{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:58:44Z","timestamp":1776347924589,"version":"3.51.2"},"reference-count":159,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018696","name":"HORIZON EUROPE Health","doi-asserted-by":"publisher","award":["101080329"],"award-info":[{"award-number":["101080329"]}],"id":[{"id":"10.13039\/100018696","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["UID\/04539\/2020"],"award-info":[{"award-number":["UID\/04539\/2020"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00070\/2020"],"award-info":[{"award-number":["UIDB\/00070\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00070\/2020"],"award-info":[{"award-number":["UIDP\/00070\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bbadis.2025.167803","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T21:58:43Z","timestamp":1742421523000},"page":"167803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Mitochondria: An overview of their origin, genome, architecture, and dynamics"],"prefix":"10.1016","volume":"1871","author":[{"given":"Jo\u00e3o P.","family":"Moura","sequence":"first","affiliation":[]},{"given":"Paulo J.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Ana M.","family":"Urbano","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.167803_bb0005","doi-asserted-by":"crossref","first-page":"9651","DOI":"10.1073\/pnas.93.18.9651","article-title":"A common evolutionary origin for mitochondria and hydrogenosomes","volume":"93","author":"Bui","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0010","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S1055-7903(03)00194-5","article-title":"Evolution of mitochondrial gene content: gene loss and transfer to the nucleus","volume":"29","author":"Adams","year":"2003","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0015","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0326","article-title":"Diversity and origins of anaerobic metabolism in mitochondria and related organelles","volume":"370","author":"Stairs","year":"2015","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0020","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/sj.embor.7400440","article-title":"Degenerate mitochondria","volume":"6","author":"van der Giezen","year":"2005","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbadis.2025.167803_bb0025","series-title":"The Cell","first-page":"410","article-title":"Chapter 7: Mitochondria","author":"Fawcett","year":"1981"},{"key":"10.1016\/j.bbadis.2025.167803_bb0030","series-title":"Molecular Biology of the Cell, Seventh International","author":"Alberts","year":"2022"},{"key":"10.1016\/j.bbadis.2025.167803_bb0035","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.cub.2016.03.053","article-title":"A eukaryote without a mitochondrial organelle","volume":"26","author":"Karnkowska","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0040","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011403","article-title":"Mitochondrial evolution","volume":"4","author":"Gray","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0045","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23908","article-title":"Mitochondrial flashes regulate ATP homeostasis in the heart","volume":"6","author":"Wang","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.bbadis.2025.167803_bb0050","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.32604\/biocell.2022.021033","article-title":"Mitochondria are an important target of photobiomodulation in cardiomyocytes","volume":"46","author":"Gao","year":"2022","journal-title":"Biocell"},{"key":"10.1016\/j.bbadis.2025.167803_bb0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1083\/jcb.42.1.68","article-title":"Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver","volume":"42","author":"Weibel","year":"1969","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.37.1.27","article-title":"A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells","volume":"37","author":"Loud","year":"1968","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0065","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jcp.1041360316","article-title":"Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells","volume":"136","author":"Robin","year":"1988","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0070","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fcell.2016.00085","article-title":"The evolution of per-cell organelle number","volume":"4","author":"Cole","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0075","series-title":"Mitochondrial Morphology and Function","first-page":"217","author":"Di Lisa","year":"2012"},{"key":"10.1016\/j.bbadis.2025.167803_bb0080","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/S0006-3495(94)80740-4","article-title":"Contribution of the mitochondrial compartment to the optical properties of the rat liver: a theoretical and practical approach","volume":"67","author":"Beauvoit","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbadis.2025.167803_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(08)61205-X","article-title":"Behavior of mitochondria in the living cell","volume":"122","author":"Bereiter-Hahn","year":"1990","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0090","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.neuron.2017.09.055","article-title":"Mitostasis in neurons: maintaining mitochondria in an extended cellular architecture","volume":"96","author":"Misgeld","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2025.167803_bb0095","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1073\/pnas.77.2.990","article-title":"Localization of mitochondria in living cells with rhodamine 123","volume":"77","author":"Johnson","year":"1980","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0100","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2014-05-573543","article-title":"Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation","volume":"124","author":"Boudreau","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2025.167803_bb0105","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1182\/blood-2016-03-705681","article-title":"Respective contributions of single and compound granule fusion to secretion by activated platelets","volume":"128","author":"Eckly","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2025.167803_bb0110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/rth2.12260","article-title":"3D ultrastructural