{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T08:29:21Z","timestamp":1747988961700,"version":"3.37.3"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.bioactmat.2024.02.035","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T15:47:44Z","timestamp":1711640864000},"page":"253-268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Prevascularized spongy-like hydrogels maintain their angiogenic potential after prolonged hypothermic storage"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-6703","authenticated-orcid":false,"given":"Sara","family":"Freitas-Ribeiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-374X","authenticated-orcid":false,"given":"Helena","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4889-7799","authenticated-orcid":false,"given":"Luc\u00edlia P.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Noro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6580-0971","authenticated-orcid":false,"given":"Bel\u00e9m","family":"Sampaio-Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4130-7167","authenticated-orcid":false,"given":"Paula","family":"Ludovico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Jarnalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Horta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra P.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-950X","authenticated-orcid":false,"given":"Rog\u00e9rio P.","family":"Pirraco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2024.02.035_bib1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/ajt.16976","article-title":"OPTN\/SRTR 2020 annual data report: dod","volume":"22","author":"Israni","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.trre.2020.100585","article-title":"Organ donation in the US and Europe: the supply vs demand imbalance","volume":"35","author":"Lewis","year":"2021","journal-title":"Transplant. Rev."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/15476278.2019.1697597","article-title":"Influence of different cell types and sources on pre-vascularisation in fibrin and agarose\u2013collagen gels","volume":"16","author":"Kniebs","year":"2020","journal-title":"Organogenesis"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib4","doi-asserted-by":"crossref","first-page":"100496","DOI":"10.1016\/j.mtbio.2022.100496","article-title":"Spongy-like hydrogels prevascularization with the adipose tissue vascular fraction delays cutaneous wound healing by sustaining inflammatory cell influx","volume":"17","author":"Moreira","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.actbio.2017.03.034","article-title":"Cell sheet engineering using the stromal vascular fraction of adipose tissue as a vascularization strategy","volume":"55","author":"Costa","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41536-022-00253-4","article-title":"Integrin-specific hydrogels for growth factor-free vasculogenesis","volume":"7","author":"Moreira","year":"2022","journal-title":"NPJ Regen. Med."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/pnasnexus\/pgac212","article-title":"Long-term and short-term preservation strategies for tissue engineering and regenerative medicine products: state of the art and emerging trends","volume":"1","author":"Freitas-Ribeiro","year":"2022","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41551-021-00784-z","article-title":"Advanced technologies for the preservation of mammalian biospecimens","volume":"5","author":"Huang","year":"2021","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.bioactmat.2024.02.035_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep38987","article-title":"Ebselen preserves tissue-engineered cell sheets and their stem cells in hypothermic conditions","volume":"6","author":"Katori","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib10","doi-asserted-by":"crossref","first-page":"658","DOI":"10.5966\/sctm.2015-0238","article-title":"Effective hypothermic storage of human pluripotent stem cell-derived cardiomyocytes compatible with global distribution of cells for clinical applications and toxicology testing","volume":"5","author":"Correia","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0222597","article-title":"Strategies for the hypothermic preservation of cell sheets of human adipose stem cells","volume":"14","author":"Freitas-Ribeiro","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib12","doi-asserted-by":"crossref","first-page":"C125","DOI":"10.1152\/ajpcell.1984.247.3.C125","article-title":"Freezing of living cells: mechanisms and implications","volume":"247","author":"Mazur","year":"1984","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0014-4827(72)90303-5","article-title":"A two-factor hypothesis of freezing injury","volume":"71","author":"Mazur","year":"1972","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib14","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1089\/ten.2004.10.1662","article-title":"Cell preservation in reparative and regenerative medicine: evolution of individualized solution composition","volume":"10","author":"Mathew","year":"2004","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib15","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1016\/j.actbio.2014.07.009","article-title":"Engineering cell-adhesive gellan gum spongy-like hydrogels for regenerative medicine purposes","volume":"10","author":"Da Silva","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib16","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1021\/bm4011062","article-title":"Human adipose stem cells cell sheet constructs impact epidermal morphogenesis in full-thickness excisional wounds","volume":"14","author":"Cerqueira","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100422","article-title":"Isolation of stromal vascular fraction cell suspensions from mouse and human adipose tissues for downstream applications","volume":"2","author":"Hearnden","year":"2021","journal-title":"STAR Protoc"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3390\/md20100623","article-title":"Growth factor-free vascularization of marine-origin collagen sponges using cryopreserved stromal vascular fractions from human adipose tissue","volume":"20","author":"Freitas-Ribeiro","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/srep10607","article-title":"Strategies to improve quantitative assessment of immunohistochemical and immunofluorescent labelling","volume":"5","author":"Johnson","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1172\/JCI73938","article-title":"Development of autophagy inducers in clinical medicine","volume":"125","author":"Levine","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s11658-016-0031-z","article-title":"p62 links the autophagy pathway and the ubiqutin\u2013proteasome system upon ubiquitinated protein degradation","volume":"21","author":"Liu","year":"2016","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib24","doi-asserted-by":"crossref","first-page":"21105","DOI":"10.1073\/pnas.1111919109","article-title":"Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress","volume":"108","author":"Bauer","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib25","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0891-5849(96)00618-1","article-title":"Injury to cultured liver endothelial cells after cold preservation: mediation by reactive oxygen species that are released independently of the known trigger hypoxia\/reoxygenation","volume":"23","author":"Rauen","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1096\/fasebj.13.1.155","article-title":"Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species","volume":"13","author":"Rauen","year":"1999","journal-title":"Faseb. J."