{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:26:17Z","timestamp":1757618777275,"version":"3.44.0"},"reference-count":216,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780323911672"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/b978-0-323-91167-2.00005-8","type":"book-chapter","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T08:31:58Z","timestamp":1660897918000},"page":"455-495","source":"Crossref","is-referenced-by-count":1,"title":["Unit operations for extraction and purification of biological products"],"prefix":"10.1016","author":[{"given":"Filipa","family":"Castro","sequence":"first","affiliation":[]},{"given":"Nuno Ribeiro","family":"da Silva","sequence":"additional","affiliation":[]},{"given":"Sara Cruz","family":"Silv\u00e9rio","sequence":"additional","affiliation":[]},{"given":"Lina Fernanda","family":"Ballesteros","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Ant\u00f3nio","family":"Teixeira","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib1","series-title":"Encyclopedia of analytical chemistry","article-title":"Planar chromatography in pharmaceutical analysis","author":"Argekar","year":"2006"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib2","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.xphs.2018.11.039","article-title":"The importance of understanding the freezing step and its impact on freeze-drying process performance","volume":"108","author":"Assegehegn","year":"2019","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.afnr.2020.04.001","article-title":"Freeze-drying: A relevant unit operation in the manufacture of foods, nutritional products, and pharmaceuticals","volume":"93","author":"Assegehegn","year":"2020","journal-title":"Advances in Food and Nutrition Research"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.foodchem.2017.05.142","article-title":"Encapsulation of antioxidant phenolic compounds extracted from spent coffee grounds by freeze-drying and spray-drying using different coating materials","volume":"237","author":"Ballesteros","year":"2017","journal-title":"Food Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib5","first-page":"547","article-title":"History of gas chromatography","volume":"21","author":"Bartle","year":"2002"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib6","first-page":"1","article-title":"Chapter 1: Chromatography: Principles and applications","volume":"18","author":"B\u00e9langer","year":"1997"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib7","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/ceat.200800068","article-title":"Extraction and purification of bioproducts and nanoparticles using aqueous two-phase systems strategies","volume":"31","author":"Benavides","year":"2008","journal-title":"Chemical Engineering & Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jctb.1844","article-title":"Practical experiences from the development of aqueous two-phase processes for the recovery of high value biological products","volume":"83","author":"Benavides","year":"2008","journal-title":"Journal of Chemical Technology & Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jssc.200900709","article-title":"Size exclusion chromatography\u2014a blessing and a curse of science and technology of synthetic polymers","volume":"33","author":"Berek","year":"2010","journal-title":"Journal of Separation Science"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib10","series-title":"Drying technologies in food processing","article-title":"Spray drying of food materials\u2014Process and product characteristics","author":"Bhandari","year":"2008"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib11","unstructured":"Biopharma Group. (2021). Freeze drying vs spray drying: Is it essentially quality vs cost? https:\/\/biopharma.co.uk\/blog\/2017\/03\/15\/freeze-drying-vs-spray-drying-is-it-essentially-quality-vs-cost\/."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3109\/13880209.2012.703678","article-title":"Using a single hydrophobic-interaction chromatography to purify pharmaceutical-grade supercoiled plasmid DNA from other isoforms","volume":"51","author":"Bo","year":"2013","journal-title":"Pharmaceutical Biology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib13","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/chromsci\/bmu169","article-title":"Recovery of proteins affected by mobile phase trifluoroacetic acid concentration in reversed-phase chromatography","volume":"53","author":"Bob\u00e1ly","year":"2015","journal-title":"Journal of Chromatographic Science"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib14","unstructured":"Borowicz, P., Slawinski, W., Plucienniczak, A., Mikolajczyk, J., Glabski, T., Kurzynoga, D., Mikiewicz-Sygula, D., Wojtowicz-Krawiec, A., Zielinski, M., M. Kesik-Brodacka, Cecuda-Adamczewska, V., Iwona, S., Plucienniczak, G., Stadnik, D., Jaroslaw, A., Pstrzoch, J., Bernat, J., Pawlukowiec, T., Stepniewski, J., & Bogiel, M. (2008). Insulin derivatives or its pharmaceutically acceptable salt, pharmaceutical composition, use of insulin derivative or its pharmaceutically acceptable salt and method of treatment (Patent No. EP2371853B1)."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib15","series-title":"Partitioning in aqueous two-phase system","first-page":"11","article-title":"2 - Theoretical aspects of partitioning","author":"Brooks","year":"1985"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.chroma.2005.03.108","article-title":"Analysis of carbohydrates by anion exchange chromatography and mass spectrometry","volume":"1085","author":"Bruggink","year":"2005","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib17","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.seppur.2011.06.018","article-title":"Extraction of gold(III) from chloride media in aqueous polyethylene glycol-based two-phase system","volume":"80","author":"Bulgariu","year":"2011","journal-title":"Separation and Purification Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0076-6879(09)63020-2","article-title":"Chapter 20: Protein precipitation techniques","volume":"463","author":"Burgess","year":"2009","journal-title":"Methods in Enzymology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jps.21886","article-title":"Spray drying technique. I: Hardware and process parameters","volume":"99","author":"Cal","year":"2010","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev-chembioeng-060718-030312","article-title":"Advances in the use of microfluidics to study crystallization fundamentals","volume":"10","author":"Candoni","year":"2019","journal-title":"Annual Review of Chemical and Biomolecular Engineering"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib21","first-page":"47","article-title":"Specific recognition of supercoiled plasmid DNA by affinity chromatography using a synthetic aromatic ligand","volume":"1286","author":"Caramelo-Nunes","year":"2015"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib22","unstructured":"Carcagno, C. M., Criscuolo, M. E., Melo, C. A., & Vidal, J. A. (2001). Methods of purifying recombinant human erythropoietin from cell culture supernatants (Patent No. US7012130B1)."