analysis of \u03b1-granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets","volume":"4","author":"Pokrovskaya","year":"2020","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"10.1016\/j.bbadis.2025.167803_bb0115","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0012-1606(84)90210-0","article-title":"Maternal inheritance of the mouse mitochondrial genome is not mediated by a loss or gross alteration of the paternal mitochondrial DNA or by methylation of the oocyte mitochondrial DNA","volume":"102","author":"Hecht","year":"1984","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0120","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0014-4827(70)90526-4","article-title":"Considerations of volume, mass, DNA, and arrangement of mitochondria in the midpiece of bull spermatozoa","volume":"60","author":"Bahr","year":"1970","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2025.167803_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0012-1606(76)90253-0","article-title":"Number of mitochondria and some properties of mitochondrial DNA in the mouse egg","volume":"49","author":"Pik\u00f3","year":"1976","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0130","first-page":"239","article-title":"Rearranged mitochondrial genomes are present in human oocytes","volume":"57","author":"Chen","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbadis.2025.167803_bb0135","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0012-1606(82)90088-4","article-title":"Mitochondrial DNA copy number in bovine oocytes and somatic cells","volume":"94","author":"Michaels","year":"1982","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0070-2153(06)77004-1","article-title":"Mitochondrial DNA and the mammalian oocyte","volume":"77","author":"Shoubridge","year":"2007","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0303-7207(98)00173-7","article-title":"The bottleneck: mitochondrial imperatives in oogenesis and ovarian follicular fate","volume":"145","author":"Jansen","year":"1998","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0150","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.celrep.2019.01.010","article-title":"Quantitative 3D mapping of the human skeletal muscle mitochondrial network","volume":"26","author":"Vincent","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2025.167803_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165887","article-title":"Intermediary metabolism: an intricate network at the crossroads of cell fate and function","volume":"1866","author":"Ferreira","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.bbadis.2025.167803_bb0160","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/scientificamerican0757-131","article-title":"Powerhouse of the cell","volume":"197","author":"Siekevitz","year":"1957","journal-title":"Sci. Am."},{"key":"10.1016\/j.bbadis.2025.167803_bb0165","series-title":"Lehninger Principles of Biochemistry","author":"Nelson","year":"2021"},{"key":"10.1016\/j.bbadis.2025.167803_bb0170","series-title":"Biochemistry","author":"Berg","year":"2023"},{"key":"10.1016\/j.bbadis.2025.167803_bb0175","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41556-018-0124-1","article-title":"The multifaceted contributions of mitochondria to cellular metabolism","volume":"20","author":"Spinelli","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0180","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.plipres.2013.07.002","article-title":"Lipids of mitochondria","volume":"52","author":"Horvath","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbadis.2025.167803_bb0185","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature12985","article-title":"Mitochondrial form and function","volume":"505","author":"Friedman","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167803_bb0190","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1073\/pnas.95.20.11715","article-title":"Mitochondrial reactive oxygen species trigger hypoxia-induced transcription","volume":"95","author":"Chandel","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0195","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death","volume":"305","author":"Green","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167803_bb0200","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2025.167803_bb0205","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1469-185X.1966.tb01501.x","article-title":"Chemiosmotic coupling in oxidative and photosynthetic phosphorylation","volume":"41","author":"Mitchell","year":"1966","journal-title":"Biol. Rev."},{"key":"10.1016\/j.bbadis.2025.167803_bb0210","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2025.167803_bb0215","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35072063","article-title":"The genetics and pathology of oxidative phosphorylation","volume":"2","author":"Smeitink","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbadis.2025.167803_bb0220","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.tibs.2020.04.001","article-title":"Cytosolic events in the biogenesis of mitochondrial proteins","volume":"45","author":"Bykov","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0225","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev-physiol-021119-034405","article-title":"Mitochondrial H+ leak and thermogenesis","volume":"84","author":"Bertholet","year":"2022","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2025.167803_bb0235","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2016.04.001","article-title":"Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling","volume":"100","author":"Brand","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2025.167803_bb0240","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0245","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-nutr-111120-111518","article-title":"Metabolic and signaling roles of ketone bodies in health and disease","volume":"41","author":"Puchalska","year":"2021","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbadis.2025.167803_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40170-015-0128-2","article-title":"Mitochondria as biosynthetic factories for cancer proliferation","volume":"3","author":"Ahn","year":"2015","journal-title":"Cancer Metab."