{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:39:09Z","timestamp":1772573949523,"version":"3.50.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0069\/2020"],"award-info":[{"award-number":["LA\/P\/0069\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/124200\/2016"],"award-info":[{"award-number":["SFRH\/BD\/124200\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04292\/2020"],"award-info":[{"award-number":["UIDB\/04292\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04292\/2020"],"award-info":[{"award-number":["UIDP\/04292\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.aquatox.2022.106300","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T01:14:09Z","timestamp":1663463649000},"page":"106300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Are tolerance processes limiting the responses of Hediste diversicolor to cadmium exposure? A multimarker approach"],"prefix":"10.1016","volume":"252","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-5243","authenticated-orcid":false,"given":"Carmen A.","family":"Pedro","sequence":"first","affiliation":[]},{"given":"Catarina S.","family":"Bruno","sequence":"additional","affiliation":[]},{"given":"Monique S.","family":"Sarly","sequence":"additional","affiliation":[]},{"given":"Gabriela","family":"Meireles","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-6449","authenticated-orcid":false,"given":"Ariana","family":"Moutinho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1306-3396","authenticated-orcid":false,"given":"Sara C.","family":"Novais","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o C.","family":"Marques","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1970-0181","authenticated-orcid":false,"given":"S\u00edlvia C.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2022.106300_bib0001","series-title":"Standard Guide for Conducting Acute, Chronic, and Life-Cycle aquatic Toxicity Tests With Polychaetous, Annelids","year":"2013"},{"key":"10.1016\/j.aquatox.2022.106300_bib0002","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00244-003-0135-0","article-title":"Accumulation and soluble binding of cadmium, copper and zinc in the polychaete Hediste diversicolor from coastal sites with different trace metal bioavailabilities","volume":"45","author":"Berthet","year":"2003","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2022.106300_bib0003","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0076-6879(84)05038-2","article-title":"Comparative studies on different methods of malonaldehyde determination","volume":"105","author":"Bird","year":"1984","journal-title":"Meth. Enzymol."},{"issue":"5","key":"10.1016\/j.aquatox.2022.106300_bib0004","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/etc.5620150528","article-title":"DNA strand breakage in freshwater mussels (Anodonta grandis) exposed to lead in the laboratory and field","volume":"15","author":"Black","year":"1996","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2022.106300_bib0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10807030802614934","article-title":"Effects of copper on the burrowing behavior of estuarine and coastal invertebrates, the polychaete Nereis diversicolor and the bivalve Scrobicularia plana","volume":"15","author":"Bonnard","year":"2009","journal-title":"Human Ecol. Risk Ass."},{"issue":"3","key":"10.1016\/j.aquatox.2022.106300_bib0006","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/eesa.2000.1919","article-title":"Toxic effects and bioaccumulation of cadmium in the aquatic oligochaete Tubifex tubifex","volume":"46","author":"Bouch\u00e9","year":"2000","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2022.106300_bib0007","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.aquatox.2022.106300_bib0008","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.chemosphere.2011.02.003","article-title":"Behavioural and biochemical responses of two marine invertebrates Scrobicularia plana and Hediste diversicolor to copper oxide nanoparticles","volume":"84","author":"Buffet","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2022.106300_bib0009","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.chemosphere.2013.12.069","article-title":"Biochemical and behavioural responses of the marine polychaete Hediste diversicolor to cadmium sulphide quantum dots (CdS QDs): waterborne and dietary exposure","volume":"100","author":"Buffet","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2022.106300_bib0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ecolind.2005.02.001","article-title":"Assessing heavy metal contamination in Sado Estuary sediment: an \u00edndex analysis approach","volume":"5","author":"Caeiro","year":"2005","journal-title":"Ecol. Indic."},{"key":"10.1016\/j.aquatox.2022.106300_bib0011","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2307\/2389587","article-title":"A physiological basis of population processes: ecotoxicological implications","volume":"4","author":"Calow","year":"1990","journal-title":"Funct. Ecol."