{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T06:34:01Z","timestamp":1718260441568},"reference-count":7,"publisher":"Elsevier","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1016\/b978-0-444-63456-6.50161-7","type":"book-chapter","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T10:23:07Z","timestamp":1403259787000},"page":"961-966","source":"Crossref","is-referenced-by-count":7,"title":["Multi-level Optimization Framework Applied to the Systematic Evaluation of Metabolic Objective Functions"],"prefix":"10.1016","author":[{"given":"Pavel","family":"Vaskan","sequence":"first","affiliation":[]},{"given":"Gonzalo","family":"Guill\u00e9n-Gos\u00e1lbez","sequence":"additional","affiliation":[]},{"given":"Albert","family":"Sorribas","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Laureano","family":"Jim\u00e9nez","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/B978-0-444-63456-6.50161-7_bb0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrg1272","article-title":"Network biology: understanding the cell\u2019s functional organization","volume":"5","author":"Barabasi","year":"2004","journal-title":"Nature Reviews Genetics"},{"key":"10.1016\/B978-0-444-63456-6.50161-7_bb0015","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/bit.10617","article-title":"Optimization-based framework for inferring and testing hypothesized metabolic objective functions","volume":"82","author":"Burgard","year":"2003","journal-title":"Biotechnology and bioengineering"},{"key":"10.1016\/B978-0-444-63456-6.50161-7_bb0020","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.mib.2010.03.003","article-title":"The biomass objective function","volume":"13","author":"Feist","year":"2010","journal-title":"Current opinion in microbiology"},{"key":"10.1016\/B978-0-444-63456-6.50161-7_bb0025","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ab.2003.10.036","article-title":"High-throughput metabolic flux analysis based on gas chromatography-mass spectrometry derived 13 C constraints","volume":"325","author":"Fischer","year":"2004","journal-title":"Analytical biochemistry"},{"issue":"4","key":"10.1016\/B978-0-444-63456-6.50161-7_bb0030","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrmicro2737","article-title":"Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods","volume":"10","author":"Lewis","year":"2012","journal-title":"Nature Reviews Microbiology"},{"issue":"2","key":"10.1016\/B978-0-444-63456-6.50161-7_bb0035","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pbi.2011.03.009","article-title":"Natural epigenetic variation in plant species: a view from the field","volume":"14","author":"Richards","year":"2011","journal-title":"Current opinion in plant biology"},{"key":"10.1016\/B978-0-444-63456-6.50161-7_bb0040","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1126\/science.1216882","article-title":"Multidimensional optimality of microbial metabolism","volume":"336","author":"Schuetz","year":"2012","journal-title":"Science"}],"container-title":["Computer Aided Chemical Engineering","24th European Symposium on Computer Aided Process Engineering"],"original-title":[],"link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780444634566501617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:B9780444634566501617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T15:38:31Z","timestamp":1565537911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9780444634566501617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":7,"URL":"https:\/\/doi.org\/10.1016\/b978-0-444-63456-6.50161-7","relation":{},"ISSN":["1570-7946"],"issn-type":[{"value":"1570-7946","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}