{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:21:48Z","timestamp":1776363708186,"version":"3.51.2"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.biochi.2024.03.014","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T17:50:56Z","timestamp":1711475456000},"page":"116-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Impact of ozone therapy on mouse liver mitochondrial function and antioxidant system"],"prefix":"10.1016","volume":"223","author":[{"given":"Maria M.","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"Sofia","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Cecilia","family":"Peirone","sequence":"additional","affiliation":[]},{"given":"Marques","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9729-7477","authenticated-orcid":false,"given":"Francisco","family":"Peixoto","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2024.03.014_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2022.842229","article-title":"Ozone in medicine: a few points of reflections","volume":"13","author":"Re","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biochi.2024.03.014_bib2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/2045-9912.215752","article-title":"Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility","volume":"7","author":"Smith","year":"2017","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.biochi.2024.03.014_bib3","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3109\/10715762.2012.693609","article-title":"How a calculated oxidative stress can yield multiple therapeutic effects","volume":"46","author":"Bocci","year":"2012","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biochi.2024.03.014_bib4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/0976-9668.82319","article-title":"Ozone therapy: a clinical review","volume":"2","author":"Elvis","year":"2011","journal-title":"J.\u00a0Nat. Sci. Biol. Med."},{"key":"10.1016\/j.biochi.2024.03.014_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.arcmed.2007.07.005","article-title":"Ozone therapy: clinical and basic evidence of its therapeutic potential","volume":"39","author":"Re","year":"2008","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.biochi.2024.03.014_bib6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2174\/1874609811003030177","article-title":"Potentiality of oxygen-ozonetherapy to improve the health of aging people","volume":"3","author":"Bocci","year":"2010","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.biochi.2024.03.014_bib7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/cbf.2930","article-title":"Modulation of age-related changes in oxidative stress markers and energy status in the rat heart and hippocampus: a significant role for ozone therapy","volume":"31","author":"El-Sawalhi","year":"2013","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.biochi.2024.03.014_bib8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s10522-012-9400-9","article-title":"The potential role of ozone in ameliorating the age-related biochemical changes in male rat cerebral cortex","volume":"13","author":"Shehata","year":"2012","journal-title":"Biogerontology"},{"key":"10.1016\/j.biochi.2024.03.014_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.etap.2012.02.006","article-title":"The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury","volume":"34","author":"Gul","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.biochi.2024.03.014_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.biopha.2018.05.018","article-title":"Ozone therapy prevents the onset of dysplasia in HPV16-transgenic mice\u2014a pre-clinical efficacy and safety analysis","volume":"104","author":"Peirone","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biochi.2024.03.014_bib11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/0976-9668.82319","article-title":"Ozone therapy: a clinical review","volume":"2","author":"Elvis","year":"2011","journal-title":"J.\u00a0Nat. Sci. Biol. Med."},{"key":"10.1016\/j.biochi.2024.03.014_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/ajplung.00102.2009","article-title":"Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis","volume":"297","author":"Chuang","year":"2019","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.biochi.2024.03.014_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fnagi.2015.00065","article-title":"Oxidative stress-dependent changes in immune responses and cell death in the substantia nigra after ozone exposure in rat","volume":"7","author":"Rivas-Arancibia","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.biochi.2024.03.014_bib14","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3109\/10715762.2012.693609","article-title":"How a calculated oxidative stress can yield multiple therapeutic effects","volume":"46","author":"Bocci","year":"2012","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biochi.2024.03.014_bib15","first-page":"1","article-title":"The mito-hormetic mechanisms of ozone in the clearance of SARS-CoV2 and in the COVID-19 therapy","volume":"10","author":"Chirumbolo","year":"2022","journal-title":"Biomedicine"},{"key":"10.1016\/j.biochi.2024.03.014_bib16","series-title":"The