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib23","first-page":"1725","article-title":"Chapter 12. Sample derivatization in separation science","volume":"5","author":"Cardinael","year":"2015"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib24","doi-asserted-by":"crossref","unstructured":"Castro, F., Ferreira, A., Rocha, F., & Teixeira, J. (2016). Protein crystallization as a process step in a novel meso oscillatory flow reactor: Study of lysozyme phase behavior. In Summer school on crystal nucleation: Fundamentals and applications, Glasgow, UK. Conference poster.","DOI":"10.1021\/acs.cgd.6b00262"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib25","article-title":"Influence of mixing intensity on lysozyme crystallization in a meso oscillatory flow reactor","volume":"8","author":"Castro","year":"2018","journal-title":"Crystal Growth and Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jfoodeng.2012.02.010","article-title":"Effect of freezing rate on quality parameters of freeze dried soursop fruit pulp","volume":"111","author":"Ceballos","year":"2012","journal-title":"Journal of Food Engineering"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib27","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1021\/cg101556s","article-title":"Pharmaceutical crystallization","volume":"11","author":"Chen","year":"2011","journal-title":"Crystal Growth and Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1021\/acs.cgd.0c01312","article-title":"Integrated continuous crystallization and spray drying of insulin for pulmonary drug delivery","volume":"21","author":"Chen","year":"2021","journal-title":"Crystal Growth and Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijpharm.2010.11.021","article-title":"Spray-freeze-drying production of thermally sensitive polymeric nanoparticle aggregates for inhaled drug delivery: Effect of freeze-drying adjuvants","volume":"404","author":"Cheow","year":"2011","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib30","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/ejlt.200700312","article-title":"Separation of squalene from palm fatty acid distillate using adsorption chromatography","volume":"109","author":"Chua","year":"2007","journal-title":"European Journal of Lipid Science and Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib31","first-page":"267","article-title":"Chapter 7: Modern size-exclusion chromatography of carbohydrates and glycoconjugates","volume":"66","author":"Churms","year":"2002"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2478\/v10222-011-0017-5","article-title":"Freeze-drying\u2014Application in food processing and biotechnology\u2014A review","volume":"61","author":"Ciurzy\u0144ska","year":"2011","journal-title":"Polish Journal of Food and Nutrition Science"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib33","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1021\/cr60090a007","article-title":"The properties and functions of the plasma proteins, with a consideration of the methods for their separation and purification","volume":"28","author":"Cohn","year":"2002","journal-title":"Chemical Reviews"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib34","first-page":"66","article-title":"The evolution of freeze-drying","author":"Corver","year":"2009","journal-title":"Innovations in Pharmaceutical Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib35","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1023\/A:1008162209596","article-title":"Scale-up of recombinant cutinase recovery by whole broth extraction with PEG-phosphate aqueous two-phase","volume":"9","author":"Costa","year":"2000","journal-title":"Bioseparation"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib36","first-page":"209","article-title":"Ion-exchange chromatography: Basic principles and application","volume":"1485","author":"Cummins","year":"2017"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib37","unstructured":"da Silva, N. R. (2019). Analysis of solute-water interactions by partitioning in multiple aqueous two-phase systems (Doctoral thesis). School of Engineering, University of Minho."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2015.08.053","article-title":"Analysis of partitioning of organic compounds and proteins in aqueous polyethylene glycol-sodium sulfate aqueous two-phase systems in terms of solute\u2013solvent interactions","volume":"1415","author":"da Silva","year":"2015","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.chroma.2015.11.019","article-title":"Effect of sodium chloride on solute\u2013solvent interactions in aqueous polyethylene glycol\u2013sodium sulfate two-phase systems","volume":"1425","author":"da Silva","year":"2015","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.chroma.2018.11.015","article-title":"Effects of sodium chloride and sodium perchlorate on properties and partition behavior of solutes in aqueous dextran-polyethylene glycol and polyethylene glycol-sodium sulfate two-phase systems","volume":"1583","author":"da Silva","year":"2019","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib41","series-title":"Green chromatographic techniques","first-page":"1","article-title":"Supercritical fluid chromatography: A green approach for separation and purification of organic and inorganic analytes","author":"Datta","year":"2014"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib42","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1080\/07373937.2011.605977","article-title":"Optimizing drying conditions for the microwave vacuum drying of enzymes","volume":"29","author":"de Jesus","year":"2011","journal-title":"Drying Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib43","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/bit.260340714","article-title":"Fundamental studies of biomolecule partitioning in aqueous two-phase systems","volume":"34","author":"Diamond","year":"1989","journal-title":"Biotechnology and Bioengineering"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib44","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/02772240500381326","article-title":"Removal of textile dyes from aqueous solution using PEG based aqueous biphasic system","volume":"87","author":"Dilip","year":"2005","journal-title":"Toxicological & Environmental Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib45","first-page":"15","article-title":"Poly(ethyleneimine) as a phase-forming polymer in aqueous two-phase systems","volume":"17","author":"Dissing","year":"1993","journal-title":"Biotechnology and Applied Biochemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2016.11.005","article-title":"Renaissance of protein crystallization and precipitation in biopharmaceuticals purification","volume":"35","author":"dos Santos","year":"2017","journal-title":"Biotechnology Advances"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib47","unstructured":"Duarte, M. L. (2018). Mathematical modelling for development, scale-up and optimization of a process of lyophilisation (Master thesis). Faculty of Pharmacy, University of Lisbon."},{"year":"1999","series-title":"Crystallization of nucleic acids and proteins\u2014A practical approach","author":"Ducruix","key":"10.1016\/B978-0-323-91167-2.00005-8_bib48"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.physchem.47.1.171","article-title":"Protein crystallization","volume":"47","author":"Durbin","year":"1996","journal-title":"Annual Review of Physical Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib50","series-title":"Microencapsulation in the food industry","first-page":"57","article-title":"New advances in spray-drying processes","author":"Dyvelkov","year":"2014"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/toxins11060309","article-title":"Separation and purification of aflatoxins by centrifugal partition chromatography","volume":"11","author":"Endre","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib52","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0076-6879(90)82024-V","article-title":"Precipitation Techniques","volume":"182","author":"Englard","year":"1990","journal-title":"Methods in Enzymology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib53","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jchromb.2004.01.033","article-title":"Purification of pharmaceutical-grade plasmid DNA by anion-exchange chromatography in an RNase-free process","volume":"804","author":"Eon-Duval","year":"2004","journal-title":"Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib54","first-page":"401","article-title":"Hydrophobic interaction chromatography","volume":"130","author":"Eriksson","year":"2018"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib55","unstructured":"e Silva, F. A. (2018). Extraction and separation of drugs using alternative solvents (Doctoral thesis). Department of Chemistry, University of Aveiro."