{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:00:50Z","timestamp":1777492850194,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.aquatox.2024.107221","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T23:57:13Z","timestamp":1735257433000},"page":"107221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Direct and transgenerational effects of simvastatin on the metabolism of the amphipod Gammarus locusta"],"prefix":"10.1016","volume":"279","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-5410","authenticated-orcid":false,"given":"Jo\u00e3o A.","family":"Rodrigues","sequence":"first","affiliation":[]},{"given":"Raquel S.","family":"Chaves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-0546","authenticated-orcid":false,"given":"Miguel M.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Teresa","family":"Neuparth","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-4364","authenticated-orcid":false,"given":"Ana M.","family":"Gil","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2024.107221_bib0001","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.marpolbul.2016.03.054","article-title":"Metabolic responses of clams, Ruditapes decussatus and Ruditapes philippinarum, to short-term exposure to lead and zinc","volume":"107","author":"Aru","year":"2016","journal-title":"Mar. Poll. Bull."},{"key":"10.1016\/j.aquatox.2024.107221_bib0002","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/cem.785","article-title":"Partial least squares for discrimination","volume":"17","author":"Barker","year":"2003","journal-title":"J. Chemom."},{"key":"10.1016\/j.aquatox.2024.107221_bib0003","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.aquatox.2018.05.014","article-title":"Chronic environmentally relevant levels of simvastatin disrupt embryonic development, biochemical and molecular responses in zebrafish (Danio rerio)","volume":"201","author":"Barros","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0004","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Series B Stat. Methodol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0005","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.ijnurstu.2012.01.015","article-title":"Effect size estimation: methods and examples","volume":"49","author":"Berben","year":"2012","journal-title":"Int. J. Nurs. Stud."},{"key":"10.1016\/j.aquatox.2024.107221_bib0006","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1038\/srep09303","article-title":"Transgenerational effects from early developmental exposures to bisphenol A or 17\u03b1-ethinylestradiol in medaka","volume":"5","author":"Bhandari","year":"2015","journal-title":"Oryzias latipes. Sci. Rep"},{"key":"10.1016\/j.aquatox.2024.107221_bib0007","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3390\/ani13050792","article-title":"Elucidating the effects of the lipids regulators fibrates and statins on the health status of finfish species: a Review","volume":"13","author":"Blon\u00e7","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.aquatox.2024.107221_bib0008","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.talanta.2019.04.028","article-title":"Untargeted analysis of nanoLC-HRMS data by ANOVA-PCA to highlight metabolites in Gammarus fossarum after in vivo exposure to pharmaceuticals","volume":"202","author":"Bonnefoy","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.aquatox.2024.107221_bib0009","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0895-4356(98)00168-1","article-title":"Increasing physicians\u2019 awareness of the impact of statistics on research utcomes: comparative power of the t-test and Wilcoxon rank-sum test in small samples applied research","volume":"52","author":"Bridge","year":"1999","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.plipres.2011.07.002","article-title":"Regulation of HMG-CoA reductase in mammals and yeast","volume":"50","author":"Burg","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.aquatox.2024.107221_bib0011","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cbpa.2014.02.009","article-title":"Tolerance of Venerupis philippinarum to salinity: osmotic and metabolic aspects","volume":"171","author":"Carregosa","year":"2014","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"issue":"4","key":"10.1016\/j.aquatox.2024.107221_bib0012","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a040584","article-title":"Amino acid metabolism","volume":"13","author":"Chandel","year":"2021","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0013","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.marpolbul.2017.02.067","article-title":"NMR-based metabolomics for the environmental assessment of Kaohsiung Harbor sediments exemplified by a marine amphipod (Hyalella azteca)","volume":"124","author":"Chiu","year":"2017","journal-title":"Mar. Poll. Bull."},{"key":"10.1016\/j.aquatox.2024.107221_bib0014","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/ac048630x","article-title":"Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets","volume":"77","author":"Cloarec","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aquatox.2024.107221_bib0015","doi-asserted-by":"crossref","first-page":"10615","DOI":"10.1007\/s11356-016-6547-y","article-title":"Simvastatin effects on detoxification mechanisms in Danio rerio embryos","volume":"23","author":"Cunha","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.aquatox.2024.107221_bib0016","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1368-504X.2004.00391.x","article-title":"Cardioprotective and other emerging effects of statins","volume":"58","author":"Davignon","year":"2004","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.aquatox.2024.107221_bib0017","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41398-023-02533-z","article-title":"The pharmacological bases for repurposing statins in depression: a review of mechanistic studies","volume":"13","author":"De Giorgi","year":"2023","journal-title":"Transl. Psychiat."