{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:32:48Z","timestamp":1773966768343,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/14603\\u20138"],"award-info":[{"award-number":["2022\/14603\\u20138"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/09789\\u20138"],"award-info":[{"award-number":["2023\/09789\\u20138"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/09175\\u20134,2022\/14603\\u20138"],"award-info":[{"award-number":["2021\/09175\\u20134,2022\/14603\\u20138"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/06686\\u20138"],"award-info":[{"award-number":["2021\/06686\\u20138"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/01368\\u20133"],"award-info":[{"award-number":["2023\/01368\\u20133"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005639","name":"Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["304166\/2022\\u20137"],"award-info":[{"award-number":["304166\/2022\\u20137"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["406564\/2022"],"award-info":[{"award-number":["406564\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["306475\/2025\\u20131"],"award-info":[{"award-number":["306475\/2025\\u20131"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Engineering Journal"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bej.2025.110065","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:18:00Z","timestamp":1767140280000},"page":"110065","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Purple-red azaphilone alkaloids from Talaromyces amestolkiae showing antimicrobial activity"],"prefix":"10.1016","volume":"228","author":[{"given":"Fernanda","family":"de Oliveira","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-6662","authenticated-orcid":false,"given":"Caio","family":"de Azevedo Lima","sequence":"additional","affiliation":[]},{"given":"Diana Cl\u00e1udia","family":"Gouveia Alves Pinto","sequence":"additional","affiliation":[]},{"given":"Laura Carmona","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Tais Maria","family":"Bauab","sequence":"additional","affiliation":[]},{"given":"Silvio Silv\u00e9rio","family":"da Silva","sequence":"additional","affiliation":[]},{"given":"Val\u00e9ria Carvalho","family":"Santos-Ebinuma","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.bej.2025.110065_bib1","unstructured":"World Health Organization. Ten threats to global health in 2019. \u3008https:\/\/www.who.int\/news-room\/spotlight\/ten-threats-to-global-health-in-2019\u3009, Accessed 03.11.2025."},{"key":"10.1016\/j.bej.2025.110065_bib2","first-page":"1","article-title":"The natural functions of secondary metabolites","volume":"69","author":"Demain","year":"2000","journal-title":"Adv. Biochem Eng. Biotechnol."},{"issue":"6","key":"10.1016\/j.bej.2025.110065_bib3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/metabo15060418","article-title":"Microbial Metabolites: A Sustainable Approach to Combat Plant Pests","volume":"15","author":"Prabhu","year":"2025","journal-title":"Metabolites"},{"key":"10.1016\/j.bej.2025.110065_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.984801","article-title":"Research advances in the structures and biological activities of secondary metabolites from Talaromyces","volume":"13","author":"Lei","year":"2022","journal-title":"Front. Microbiol."},{"issue":"33","key":"10.1016\/j.bej.2025.110065_bib5","article-title":"Sequencing and phylogenetic analyses of Talaromyces amestolkiae from the Amazon, a producer of natural colorants","volume":"2","author":"Zaccarim","year":"2018","journal-title":"Biotechnol. Prog."},{"issue":"11","key":"10.1016\/j.bej.2025.110065_bib6","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1007\/s00253-023-12491-7","article-title":"Red biocolorant from endophytic Talaromyces minnesotensis: production, properties, and potential applications","volume":"107","author":"Sousa","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bej.2025.110065_bib7","doi-asserted-by":"crossref","first-page":"10197","DOI":"10.1039\/D0RA00894J","article-title":"Recent advances in the chemistry and biology of azaphilones","volume":"10","author":"Ch","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.bej.2025.110065_bib8","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1039\/D0NP00080A","article-title":"Biosynthesis of azaphilones: a review","volume":"38","author":"Pavesi","year":"2021","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bej.2025.110065_sbref8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00253-021-11729-6","article-title":"Azaphilone alkaloids: prospective source of natural food pigments","volume":"106","author":"Liu","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bej.2025.110065_sbref9","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1039\/D0NP00080A","article-title":"Biosynthesis of azaphilones: a review","volume":"38","author":"Pavesi","year":"2021","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bej.2025.110065_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1134\/S0026261722601737","article-title":"Fungal Azaphilone Pigments as Promising Natural Colorants","volume":"92","author":"Antipova","year":"2023","journal-title":"Microbiol"},{"key":"10.1016\/j.bej.2025.110065_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131214","article-title":"Identification of Azaphilone Derivatives of Monascus Colorants from Talaromyces amestolkiae and Their Halochromic Properties","volume":"372","author":"De Oliveira","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.bej.2025.110065_bib12","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1021\/jo050414g","article-title":"Synthesis studies toward chloroazaphilone and vinylogous \u03b3-pyridones: two common natural product core structures","volume":"70","author":"Wei","year":"2005","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bej.2025.110065_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11101-010-9171-3","article-title":"Azaphilones: a class of fungal metabolites with diverse biological activities","volume":"9","author":"Osmanova","year":"2010","journal-title":"Phytochem. Rev."