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib56","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.seppur.2013.11.018","article-title":"Recovery of paracetamol from pharmaceutical wastes","volume":"122","author":"e Silva","year":"2014","journal-title":"Separation and Purification Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib57","unstructured":"European Medicines Agency. European public assessment report (EPAR) Exubera. Retrieved May 26, 2021, from http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Scientific_Discussion\/human\/000634\/WC500034387.pdf, EMEA. Intrinsa: European Public Assessment Report scientific discussion. EMEA 2006; Osborne, V., Layton, D., Shakir, S., Androgenic events rep."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2018.07.082","article-title":"Review on biomimetic affinity chromatography with short peptide ligands and its application to protein purification","volume":"1571","author":"Fang","year":"2018","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib59","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1039\/D0CE00517G","article-title":"Controlled protein crystal nucleation in microreactors: The effect of the droplet volume: vs high supersaturation ratios","volume":"22","author":"Ferreira","year":"2020","journal-title":"CrystEngComm"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib60","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.chroma.2016.03.032","article-title":"Interrelationship between partition behavior of organic compounds and proteins in aqueous dextran-polyethylene glycol and polyethylene glycol-sodium sulfate two-phase systems","volume":"1443","author":"Ferreira","year":"2016","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib61","unstructured":"Flores, H., Lin, T. P., Matthews, T. C., Pai, R., & Shahrokh, Z. (2010). ApO2 ligand\/TRAIL formulations (Patent No. US7741282B2)."},{"year":"2007","series-title":"Freeze-drying of pharmaceuticals and biopharmaceuticals: Principles and practice","author":"Franks","key":"10.1016\/B978-0-323-91167-2.00005-8_bib62"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib63","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/jssc.201901066","article-title":"Separation and isolation of major polyphenols from maritime pine (Pinus pinaster) knots by two-step centrifugal partition chromatography monitored by LC-MS and NMR spectroscopy","volume":"43","author":"Gabaston","year":"2020","journal-title":"Journal of Separation Science"},{"year":"2007","series-title":"Cryopreservation and freeze-drying protocols","author":"Gerald","key":"10.1016\/B978-0-323-91167-2.00005-8_bib64"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib65","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.phytol.2018.03.016","article-title":"GC\u2013MS detection of plant pigments and metabolites in Roman Julio-Claudian wall paintings","volume":"25","author":"Gismondi","year":"2018","journal-title":"Phytochemistry Letters"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib66","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/15422119.2014.983128","article-title":"Partitioning in aqueous two-phase systems: Fundamentals, applications and trends","volume":"45","author":"Grilo","year":"2016","journal-title":"Separation & Purification Reviews"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib67","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-1-59745-324-0_4","article-title":"Antibody purification: Ion-exchange chromatography","volume":"588","author":"Grodzki","year":"2010","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib68","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/bioengineering1040188","article-title":"Trends in upstream and downstream process development for antibody manufacturing","volume":"1","author":"Gronemeyer","year":"2014","journal-title":"Bioengineering"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib69","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/ceat.201500582","article-title":"Bulk crystallization of proteins by low-pressure water evaporation experimental materials","volume":"39","author":"Gro\u00df","year":"2016","journal-title":"Chemical Engineering & Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib70","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1016\/S0032-3861(02)00117-9","article-title":"Role of water structure on phase separation in polyelectrolyte\u2013polyethyleneglycol based aqueous two-phase systems","volume":"43","author":"Gupta","year":"2002","journal-title":"Polymer"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib71","first-page":"277","article-title":"Distribution of proteins in aqueous two-phase systems formed by dextran and polyethylene glycol. Influence of protein hydrophobicity","volume":"14","author":"Hagarova","year":"1995","journal-title":"General Physiology and Biophysics"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib72","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jpba.2012.01.004","article-title":"Pharmaceutical and biomedical applications of affinity chromatography: Recent trends and developments","volume":"69","author":"Hage","year":"2012","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib73","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0378-3812(00)00354-X","article-title":"An excess Gibbs energy model to study the phase behavior of aqueous two-phase systems of polyethylene glycol+dextran","volume":"171","author":"Haghtalab","year":"2000","journal-title":"Fluid Phase Equilibria"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib74","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/biot.201400608","article-title":"Continuous precipitation of IgG from CHO cell culture supernatant in a tubular reactor","volume":"10","author":"Hammerschmidt","year":"2015","journal-title":"Biotechnology Journal"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib75","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.procbio.2015.11.032","article-title":"Continuous polyethylene glycol precipitation of recombinant antibodies: Sequential precipitation and resolubilization","volume":"51","author":"Hammerschmidt","year":"2016","journal-title":"Process Biochemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib76","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molliq.2013.12.022","article-title":"Liquid+liquid) equilibria and extraction capacity of (imidazolium ionic liquids+potassium tartrate) aqueous two-phase systems","volume":"193","author":"Han","year":"2014","journal-title":"Journal of Molecular Liquids"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib77","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.tibtech.2014.02.001","article-title":"Purifying biopharmaceuticals: Knowledge-based chromatographic process development","volume":"32","author":"Hanke","year":"2014","journal-title":"Trends in Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib78","series-title":"Quantitative chemical analysis","first-page":"641","article-title":"Introduction to analytical separations","author":"Harris","year":"1998"},{"year":"2015","series-title":"Bioseparation science and engineering","author":"Harrison","key":"10.1016\/B978-0-323-91167-2.00005-8_bib79"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib80","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/nbt1194-1113","article-title":"Large scale, in situ isolation of periplasmic IGF-I from E. coli","volume":"12","author":"Hart","year":"1994","journal-title":"Bio\/Technology (Nature Publishing Company)"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib81","first-page":"269","article-title":"Aqueous two-phase systems: A general overview","volume":"19","author":"Hatti-Kaul","year":"2001","journal-title":"Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib82","unstructured":"Hayenga, K., & Valex, P. (2002). Methods for protein purification using Aqueous Two-Phase Extraction (Patent No. US Patent No. 6,437,101)."