},{"key":"10.1016\/j.aquatox.2022.106300_bib0012","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ecoenv.2017.11.048","article-title":"Toxicological responses of Laeonereis acuta (Polychaeta, Nereididae) after acute, Subchronic and chronic exposure to cadmium","volume":"149","author":"Carricavur","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2022.106300_bib0013","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.chemosphere.2011.10.040","article-title":"Can Hediste diversicolor (Nereidae, Polychaete) be considered a good candidate in evaluating PAH contamination? A multimarker approach","volume":"86","author":"Catalano","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2022.106300_bib0014","series-title":"CRC Handbook of Methods for Oxygen Radical Research","article-title":"Catalase activity","author":"Clairborne","year":"1985"},{"issue":"8","key":"10.1016\/j.aquatox.2022.106300_bib0015","doi-asserted-by":"crossref","first-page":"7752","DOI":"10.1007\/s11356-018-04113-x","article-title":"Effects of cadmium exposure on antioxidant enzymes and histological changes in the mud shrimp Austinogebia edulis (Crustacea: decapoda)","volume":"26","author":"Das","year":"2019","journal-title":"Environ. Sci. Pol. Res."},{"key":"10.1016\/j.aquatox.2022.106300_bib0016","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1008228517955","article-title":"The use of biomarkers in Daphnia magna toxicity testing. IV. Cellular energy allocation: a new methodology to assess the energy budget of toxicant-stressed Daphnia populations","volume":"6","author":"De Coen","year":"1997","journal-title":"J. Aquat. Ecosyst. Stress Recov."},{"key":"10.1016\/j.aquatox.2022.106300_bib0017","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0166-445X(99)00094-6","article-title":"Biomarkers in zebra mussels (Dreissena polymorpha) for the assessment and monitoring of water quality of St Lawrence River (Canada)","volume":"50","author":"De LaFontaine","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2022.106300_bib0018","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.envres.2016.12.018","article-title":"Physiological and biochemical responses of two keystone polychaete species: dioppatra neopolitana and Hediste diversicolor to Multi-walled carbon nanotubes","volume":"154","author":"De Marchi","year":"2017","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.aquatox.2022.106300_bib0019","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1007\/s11356-013-2169-9","article-title":"The integrated biomarker response revisited: optimization to avoid misuse","volume":"21","author":"Devin","year":"2014","journal-title":"Environ. Sci. Pol. Res."},{"key":"10.1016\/j.aquatox.2022.106300_bib0020","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0045-6535(01)00029-7","article-title":"Lactate dehydrogenase activity as an effect criterion in toxicity tests with Daphnia magna straus","volume":"45","author":"Diamantino","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2022.106300_bib0021","unstructured":"Directive 2013\/39\/EU of the European Parliament and of the Council of 12 August 2013. On environmental quality standards in the field of water policy, amending Directives 2000\/60\/EC and 2008\/105\/EC of the European Parliament and of the Council. L.226 (24.08.2013), 1\u201316."},{"key":"10.1016\/j.aquatox.2022.106300_bib0022","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/j.watres.2007.11.028","article-title":"Environmental quality assessment in estuarine ecosystems: use of biometric measurements and fecundity of the ragworm Nereis diversicolor (Polychaete, Nereididae)","volume":"42","author":"Durou","year":"2008","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2022.106300_bib0023","series-title":"Eisler's Encyclopedia of Environmentally Hazardous Priority Chemicals","author":"Eisler","year":"2007"},{"issue":"1\u20136","key":"10.1016\/j.aquatox.2022.106300_bib0024","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0009-9120(71)91363-4","article-title":"An improved manual and semi-automatic assay for NADP-dependent isocitrate dehydrogenase activity, with a description of some kinetic properties of human liver and serum enzyme","volume":"4","author":"Ellis","year":"1971","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.aquatox.2022.106300_bib0025","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.scitotenv.2017.04.005","article-title":"Physiological and biochemical impacts induced by Mercury pollution and seawater acidification in Hediste diversicolor","volume":"595","author":"Freitas","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2022.106300_bib0026","series-title":"Metal Pollution in Aquatic Environment","first-page":"30","author":"F\u00f6rstner","year":"1983"},{"key":"10.1016\/j.aquatox.2022.106300_bib60","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.marpolbul.2005.08.003","article-title":"Polychaetes as environmental indicators revisited","volume":"50","author":"Giangrande","year":"2005","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.aquatox.2022.106300_bib0027","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3989\/scimar.03731.27F","article-title":"Biomarkers in Nereis diversicolor (Polychaeta: nereididae) as management tools for environmental assessment on the southwest Iberian coast","volume":"77","author":"Gomes","year":"2013","journal-title":"Sci. Mar."