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Med."},{"key":"10.1016\/j.bbadis.2020.165887_bb0925","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1158\/0008-5472.CAN-09-2587","article-title":"Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine","volume":"70","author":"Srivastava","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2020.165887_bb0930","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nature12297","article-title":"mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function","volume":"499","author":"Zeng","year":"2013","journal-title":"Nature."},{"key":"10.1016\/j.bbadis.2020.165887_bb0935","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature11132","article-title":"PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells","volume":"486","author":"Cipolletta","year":"2012","journal-title":"Nature."},{"key":"10.1016\/j.bbadis.2020.165887_bb0940","doi-asserted-by":"crossref","first-page":"12055","DOI":"10.1073\/pnas.0903919106","article-title":"Infectious tolerance via the consumption of essential amino acids and mTOR signaling","volume":"106","author":"Cobbold","year":"2009","journal-title":"Proc. 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