{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T09:15:24Z","timestamp":1788081324313,"version":"build-2784847793"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012337","name":"Nanhu Scholars Program for Young Scholars of Xinyang Normal University","doi-asserted-by":"publisher","award":["SSD2025025"],"award-info":[{"award-number":["SSD2025025"]}],"id":[{"id":"10.13039\/501100012337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82120108017"],"award-info":[{"award-number":["82120108017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302683"],"award-info":[{"award-number":["82302683"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572769"],"award-info":[{"award-number":["82572769"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372484"],"award-info":[{"award-number":["82372484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272501"],"award-info":[{"award-number":["82272501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M782215"],"award-info":[{"award-number":["2025M782215"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007824","name":"Soochow University","doi-asserted-by":"publisher","award":["ML12202923"],"award-info":[{"award-number":["ML12202923"]}],"id":[{"id":"10.13039\/501100007824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20230215"],"award-info":[{"award-number":["BK20230215"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20250123"],"award-info":[{"award-number":["BK20250123"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017534","name":"333 Project of Jiangsu Province","doi-asserted-by":"publisher","award":["2069999"],"award-info":[{"award-number":["2069999"]}],"id":[{"id":"10.13039\/501100017534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bioactmat.2026.08.017","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:28:38Z","timestamp":1787232518000},"page":"620-642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A dual-targeting mRNA lipid nanoparticle restores ABCA1-dependent cholesterol homeostasis to promote repair of age-related bone defects"],"prefix":"10.1016","volume":"67","author":[{"given":"Mengze","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxia","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjie","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changdong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0482-1610","authenticated-orcid":false,"given":"Yong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2026.08.017_bib1","doi-asserted-by":"crossref","first-page":"7489","DOI":"10.3390\/ijerph18147489","article-title":"A qualitative study toward technologies for active and healthy aging: a thematic analysis of perspectives among primary, secondary, and tertiary end users","volume":"18","author":"Rampioni","year":"2021","journal-title":"IJERPH"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s43556-025-00349-5","article-title":"Osteoporosis: molecular pathogenesis and therapeutic interventions","volume":"6","author":"Zhang","year":"2025","journal-title":"Mol Biomed"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib3","doi-asserted-by":"crossref","first-page":"7411","DOI":"10.3390\/ijms25137411","article-title":"Cellular senescence and inflammaging in the bone: pathways, genetics, anti-aging strategies and interventions","volume":"25","author":"Lawrence","year":"2024","journal-title":"IJMS"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2015.01.036","article-title":"A century of cholesterol and coronaries: from plaques to genes to statins","volume":"161","author":"Goldstein","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.tcb.2020.01.009","article-title":"Lipid rafts: controversies resolved, mysteries remain","volume":"30","author":"Levental","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41514-023-00128-y","article-title":"Cholesterol biosynthetic pathway induces cellular senescence through ERR\u03b1","volume":"10","author":"Ziegler","year":"2024","journal-title":"npj Aging"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13024-025-00802-7","article-title":"Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD","volume":"20","author":"Wang","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s42255-023-00747-5","article-title":"Lysosomal control of senescence and inflammation through cholesterol partitioning","volume":"5","author":"Roh","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nri3793","article-title":"Cholesterol, inflammation and innate immunity","volume":"15","author":"Tall","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s43556-025-00321-3","article-title":"Cholesterol metabolism: molecular mechanisms, biological functions, diseases, and therapeutic targets","volume":"6","author":"Cui","year":"2025","journal-title":"Mol Biomed"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib11","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.aag1417","article-title":"Lysosomal cholesterol activates mTORC1 via an SLC38A9\u2013Niemann-Pick C1 signaling complex","volume":"355","author":"Castellano","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib12","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1126\/science.abg6621","article-title":"Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1","volume":"377","author":"Shin","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib13","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.devcel.2022.02.024","article-title":"The central moTOR of metabolism","volume":"57","author":"Simcox","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib14","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.1038\/s41467-022-33933-2","article-title":"The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics","volume":"13","author":"Ng","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/hr.2015.85","article-title":"Augmentation of autophagy by atorvastatin via Akt\/mTOR pathway in spontaneously hypertensive rats","volume":"38","author":"Wang","year":"2015","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib16","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/pros.21131","article-title":"Statin\u2010induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells","volume":"70","author":"Parikh","year":"2010","journal-title":"Prostate"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib17","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1080\/15548627.2021.1920814","article-title":"Upregulation of brain cholesterol levels inhibits mitophagy in Alzheimer disease","volume":"17","author":"Roca-Agujetas","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13024-021-00435-6","article-title":"Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease","volume":"16","author":"Roca-Agujetas","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101915","article-title":"Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis","volume":"41","author":"Guo","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-16046-w","article-title":"HIF1A overexpression promotes osteoblast differentiation through activation of autophagy to alleviate osteoporosis","volume":"15","author":"Qiao","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157346","article-title":"Therapeutic potential of xanthohumol in senile