},{"key":"10.1016\/j.aquatox.2022.106300_bib0028","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3354\/meps08239","article-title":"Assessment of the health status of populations of the ragworm Nereis diversicolor using biomarkers at different levels of biological organisation","volume":"393","author":"Kalman","year":"2009","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.aquatox.2022.106300_bib0029","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s10021-001-0021-4","article-title":"The function of marine critical transition zones and the importance of sediment biodiversity","volume":"4","author":"Levin","year":"2001","journal-title":"Ecosystems"},{"key":"10.1016\/j.aquatox.2022.106300_bib0030","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.chemosphere.2006.07.057","article-title":"Biochemical responses of the marine mussel Mytilus galloprovincialis to petrochemical environmental contamination along the North-western coast of Portugal","volume":"66","author":"Lima","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2022.106300_bib0031","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ecoenv.2018.11.098","article-title":"Dose-dependent effects induced by cadmium in polychaetes Perinereis ibuhitensis","volume":"169","author":"Liu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"22","key":"10.1016\/j.aquatox.2022.106300_bib0032","first-page":"49","article-title":"Superoxide dismutase, an enzymatic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.aquatox.2022.106300_bib0033","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.marpolbul.2019.03.026","article-title":"Is there a link between acetylcholinesterase, behaviour and density populations of the ragworm Hediste diversicolor?","volume":"142","author":"M\u00e9tais","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.aquatox.2022.106300_bib0034","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.chemosphere.2018.12.064","article-title":"Biological responses of the polychaete Hediste diversicolor (O.F.M\u00fcller, 1776) to inorganic Mercury exposure: a multimarker approach","volume":"219","author":"Moltedo","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2022.106300_bib0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.aquatox.2006.03.001","article-title":"Effects of estuarine sediment contamination on feeding and on key physiological functions of the polychaete Hediste diversicolor: laboratory and in situ assays","volume":"78","author":"Moreira","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2022.106300_bib0036","doi-asserted-by":"crossref","unstructured":"Mouneyrac, C., Mastain, O., Amiard, J.C., Amiard-Triquet, C., Beaunier, P., Jeantet, A.-.Y., Smith, B.D., Rainbow, P.S., 2003. Trace-metal detoxification and tolerance of the estuarine worm Hediste diversicolor chronically exposed in their environment. 143, 731\u2013744. DOI 10.1007\/s00227-003-1124-6.","DOI":"10.1007\/s00227-003-1124-6"},{"key":"10.1016\/j.aquatox.2022.106300_bib0037","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.envpol.2009.07.028","article-title":"Influence of anthropogenic stress on fitness and behaviour of a key-species of estuarine ecosystems, the ragworm Nereis diversicolor","volume":"158","author":"Mouneyrac","year":"2010","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.aquatox.2022.106300_bib61","unstructured":"O. F. Muller, 1776 is the zoological authority of the species name."},{"key":"10.1016\/j.aquatox.2022.106300_bib0038","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by Thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.aquatox.2022.106300_bib0039","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/em.2850110409","article-title":"DNA precipitation assay: a rapid and simple method for detecting DNA damage in mammalian cells","volume":"11","author":"Olive","year":"1988","journal-title":"Environ. Mol. Mutagen."},{"issue":"12","key":"10.1016\/j.aquatox.2022.106300_bib0040","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1897\/02-474","article-title":"Biotransformation and genotoxicity of fluoranthene in the deposit-feeding polychaete Capitella sp. I","volume":"22","author":"Palmqvist","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"issue":"2","key":"10.1016\/j.aquatox.2022.106300_bib0041","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1081\/ESE-200045539","article-title":"Seasonal variation of surface sediments composition in Mondego River Estuary","volume":"40","author":"Pereira","year":"2005","journal-title":"J. Environ. Sci. Health, Part A"},{"key":"10.1016\/j.aquatox.2022.106300_bib0042","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10661-008-0355-x","article-title":"Spatial and seasonal variation of water quality in an impacted coastal lagoon (\u00d3bidos Lagoon, Portugal)","volume":"153","author":"Pereira","year":"2009","journal-title":"Environ. Monit. Assess"},{"key":"10.1016\/j.aquatox.2022.106300_bib0043","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.marpolbul.2009.02.003","article-title":"The metabolic and fitness costs associated with metal resistance in Nereis diversicolor","volume":"58","author":"Pook","year":"2009","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.aquatox.2022.106300_bib0044","first-page":"3676","article-title":"establishing standards, criteria and quality objectives in order to protect the aquatic