{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T14:04:21Z","timestamp":1773065061038,"version":"3.50.1"},"reference-count":84,"publisher":"Elsevier","isbn-type":[{"value":"9780128244647","type":"print"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/b978-0-12-824464-7.00016-7","type":"book-chapter","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T17:39:12Z","timestamp":1686591552000},"page":"55-62","source":"Crossref","is-referenced-by-count":1,"title":["Endocrine-disrupting chemicals and their mode of action: The case of nuclear receptors and the evolution of the Metazoa"],"prefix":"10.1016","author":[{"given":"Elza","family":"Fonseca","sequence":"first","affiliation":[]},{"given":"Raquel","family":"Ruivo","sequence":"additional","affiliation":[]},{"given":"Miguel M.","family":"Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-386X","authenticated-orcid":false,"given":"L. Filipe C.","family":"Castro","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0010","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1021\/es048504a","article-title":"Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment","volume":"39","author":"Sumpter","year":"2005","journal-title":"Environ Sci Technol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0015","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jhazmat.2016.04.058","article-title":"Lessons learned from more than two decades of research on emerging contaminants in the environment","volume":"316","author":"Noguera-Oviedo","year":"2016","journal-title":"J Hazard Mater"},{"issue":"6","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0020","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1210\/en.2005-1129","article-title":"Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling","volume":"147","author":"Gr\u00fcn","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0025","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an endocrine society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr Rev"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0030","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1289\/ehp.1205448","article-title":"Perspectives | editorial the impact of endocrine disruption: a consensus statement on the state of the science","volume":"121","author":"Bergman","year":"2013","journal-title":"Environ Health Perspect"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0035","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.etap.2015.06.009","article-title":"A review on endocrine disruptors and their possible impacts on human health","volume":"40","author":"Kabir","year":"2015","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0040","series-title":"Endocrine disruption and human health. Overview of EDCs and human health which sets the bigger picture","author":"Darbre","year":"2015"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2016.02.001","article-title":"Statins: an undesirable class of aquatic contaminants?","volume":"174","author":"Santos","year":"2016","journal-title":"Aquat Toxicol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.envint.2017.06.003","article-title":"Obesogens in the aquatic environment: an evolutionary and toxicological perspective","volume":"106","author":"Capit\u00e3o","year":"2017","journal-title":"Environ Int"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.coesh.2019.06.005","article-title":"Are marine invertebrates really at risk from endocrine-disrupting chemicals?","volume":"11","author":"Katsiadaki","year":"2019","journal-title":"Curr Opin Environ Sci Health"},{"issue":"10","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0060","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.3390\/ijms21103480","article-title":"The GOLIATH project: towards an internationally harmonised approach for testing metabolism disrupting compounds","volume":"21","author":"Legler","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0065","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/10408449891344236","article-title":"Endocrine disruption in wildlife: a critical review of the evidence","volume":"28","author":"Tyler","year":"1998","journal-title":"Crit Rev Toxicol"},{"issue":"11","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0070","first-page":"112","article-title":"Climate change and pollution speed declines in zebrafish populations","author":"Brown","year":"2015","journal-title":"Proc Natl Acad Sci"},{"issue":"1\u20132","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mce.2009.02.018","article-title":"Endocrine disrupters as obesogens","volume":"304","author":"Gr\u00fcn","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0080","series-title":"The Praeger handbook of environmental health","first-page":"475","author":"Baker","year":"2012"},{"issue":"8","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0085","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/10408444.2012.692114","article-title":"Endocrine disrupting chemicals and sexual behaviors in fish\u2014a critical review on effects and possible consequences","volume":"42","author":"S\u00f6ffker","year":"2012","journal-title":"Crit Rev Toxicol"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0090","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/toxics10010006","article-title":"From extrapolation to precision chemical hazard assessment: the ecdysone receptor case