},{"key":"10.1016\/j.bbadis.2025.167803_bb0255","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1471-4159.2006.03913.x","article-title":"The glutamate\/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer","volume":"98","author":"Bak","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2025.167803_bb0260","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1515\/hsz-2020-0117","article-title":"From the discovery to molecular understanding of cellular iron-sulfur protein biogenesis","volume":"401","author":"Lill","year":"2020","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167803_bb0265","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/cells9030579","article-title":"From synthesis to utilization: the ins and outs of mitochondrial heme","volume":"9","author":"Swenson","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167803_bb0270","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2025.167803_bb0275","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm3412","article-title":"Mitochondria as sensors and regulators of calcium signalling","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0280","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","article-title":"The machineries, regulation and cellular functions of mitochondrial calcium","volume":"19","author":"Giorgi","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0285","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2025.167803_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41420-023-01581-0","article-title":"Different types of cell death and their shift in shaping disease","volume":"9","author":"Shen","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbadis.2025.167803_bb0295","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.ceb.2009.08.005","article-title":"Mitochondrial reactive oxygen species regulate hypoxic signaling","volume":"21","author":"Hamanaka","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0300","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mam.2016.01.002","article-title":"O2 sensing, mitochondria and ROS signaling: the fog is lifting","volume":"47\u201348","author":"Waypa","year":"2016","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbadis.2025.167803_bb0305","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s12276-023-00965-7","article-title":"Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167803_bb0310","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1016\/j.jmb.2013.10.007","article-title":"Mechanisms of MAVS regulation at the mitochondrial membrane","volume":"425","author":"Jacobs","year":"2013","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tcb.2019.11.001","article-title":"Nicotinamide nucleotide transhydrogenase as a sensor of mitochondrial biology","volume":"30","author":"Nesci","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0320","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.molcel.2016.01.031","article-title":"The emerging network of mitochondria-organelle contacts","volume":"61","author":"Murley","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2025.167803_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241813835","article-title":"Mitochondrial-derived vesicles: the good, the bad, and the ugly","volume":"24","author":"Picca","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0330","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrn.2017.170","article-title":"Mitochondria at the neuronal presynapse in health and disease","volume":"19","author":"Devine","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0335","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1113\/JP278853","article-title":"Exercise and mitochondrial health","volume":"599","author":"Memme","year":"2021","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0340","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1042\/bse0470085","article-title":"Mitochondrial fission and fusion","volume":"47","author":"Scott","year":"2010","journal-title":"Essays Biochem."},{"key":"10.1016\/j.bbadis.2025.167803_bb0345","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0350","doi-asserted-by":"crossref","first-page":"C689","DOI":"10.1152\/ajpcell.00108.2006","article-title":"Tissue heterogeneity of the mammalian mitochondrial proteome","volume":"292","author":"Johnson","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0355","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbabio.2004.07.011","article-title":"Shaping the mitochondrial proteome","volume":"1659","author":"Gabald\u00f3n","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2025.167803_bb0360","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0092-8674(03)00926-7","article-title":"Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria","volume":"115","author":"Mootha","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167803_bb0365","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.cmet.2021.11.001","article-title":"Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context","volume":"33","author":"Morgenstern","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2025.167803_bb0370","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1126\/science.283.5407.1482","article-title":"Mitochondrial diseases in man and mouse","volume":"283","author":"Wallace","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167803_bb0375","first-page":"1","article-title":"Mitochondrial dysfunction: mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2025.167803_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.166016","article-title":"Cancer cell metabolism: rewiring the mitochondrial hub","volume":"1867","author":"Oliveira","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.bbadis.2025.167803_bb0385","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/nrg3275","article-title":"Human mitochondrial DNA: roles of inherited and somatic mutations","volume":"13","author":"Schon","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbadis.2025.167803_bb0390","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nature11707","article-title":"Mitochondrial disorders as windows into an ancient organelle","volume":"491","author":"Vafai","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167803_bb0395","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrc3365","article-title":"Mitochondria and cancer","volume":"12","author":"Wallace","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2025.167803_bb0400","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJMra1012478","article-title":"Monogenic mitochondrial