},{"key":"10.1016\/j.aquatox.2024.107221_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dsr.2018.05.008","article-title":"Organic osmolytes of amphipods from littoral to hadal zones: increases with depth in trimethylamine N-oxide, scyllo-inositol and other potential pressure counteractants","volume":"138","author":"Downing","year":"2018","journal-title":"Deep Sea Res. Part I: Oceanographic Research Papers"},{"key":"10.1016\/j.aquatox.2024.107221_bib0019","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","article-title":"Ecotoxicology of human pharmaceuticals","volume":"76","author":"Fent","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0020","doi-asserted-by":"crossref","first-page":"1539S","DOI":"10.1093\/jn\/137.6.1539S","article-title":"Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain","volume":"137","author":"Fernstrom","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.aquatox.2024.107221_bib0021","doi-asserted-by":"crossref","first-page":"12734","DOI":"10.1021\/acs.est.9b03393","article-title":"Paternal exposure to carbamazepine impacts zebrafish offspring reproduction over multiple generations","volume":"53","author":"Fraz","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0022","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1021\/es062745w","article-title":"Direct sampling of organisms from the field and knowledge of their phenotype:\u2009 Key recommendations for environmental metabolomics","volume":"41","author":"Hines","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0023","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ibmb.2009.01.008","article-title":"The molecular mechanisms of cuticular melanization: the ecdysone cascade leading to dopa decarboxylase expression in Manduca sexta","volume":"39","author":"Hiruma","year":"2009","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0024","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.marpolbul.2016.02.052","article-title":"Impact of metal pollution on shrimp Crangon affinis by NMR-based metabolomics","volume":"106","author":"Ji","year":"2016","journal-title":"Mar. Poll. Bull."},{"key":"10.1016\/j.aquatox.2024.107221_bib0025","series-title":"Principal Component Analysis","author":"Jolliffe","year":"2002"},{"key":"10.1016\/j.aquatox.2024.107221_bib0026","doi-asserted-by":"crossref","first-page":"26293","DOI":"10.1007\/s11356-019-05890-9","article-title":"Persistent and transgenerational effects of risperidone in zebrafish","volume":"26","author":"Kalichak","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.aquatox.2024.107221_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148484","article-title":"Effect of seasonal variation on the occurrences of high-risk pharmaceutical in drain-laden surface water: a risk analysis of Yamuna River","volume":"794","author":"Khan","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2024.107221_bib0028","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.psep.2021.04.045","article-title":"Occurrence and removal of pharmaceuticals in wastewater treatment plants","volume":"150","author":"Khasawneh","year":"2021","journal-title":"Process Saf. Environ. Prot."},{"key":"10.1016\/j.aquatox.2024.107221_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105816","article-title":"Co-expression network analysis identifies novel molecular pathways associated with cadmium and pyriproxyfen testicular toxicity in Gammarus fossarum","volume":"235","author":"Koenig","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0030","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ecoenv.2018.12.008","article-title":"The concentration of dissolved organic matter impacts the metabolic response in Daphnia magna exposed to 17\u03b1-ethynylestradiol and perfluorooctane sulfonate","volume":"170","author":"Kovacevic","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2024.107221_bib0031","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front. Psychol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0032","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1039\/C0EM00342E","article-title":"Input of selected human pharmaceutical metabolites into the Norwegian aquatic environment","volume":"13","author":"Langford","year":"2011","journal-title":"J. Environ. Monitor."},{"key":"10.1016\/j.aquatox.2024.107221_bib0033","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pharmthera.2018.10.004","article-title":"Statins: adverse reactions, oxidative stress and metabolic interactions","volume":"195","author":"Liu","year":"2019","journal-title":"Pharmacol. Therapeut"},{"key":"10.1016\/j.aquatox.2024.107221_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109389","article-title":"Simvastatin affect the expression of detoxification-related genes and enzymes in Daphnia magna and alter its life history parameters","volume":"182","author":"Liu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2024.107221_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2019.110688","article-title":"Evaluation of metal pollution-induced biological effects in Chinese shrimp Fenneropenaeus chinensis by NMR-based metabolomics","volume":"150","author":"Lu","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.aquatox.2024.107221_bib0036","series-title":"Comprehensive Natural Products II","first-page":"127","article-title":"Insect Hormones","author":"Morgan","year":"2010"},{"key":"10.1016\/j.aquatox.2024.107221_bib0037","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.aquatox.2015.11.023","article-title":"Metabolomics reveals energetic impairments in Daphnia magna exposed to diazinon, malathion and bisphenol-A","volume":"170","author":"Nagato","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106095","article-title":"Neuroendocrine pathways at risk? Simvastatin induces inter and transgenerational disruption in the keystone amphipod Gammarus locusta","volume":"244","author":"Neuparth","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106020","article-title":"Transgenerational