{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:49:28Z","timestamp":1771868968689,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.biocel.2014.01.023","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T22:33:06Z","timestamp":1391639586000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin"],"prefix":"10.1016","volume":"50","author":[{"given":"Nuno","family":"Bernardes","sequence":"first","affiliation":[]},{"given":"Ana Sofia","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Abreu","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9 F.","family":"Vieira","sequence":"additional","affiliation":[]},{"given":"Laura","family":"Carreto","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Seruca","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Paredes","sequence":"additional","affiliation":[]},{"given":"Arsenio M.","family":"Fialho","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2014.01.023_bib0005","doi-asserted-by":"crossref","first-page":"E973","DOI":"10.1152\/ajpendo.90857.2008","article-title":"Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases","volume":"296","author":"Abella","year":"2009","journal-title":"American Journal of Physiology Endocrinology and Metabolism"},{"key":"10.1016\/j.biocel.2014.01.023_bib0010","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1387\/ijdb.113382aa","article-title":"P-cadherin role in normal breast development and cancer","volume":"55","author":"Albergaria","year":"2011","journal-title":"International Journal of Developmental Biology"},{"issue":"7","key":"10.1016\/j.biocel.2014.01.023_bib0020","doi-asserted-by":"crossref","first-page":"e69023","DOI":"10.1371\/journal.pone.0069023","article-title":"The bacterial protein azurin impairs invasion and FAK\/Src signaling in P-cadherin-overexpressing breast cancer models","volume":"8","author":"Bernardes","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.biocel.2014.01.023_bib0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nm.2328","article-title":"Why don\u2019t we get more cancer? A proposed role of the microenvironment in restraining cancer progression","volume":"17","author":"Bissell","year":"2011","journal-title":"Nature Medicine"},{"key":"10.1016\/j.biocel.2014.01.023_bib0030","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/bjc.1991.191","article-title":"Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro","volume":"63","author":"Bracke","year":"1991","journal-title":"British Journal of Cancer"},{"issue":"9","key":"10.1016\/j.biocel.2014.01.023_bib0035","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1016\/S0021-9258(18)42622-1","article-title":"Characterization of the integrin avP6 as a fibronectin-binding protein","volume":"267","author":"Busk","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2014.01.023_bib0040","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/ijc.23103","article-title":"Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line","volume":"122","author":"Cariati","year":"2008","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.biocel.2014.01.023_bib0045","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1158\/1541-7786.MCR-08-0148","article-title":"Motility induction in breast carcinoma by mammary epithelial laminin 332 (laminin 5)","volume":"7","author":"Carpenter","year":"2009","journal-title":"Molecular Cancer Research"},{"key":"10.1016\/j.biocel.2014.01.023_bib0050","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1387\/ijdb.113396se","article-title":"The epidermal growth factor receptor\/Erb-B\/HER family in normal and malignant breast biology","volume":"44","author":"Eccles","year":"2011","journal-title":"International Journal of Developmental Biology"},{"key":"10.1016\/j.biocel.2014.01.023_bib0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2014.01.023_bib0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nature Protocols"},{"key":"10.1016\/j.biocel.2014.01.023_bib0075","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1158\/1541-7786.MCR-11-0498","article-title":"New insight into the SDF-1\/CXCR4 axis in a breast carcinoma model: hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation","volume":"10","author":"Jin","year":"2012","journal-title":"Molecular Cancer Research"},{"key":"10.1016\/j.biocel.2014.01.023_bib0080","doi-asserted-by":"crossref","first-page":"219196","DOI":"10.1155\/2012\/219196","article-title":"Alterations in cell-extracellular matrix interactions during progression of cancers","volume":"2012","author":"Jinka","year":"2012","journal-title":"International Journal of Cell Biology"},{"key":"10.1016\/j.biocel.2014.01.023_bib0095","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1158\/0008-5472.CAN-05-2327","article-title":"The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo","volume":"65","author":"Lipscomb","year":"2005","journal-title":"Cancer Research"},{"key":"10.1016\/j.biocel.2014.01.023_bib0100","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1158\/0008-5472.CAN-08-3078","article-title":"Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem\/progenitor cells","author":"Luo","year":"2009","journal-title":"Cancer Research"},{"key":"10.1016\/j.biocel.2014.01.023_bib0105","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10456-011-9220-6","article-title":"A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt","volume":"14","author":"Mehta","year":"2011","journal-title":"Angiogenesis"},{"key":"10.1016\/j.biocel.2014.01.023_bib0120","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.1158\/0008-5472.CAN-04-0795","article-title":"P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells","volume":"64","author":"Paredes","year":"2004","journal-title":"Cancer Research"},{"key":"10.1016\/j.biocel.2014.01.023_bib0125","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1158\/1078-0432.CCR-05-0059","article-title":"P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation","volume":"11","author":"Paredes","year":"2005","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.biocel.2014.01.023_bib0130","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/bcr1774","article-title":"P-cadherin expression in breast cancer: a review","volume":"9","author":"Paredes","year":"2007","journal-title":"Breast Cancer Research"},{"key":"10.1016\/j.biocel.2014.01.023_bib0140","first-page":"109","article-title":"Bacterial cupredoxin azurin and its interactions with the tumor suppressor protein p53","volume":"312","author":"Punj","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.biocel.2014.01.023_bib0145","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/onc.2009.338","article-title":"Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells","volume":"29","author":"Ribeiro","year":"2010","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.biocel.2014.01.023_bib0150","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/path.4143","article-title":"P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model","volume":"229","author":"Ribeiro","year":"2012","journal-title":"Journal of Pathology"},{"key":"10.1016\/j.biocel.2014.01.023_bib0160","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1158\/0008-5472.CAN-08-2932","article-title":"Noncationic peptides obtained from azurin preferentially enter cancer cells","volume":"69","author":"Taylor","year":"2009","journal-title":"Cancer Research"},{"key":"10.1016\/j.biocel.2014.01.023_bib0165","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/stem.1075","article-title":"P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer","volume":"30","author":"Vieira","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.biocel.2014.01.023_bib0170","doi-asserted-by":"crossref","first-page":"37728","DOI":"10.1074\/jbc.M606532200","article-title":"Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells","volume":"281","author":"Willmarth","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2014.01.023_bib0175","doi-asserted-by":"crossref","first-page":"14098","DOI":"10.1073\/pnas.222539699","article-title":"Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer","volume":"99","author":"Yamada","year":"2002","journal-title":"Proceedings of the National Academy of Science"},{"key":"10.1016\/j.biocel.2014.01.023_bib0180","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1073\/pnas.0400899101","article-title":"Apoptosis or growth arrest: modulation of tumor suppressor p53 specificity by bacterial redox protein azurin","volume":"101","author":"Yamada","year":"2004","journal-title":"Proceedings of the National Academy of Science"},{"key":"10.1016\/j.biocel.2014.01.023_bib0185","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/j.1462-5822.2005.00567.x","article-title":"Internalization of bacterial redox protein azurin in mammalian cells: entry domain and specificity","volume":"7","author":"Yamada","year":"2005","journal-title":"Cellular Microbiology"},{"key":"10.1016\/j.biocel.2014.01.023_bib0190","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1158\/1535-7163.MCT-09-0444","article-title":"A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells","volume":"8","author":"Yamada","year":"2009","journal-title":"Molecular Cancer Therapeutics"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514000405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514000405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:54:05Z","timestamp":1761202445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272514000405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":29,"alternative-id":["S1357272514000405"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2014.01.023","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2014.01.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}