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib83","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00449-015-1374-y","article-title":"Large-scale crystallization of proteins for purification and formulation","volume":"38","author":"Hekmat","year":"2015","journal-title":"Bioprocess and Biosystems Engineering"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib84","doi-asserted-by":"crossref","DOI":"10.1021\/acs.cgd.7b00436","article-title":"Continuous crystallization of proteins in a stirred classified product removal tank with a tubular reactor in bypass","volume":"17","author":"Hekmat","year":"2017","journal-title":"Crystal Growth and Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib85","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jbiotec.2014.11.027","article-title":"Non-chromatographic preparative purification of enhanced green fluorescent protein","volume":"194","author":"Hekmat","year":"2015","journal-title":"Journal of Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib86","unstructured":"Hewick, R. M., & Seehra, J. S. (1987). Rodney M. Hewick Jasbir S. Seehra (Patent No. US4677195A)."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib87","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1080\/10826076.2012.743724","article-title":"A review size-exclusion chromatography for the analysis of protein biotherapeutics and their aggregates","volume":"35","author":"Hong","year":"2012","journal-title":"Journal of Liquid Chromatography & Related Technologies"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib88","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/ceat.201800627","article-title":"Preparative protein crystallization","volume":"42","author":"Hubbuch","year":"2019","journal-title":"Chemical Engineering and Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib89","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF00500828","article-title":"Large scale production of d-lactate dehydrogenase for the stereospecific reduction of pyruvate and phenylpyruvate","volume":"18","author":"Hummel","year":"1983","journal-title":"European Journal of Applied Microbiology and Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib90","doi-asserted-by":"crossref","first-page":"e4495","DOI":"10.1002\/jms.4495","article-title":"Development of two-dimensional gas chromatography (GC\u00d7GC) coupled with Orbitrap-technology-based mass spectrometry: Interest in the identification of biofuel composition","volume":"55","author":"Hung","year":"2020","journal-title":"Journal of Mass Spectrometry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib91","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1081\/DRT-120038730","article-title":"The influence of the spray drying process on product properties","volume":"22","author":"Huntington","year":"2004","journal-title":"Drying Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12575-016-0048-8","article-title":"Aqueous two-phase system (ATPS): An overview and advances in its applications","volume":"18","author":"Iqbal","year":"2016","journal-title":"Biological Procedures Online"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib93","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tifs.2014.10.008","article-title":"Spray-freeze-drying: A novel process for the drying of foods and bioproducts","volume":"41","author":"Ishwarya","year":"2015","journal-title":"Trends in Food Science and Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib94","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/separations3040031","article-title":"Comparison in partition efficiency of protein separation between four different tubing modifications in spiral high-speed countercurrent chromatography","volume":"3","author":"Ito","year":"2016","journal-title":"Separations"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib95","unstructured":"Jackson, R. (1973). Eli Lilly and Company. (1973). Processor the crystallization of the ammonium and alkali metal salts in insulin. (Patent No. 3719655)."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib96","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/(SICI)1097-0290(19980320)57:6<666::AID-BIT4>3.0.CO;2-J","article-title":"Nucleation and growth of microbial lipase crystals from clarified concentrated fermentation broths","volume":"57","author":"Jacobsen","year":"1998","journal-title":"Biotechnology and Bioengineering"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib97","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/10826068.2017.1421967","article-title":"Fermentative production of rhamnolipid and purification by adsorption chromatography","volume":"48","author":"Jadhav","year":"2018","journal-title":"Preparative Biochemistry and Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib98","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.tifs.2021.01.061","article-title":"Nano spray drying of food ingredients; materials, processing and applications","volume":"109","author":"Jafari","year":"2021","journal-title":"Trends in Food Science and Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib99","first-page":"88","article-title":"Liquid chromatography, 1. Fundamentals, history, instrumentation, materials","volume":"21","author":"Jandera","year":"2011","journal-title":"Ullmann\u2019s Encyclopedia of Industrial Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/0250-474X.103837","article-title":"Vacuum foam drying: An alternative to lyophilization for biomolecule preservation","volume":"74","author":"Jangle","year":"2012","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib101","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1016\/j.vaccine.2010.04.059","article-title":"Stabilizing formulations for inhalable powders of an adenovirus 35-vectored tuberculosis (TB) vaccine (AERAS-402)","volume":"28","author":"Jin","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib102","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.tibtech.2013.05.011","article-title":"Continuous downstream processing of biopharmaceuticals","volume":"31","author":"Jungbauer","year":"2013","journal-title":"Trends in Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib103","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/biot.201600271","article-title":"Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow inversion reactor (CFIR)","volume":"11","author":"Kateja","year":"2016","journal-title":"Biotechnology Journal"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib104","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1021\/ci034194o","article-title":"Aqueous biphasic systems. Partitioning of organic molecules: A QSPR treatment","volume":"44","author":"Katritzky","year":"2003","journal-title":"Journal of Chemical Information and Computer Sciences"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib105","doi-asserted-by":"crossref","unstructured":"Katti, D. (2020). Strategies for the development of process chromatography as a unit operation for the pharmaceutical industry. In Handbook of analytical separations (Vol. 8, pp. 349\u2013451). Elsevier.","DOI":"10.1016\/B978-0-444-64070-3.00008-4"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib106","first-page":"995","article-title":"Very large scale monoclonal antibody purification: The case for conventional unit operations","volume":"23","author":"Kelley","year":"2007","journal-title":"Biotechnol Progress"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib107","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0168-1656(03)00104-4","article-title":"Pilot-scale extraction of an intracellular recombinant cutinase from E. coli cell homogenate using a thermoseparating aqueous two-phase system","volume":"103","author":"Kepka","year":"2003","journal-title":"Journal of Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib108","series-title":"Ullmann\u2019s encyclopedia of industrial chemistry","first-page":"1","article-title":"Freeze-drying","author":"Kharaghani","year":"2017"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib109","unstructured":"Kornmann, H., & Baer, G. (2008). Process for the purification of IL-18-binding protein (Patent No. US Patent No. 7,439,336)."