Potential Toxicity of Ozone: Side Effects and Contraindications of Ozonetherapy, OZONE: A New Medical Drug","first-page":"75","author":"Bocci","year":"2010"},{"key":"10.1016\/j.biochi.2024.03.014_bib17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(03)00116-8","article-title":"Mitochondria: releasing power for life and unleashing the machineries of death","volume":"112","author":"Newmeyer","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2024.03.014_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.redox.2013.12.011","article-title":"Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions","volume":"2","author":"Mailloux","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.biochi.2024.03.014_bib19","first-page":"1","article-title":"Medical ozone is now ready for a scientific challenge: current status and future perspectives","volume":"2","author":"Re","year":"2012","journal-title":"J.\u00a0Exp. Integr. Med."},{"key":"10.1016\/j.biochi.2024.03.014_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bj2470069","article-title":"Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA","volume":"247","author":"Van der Zee","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/j.biochi.2024.03.014_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.14302\/issn.2471-2140.jaa-21-3910","article-title":"Antioxidative protective effect of ozone therapy on isolated mitochondria from human sperm","volume":"2","author":"Parvaneh","year":"2021","journal-title":"Journal of Antioxidant Activity"},{"key":"10.1016\/j.biochi.2024.03.014_bib22","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s10522-012-9400-9","article-title":"The potential role of ozone in ameliorating the age-related biochemical changes in male rat cerebral cortex","volume":"13","author":"Shehata","year":"2012","journal-title":"Biogerontology"},{"key":"10.1016\/j.biochi.2024.03.014_bib23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.biopha.2018.05.018","article-title":"Ozone therapy prevents the onset of dysplasia in HPV16-transgenic mice\u2014a pre-clinical efficacy and safety analysis","volume":"104","author":"Peirone","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biochi.2024.03.014_bib24","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum proteins by means of the biuret reaction","volume":"177","author":"Gornall","year":"1949","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2024.03.014_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox9121302","article-title":"Use of parabens (Methyl and butyl) during the gestation period: mitochondrial bioenergetics of the testes and antioxidant capacity alterations in testes and other vital organs of the f1 generation","volume":"9","author":"Oliveira","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.biochi.2024.03.014_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/0471142905.hg1903s63","article-title":"Evaluation of the mitochondrial respiratory Chain and oxidative phosphorylation system using polarography and spectrophotometric enzyme assays","author":"Barrientos","year":"2009","journal-title":"Curr Protoc Hum Genet"},{"key":"10.1016\/j.biochi.2024.03.014_bib27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0891-5849(99)00061-1","article-title":"Dihydrofluorescein diacetate is superior for detecting intracellular oxidants","volume":"27","author":"Hempel","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biochi.2024.03.014_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/abio.1993.1002","article-title":"Lipoprotein oxidation and measurement of thiobarbituric acid reacting substances formation in a single microtiter plate: its use for evaluation of antioxidants","volume":"208","author":"Wallin","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biochi.2024.03.014_bib29","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A\u00a0fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biochi.2024.03.014_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-2952(92)90002-Z","article-title":"Interactions of a series of coumarins with reactive oxygen species: scavenging of superoxide, hypochlorous acid and hydroxyl radicals","volume":"44","author":"Pay\u00e1","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biochi.2024.03.014_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104996","article-title":"Development of a 96-well based assay for kinetic determination of catalase enzymatic-activity in biological samples","volume":"69","author":"Grilo","year":"2020","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.biochi.2024.03.014_bib32","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.chemosphere.2016.11.004","article-title":"Glutathione and zebrafish: old assays to address a current issue","volume":"168","author":"Massarsky","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.biochi.2024.03.014_bib33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jplph.2007.12.013","article-title":"Comparative effects of the herbicides dicamba, 2,4-D and paraquat on non-green potato tuber calli","volume":"165","author":"Peixoto","year":"2008","journal-title":"J.