environment and improve the water quality, according to its main applications","volume":"176","year":"1998","journal-title":"J. Oficial da Rep\u00fablica Portuguesa, Di\u00e1rio da Rep\u00fablica,"},{"key":"10.1016\/j.aquatox.2022.106300_bib0045","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.aquatox.2016.09.017","article-title":"Enzymatic biomarkers can portray nanoCuO-induced oxidative and neuronal stress in freshwater shredders","volume":"180","author":"Pradhan","year":"2016","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.aquatox.2022.106300_bib0046","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0166-445X(01)00192-8","article-title":"Effects of cadmium on nuclear integrity and DNA repair efficiency in the gill cells of Mytilus edulis L","volume":"57","author":"Pruski","year":"2002","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2022.106300_bib0047","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1015681605656","article-title":"A review of the biology, ecology and potential use of the common ragworm Hediste diversicolor (O.F. M\u00fcller) (Annelida: polychaeta)","volume":"470","author":"Scaps","year":"2002","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.aquatox.2022.106300_bib0048","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.aquatox.2004.03.016","article-title":"The effects of environmental pollutants on complex fish behaviour: integrating behavioural and physiological indicators of toxicity","volume":"68","author":"Scott","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2022.106300_bib0049","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.scitotenv.2016.04.091","article-title":"Effects of ocean acidification on the swimming ability, development and biochemical responses of sand smelt larvae","volume":"563-564","author":"Silva","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2022.106300_bib0050","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0025-326X(02)00142-X","article-title":"Oxidative stress in the mussel Mytella guanensis from polluted mangroves on Santa Catarina Island, Brazil","volume":"44","author":"Torres","year":"2002","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.aquatox.2022.106300_bib0051","series-title":"Experiments in Ecology: Their Logical Design and Interpretation Using Analysis of Variance","first-page":"503","author":"Underwood","year":"1997"},{"key":"10.1016\/j.aquatox.2022.106300_bib0052","series-title":"2001 Uptake of Ambient Water Quality Criteria For Cadmium","year":"2001"},{"key":"10.1016\/j.aquatox.2022.106300_bib0053","series-title":"Aquatic Ecology of the Mondego River Basin: Global Importance of Local Experience","first-page":"541","article-title":"Elemental composition and contaminants in surface sediments of the Mondego river estuary","author":"Vale","year":"2002"},{"issue":"1","key":"10.1016\/j.aquatox.2022.106300_bib0054","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3989\/scimar.2011.75n1155","article-title":"Trace metals (Cu, Zn, Cd and Pb) in juvenile fish from estuarine nurseries along the portuguese coast","volume":"75","author":"Vasconcelos","year":"2011","journal-title":"Sci. Mar."},{"key":"10.1016\/j.aquatox.2022.106300_bib0055","series-title":"Methods of Enzymatic Analysis","first-page":"118","author":"Vassault","year":"1983"},{"key":"10.1016\/j.aquatox.2022.106300_bib0056","article-title":"Monitoring metal pollution on coastal lagoons using Cerastoderma edule \u2013 a report from a moderately impacted system in Western Portugal (\u00d3bidos Lagoon)","volume":"26","author":"Veiga","year":"2018","journal-title":"Environ. Sci. Pol. Res."},{"key":"10.1016\/j.aquatox.2022.106300_bib0057","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ecoenv.2005.01.008","article-title":"Influence of metal exposure history on trace metal uptake and accumulation by marine invertebrates","volume":"61","author":"Wang","year":"2005","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2022.106300_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105674","article-title":"Detecting the effects of chronic metal exposure on benthic systems: importance of biomarker and endpoint selection","volume":"230","author":"Watson","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2022.106300_bib0059","first-page":"344","article-title":"Susceptibility to oxidative stress and modulated expression of antioxidant genes in the copper-exposed polychaete Perinereis Nuntia","volume":"155","author":"Won","year":"2012","journal-title":"Comp. Biochem. Physiol. Part C"}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X22002260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X22002260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T14:03:42Z","timestamp":1759068222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X22002260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":61,"alternative-id":["S0166445X22002260"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2022.106300","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are tolerance processes limiting the responses of Hediste diversicolor to cadmium exposure? A multimarker approach","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2022.106300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106300"}}