osteoporosis: mTOR-driven regulation of AKT\/mTOR\/p70S6K autophagy axis in D-galactose models","volume":"148","author":"Xia","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.139703","article-title":"Bisphenol A and Di-n-butyl phthalate disrupt bone homeostasis bidirectionally via CD36-mediated BMSCs autophagy inhibition and exosome-promoted osteoclastogenesis","volume":"497","author":"Wang","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib23","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/s41580-019-0123-5","article-title":"Metabolic regulation of cell growth and proliferation","volume":"20","author":"Zhu","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib24","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s42255-021-00483-8","article-title":"The metabolic roots of senescence: mechanisms and opportunities for intervention","volume":"3","author":"Wiley","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib25","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cmet.2016.05.010","article-title":"From Ancient pathways to aging Cells\u2014Connecting metabolism and cellular senescence","volume":"23","author":"Wiley","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev-neuro-091922-034237","article-title":"Cholesterol metabolism in aging and age-related disorders","volume":"46","author":"Saher","year":"2023","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib27","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1042\/CS20220752","article-title":"Regulation of cholesterol homeostasis in osteoporosis mechanisms and therapeutics","volume":"137","author":"Bao","year":"2023","journal-title":"Clinical Science"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41420-025-02445-5","article-title":"A high-fructose diet leads to osteoporosis by suppressing the expression of Thrb and facilitating the accumulation of cholesterol","volume":"11","author":"Chen","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.plipres.2015.06.002","article-title":"Understanding the local actions of lipids in bone physiology","volume":"59","author":"During","year":"2015","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib30","article-title":"The role of lipid metabolism in osteoporosis: clinical implication and cellular mechanism","volume":"11","author":"Zhang","year":"2024","journal-title":"Genes Dis."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib31","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41580-024-00700-8","article-title":"Mechanisms and functions of protein S-acylation","volume":"25","author":"Mesquita, F","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib32","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.bbalip.2013.01.019","article-title":"Characterization of palmitoylation of ATP binding cassette transporter G1: effect on protein trafficking and function","volume":"1831","author":"Gu","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adr5703","article-title":"Niemann Pick C1 mistargeting disrupts lysosomal cholesterol homeostasis contributing to neurodegeneration in a Batten disease model","volume":"11","author":"Appu","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib34","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCRESAHA.108.193011","article-title":"Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function","volume":"105","author":"Singaraja","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib35","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1007\/s11033-020-05800-0","article-title":"ATP-binding cassette g1 regulates osteogenesis via Wnt\/\u03b2-catenin and AMPK signaling pathways","volume":"47","author":"Zhou","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib36","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41467-025-56344-5","article-title":"Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113961","article-title":"Posttranslational remodeling micelle reverses cell-surface and exosomal PD-L1 immunosuppression in tumors resistant to PD-L1 antibody therapy","volume":"384","author":"Shi","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib38","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41392-024-01759-7","article-title":"Protein lipidation in health and disease: molecular basis, physiological function and pathological implication","volume":"9","author":"Yuan","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075232","article-title":"2-Bromopalmitate reduces protein deacylation by inhibition of acyl-protein thioesterase enzymatic activities","volume":"8","author":"Pedro","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1259989","article-title":"Surface toll-like receptor 9 on immune cells and its immunomodulatory effect","volume":"14","author":"Kou","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-023-43650-z","article-title":"Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice","volume":"15","author":"Ni","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib42","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib43","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/s41556-018-0235-8","article-title":"Autophagy and the cell biology of age-related disease","volume":"20","author":"Leidal","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib44","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib45","doi-asserted-by":"crossref","DOI":"10.4172\/2161-0681.S4-006","article-title":"Autophagy - an emerging anti-aging mechanism?","volume":"s4","author":"Hansen","year":"2012","journal-title":"J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib46","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib47","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.cub.2017.07.033","article-title":"Unmasking transcriptional heterogeneity in senescent cells","volume":"27","author":"Hernandez-Segura","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib48","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1152\/physrev.00026.2020","article-title":"Regulation and metabolic functions of mTORC1 and mTORC2","volume":"101","author":"Szwed","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib49","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s43587-024-00635-x","article-title":"A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan","volume":"4","author":"Ortega-Molina","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib50","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/078538902320772098","article-title":"ABCA1: regulation, trafficking and association with heteromeric proteins","volume":"34","author":"Schmitz","year":"2002","journal-title":"Ann. Med."