disorders","volume":"366","author":"Koopman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2025.167803_bb0405","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1098\/rstb.2002.1193","article-title":"On the origin of mitochondria: a genomics perspective","volume":"358","author":"Andersson","year":"2003","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0410","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s41586-023-06186-2","article-title":"Inference and reconstruction of the heimdallarchaeial ancestry of eukaryotes","volume":"618","author":"Eme","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167803_bb0415","doi-asserted-by":"crossref","first-page":"R1177","DOI":"10.1016\/j.cub.2017.09.015","article-title":"The origin and diversification of mitochondria","volume":"27","author":"Roger","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0420","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/326332a0","article-title":"Eukaryotes with no mitochondria","volume":"326","author":"Cavalier-Smith","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167803_bb0425","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1126\/science.285.5430.1033","article-title":"Archean molecular fossils and the early rise of eukaryotes","volume":"285","author":"Brocks","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167803_bb0430","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature14447","article-title":"Complex archaea that bridge the gap between prokaryotes and eukaryotes","volume":"521","author":"Spang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167803_bb0435","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/s41564-022-01215-8","article-title":"The cell biology of archaea","volume":"7","author":"Van Wolferen","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0440","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1126\/science.1127895","article-title":"Evolution of the molecular machines for protein import into mitochondria","volume":"313","author":"Dolezal","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167803_bb0445","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0966-842X(02)00033-1","article-title":"Converting bacteria to organelles: evolution of mitochondrial protein sorting","volume":"11","author":"Herrmann","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0450","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0014-5793(99)00783-8","article-title":"Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms","volume":"454","author":"Chandel","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2025.167803_bb0455","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0076-6879(96)64029-4","article-title":"Isolation of human cell lines lacking mitochondrial DNA","volume":"264","author":"King","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0460","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.trecan.2022.08.001","article-title":"Mitochondrial DNA is a major source of driver mutations in cancer","volume":"8","author":"Kim","year":"2022","journal-title":"Trends Cancer"},{"key":"10.1016\/j.bbadis.2025.167803_bb0465","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0074-7696(08)62066-5","article-title":"Animal mitochondrial DNA: structure and evolution","volume":"141","author":"Wolstenholme","year":"1992","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0470","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0005-2728(98)00161-3","article-title":"The mitochondrial genome: structure, transcription, translation and replication","volume":"1410","author":"Taanman","year":"1999","journal-title":"Biochim. Biophys. Acta BBA - Bioenerg."},{"key":"10.1016\/j.bbadis.2025.167803_bb0475","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrg1271","article-title":"Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes","volume":"5","author":"Timmis","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbadis.2025.167803_bb0480","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.abj6987","article-title":"The complete sequence of a human genome","volume":"376","author":"Nurk","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167803_bb0485","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1002\/pmic.201000329","article-title":"Mosaic origin of the mitochondrial proteome","volume":"10","author":"Szklarczyk","year":"2010","journal-title":"PROTEOMICS"},{"key":"10.1016\/j.bbadis.2025.167803_bb0490","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167803_bb0495","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12967-023-03885-2","article-title":"Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging","volume":"21","author":"Wan","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbadis.2025.167803_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112056","article-title":"Peptides derived from small mitochondrial open reading frames: genomic, biological, and therapeutic implications","volume":"393","author":"Miller","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2025.167803_bb0505","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1046\/j.1365-294X.2003.02063.x","article-title":"The incomplete natural history of mitochondria","volume":"13","author":"Ballard","year":"2004","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0510","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1016\/j.cell.2024.05.022","article-title":"The rate and nature of mitochondrial DNA mutations in human pedigrees","volume":"187","author":"\u00c1rnad\u00f3ttir","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167803_bb0515","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/cells9010017","article-title":"Mitochondrial gene expression and beyond\u2014novel aspects of cellular physiology","volume":"9","author":"Kotrys","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167803_bb0520","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.dnarep.2014.03.010","article-title":"Mitochondrial genome maintenance in health and disease","volume":"19","author":"Copeland","year":"2014","journal-title":"DNA Repair"},{"key":"10.1016\/j.bbadis.2025.167803_bb0525","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41594-020-0474-9","article-title":"Safeguarding mitochondrial genomes in higher eukaryotes","volume":"27","author":"Fu","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0530","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3390\/antiox10111824","article-title":"Mitochondrial management of reactive oxygen species","volume":"10","author":"Napolitano","year":"2021","journal-title":"Antioxid. Basel Switz."