{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:39:33Z","timestamp":1792773573802,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ADDITIVES"],"award-info":[{"award-number":["ADDITIVES"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2018-StG- 804135 INVADERS"],"award-info":[{"award-number":["ERC-2018-StG- 804135 INVADERS"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["864219"],"award-info":[{"award-number":["864219"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["INCa_14059"],"award-info":[{"award-number":["INCa_14059"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014630","name":"Minist\u00e8re des Solidarit\u00e9s et de la Sant\u00e9","doi-asserted-by":"publisher","award":["arr\\u00EAt\\u00E9 29.11.19"],"award-info":[{"award-number":["arr\\u00EAt\\u00E9 29.11.19"]}],"id":[{"id":"10.13039\/501100014630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013943","name":"Conservatoire National des Arts et M\u00e9tiers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013943","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022077","name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004690","name":"Minist\u00e8re de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007492","name":"Fondation Bettencourt Schueller","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ajcnut.2026.101462","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:01:18Z","timestamp":1786201278000},"page":"101462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Food additive and naturally occurring glutamate and risk of cardiovascular diseases in the NutriNet-Sant\u00e9 prospective cohort"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3256-8836","authenticated-orcid":false,"given":"Ana\u00efs","family":"Hasenb\u00f6hler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Javaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Payen de la","family":"Garanderie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien Szabo de","family":"Edelenyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bourhis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Aga\u00ebsse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre De","family":"Sa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Huybrechts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Coumoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Julia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Kesse-Guyot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"All\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9opold K","family":"Fezeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Hercberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Galan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Deschasaux-Tanguy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Chassaing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Srour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Touvier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajcnut.2026.101462_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1021\/cr60033a001","article-title":"The history of the discovery of the amino acids","volume":"9","author":"Vickery","year":"1931","journal-title":"Chem. Rev. Am. Chem. Soc."},{"key":"10.1016\/j.ajcnut.2026.101462_bib2","first-page":"88","article-title":"The work of Emil Fischer and his school on the chemistry of the proteins, Sci. Prog. Twent. Century 1906-1916","volume":"2","author":"Plimmer","year":"1907","journal-title":"Sci. Rev."},{"key":"10.1016\/j.ajcnut.2026.101462_bib3","doi-asserted-by":"crossref","first-page":"719S","DOI":"10.3945\/ajcn.2009.27462D","article-title":"Glutamate: from discovery as a food flavor to role as a basic taste (umami)","volume":"90","author":"Kurihara","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib4","series-title":"E621 - Glutamate monosodique [Internet]","year":"2023"},{"key":"10.1016\/j.ajcnut.2026.101462_bib5","series-title":"Codex General Standard for Food Additives (GSFA) Online Food Additive Index [Internet]","year":"2024"},{"key":"10.1016\/j.ajcnut.2026.101462_bib6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0091-6749(97)80008-5","article-title":"The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study1","volume":"99","author":"Yang","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ajcnut.2026.101462_bib7","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/1541-4337.12448","article-title":"A review of the alleged health hazards of monosodium glutamate","volume":"18","author":"Zanfirescu","year":"2019","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.ajcnut.2026.101462_bib8","doi-asserted-by":"crossref","first-page":"20014","DOI":"10.1007\/s11356-020-08436-6","article-title":"Monosodium glutamate induces cardiac toxicity via oxidative stress, fibrosis, and P53 proapoptotic protein expression in rats","volume":"27","author":"Hazzaa","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ajcnut.2026.101462_bib9","doi-asserted-by":"crossref","first-page":"S359","DOI":"10.1177\/09603271211049550","article-title":"Monosodium glutamate causes hepato-cardiac derangement in male rats","volume":"40","author":"Banerjee","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ajcnut.2026.101462_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0041-008X(79)90152-2","article-title":"A developmental test battery for neurobehavioral toxicity in rats: a preliminary analysis using monosodium glutamate calcium carrageenan, and hydroxyurea","volume":"50","author":"Vorhees","year":"1979","journal-title":"Toxicol Appl. Pharmacol."