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib110","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/jctb.5030320117","article-title":"Scale-up of formate dehydrogenase by partition","volume":"32","author":"Kroner","year":"1982","journal-title":"Journal of Chemical Technology and Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib111","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.nbt.2010.05.008","article-title":"Purification of fructooligosaccharides in an activated charcoal fixed bed column","volume":"27","author":"Kuhn","year":"2010","journal-title":"New Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib112","unstructured":"Labconco Corporation. (2020). A guide to freeze drying for the laboratory. In An industrial service publication. Labconco Corporation."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib113","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0021-9673(95)00309-6","article-title":"Supercritical fluid chromatography of carbohydrates","volume":"720","author":"Lafosse","year":"1996","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib114","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1093\/nar\/gku751","article-title":"Shape matters: Size-exclusion HPLC for the study of nucleic acid structural polymorphism","volume":"42","author":"Largy","year":"2014","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib115","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10337-018-3649-3","article-title":"Multidimensional gas chromatography in essential oil analysis. Part 1: Technical developments","volume":"82","author":"Lebanov","year":"2019","journal-title":"Chromatographia"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib116","series-title":"Isolation and purification of proteins","article-title":"Protein crystallization for large-scale bioseparation","author":"Lee","year":"2003"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib117","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1021\/acs.cgd.8b00095","article-title":"Electric-field-assisted protein crystallization in continuous flow","volume":"18","author":"Li","year":"2018","journal-title":"Crystal Growth & Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib118","first-page":"1074","article-title":"Ionic liquid-salt aqueous two-phase system, a novel system for the extraction of abused drugs","volume":"16","author":"Li","year":"2005","journal-title":"Chinese Chemical Letters"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.115324","article-title":"Purification of anthocyanins from grape pomace by centrifugal partition chromatography","volume":"326","author":"Lima","year":"2021","journal-title":"Journal of Molecular Liquids"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib120","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/17460441.2018.1465924","article-title":"What\u2019s happened over the last five years with high-throughput protein crystallization screening?","volume":"13","author":"Lin","year":"2018","journal-title":"Expert Opinion on Drug Discovery"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib121","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0144-8617(89)90042-8","article-title":"Reppal PES\u2014a starch derivative for aqueous two-phase systems","volume":"11","author":"Ling","year":"1989","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib122","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/10408347.2019.1586520","article-title":"The application of supercritical fluid chromatography in food quality and food safety: An overview","volume":"50","author":"Liu","year":"2020","journal-title":"Critical Reviews in Analytical Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib123","doi-asserted-by":"crossref","DOI":"10.3390\/pr8010058","article-title":"Accelerating biologics manufacturing by modeling: Process integration of precipitation in mAb downstream processing","volume":"8","author":"Lohmann","year":"2020","journal-title":"Processes"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib124","unstructured":"Lyohub. (2017). Lyophilization technology roadmap. file:\/\/\/C:\/Users\/linaf\/Downloads\/LyoHUB_roadmap_Final_2017.pdf."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib125","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1007\/s12161-015-0166-y","article-title":"Chromatographic determination of phenolic acids and flavonoids in Lycium barbarum L. and evaluation of antioxidant activity","volume":"8","author":"Magiera","year":"2015","journal-title":"Food Analytical Methods"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib126","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jcrysgro.2016.09.049","article-title":"Crystallization of lysozyme from lysozyme \u2013 ovalbumin mixtures: Separation potential and crystal growth kinetics","volume":"469","author":"Maosoongnern","year":"2017","journal-title":"Journal of Crystal Growth"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib127","unstructured":"Market Research. (2021). Spray drying equipment market size and growth prospects with CAGR of 6.8% by 2025. https:\/\/issuu.com\/marketresearchmi\/docs\/spray_drying_equipment_market_size_and_growth_pros."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib128","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tibtech.2018.09.001","article-title":"Precipitation as an enabling technology for the intensification of biopharmaceutical manufacture","volume":"37","author":"Martinez","year":"2019","journal-title":"Trends in Biotechnology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib129","first-page":"1","article-title":"Effect of freeze-drying on quality and grinding process of food produce: A review","volume":"8","author":"Martins","year":"2020","journal-title":"Processes"},{"year":"2018","series-title":"Freeze-drying fundamentals","author":"McHugh","key":"10.1016\/B978-0-323-91167-2.00005-8_bib130"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib131","unstructured":"McHugh, T. (2018b). The significance of spray-drying. IFT-Food Technology Magazine."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib132","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1107\/S2053230X13033141","article-title":"Introduction to protein crystallization","volume":"70","author":"McPherson","year":"2014","journal-title":"Acta Crystallographica. Section F, Structural Biology Communications F"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib133","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0144-8617(93)90075-F","article-title":"Studies on aqueous polymer two-phase systems containing agarose","volume":"22","author":"Medin","year":"1993","journal-title":"Carbohydrate Polymers"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib134","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00216-013-7017-8","article-title":"New advances in countercurrent chromatography and centrifugal partition chromatography: Focus on coupling strategy","volume":"406","author":"Michel","year":"2014","journal-title":"Analytical and Bioanalytical Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1007913300427","article-title":"Partition of horseradish in aqueous two-phase systems containing polyvinylpyrrolidone","volume":"7","author":"Miranda","year":"1998","journal-title":"Bioseparation"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib136","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1016\/S0021-9258(19)63387-9","article-title":"Purification of human erythropoietin","volume":"252","author":"Miyake","year":"1977","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib137","series-title":"Ingredients extraction by physicochemical methods in food","article-title":"Extraction technologies and solvents of phytocompounds from plant materials: Physicochemical characterization and identification of ingredients and bioactive compounds from plant extract using various instrumentations","author":"Muhamad","year":"2017"},{"year":"2001","series-title":"Crystallization","author":"Mullin","key":"10.1016\/B978-0-323-91167-2.00005-8_bib138"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib139","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1208\/s12248-010-9192-2","article-title":"Immunization of guinea pigs with novel hepatitis B antigen as nanoparticle aggregate powders administered by the pulmonary