study","volume":"10","author":"Ruivo","year":"2021","journal-title":"Toxics"},{"issue":"10","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0095","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/molbev\/msh200","article-title":"Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems","volume":"21","author":"Bertrand","year":"2004","journal-title":"Mol Biol Evol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ctdb.2017.02.003","article-title":"Evolution of nuclear receptors and ligand signaling: toward a soft key-lock model?","volume":"125","author":"Holzer","year":"2017","journal-title":"Curr Top Dev Biol"},{"issue":"10","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0105","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1021\/es501697b","article-title":"To bind or not to bind: the taxonomic scope of nuclear receptor mediated endocrine disruption in invertebrate phyla","volume":"48","author":"Castro","year":"2014","journal-title":"Environ Sci Technol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0110","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jsbmb.2015.12.009","article-title":"Evolution of estrogen receptors in ray-finned fish and their comparative responses to estrogenic substances","volume":"158","author":"Tohyama","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"10","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0115","doi-asserted-by":"crossref","first-page":"e1000497","DOI":"10.1371\/journal.pbio.1000497","article-title":"Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor","volume":"8","author":"Bridgham","year":"2010","journal-title":"PLoS Biol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0120","doi-asserted-by":"crossref","first-page":"113527","DOI":"10.1016\/j.ygcen.2020.113527","article-title":"Cartilaginous fishes offer unique insights into the evolution of the nuclear receptor gene repertoire in gnathostomes","volume":"295","author":"Fonseca","year":"2020","journal-title":"Gen Comp Endocrinol"},{"issue":"3","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0125","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/j.1460-2075.1992.tb05139.x","article-title":"Evolution of the nuclear receptor gene superfamily","volume":"11","author":"Laudet","year":"1992","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0130","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/s41467-018-04136-5","article-title":"Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty","volume":"9","author":"Paps","year":"2018","journal-title":"Nat Commun"},{"issue":"7180","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0135","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nature06617","article-title":"The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans","volume":"451","author":"King","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0140","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s000180050043","article-title":"Origins and evolutionary diversification of the nuclear receptor superfamily","volume":"57","author":"Owen","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/bse0400011","article-title":"The evolution of the nuclear receptor superfamily","volume":"40","author":"Escriva","year":"2004","journal-title":"Essays Biochem"},{"issue":"5640","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0150","first-page":"1714","article-title":"Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling","volume":"301","author":"Thornton","year":"2003","journal-title":"Science (1979)"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0155","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1186\/1471-2164-15-369","article-title":"The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group","volume":"15","author":"Vogeler","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0160","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aquatox.2016.02.007","article-title":"A mollusk VDR\/PXR\/CAR-like (NR1J) nuclear receptor provides insight into ancient detoxification mechanisms","volume":"174","author":"Cruzeiro","year":"2016","journal-title":"Aquat Toxicol"},{"issue":"10","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0165","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1073\/pnas.091553298","article-title":"Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions","volume":"98","author":"Thornton","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0170","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1210\/en.2008-1338","article-title":"Hormone-activated estrogen receptors in annelid invertebrates: implications for evolution and endocrine disruption","volume":"150","author":"Keay","year":"2009","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0175","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12862-017-0909-z","article-title":"Conservation of estrogen receptor function in invertebrate reproduction","volume":"17","author":"Jones","year":"2017","journal-title":"BMC Evol Biol"},{"issue":"38","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0180","doi-asserted-by":"crossref","first-page":"42","DOI":"10.7748\/ns.28.38.42.e7471","article-title":"Endocrine system: part 1","volume":"28","author":"Johnstone","year":"2014","journal-title":"Nurs Stand"},{"issue":"3","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0185","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1677\/joe.1.06964","article-title":"The neuroendocrine system of invertebrates: a developmental and evolutionary perspective","volume":"190","author":"Hartenstein","year":"2006","journal-title":"J Endocrinol"},{"issue":"5","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0190","first-page":"377","article-title":"Sexuality in the American mud snail, Nassarius obsoletus Say","volume":"39","author":"Smith","year":"1971","journal-title":"Proc Malacol Soc Lond"},{"issue":"3","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0195","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1017\/S0025315400042247","article-title":"The decline of the gastropod Nucella lapillus around South-West England: evidence for the effect of tributyltin from antifouling paints","volume":"66","author":"Bryan","year":"1986","journal-title":"J Mar Biol Assoc U K"},{"issue":"7","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0200","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0025-326X(00)00017-5","article-title":"Imposex in the dogwelk Nucella lapillus (L.) along the Portuguese coast","volume":"40","author":"Santos","year":"2000","journal-title":"Mar Pollut Bull"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0205","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0025315408002282","article-title":"Effects of TBT on the imposex development, reproduction and mortality in Hexaplex trunculus (Gastropoda: Muricidae)","volume":"89","author":"Abidli","year":"2009","journal-title":"J Mar Biol Assoc U K"},{"issue":"6","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0210","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1111\/mec.12137","article-title":"Transcriptomics and in vivo tests reveal novel mechanisms underlying endocrine disruption in an ecological sentinel, Nucella lapillus","volume":"22","author":"Pascoal","year":"2013","journal-title":"Mol Ecol"},{"issue":"3","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0215","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02367105","article-title":"TBT-induced imposex in marine neogastropods is mediated by an increasing androgen level","volume":"50","author":"Bettin","year":"1996","journal-title":"Helgol\u00e4nder Meeresun"},{"issue":"9","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0220","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1210\/me.2005-0367","article-title":"Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates","volume":"20","author":"Gr\u00fcn","year":"2006","journal-title":"Mol Endocrinol"},{"issue":"11","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0225","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1641\/B581109","article-title":"Commonality in signaling of endocrine disruption from snail to human","volume":"58","author":"Iguchi","year":"2008","journal-title":"Bioscience"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0230","series-title":"Biochemical and biological effects of organotins","first-page":"83","article-title":"Lipid homeostasis perturbation by organotins: biochemical and biological effects of organotins","author":"Santos","year":"2012"},{"issue":"12","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0235","doi-asserted-by":"crossref","first-page":"e0143911","DOI":"10.1371\/journal.pone.0143911","article-title":"The mammalian \u201cobesogen\u201d tributyltin targets hepatic triglyceride accumulation and the transcriptional regulation of lipid metabolism in the liver and brain of zebrafish","volume":"10","author":"Lyssimachou","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0240","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1289\/ehp.1409163","article-title":"Obesogens beyond vertebrates: lipid perturbation by tributyltin in the crustacean Daphnia magna","volume":"123","author":"Jord\u00e3o","year":"2015","journal-title":"Environ Health Perspect"},{"issue":"4","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0245","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.aquatox.2009.07.021","article-title":"Disruption of zebrafish (Danio rerio) embryonic development after full life-cycle parental exposure to low levels of ethinylestradiol","volume":"95","author":"Soares","year":"2009","journal-title":"Aquat Toxicol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0250","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.aquatox.2015.10.009","article-title":"From single chemicals to mixtures-reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow","volume":"169","author":"Runnalls","year":"2015","journal-title":"Aquat Toxicol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0255","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.aquatox.2015.01.013","article-title":"Chronic effects of clofibric acid in zebrafish (Danio rerio): a multigenerational study","volume":"160","author":"Coimbra","year":"2015","journal-title":"Aquat Toxicol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0260","series-title":"Monitoring water quality: Pollution assessment, analysis, and remediation","first-page":"103","article-title":"Thinking outside the box: assessing endocrine disruption in aquatic life","author":"Brander","year":"2013"},{"issue":"2","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0265","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jhazmat.2013.10.043","article-title":"Estrogenic chemical effects are independent from the degree of sex role reversal in pipefish","volume":"263","author":"S\u00e1rria","year":"2013","journal-title":"J Hazard