inheritance of chemical-induced signature: a case study with simvastatin","volume":"144","author":"Neuparth","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.aquatox.2024.107221_bib0040","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.aquatox.2014.07.009","article-title":"Hypocholesterolaemic pharmaceutical simvastatin disrupts reproduction and population growth of the amphipod Gammarus locusta at the ng\/L range","volume":"155","author":"Neuparth","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2024.107221_bib0041","series-title":"Guidance Document On Aquatic Toxicity Testing of Difficult Substances and mixtures, OECD Series on Testing and Assessment","year":"2019"},{"key":"10.1016\/j.aquatox.2024.107221_bib0042","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4093\/dmj.2016.40.5.376","article-title":"Statins increase mitochondrial and peroxisomal fatty acid oxidation in the liver and prevent non-alcoholic steatohepatitis in mice","volume":"40","author":"Park","year":"2016","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.aquatox.2024.107221_bib0043","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1021\/acs.chemrev.8b00299","article-title":"Pharmaceuticals of emerging concern in aquatic systems: chemistry, occurrence, effects, and removal methods","volume":"119","author":"Patel","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.aquatox.2024.107221_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fenvs.2022.1077974","article-title":"Minimizing the environmental impact of unused pharmaceuticals: review focused on prevention","volume":"10","author":"Paut Kusturica","year":"2022","journal-title":"Front. Environ. Sci."},{"key":"10.1016\/j.aquatox.2024.107221_bib0045","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.envres.2014.09.041","article-title":"Environmental impact of pharmaceuticals from Portuguese wastewaters: geographical and seasonal occurrence, removal and risk assessment","volume":"136","author":"Pereira","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.aquatox.2024.107221_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162898","article-title":"The influence of temperature rise on the metabolic response of Ruditapes philippinarum clams to 17-\u03b1-ethinylestradiol","volume":"877","author":"Rodrigues","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2024.107221_bib0047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2016.02.001","article-title":"Statins: an undesirable class of aquatic contaminants?","volume":"174","author":"Santos","year":"2016","journal-title":"Aquat. Toxicol."},{"issue":"17","key":"10.1016\/j.aquatox.2024.107221_bib0048","doi-asserted-by":"crossref","first-page":"9433","DOI":"10.1021\/acs.est.7b01094","article-title":"Incorporating transgenerational epigenetic inheritance into ecological risk assessment frameworks","volume":"51","author":"Shaw","year":"2017","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.aquatox.2024.107221_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127479","article-title":"Untargeted metabolomics changes on Gammarus pulex induced by propranolol, triclosan, and nimesulide pharmaceutical drugs","volume":"260","author":"Sheikholeslami","year":"2020","journal-title":"Chemosphere"},{"issue":"12","key":"10.1016\/j.aquatox.2024.107221_bib0050","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3390\/metabo11120835","article-title":"Which role plays 2-Hydroxybutyric acid on insulin resistance?","volume":"11","author":"Sousa","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.aquatox.2024.107221_bib0051","doi-asserted-by":"crossref","first-page":"12237","DOI":"10.1007\/s11356-020-07834-0","article-title":"Investigation of antioxidant responses in Gammarus pulex exposed to Bisphenol A","volume":"27","author":"Tatar","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.aquatox.2024.107221_bib0052","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10482-015-0629-6","article-title":"The role of formate in combatting oxidative stress","volume":"109","author":"Thomas","year":"2016","journal-title":"Antonie van Leeuwenhoek"},{"key":"10.1016\/j.aquatox.2024.107221_bib0053","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1021\/ac8011544","article-title":"Recursive segment-wise peak alignment of biological 1H NMR spectra for improved metabolic biomarker recovery","volume":"81","author":"Veselkov","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aquatox.2024.107221_bib0054","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/etc.5620210230","article-title":"Population responses of the freshwater amphipod Gammarus pulex (L.) to an environmental estrogen, 17\u03b1-ethinylestradiol","volume":"21","author":"Watts","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2024.107221_bib0055","series-title":"ggplot2: Elegant graphics For Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.aquatox.2024.107221_bib0056","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: the human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.aquatox.2024.107221_bib0057","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1021\/acs.est.7b06494","article-title":"Omics advances in Ecotoxicology","volume":"52","author":"Zhang","year":"2018","journal-title":"Environ. Sci. Technol."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X24003904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X24003904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T13:50:18Z","timestamp":1739195418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X24003904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":57,"alternative-id":["S0166445X24003904"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2024.107221","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct and transgenerational effects of simvastatin on the metabolism of the amphipod Gammarus locusta","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2024.107221","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107221"}}