route","volume":"12","author":"Muttil","year":"2010","journal-title":"AAPS Journal"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.apt.2010.09.011","article-title":"Progress in developing spray-drying methods for the production of controlled morphology particles: From the nanometer to submicrometer size ranges","volume":"22","author":"Nandiyanto","year":"2011","journal-title":"Advanced Powder Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib141","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1021\/cg501359h","article-title":"Continuous crystallization of proteins in a tubular plug-flow crystallizer","volume":"15","author":"Neugebauer","year":"2015","journal-title":"Crystal Growth & Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib142","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/chromsci\/bms046","article-title":"Ion-exclusion chromatography determination of organic acid in uridine 5\u2019-monophosphate fermentation broth","volume":"50","author":"Niu","year":"2012","journal-title":"Journal of Chromatographic Science"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib143","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/bit.22900","article-title":"Application of an aqueous two-phase systems high-throughput screening method to evaluate mAb HCP separation","volume":"108","author":"Oelmeier","year":"2011","journal-title":"Biotechnology and Bioengineering"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib144","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.chroma.2013.10.043","article-title":"Alternative separation steps for monoclonal antibody purification: Combination of centrifugal partitioning chromatography and precipitation","volume":"1319","author":"Oelmeier","year":"2013","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib145","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.vaccine.2009.11.024","article-title":"Heat-stable measles vaccine produced by spray drying","volume":"28","author":"Ohtake","year":"2010","journal-title":"Vaccine"},{"year":"2008","series-title":"Congelaci\u00f3n y Liofilizaci\u00f3n de alimentos","author":"Orrego","key":"10.1016\/B978-0-323-91167-2.00005-8_bib146"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib147","series-title":"Separation, extraction and concentration processes in the food, beverage and nutraceutical industries","first-page":"109","article-title":"Advances in process chromatography and applications in the food, beverage and nutraceutical industries","author":"Ottens","year":"2010"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib148","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1080\/10826070701540076","article-title":"Application of size exclusion chromatography in the development and characterization of nanoparticulate drug delivery systems","volume":"30","author":"Otto","year":"2007","journal-title":"Journal of Liquid Chromatography and Related Technologies"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib149","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4216060","article-title":"A brief reminder of systems of production and chromatography-based recovery of recombinant protein biopharmaceuticals","volume":"2019","author":"Owczarek","year":"2019","journal-title":"BioMed Research International"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128117","article-title":"Effects of sugar matrices on the release of key aroma compounds in fresh and high hydrostatic pressure processed Tainong mango juices","volume":"338","author":"Pan","year":"2021","journal-title":"Food Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib151","first-page":"1993","article-title":"Partitioning behavior of tetracycline in hydrophilic ionic liquids two-phase systems","volume":"50","author":"Pang","year":"2015","journal-title":"Separation Science and Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib152","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1021\/cg200158z","article-title":"Effects of oscillatory flow on the nucleation and crystallization of insulin","volume":"11","author":"Parambil","year":"2011","journal-title":"Crystal Growth & Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib153","series-title":"Nanotechnology-based targeted drug delivery systems for brain tumors","article-title":"Solid lipid nanoparticles for targeted brain drug delivery","author":"Patel","year":"2018"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib154","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jhazmat.2011.07.062","article-title":"Application of aqueous two-phase systems for the development of a new method of cobalt(II), iron(III) and nickel(II) extraction: A green chemistry approach","volume":"193","author":"Patr\u00edcio","year":"2011","journal-title":"Journal of Hazardous Materials"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib155","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0301-4770(05)80005-3","article-title":"Chiral separation of amino acids by gas chromatography","volume":"70","author":"P\u00e4tzold","year":"2005","journal-title":"Journal of Chromatography Library"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib157","series-title":"Liquid-phase extraction","first-page":"157","article-title":"Chapter 5 - Aqueous two-phase systems","author":"Pereira","year":"2020"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib158","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1021\/je034038d","volume":"49","author":"Pereira","year":"2004","journal-title":"Journal of Chemical & Engineering Data"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib156","article-title":"Hydrophobic interaction chromatography as polishing step enables obtaining ultra-pure recombinant antibodies","volume":"6","author":"Pereira Bresolin","year":"2020","journal-title":"Journal of Biotechnology: X"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib159","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/cbf.290050311","article-title":"Partition of cell particles and macromolecules: Separation and purification of biomolecules, cell organelles, membranes and cells in aqueous polymer two phase systems and their use in biochemical analysis and biotechnology","volume":"5","author":"Peters","year":"1987","journal-title":"Cell Biochemistry and Function"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ejpb.2019.06.027","article-title":"Achieving continuous manufacturing in lyophilization: Technologies and approaches","volume":"142","author":"Pisano","year":"2019","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib161","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/jps.23146","article-title":"Molecular nanomedicine towards cancer","volume":"101","author":"Psimadas","year":"2012","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib162","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cherd.2020.05.004","article-title":"Continuous crystallization as a downstream processing step of pharmaceutical proteins: A review","volume":"160","author":"Pu","year":"2020","journal-title":"Chemical Engineering Research and Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib163","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0168-1656(01)00237-1","article-title":"Hydrophobic interaction chromatography of proteins","volume":"87","author":"Queiroz","year":"2001","journal-title":"Journal of Biotechnology"},{"year":"2000","series-title":"Aqueous two-phase systems: Methods and protocols","author":"Rajni","key":"10.1016\/B978-0-323-91167-2.00005-8_bib164"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib165","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1080\/07373930600611877","article-title":"Formulating drug delivery systems by spray drying","volume":"24","author":"R\u00e9","year":"2006","journal-title":"Drying Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib166","doi-asserted-by":"crossref","unstructured":"\u0158ezanka, T., P\u00e1drov\u00e1, K., & Sigler, K. (2016). Derivatization in gas chromatography of lipids. In M. Wenk (Ed.), Encyclopedia of lipidomics (pp. 