},{"key":"10.1016\/j.bbadis.2025.167803_bb0535","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2025.167803_bb0540","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1073\/pnas.0500253102","article-title":"DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity","volume":"102","author":"Song","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0545","doi-asserted-by":"crossref","first-page":"16992","DOI":"10.1074\/jbc.M111.236968","article-title":"Nucleoside triphosphate pool asymmetry in mammalian mitochondria","volume":"286","author":"Wheeler","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167803_bb0550","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/gbe\/evr066","article-title":"The lower bound to the evolution of mutation rates","volume":"3","author":"Lynch","year":"2011","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0555","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.gde.2016.03.005","article-title":"Human mitochondrial DNA replication machinery and disease","volume":"38","author":"Young","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.bbadis.2025.167803_bb0560","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/S0140-6736(11)61305-6","article-title":"Mitochondrial diseases","volume":"379","author":"Schapira","year":"2012","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.bbadis.2025.167803_bb0565","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.exger.2007.10.001","article-title":"The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging","volume":"43","author":"Hiona","year":"2008","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0570","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.aac7516","article-title":"Mutations causing mitochondrial disease: what is new and what challenges remain?","volume":"349","author":"Lightowlers","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167803_bb0575","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167803_bb0580","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1158\/jcr.1925.148","article-title":"The metabolism of carcinoma cells","volume":"9","author":"Warburg","year":"1925","journal-title":"J. Cancer Res."},{"key":"10.1016\/j.bbadis.2025.167803_bb0585","article-title":"The journey towards the seminal discovery of tumor cell bioenergetic reprogramming","volume":"1867","author":"Urbano","year":"2021","journal-title":"Biochim. Biophys. Acta BBA - Mol. Basis Dis."},{"key":"10.1016\/j.bbadis.2025.167803_bb0590","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167803_bb0595","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.124.3215.269","article-title":"On respiratory impairment in cancer cells","volume":"124","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167803_bb0600","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/9781681082899116030006","article-title":"Targeting the Warburg effect for cancer therapy: a long and winding road","volume":"3","author":"Abreu","year":"2016","journal-title":"Front. Clin. Drug Res. - Anti-Cancer Agents"},{"key":"10.1016\/j.bbadis.2025.167803_bb0605","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167803_bb0610","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbadis.2025.167803_bb0615","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrg3966","article-title":"The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease","volume":"16","author":"Stewart","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbadis.2025.167803_bb0620","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s40291-020-00510-6","article-title":"Current and emerging clinical treatment in mitochondrial disease","volume":"25","author":"Tinker","year":"2021","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.bbadis.2025.167803_bb0625","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrm3234","article-title":"Autophagy eliminates paternal mitochondria","volume":"12","author":"Wrighton","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0630","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3390\/cells8050433","article-title":"Mitochondrial DNA, a powerful tool to decipher ancient human civilization from domestication to music, and to uncover historical murder cases","volume":"8","author":"Merheb","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167803_bb0635","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/1.4.188","article-title":"An electron microscope study of the mitochondrial structure","volume":"1","author":"Palade","year":"1953","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbadis.2025.167803_bb0640","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/BJ20100371","article-title":"Porins in prokaryotes and eukaryotes: common themes and variations","volume":"431","author":"Zeth","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2025.167803_bb0645","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/emboj\/21.7.1616","article-title":"Mitochondria are morphologically and functionally heterogeneous within cells","volume":"21","author":"Collins","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2025.167803_bb0650","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/171030a0","article-title":"Electron microscopy of mitochondria and cytoplasmic double membranes: ultra-structure of rod-shaped mitochondria","volume":"171","author":"Sj\u00f6strand","year":"1953","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167803_bb0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbabio.2020.148305","article-title":"Protein crowding in the inner mitochondrial membrane","volume":"1862","author":"Schlame","year":"2021","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.bbadis.2025.167803_bb0660","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fphys.2020.00536","article-title":"Consequences of folding the mitochondrial inner membrane","volume":"11","author":"Mannella","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0665","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/191144a0","article-title":"Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism","volume":"191","author":"Mitchell","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167803_bb0670","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1111\/brv.12764","article-title":"The mitochondrial permeability transition pore: an evolving concept critical for cell life and