},{"key":"10.1016\/j.ajcnut.2026.101462_bib11","article-title":"Monosodium glutamate and atrial fibrillation in a 78-year-old woman: a case report","volume":"4","author":"Purvez","year":"2025","journal-title":"Ann. Intern. Med. Clin. Cases American College of Physicians"},{"key":"10.1016\/j.ajcnut.2026.101462_bib12","article-title":"Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives","volume":"15","author":"European Food Safety Authority (EFSA) Panel on Food additives and Nutrient Sources added to Food (ANS)","year":"2017","journal-title":"EFSA J"},{"key":"10.1016\/j.ajcnut.2026.101462_bib13","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1016\/j.tjnut.2023.08.031","article-title":"Dietary glutamine and glutamate in relation to cardiovascular disease incidence and mortality in the United States men and women with diabetes mellitus","volume":"153","author":"Chen","year":"2023","journal-title":"J. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/ije\/dyx234","article-title":"Dietary glutamine, glutamate and mortality: two large prospective studies in US men and women","volume":"47","author":"Ma","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.ajcnut.2026.101462_bib15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.numecd.2017.05.003","article-title":"Contribution of dietary amino acids composition to incidence of cardiovascular outcomes: a prospective population-based study","volume":"27","author":"Mirmiran","year":"2017","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.ajcnut.2026.101462_bib16","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3945\/jn.114.201293","article-title":"Dietary intakes of glutamic acid and glycine are associated with stroke mortality in Japanese adults1,2","volume":"145","author":"Nagata","year":"2015","journal-title":"J. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib17","article-title":"Relationship between plasma glutamate and cardiovascular disease risk in Chinese patients with type 2 diabetes mellitus by gender","volume":"14","author":"Li","year":"2023","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.ajcnut.2026.101462_bib18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.numecd.2021.09.021","article-title":"Serum glutamate and glutamine-to-glutamate ratio are associated with coronary angiography defined coronary artery disease","volume":"32","author":"Wang","year":"2022","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.ajcnut.2026.101462_bib19","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/ajcn\/nqy362","article-title":"Effect of glutamate and aspartate on ischemic heart disease, blood pressure, and diabetes: a Mendelian randomization study","volume":"109","author":"Zhao","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib20","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/jama.2013.276305","article-title":"Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes","volume":"310","author":"Qi","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ajcnut.2026.101462_bib21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/1471-2458-10-242","article-title":"The NutriNet-Sant\u00e9 Study: a web-based prospective study on the relationship between nutrition and health and determinants of dietary patterns and nutritional status","volume":"10","author":"Hercberg","year":"2010","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ajcnut.2026.101462_bib22","doi-asserted-by":"crossref","DOI":"10.2196\/jmir.2575","article-title":"Validity of web-based self-reported weight and height: results of the NutriNet-Sant\u00e9 study","volume":"15","author":"Lassale","year":"2013","journal-title":"J. Med. Internet Res."},{"key":"10.1016\/j.ajcnut.2026.101462_bib23","unstructured":"Committee IR. Guidelines for Data Processing and Analysis of the International Physical Activity Questionnaire (IPAQ)-Short and Long Forms. http:\/\/www.ipaq.ki.se\/scoring.pdf [Internet] 2005 [cited 26 February 2023]; Available from: https:\/\/cir.nii.ac.jp\/crid\/1573950400545533440."},{"key":"10.1016\/j.ajcnut.2026.101462_bib24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jand.2015.09.017","article-title":"Correlations between fruit, vegetables, fish, vitamins, and fatty acids estimated by web-based nonconsecutive dietary records and respective biomarkers of nutritional status","volume":"116","author":"Lassale","year":"2016","journal-title":"J. Acad. Nutr. Diet."