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib51","doi-asserted-by":"crossref","first-page":"eabb0799","DOI":"10.1126\/sciadv.abb0799","article-title":"Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice","volume":"7","author":"Virlogeux","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib52","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s41467-025-56716-x","article-title":"Nanobody-thioesterase chimeras to specifically target protein palmitoylation","volume":"16","author":"Kuo","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib53","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1038\/s41467-025-58908-x","article-title":"Engineered depalmitoylases enable selective manipulation of protein localization and function","volume":"16","author":"Jayaraman","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib54","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1104\/pp.011569","article-title":"Deciphering an enigmatic inhibitor of secretion","volume":"130","author":"Nebenf\u00fchr","year":"2002","journal-title":"Plant Physiol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001812","article-title":"Next\u2010generation vaccines: nanoparticle-mediated DNA and mRNA delivery","volume":"10","author":"Ho","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib56","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1016\/j.cell.2022.03.045","article-title":"Therapeutic in vivo delivery of gene editing agents","volume":"185","author":"Raguram","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib57","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1021\/acs.nanolett.4c05186","article-title":"Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain","volume":"25","author":"Han","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib58","doi-asserted-by":"crossref","first-page":"eadd4623","DOI":"10.1126\/sciadv.add4623","article-title":"Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates","volume":"9","author":"Herrera-Barrera","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib59","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s43587-024-00750-9","article-title":"A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging","volume":"5","author":"Ming","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib60","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-020-2403-9","article-title":"Senolytic CAR T cells reverse senescence-associated pathologies","volume":"583","author":"Amor","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-43934-w","article-title":"Targeted imaging of uPAR expression in vivo with cyclic AE105 variants","volume":"13","author":"Leth","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib62","doi-asserted-by":"crossref","first-page":"52","DOI":"10.7150\/thno.100042","article-title":"Optical molecular imaging in oral- and oropharyngeal squamous cell carcinoma using a novel uPAR-targeting near-infrared imaging agent FG001 (ICG-glu-glu-AE105): an explorative phase II clinical trial","volume":"15","author":"Andersen","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib63","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41596-022-00755-x","article-title":"Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery","volume":"18","author":"Wang","year":"2023","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib64","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/s41565-025-01974-5","article-title":"Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape","volume":"20","author":"Omo-Lamai","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115175","article-title":"The immunostimulatory nature of mRNA lipid nanoparticles","volume":"205","author":"Sharma","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103479","article-title":"The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory","volume":"24","author":"Ndeupen","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib67","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.ymthe.2022.04.011","article-title":"Pro-inflammatory concerns with lipid nanoparticles","volume":"30","author":"Moghimi","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib68","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jconrel.2021.12.027","article-title":"Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)","volume":"344","author":"Parhiz","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib69","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41565-025-01972-7","article-title":"An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing","volume":"20","author":"Chen","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101963","article-title":"LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss","volume":"43","author":"Liu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib71","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41413-024-00351-7","article-title":"Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice","volume":"12","author":"Luo","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib72","article-title":"Senescence\u2010Targeted and NAD+ \u2010dependent SIRT1\u2010Activated nanoplatform to counteract stem cell senescence for promoting aged bone regeneration","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib73","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1050-1738(02)00159-7","article-title":"The cholesterol mobilizing transporter ABCA1 as a new therapeutic target for cardiovascular disease","volume":"12","author":"Oram","year":"2002","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib74","doi-asserted-by":"crossref","DOI":"10.1172\/JCI186509","article-title":"E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1","volume":"135","author":"Cao","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bioactmat.2026.08.017_bib75","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/14728222.2023.2235718","article-title":"The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review","volume":"27","author":"Paseban","year":"2023","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib76","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2144\/04362RR02","article-title":"Labeling and quantifying sites of protein palmitoylation","volume":"36","author":"Drisdel","year":"2004","journal-title":"Biotechniques"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib77","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.devcel.2011.05.015","article-title":"The ESCRT pathway","volume":"21","author":"Henne","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib78","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1161\/ATVBAHA.116.308418","article-title":"Small GTPase ARF6 regulates endocytic pathway leading to degradation of ATP-binding cassette transporter A1","volume":"36","author":"Mukhamedova","year":"2016","journal-title":"ATVB"},{"key":"10.1016\/j.bioactmat.2026.08.017_bib79","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.cell.2006.03.042","article-title":"Global analysis of protein palmitoylation in yeast","volume":"125","author":"Roth","year":"2006","journal-title":"Cell"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26004809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X26004809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T08:55:36Z","timestamp":1788080136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X26004809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":79,"alternative-id":["S2452199X26004809"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.017","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dual-targeting mRNA lipid nanoparticle restores ABCA1-dependent cholesterol homeostasis to promote repair of age-related bone defects","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2026.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}