administration of the mitochondria-targeted antioxidant mitoquinone mesylate fails to attenuate age-related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle","volume":"30","author":"Sakellariou","year":"2016","journal-title":"FASEB J: Off Publ Feder Am Soc Exp Biol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib557","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.freeradbiomed.2018.12.031","article-title":"Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice","volume":"134","author":"Campbell","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib558","doi-asserted-by":"crossref","first-page":"R227","DOI":"10.1152\/ajpregu.00299.2019","article-title":"Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle","volume":"318","author":"Montalvo","year":"2020","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib559","doi-asserted-by":"crossref","first-page":"15862","DOI":"10.1038\/s41598-018-34251-8","article-title":"The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes","volume":"8","author":"Escribano-Lopez","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib560","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1681\/ASN.2012121216","article-title":"The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin","volume":"24","author":"Birk","year":"2013","journal-title":"J Am Soc Nephrol: JASN"},{"key":"10.1016\/B978-0-12-823761-8.00024-0_bib561","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1248\/bpb.23.897","article-title":"Role of reactive oxygen species in the regulation of physiological functions","volume":"23","author":"Nose","year":"2000","journal-title":"Biol Pharm Bull"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128237618000240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128237618000240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T23:25:55Z","timestamp":1757028355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780128237618000240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9780128237618"],"references-count":561,"URL":"https:\/\/doi.org\/10.1016\/b978-0-12-823761-8.00024-0","relation":{},"subject":[],"published":{"date-parts":[[2023]]}}}