1\u20139). Springer.","DOI":"10.1007\/978-94-007-7864-1_71-1"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib167","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1385-8947(01)00241-8","article-title":"Process integration using aqueous two-phase partition for the recovery of intracellular proteins","volume":"87","author":"Rito-Palomares","year":"2002","journal-title":"Chemical Engineering Journal"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib168","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.chroma.2010.12.088","article-title":"Evaluation of beer deterioration by gas chromatography-mass spectrometry\/multivariate analysis: A rapid tool for assessing beer composition","volume":"1218","author":"Rodrigues","year":"2011","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib169","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0378-4347(97)00661-0","article-title":"Partitioning of small organic molecules in aqueous biphasic systems","volume":"711","author":"Rogers","year":"1998","journal-title":"Journal of Chromatography B, Biomedical Sciences and Applications"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib170","doi-asserted-by":"crossref","DOI":"10.1002\/biot.201900274","article-title":"Anything but conventional chromatography approaches in bioseparation","volume":"15","author":"Roque","year":"2020","journal-title":"Biotechnology Journal"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib171","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.procbio.2013.02.010","article-title":"Scaling-up of a B-phycoerythrin production and purification bioprocess involving aqueous two-phase systems: Practical experiences","volume":"48","author":"Ruiz-Ruiz","year":"2013","journal-title":"Process Biochemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib172","first-page":"247","article-title":"Origin and use of crystallization phase diagrams","volume":"71","author":"Rupp","year":"2015","journal-title":"Acta Crystallographica Section F: Structural Biology Communications"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib173","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0021-9797(71)90283-9","article-title":"Interfacial tension of dextran\u2014polyethylene glycol\u2014water two\u2014phase systems","volume":"37","author":"Ryden","year":"1971","journal-title":"Journal of Colloid and Interface Science"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib174","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1021\/cg301258t","article-title":"Controlled nucleation and growth of protein crystals by solvent freeze-out","volume":"12","author":"Ryu","year":"2012","journal-title":"Crystal Growth & Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib175","series-title":"Biomaterials\u2014Physics and chemistry\u2014New edition","article-title":"Spray drying: An overview","author":"Santos","year":"2018"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib176","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/2041-210X.12406","article-title":"Phytoplankton pigment biomarkers: HPLC separation using a pentafluorophenyloctadecyl silica column","volume":"6","author":"Sanz","year":"2015","journal-title":"Methods in Ecology and Evolution"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib177","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0378-4347(99)00516-2","article-title":"New aqueous two-phase system based on cashew-nut tree gum and poly(ethylene glycol)","volume":"743","author":"Sarubbo","year":"2000","journal-title":"Journal of Chromatography B, Biomedical Sciences and Applications"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib178","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2478\/acph-2021-0026","article-title":"Determination of carbohydrates in the herbal antidiabetic mixtures by GC-MC","volume":"71","author":"Savych","year":"2021","journal-title":"Acta Pharmaceutica"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib179","doi-asserted-by":"crossref","DOI":"10.1021\/ed020p415.2","article-title":"). Proteins, amino acids and peptides as ions and dipolar ions","volume":"20","author":"Schmidt","year":"1943","journal-title":"Journal of Chemical Education"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib180","unstructured":"Schneider, W., Frohlich, C., Fiedler, H., & Lefevre, H. (1979). Process for isolating albumin from blood. US4156681A Patent."},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib181","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev-anchem-060908-155133","article-title":"Chromatography in industry","volume":"2","author":"Schoenmakers","year":"2009","journal-title":"Annual Review of Analytical Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib182","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0032-9592(03)00198-5","article-title":"Large-scale separation and production of engineered proteins, designed for facilitated recovery in detergent-based aqueous two-phase extraction systems","volume":"39","author":"Selber","year":"2004","journal-title":"Process Biochemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib183","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1080\/17425247.2016.1198767","article-title":"Application of freeze-drying in the development of oral drug delivery systems","volume":"13","author":"Siow","year":"2016","journal-title":"Expert Opinion on Drug Delivery"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib184","series-title":"Principles of instrumental analysis","first-page":"673","article-title":"An introduction to chromatographic separation","author":"Skoog","year":"1997"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib185","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1309320111","article-title":"Role of clusters in nonclassical nucleation and growth of protein crystals","author":"Sleutel","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib186","doi-asserted-by":"crossref","first-page":"12256","DOI":"10.1039\/C8NR02867B","article-title":"Nucleation of protein crystals\u2014A nanoscopic perspective","volume":"10","author":"Sleutel","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib187","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1002\/bit.24908","article-title":"Fast and scalable purification of a therapeutic full-length antibody based on process crystallization","volume":"110","author":"Smejkal","year":"2013","journal-title":"Biotechnology and Bioengineering"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib188","series-title":"Principles of fermentation technology","first-page":"619","article-title":"The recovery and purification of fermentation products","author":"Stanbury","year":"2017"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib189","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/biot.201500354","article-title":"Continuous counter-current chromatography for the capture and polishing steps in biopharmaceuticals production","volume":"11","author":"Steinebach","year":"2016","journal-title":"Biotechnology Journal"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib190","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01875542","article-title":"A low-cost aqueous two phase system for enzyme extraction","volume":"2","author":"Szlag","year":"1988","journal-title":"Biotechnology Techniques"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib191","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1080\/10942912.2012.740645","article-title":"Analysis of polyphenols in apple pomace using gas chromatography-mass spectrometry with derivatization","volume":"17","author":"Tao","year":"2014","journal-title":"International Journal of Food Properties"},{"year":"2015","series-title":"World erythropoietin drugs market\u2014Opportunities and forecasts","author":"Tatkare","key":"10.1016\/B978-0-323-91167-2.00005-8_bib192"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib193","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1021\/ac101194x","article-title":"Supercritical fluid chromatography","volume":"82","author":"Taylor","year":"2010","journal-title":"Analytical