},{"key":"10.1016\/j.ajcnut.2026.101462_bib25","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1017\/S0007114515000057","article-title":"Validation of a web-based, self-administered, non-consecutive-day dietary record tool against urinary biomarkers","volume":"113","author":"Lassale","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib26","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1017\/S0007114510004617","article-title":"Comparison between an interactive web-based self-administered 24 h dietary record and an interview by a dietitian for large-scale epidemiological studies","volume":"105","author":"Touvier","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib27","first-page":"158","article-title":"Validation du manuel-photos utilis\u00e9 pour l\u2019enqu\u00eate alimentaire de l\u2019\u00e9tude SU.VI.MAX","volume":"31","author":"Moullec","year":"1996","journal-title":"Nutr. Clin. Metab."},{"key":"10.1016\/j.ajcnut.2026.101462_bib28","series-title":"Table de Composition des Aliments NutriNet-Sant\u00e9","author":"Arnault","year":"2013"},{"key":"10.1016\/j.ajcnut.2026.101462_bib29","first-page":"569","article-title":"Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording","volume":"45","author":"Goldberg","year":"1991","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib30","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/sj.ijo.0801376","article-title":"Critical evaluation of energy intake using the Goldberg cut-off for energy intake: basal metabolic rate. A practical guide to its calculation, use and limitations","volume":"24","author":"Black","year":"2000","journal-title":"Int. J. Obes. Relat. Metab. Disord J. Int. Assoc. Study Obes."},{"key":"10.1016\/j.ajcnut.2026.101462_bib31","series-title":"USDA Food Composition Tables - FoodData Central Version 10.0 [Internet]","year":"2023"},{"key":"10.1016\/j.ajcnut.2026.101462_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98496-6","article-title":"Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Sant\u00e9 cohort","volume":"11","author":"Chazelas","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ajcnut.2026.101462_bib33","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/ije\/dyr213","article-title":"Competing risks in epidemiology: possibilities and pitfalls","volume":"41","author":"Andersen","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.ajcnut.2026.101462_bib34","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/EDE.0000000000000457","article-title":"Sensitivity analysis without assumptions","volume":"27","author":"Ding","year":"2016","journal-title":"Epidemiology"},{"key":"10.1016\/j.ajcnut.2026.101462_bib35","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/sim.3841","article-title":"Dose-response analyses using restricted cubic spline functions in public health research","volume":"29","author":"Desquilbet","year":"2010","journal-title":"Stat. Med."},{"key":"10.1016\/j.ajcnut.2026.101462_bib36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000494778","article-title":"Review of glutamate intake from both food additive and non-additive sources in the European Union","volume":"73","author":"Tennant","year":"2018","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.ajcnut.2026.101462_bib37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/CIRCULATIONAHA.108.839241","article-title":"Glutamic acid, the main dietary amino acid, and blood pressure: the INTERMAP Study (International Collaborative Study of Macronutrients, Micronutrients and blood pressure)","volume":"120","author":"Stamler","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ajcnut.2026.101462_bib38","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.3390\/nu15112444","article-title":"Monosodium glutamate intake and risk assessment in China nationwide, and a comparative analysis worldwide","volume":"15","author":"Yu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ajcnut.2026.101462_bib39","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003755","article-title":"Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvenci\u00f3n con DIeta MEDiterr\u00e1nea (PREDIMED) trial","volume":"5","author":"Zheng","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ajcnut.2026.101462_bib40","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1210\/jc.2018-00546","article-title":"Altered asparagine and glutamate homeostasis precede coronary artery disease and type 2 diabetes","volume":"103","author":"Ottosson","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ajcnut.2026.101462_bib41","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.033201","article-title":"Associations of plasma metabolites with risks of incident stroke and its subtypes in Chinese adults","volume":"13","author":"Niu","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ajcnut.2026.101462_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/HYPERTENSIONAHA.119.14240","article-title":"High blood pressure and cardiovascular disease","volume":"75","author":"Fuchs","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.ajcnut.2026.101462_bib43","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000032726","article-title":"The low glutamate diet reduces blood pressure in veterans with Gulf War Illness: A CONSORT randomized clinical