},{"issue":"8","key":"10.1016\/j.bej.2025.110065_bib14","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.3390\/nu15081923","article-title":"Natural Pigments Production and Their Application in Food, Health and Other Industries","volume":"15","author":"Di Salvo","year":"2023","journal-title":"Nutrients"},{"issue":"13","key":"10.1016\/j.bej.2025.110065_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e33646","article-title":"A review of history, properties, classification, applications and challenges of natural and synthetic dyes","volume":"10","author":"Alegbe","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bej.2025.110065_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.136338","article-title":"Terminal carboxylation of branched carbon chain contributing to acidic stability of azaphilone pigments from a new isolate of Talaromyces amestolkiae","volume":"424","author":"Xue","year":"2023","journal-title":"Food Chem."},{"issue":"12","key":"10.1016\/j.bej.2025.110065_bib17","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.funbio.2015.08.020","article-title":"PP-O and PP-V, Monascus pigment homologues, production, and phylogenetic analysis in Penicillium purpurogenum","volume":"119","author":"Arai","year":"2015","journal-title":"Fungal Biol."},{"key":"10.1016\/j.bej.2025.110065_bib18","first-page":"300","article-title":"Amazonian biodiversity: Pigments from Aspergillus and Penicillium characterizations, antibacterial activities and their toxicities","volume":"6","author":"Teixeira","year":"2012","journal-title":"Curr. Trends Biotechnol. Pharm."},{"key":"10.1016\/j.bej.2025.110065_bib19","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1590\/S1517-83822014000200049","article-title":"Improvement of submerged culture conditions to produce colorants by Penicillium purpurogenum","volume":"45","author":"Santos-Ebinuma","year":"2014","journal-title":"Braz. J. Microbiol"},{"key":"10.1016\/j.bej.2025.110065_bib20","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1007\/s00253-019-09972-z","article-title":"Water-soluble fluorescent red colorant production by Talaromyces amestolkiae","volume":"103","author":"De Oliveira","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bej.2025.110065_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2020.107694","article-title":"Biosynthesis of natural colorants by Talaromyces amestolkiae: mycelium accumulation and colorant formation in incubator shaker and in bioreactor","volume":"161","author":"De Oliveira","year":"2020","journal-title":"Biochem Eng. J."},{"issue":"43","key":"10.1016\/j.bej.2025.110065_bib22","doi-asserted-by":"crossref","first-page":"14136","DOI":"10.1021\/acssuschemeng.2c02960","article-title":"Improving the Environmental Sustainability of Polyketides Colorants Production by Talaromyces Strain through Better Hydrodynamic Design in Bioreactors","volume":"10","author":"De Oliveira","year":"2022","journal-title":"ACS Sustain. Chem. Eng."},{"issue":"12","key":"10.1016\/j.bej.2025.110065_bib23","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1002\/bit.24978","article-title":"Automated disposable small scale reactor for high throughput bioprocess development: a proof of concept study","volume":"110","author":"Bareither","year":"2013","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.bej.2025.110065_bib24","series-title":"Supplement M100-S16. Clinical and Laboratory Standards Institute","article-title":"Performance standardsfor antimicrobial susceptibility testing","author":"Clinical and Laboratory Standards Institute","year":"2006"},{"issue":"1","key":"10.1016\/j.bej.2025.110065_bib25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/fermentation9010077","article-title":"Scale-up of pigment production by the marine-derived filamentous fungus, Talaromyces albobiverticillius 30548, from shake flask to stirred bioreactor","volume":"9","author":"Venkatachalam","year":"2023","journal-title":"Fermentation"},{"issue":"1","key":"10.1016\/j.bej.2025.110065_bib26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40694-017-0033-2","article-title":"Filamentous ascomycetes fungi as a source of natural pigments","volume":"4","author":"Gmoser","year":"2017","journal-title":"Fungal Biol. Biotechnol."