Chemistry"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib194","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1021\/acs.cgd.0c00885","article-title":"Continuous protein crystallization in mixed-suspension mixed-product-removal crystallizers","volume":"21","author":"Thomas","year":"2021","journal-title":"Crystal Growth and Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib195","doi-asserted-by":"crossref","first-page":"20381","DOI":"10.1021\/acs.iecr.9b03535","article-title":"An airlift crystallizer for protein crystallization","volume":"58","author":"Thomas","year":"2019","journal-title":"Industrial and Engineering Chemistry Research"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib196","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1080\/01496395.2014.926372","article-title":"Separation of amino-acids by reversed phase chromatography: Development of a model mixture dedicated to the study of solvent gradient chromatography processes","volume":"49","author":"Tlili","year":"2014","journal-title":"Separation Science and Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib197","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1080\/10826079308021679","article-title":"History of chromatography","volume":"16","author":"Touchstone","year":"1993","journal-title":"Journal of Liquid Chromatography"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib198","series-title":"Molecular interactions in bioseparations","first-page":"113","article-title":"Affinity chromatography of oligosaccharides and glycopeptides with immobilized lectins","author":"Tsuji","year":"1993"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib199","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/btpr.2622","article-title":"Development of a novel affinity chromatography resin for platform purification of bispecific antibodies with modified protein a binding avidity","volume":"34","author":"Tustian","year":"2018","journal-title":"Biotechnology Progress"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib200","series-title":"Methods in enzymology","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0076-6879(09)63026-3","article-title":"Chapter 26 \u2013 Affinity chromatography. General methods","author":"Urh","year":"2009"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib201","doi-asserted-by":"crossref","unstructured":"Van Alstine, J. M., Jagschies, G., & \u0141acki, K. M. (2018a). Alternative separation methods: Crystallization and aqueous polymer two-phase extraction. In Biopharmaceutical processing: Development, design, and implementation of manufacturing processes (pp. 241\u2013267). Elsevier.","DOI":"10.1016\/B978-0-08-100623-8.00012-8"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib202","doi-asserted-by":"crossref","unstructured":"Van Alstine, J. M., Jagschies, G., & \u0141acki, K. M. (2018b). Alternative separation methods: Flocculation and precipitation. In Biopharmaceutical processing: Development, design, and implementation of manufacturing processes (pp. 221\u2013239). Elsevier.","DOI":"10.1016\/B978-0-08-100623-8.00011-6"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib203","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1039\/c0nr00628a","article-title":"Nucleation of crystals in solution","volume":"2","author":"Vekilov","year":"2010","journal-title":"Nanoscale"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib204","doi-asserted-by":"crossref","unstructured":"Velickovic, T. C., Ognjenovic, J., & Mihajlovic, L. (2012). Separation of amino acids, peptides, and proteins by ion exchange chromatography. In D. Inamuddin & M. Luqman (Eds.), Ion exchange technology II: Applications (pp. 1\u201334). Springer.","DOI":"10.1007\/978-94-007-4026-6_1"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib205","first-page":"253","article-title":"Protein partition on a derivative guar gum based aqueous two-phase system","volume":"5","author":"Ven\u00e2ncio","year":"1995","journal-title":"Bioseparation"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib206","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1002\/jps.23998","article-title":"Next generation drying technologies for pharmaceutical applications","volume":"103","author":"Walters","year":"2014","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib207","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.chemosphere.2008.03.065","article-title":"Benzene removal from waste water using aqueous surfactant two-phase extraction with cationic and anionic surfactant mixtures","volume":"72","author":"Weschayanwiwat","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib208","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1089\/dia.2005.7.896","article-title":"EXUBERA\u00ae: Pharmaceutical development of a novel product for pulmonary delivery of insulin","volume":"7","author":"White","year":"2005","journal-title":"Diabetes Technology and Therapeutics"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib500","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1080\/01496399908951081","article-title":"Partitioning of aromatic molecules in Aqueous Biphasic Systems","volume":"34","author":"Willauer","year":"1999","journal-title":"Separation Science and Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib209","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1021\/ie010598z","article-title":"Solute partitioning in aqueous biphasic systems composed of polyethylene glycol and salt: The partitioning of small neutral organic species","volume":"41","author":"Willauer","year":"2002","journal-title":"Industrial & Engineering Chemistry Research"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib210","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1021\/ie0107800","article-title":"Solvent properties of aqueous biphasic systems composed of polyethylene glycol and salt characterized by the free energy of transfer of a methylene group between the phases and by a linear solvation energy relationship","volume":"41","author":"Willauer","year":"2002","journal-title":"Industrial & Engineering Chemistry Research"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib212","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/acs.cgd.8b01534","article-title":"Development and workflow of a continuous protein crystallization process: A case of lysozyme","volume":"19","author":"Yang","year":"2019","journal-title":"Crystal Growth and Design"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib213","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/ceat.201300832","article-title":"Purification of lysozyme from protein mixtures by solvent-freeze-out technology","volume":"37","author":"Yu","year":"2014","journal-title":"Chemical Engineering & Technology"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib214","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025282","article-title":"Towards protein crystallization as a process step in downstream processing of therapeutic antibodies: Screening and optimization at microbatch scale","volume":"6","author":"Zang","year":"2011","journal-title":"PLoS One"},{"year":"1995","series-title":"Aqueous two-phase partitioning: Physical chemistry and bioanalytical applications","author":"Zaslavsky","key":"10.1016\/B978-0-323-91167-2.00005-8_bib215"},{"key":"10.1016\/B978-0-323-91167-2.00005-8_bib216","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.desal.2007.01.018","article-title":"The study of continuous membrane crystallization on lysozyme","volume":"219","author":"Zhang","year":"2008","journal-title":"Desalination"}],"container-title":["Current Developments in Biotechnology and Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780323911672000058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780323911672000058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T08:32:09Z","timestamp":1757233929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780323911672000058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9780323911672"],"references-count":216,"URL":"https:\/\/doi.org\/10.1016\/b978-0-323-91167-2.00005-8","relation":{},"subject":[],"published":{"date-parts":[[2022]]}}}