Mater"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0270","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.aquatox.2018.05.014","article-title":"Chronic environmentally relevant levels of simvastatin disrupt embryonic development, biochemical and molecular responses in zebrafish (Danio rerio)","volume":"201","author":"Barros","year":"2018","journal-title":"Aquat Toxicol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0275","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1210\/me.2016-1096","article-title":"Minireview: endocrine disruptors: past lessons and future directions","volume":"30","author":"Schug","year":"2016","journal-title":"Mol Endocrinol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0280","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.envint.2015.05.012","article-title":"Estrogenic endocrine disruptors: molecular mechanisms of action","volume":"83","author":"Kiyama","year":"2015","journal-title":"Environ Int"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0285","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fendo.2019.00178","article-title":"Endocrine disrupting chemicals: effects on endocrine glands","volume":"10","author":"Lauretta","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0290","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00018-009-0249-2","article-title":"A structural view of nuclear hormone receptor: endocrine disruptor interactions","volume":"67","author":"le Maire","year":"2010","journal-title":"Cell Mol Life Sci"},{"issue":"23","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0295","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1021\/es049593u","article-title":"Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods","volume":"38","author":"Nishikawa","year":"2004","journal-title":"Environ Sci Technol"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0300","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.aquatox.2007.07.016","article-title":"Imposex induction is mediated through the retinoid X receptor signalling pathway in the neogastropod Nucella lapillus","volume":"85","author":"Castro","year":"2007","journal-title":"Aquat Toxicol"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0305","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.aquatox.2010.09.022","article-title":"Tributyltin-induced imposex in marine gastropods involves tissue-specific modulation of the retinoid X receptor","volume":"101","author":"Lima","year":"2011","journal-title":"Aquat Toxicol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0310","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.aquatox.2011.10.010","article-title":"Imposex development in Nucella lapillus\u2014evidence for the involvement of retinoid X receptor and androgen signalling pathways in vivo","volume":"106\u2013107","author":"Stange","year":"2012","journal-title":"Aquat Toxicol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0315","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.chemosphere.2017.05.064","article-title":"Cloning and functional characterization of a retinoid X receptor orthologue in Platynereis dumerilii: Na evolutionary and toxicological perspective","volume":"182","author":"Andr\u00e9","year":"2017","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0320","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/toxsci\/kfr132","article-title":"Characterization of novel ligands of ER\u03b1, Er \u03b2, and PPAR\u03b3: the case of halogenated bisphenol A and their conjugated metabolites","volume":"122","author":"Riu","year":"2011","journal-title":"Toxicol Sci"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0325","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.taap.2016.01.014","article-title":"Pharmacological evaluation of the mechanisms involved in increased adiposity in zebrafish triggered by the environmental contaminant tributyltin","volume":"294","author":"Ouadah-Boussouf","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"issue":"23","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0330","doi-asserted-by":"crossref","first-page":"13951","DOI":"10.1021\/acs.est.8b04399","article-title":"Evolutionary exploitation of vertebrate peroxisome proliferator-activated receptor \u03b3 by organotins","volume":"52","author":"Capit\u00e3o","year":"2018","journal-title":"Environ Sci Technol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0335","doi-asserted-by":"crossref","first-page":"109406","DOI":"10.1016\/j.ecoenv.2019.109406","article-title":"Linking chemical exposure to lipid homeostasis: a municipal waste water treatment plant influent is obesogenic for zebrafish larvae","volume":"182","author":"Barbosa","year":"2019","journal-title":"Ecotoxicol Environ Saf"},{"issue":"11","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0340","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1002\/pro.3496","article-title":"The nuclear receptor superfamily: a structural perspective","volume":"27","author":"Weikum","year":"2018","journal-title":"Protein Sci"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0345","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/msb.2010.102","article-title":"Design principles of nuclear receptor signaling: how complex networking improves signal transduction","volume":"6","author":"Kolodkin","year":"2010","journal-title":"Mol Syst