},{"key":"10.1016\/j.bej.2025.110065_bib27","doi-asserted-by":"crossref","first-page":"8331","DOI":"10.1038\/srep08331","article-title":"Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1","volume":"5","author":"Yang","year":"2015","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bej.2025.110065_bib28","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1007\/s00253-018-8818-7","article-title":"The filamentous fungal pellet\u2014relationship between morphology and productivity","volume":"102","author":"Veiter","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bej.2025.110065_bib29","series-title":"In Current developments in biotechnology and bioengineering","first-page":"219","article-title":"Bioreactors and engineering of filamentous fungi cultivation","author":"Gomes","year":"2023"},{"key":"10.1016\/j.bej.2025.110065_bib30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1590\/S0104-66322008000200004","article-title":"Effect of dissolved oxygen concentration on red pigment and citrinin production by Monascus purpureus ATCC 36928","volume":"25","author":"Pereira","year":"2008","journal-title":"Braz. J. Chem. Eng."},{"issue":"5","key":"10.1016\/j.bej.2025.110065_bib31","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jbiosc.2014.10.014","article-title":"Effect of oxygen supply on Monascus pigments and citrinin production in submerged fermentation","volume":"119","author":"Yang","year":"2015","journal-title":"J. Biosci. Bioeng."},{"issue":"13","key":"10.1016\/j.bej.2025.110065_bib32","doi-asserted-by":"crossref","first-page":"11184","DOI":"10.3390\/ijms241311184","article-title":"Fungal BGCs for production of secondary metabolites: main types, central roles in strain improvement, and regulation according to the piano principle","volume":"24","author":"Zhgun","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bej.2025.110065_bib33","first-page":"5","article-title":"Antimicrobial activity of red pigments derived from Monascus purpureus: A comparison to industrial red pigments","volume":"1","author":"G\u00f6kmen","year":"2021","journal-title":"JSFA Rep."},{"issue":"1","key":"10.1016\/j.bej.2025.110065_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1574-6968.2006.00451.x","article-title":"Antimicrobial activities of amino acid derivatives of monascus pigments","volume":"264","author":"Kim","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.bej.2025.110065_bib35","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3390\/fermentation9040328","article-title":"Characterization of the Red Biochromes Produced by the Endophytic Fungus Monascus purpureus CPEF02 with Antimicrobial and Antioxidant Activities","volume":"9","author":"Kaur","year":"2023","journal-title":"Fermentation"},{"issue":"4","key":"10.1016\/j.bej.2025.110065_bib36","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1111\/jfpp.12157","article-title":"Antimicrobial Activity ofMonascusPigments Produced in Submerged Fermentation","volume":"38","author":"Vendruscolo","year":"2013","journal-title":"J. Food Process Preserv"},{"key":"10.1016\/j.bej.2025.110065_bib37","first-page":"609","article-title":"Biological activity of polyketide pigments produced by the fungus Monascus","volume":"79","author":"Mart\u00ednkov\u00e1","year":"1995","journal-title":"J. Appl. Microbiol"},{"key":"10.1016\/j.bej.2025.110065_bib38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jfca.2017.12.036","article-title":"Partial characterization of the pigments produced by the marine-derived fungus Talaromyces albobiverticillius 30548. Towards a new fungal red colorant for the food industry","volume":"67","author":"Venkatachalam","year":"2018","journal-title":"J. Food Comp. Anal."},{"key":"10.1016\/j.bej.2025.110065_bib39","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1389-1723(01)80039-6","article-title":"Production and structural analysis of PP-V, a homologue of monascorubramine, produced by anew isolate of Penicillium sp","volume":"90","author":"Ogihara","year":"2020","journal-title":"J. Biosc. Bioeng."},{"key":"10.1016\/j.bej.2025.110065_bib40","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S1389-1723(00)90017-3","article-title":"Biosynthesis of PP-V, a monascorubramine homologue, by Penicillium sp. AZ","volume":"90","author":"Ogihara","year":"2021","journal-title":"J. Biosc. Bioeng."},{"issue":"2","key":"10.1016\/j.bej.2025.110065_bib41","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00253-019-10216-3","article-title":"Atrorosins: a new subgroup of Monascus pigments from Talaromyces atroroseus","volume":"104","author":"Isbrandt","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"2","key":"10.1016\/j.bej.2025.110065_bib42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.trechm.2024.12.007","article-title":"Driving non-enzymatic reactions towards biocompatible chemistry","volume":"7","author":"Xue","year":"2025","journal-title":"Trends Chem."}],"container-title":["Biochemical Engineering Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369703X25004395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1369703X25004395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:32:26Z","timestamp":1773959546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1369703X25004395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["S1369703X25004395"],"URL":"https:\/\/doi.org\/10.1016\/j.bej.2025.110065","relation":{},"ISSN":["1369-703X"],"issn-type":[{"value":"1369-703X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Purple-red azaphilone alkaloids from Talaromyces amestolkiae showing antimicrobial activity","name":"articletitle","label":"Article Title"},{"value":"Biochemical Engineering Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bej.2025.110065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110065"}}