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib27","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1096\/fj.00-0071com","article-title":"Hypothermia injury\/cold-induced apoptosis\u2014evidence of an increase in chelatable iron causing oxidative injury in spite of low O2\u2212\/H2O2 formation","volume":"14","author":"Rauen","year":"2000","journal-title":"Faseb. J."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib28","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1089\/ten.teb.2021.0012","article-title":"Highlights on advancing frontiers in tissue engineering","volume":"28","author":"Ashammakhi","year":"2022","journal-title":"Tissue Eng., Part B"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41551-019-0471-7","article-title":"Opportunities and challenges of translational 3D bioprinting","volume":"4","author":"Murphy","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib30","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/01.CIR.0000121425.42966.F1","article-title":"Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells","volume":"109","author":"Rehman","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0922-3371(90)90046-Y","article-title":"Proteolytic balance and capillary morphogenesis","volume":"32","author":"Pepper","year":"1990","journal-title":"Cell Differ. Dev."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12013-008-9040-5","article-title":"Integrin and growth factor receptor alliance in angiogenesis","volume":"53","author":"Somanath","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib33","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/CIRCRESAHA.107.155655","article-title":"Mechanisms of integrin\u2013vascular endothelial growth factor receptor cross-activation in angiogenesis","volume":"101","author":"Mahabeleshwar","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib34","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cardiores.2004.04.027","article-title":"Molecular and mechanical synergy: cross-talk between integrins and growth factor receptors*1","volume":"63","author":"Ross","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10456-009-9141-9","article-title":"Cooperation between integrin \u03b1\u03bd\u03b23 and VEGFR2 in angiogenesis","volume":"12","author":"Somanath","year":"2009","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib36","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1742-4658.2008.06781.x","article-title":"Biochemical insights into the mechanisms central to the response of mammalian cells to cold stress and subsequent rewarming","volume":"276","author":"Roobol","year":"2009","journal-title":"FEBS J."},{"issue":"9","key":"10.1016\/j.bioactmat.2024.02.035_bib37","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib38","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib39","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1242\/jeb.204.18.3171","article-title":"Mechanisms of cell survival in hypoxia and hypothermia","volume":"204","author":"Boutilier","year":"2001","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0005-2728(98)00112-1","article-title":"The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy","volume":"1366","author":"Lemasters","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/01.TP.0000069830.78758.1C","article-title":"Cold-induced apoptosis of rat liver endothelial cells: contribution of mitochondrial alterations","volume":"76","author":"Kerkweg","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib42","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molcel.2006.12.009","article-title":"Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-\u03b2, and Bcl-2","volume":"25","author":"H\u00f8yer-Hansen","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib43","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1089\/ten.2004.10.1662","article-title":"Cell preservation in reparative and regenerative medicine: evolution of individualized solution composition","volume":"10","author":"Mathew","year":"2004","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib44","first-page":"239","volume":"vol. 1","author":"Mathew","year":"2004"},{"key":"10.1016\/j.bioactmat.2024.02.035_bib45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3390\/ijms23010185","article-title":"Asc and svf cells synergistically induce neovascularization in ischemic hindlimb following cotransplantation","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib46","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1634\/stemcells.2006-0006","article-title":"Autocrine fibroblast growth factor 2 signaling is critical for self\u2010renewal of human multipotent adipose\u2010derived stem cells","volume":"24","author":"Zaragosi","year":"2006","journal-title":"Stem Cell."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00383-015-3808-7","article-title":"Characterization of vasculogenic potential of human adipose-derived endothelial cells in a three-dimensional vascularized skin substitute","volume":"32","author":"Klar","year":"2016","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib48","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/ATVBAHA.110.218206","article-title":"Stromal vascular fraction from adipose tissue forms profound vascular network through the dynamic reassembly of blood endothelial cells","volume":"31","author":"Koh","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib49","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.lfs.2006.10.020","article-title":"Transplantation of adipose stromal cells, but not mature adipocytes, augments ischemia-induced angiogenesis","volume":"80","author":"Sumi","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.bioactmat.2024.02.035_bib50","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1161\/01.ATV.0000190701.92007.6d","article-title":"Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue\u2013derived stromal cells","volume":"25","author":"Nakagami","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X2400080X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X2400080X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T18:33:10Z","timestamp":1723314790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X2400080X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":50,"alternative-id":["S2452199X2400080X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.02.035","relation":{},"ISSN":["2452-199X"],"issn-type":[{"type":"print","value":"2452-199X"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevascularized spongy-like hydrogels maintain their angiogenic potential after prolonged hypothermic storage","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2024.02.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}