trial","volume":"102","author":"Fiebel","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ajcnut.2026.101462_bib44","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/HJH.0b013e328344da8e","article-title":"Monosodium glutamate is related to a higher increase in blood pressure over 5 years: findings from the Jiangsu nutrition study of Chinese adults","volume":"29","author":"Shi","year":"2011","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ajcnut.2026.101462_bib45","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3945\/ajcn.110.008870","article-title":"Consumption of monosodium glutamate in relation to incidence of overweight in Chinese adults: China health and nutrition survey (CHNS)","volume":"93","author":"He","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib46","series-title":"Biochemistry, glutamate. StatPearls. [Internet] Treasure Island (FL)","author":"Stallard","year":"2024"},{"key":"10.1016\/j.ajcnut.2026.101462_bib47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbpa.2015.06.015","article-title":"The neurotransmitters serotonin and glutamate accelerate the heart rate of the mosquito Anopheles gambiae","volume":"188","author":"Hillyer","year":"2015","journal-title":"Comp. Biochem. Physiol. A. Mol. Integr. Physiol."},{"key":"10.1016\/j.ajcnut.2026.101462_bib48","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s11248-012-9680-5","article-title":"Glutamate transporter type 3 knockout leads to decreased heart rate possibly via parasympathetic mechanism","volume":"22","author":"Deng","year":"2013","journal-title":"Transgenic Res"},{"key":"10.1016\/j.ajcnut.2026.101462_bib49","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41422-022-00693-z","article-title":"Glutamate drives \u2018local Ca2+ release\u2019 in cardiac pacemaker cells","volume":"32","author":"Xie","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.ajcnut.2026.101462_bib50","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF02893040","article-title":"Alteration in some antioxidant enzymes in cardiac tissue upon monosodium glutamate [MSG] administration to adult male mice","volume":"20","author":"Singh","year":"2005","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.ajcnut.2026.101462_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10942912.2017.1295260","article-title":"Monosodium glutamate: Review on clinical reports","volume":"20","author":"Kazmi","year":"2017","journal-title":"Int. J. Food Prop."},{"key":"10.1016\/j.ajcnut.2026.101462_bib52","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/ajcn\/70.4.484","article-title":"Determination of glutamine in muscle protein facilitates accurate assessment of proteolysis and de novo synthesis\u2013derived endogenous glutamine production","volume":"70","author":"Kuhn","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib53","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1021\/jf950511i","article-title":"Quantitative analyses of glutamine in peptides and proteins","volume":"44","author":"Kuhn","year":"1996","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ajcnut.2026.101462_bib54","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/ejcn.2009.110","article-title":"Evaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing data","volume":"63","author":"Lenders","year":"2009","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101462_bib55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s40471-020-00241-6","article-title":"Selection mechanisms and their consequences: Understanding and addressing Selection bias","volume":"7","author":"Smith","year":"2020","journal-title":"Curr. Epidemiol. Rep."},{"key":"10.1016\/j.ajcnut.2026.101462_bib56","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/aje\/kww016","article-title":"Comparison of dietary intakes between a large online cohort study (Etude NutriNet-Sant\u00e9) and a Nationally Representative Cross-Sectional Study (Etude Nationale Nutrition Sant\u00e9) in France: Addressing the issue of generalizability in E-epidemiology","volume":"184","author":"Andreeva","year":"2016","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ajcnut.2026.101462_bib57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.numecd.2021.09.012","article-title":"Evaluation of protein and amino acid intake estimates from the EPIC dietary questionnaires and 24-h dietary recalls using different food composition databases","volume":"32","author":"Iguacel","year":"2022","journal-title":"Nutr. Metab. Cardiovasc. Dis."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916526002716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916526002716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:37:23Z","timestamp":1792769843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916526002716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0002916526002716"],"URL":"https:\/\/doi.org\/10.1016\/j.ajcnut.2026.101462","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Food additive and naturally occurring glutamate and risk of cardiovascular diseases in the NutriNet-Sant\u00e9 prospective cohort","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajcnut.2026.101462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101462"}}