death","volume":"96","author":"Morciano","year":"2021","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.bbadis.2025.167803_bb0675","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mam.2010.03.002","article-title":"VDAC, a multi-functional mitochondrial protein regulating cell life and death","volume":"31","author":"Shoshan-Barmatz","year":"2010","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbadis.2025.167803_bb0680","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm1426","article-title":"Mitochondrial import and the twin-pore translocase","volume":"5","author":"Rehling","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0685","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.762005","article-title":"How do chaperones bind (partly) unfolded client proteins?","volume":"8","author":"Su\u010dec","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0690","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.3390\/ijms23031297","article-title":"Mitochondrial processing peptidases-structure, function and the role in human diseases","volume":"23","author":"Kunov\u00e1","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0695","doi-asserted-by":"crossref","DOI":"10.1093\/femsyr\/foy040","article-title":"Yeast mitochondria: an overview of mitochondrial biology and the potential of mitochondrial systems biology","volume":"18","author":"Malina","year":"2018","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.bbadis.2025.167803_bb0700","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1074\/jbc.R111.270678","article-title":"Mitochondrial disulfide relay: redox-regulated protein import into the intermembrane space","volume":"287","author":"Herrmann","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167803_bb0705","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/2211-5463.13905","article-title":"Biogenesis of mitochondrial \u03b2-barrel membrane proteins","volume":"14","author":"Ganesan","year":"2024","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bbadis.2025.167803_bb0710","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0968-0004(00)01735-7","article-title":"Mitochondrial filaments and clusters as intracellular power-transmitting cables","volume":"26","author":"Skulachev","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbadis.2025.167803_bb0715","first-page":"1833","article-title":"Bioenergetic role of mitochondrial fusion and fission","volume":"2012","author":"Westermann","year":"1817","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2025.167803_bb0720","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10565-022-09712-6","article-title":"High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for OXPHOS complex I, III, and V inhibitors","volume":"39","author":"van der Stel","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0725","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tem.2015.12.001","article-title":"Mitochondrial dynamics and metabolic regulation","volume":"27","author":"Wai","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2025.167803_bb0730","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2025.167803_bb0735","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2023.02.012","article-title":"Determinants and outcomes of mitochondrial dynamics","volume":"83","author":"Quintana-Cabrera","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2025.167803_bb0740","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.semcdb.2022.03.040","article-title":"Mitochondrial respiratory quiescence: a new model for examining the role of mitochondrial metabolism in development","volume":"138","author":"Hocaoglu","year":"2023","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0745","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tcb.2009.11.002","article-title":"Control of mitochondrial transport and localization in neurons","volume":"20","author":"MacAskill","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0750","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1146\/annurev.biochem.76.071905.090048","article-title":"The machines that divide and fuse mitochondria","volume":"76","author":"Hoppins","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbadis.2025.167803_bb0755","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/rej.2005.8.3","article-title":"Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging","volume":"8","author":"Lemasters","year":"2005","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.bbadis.2025.167803_bb0760","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167803_bb0765","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy in human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbadis.2025.167803_bb0770","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","article-title":"Mechanisms of mitophagy in cellular homeostasis, physiology and pathology","volume":"20","author":"Palikaras","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0775","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2025.167803_bb0780","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.devcel.2021.02.009","article-title":"Quality control of the mitochondrion","volume":"56","author":"Ng","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbadis.2025.167803_bb0785","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41580-020-00300-2","article-title":"Quality control of the mitochondrial proteome","volume":"22","author":"Song","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167803_bb0790","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: an update","volume":"24","author":"Popov","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167803_bb0795","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.4161\/auto.24135","article-title":"After the banquet: mitochondrial biogenesis, mitophagy, and cell survival","volume":"9","author":"Zhu","year":"2013","journal-title":"Autophagy"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:26:51Z","timestamp":1762324011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925001486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":159,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0925443925001486"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167803","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondria: An overview of their origin, genome, architecture, and dynamics","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167803","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"167803"}}