Biol"},{"issue":"4","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0350","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2006.06.049","article-title":"Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network","volume":"126","author":"Bookout","year":"2006","journal-title":"Cell"},{"issue":"4","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0355","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3390\/biom10040594","article-title":"Of retinoids and organotins: the evolution of the retinoid X receptor in Metazoa","volume":"10","author":"Fonseca","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0360","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/1471-2148-8-219","article-title":"An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolution","volume":"8","author":"Paris","year":"2008","journal-title":"BMC Evol Biol"},{"issue":"3\u20135","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0365","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jsbmb.2011.03.022","article-title":"Evolutionary origins of the estrogen signaling system: insights from amphioxus","volume":"127","author":"Callard","year":"2011","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0370","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.taap.2004.06.004","article-title":"Activation of retinoic acid receptor-dependent transcription by organochlorine pesticides","volume":"202","author":"Lemaire","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"issue":"11","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0375","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/dvg.20444","article-title":"Retinoic acid signaling in development: tissue-specific functions and evolutionary origins","volume":"46","author":"Campo-Paysaa","year":"2008","journal-title":"Genesis"},{"issue":"11","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0380","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1210\/en.2014-1181","article-title":"A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding","volume":"155","author":"Gutierrez-Mazariegos","year":"2014","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0385","doi-asserted-by":"crossref","first-page":"eaao1261","DOI":"10.1126\/sciadv.aao1261","article-title":"The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation","volume":"4","author":"Handberg-Thorsager","year":"2018","journal-title":"Sci Adv"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0390","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.aquatox.2019.01.002","article-title":"The retinoic acid receptor (RAR) in molluscs: function, evolution and endocrine disruption insights","volume":"208","author":"Andr\u00e9","year":"2019","journal-title":"Aquat Toxicol"},{"issue":"12","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0395","doi-asserted-by":"crossref","first-page":"E985","DOI":"10.3390\/genes10120985","article-title":"An orthologue of the retinoic acid receptor (RAR) is present in the Ecdysozoa phylum Priapulida","volume":"10","author":"Fonseca","year":"2019","journal-title":"Genes (Basel)"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0400","doi-asserted-by":"crossref","first-page":"10404","DOI":"10.1038\/s41598-018-28498-4","article-title":"Independent losses of a xenobiotics receptor across teleost evolution","volume":"8","author":"Eide","year":"2018","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0405","doi-asserted-by":"crossref","first-page":"E2331","DOI":"10.3390\/ijms20092331","article-title":"Evolutionary plasticity in detoxification gene modules: the preservation and loss of the pregnane X receptor in Chondrichthyes lineages","volume":"10","author":"Fonseca","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/B978-0-12-824464-7.00016-7_bb0410","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ydbio.2006.08.066","article-title":"The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome","volume":"300","author":"Goldstone","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0415","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.aquatox.2013.09.014","article-title":"Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio)","volume":"142\u2013143","author":"Bainy","year":"2013","journal-title":"Aquat Toxicol"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0420","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1289\/ehp.10853","article-title":"Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species","volume":"116","author":"Milnes","year":"2008","journal-title":"Environ Health Perspect"},{"key":"10.1016\/B978-0-12-824464-7.00016-7_bb0425","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jhazmat.2018.04.076","article-title":"Identifying the gaps: resources and perspectives on the use of nuclear receptor based-assays to improve hazard assessment of emerging contaminants","volume":"358","author":"Santos","year":"2018","journal-title":"J Hazard Mater"}],"container-title":["Environmental Contaminants and Endocrine Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128244647000167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780128244647000167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T05:34:05Z","timestamp":1758692045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780128244647000167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9780128244647"],"references-count":84,"URL":"https:\/\/doi.org\/10.1016\/b978-0-12-824464-7.00016-7","relation":{},"subject":[],"published":{"date-parts":[[2023]]}}}