\u00a0Plant Physiol."},{"key":"10.1016\/j.biochi.2024.03.014_bib34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/1091581809360069","article-title":"Effects of ozone blood treatment on the metabolite profile of human blood","volume":"29","author":"Travagli","year":"2010","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.biochi.2024.03.014_bib35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0955-0674(98)80147-6","article-title":"Oxygen radicals and signaling","volume":"10","author":"Finkel","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.biochi.2024.03.014_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jfbc.12877","article-title":"Hormesis effect of hydrogen peroxide on the promoter activity of neuropeptide receptor PAC1-R","volume":"43","author":"Huang","year":"2019","journal-title":"J.\u00a0Food Biochem."},{"key":"10.1016\/j.biochi.2024.03.014_bib37","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/cdd.2009.107","article-title":"Apoptosis and glutathione: beyond an antioxidant","volume":"16","author":"Franco","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biochi.2024.03.014_bib38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/biof.5520080102","article-title":"Oxidative stress: role of mitochondria and protection by glutathione","volume":"8","author":"Fern\u00e1ndez-Checa","year":"1998","journal-title":"Biofactors"},{"key":"10.1016\/j.biochi.2024.03.014_bib39","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1172\/JCI107990","article-title":"Ozone interaction with rodent lung. III. Oxidation of reduced glutathione and formation of mixed disulfides between protein and nonprotein sulfhydryls","volume":"55","author":"DeLucia","year":"1975","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.biochi.2024.03.014_bib40","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1134\/S0006297914050095","article-title":"Ozone ameliorates age-related oxidative stress changes in rat liver and kidney: effects of pre- and post-ageing administration","volume":"79","author":"Safwat","year":"2014","journal-title":"Biochemistry (Moscow)"},{"key":"10.1016\/j.biochi.2024.03.014_bib41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0378-4274(87)90003-8","article-title":"The effects of ozone on lung, heart, and liver superoxide Dismutase and Glutathione Peroxidase activities in the protein-deficient rat","volume":"38","author":"Heng","year":"1987","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biochi.2024.03.014_bib42","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s11845-011-0675-7","article-title":"The effects of ozone therapy and coenzyme Q 10 combination on oxidative stress markers in healthy subjects","volume":"180","author":"\u0130nal","year":"2011","journal-title":"Ir. J. Med. Sci."},{"key":"10.1016\/j.biochi.2024.03.014_bib43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/phrs.2001.0867","article-title":"Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats","volume":"44","author":"Mohammed Al-Dalain","year":"2001","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biochi.2024.03.014_bib44","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/09629350400008836","article-title":"Reversion by ozone treatment of acute nephrotoxicity induced by cisplatin in rats","volume":"13","author":"Gonz\u00e1lez","year":"2004","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.biochi.2024.03.014_bib45","first-page":"35","article-title":"Evaluation of intraperitoneal ozone application effects to rat's antioxidant enzymes, superoxide dismutase and glutathione peroxidase","volume":"3","author":"Simos","year":"2013","journal-title":"J.\u00a0Appl. Pharmaceut. Sci."},{"key":"10.1016\/j.biochi.2024.03.014_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/pr9061030","article-title":"Low ozone concentrations affect the structural and functional features of jurkat T cells","volume":"9","author":"Cappellozza","year":"2021","journal-title":"Processes"},{"key":"10.1016\/j.biochi.2024.03.014_bib47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10753-007-9023-5","article-title":"Ozone therapy in induced endotoxemic shock. II. The effect of ozone therapy upon selected histochemical reactions in organs of rats in endotoxemic shock","volume":"30","author":"Madej","year":"2007","journal-title":"Inflammation"},{"key":"10.1016\/j.biochi.2024.03.014_bib48","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.3390\/ijms20246303","article-title":"Mitochondrial bioenergetics in brain following ozone exposure in rats maintained on coconut, fish and olive oil-rich diets","volume":"20","author":"Valdez","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2024.03.014_bib49","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1479-5876-9-66","article-title":"Ozone acting on human blood yields a hormetic dose-response relationship","volume":"9","author":"Bocci","year":"2011","journal-title":"J.\u00a0Transl. Med."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424000725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424000725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T02:13:44Z","timestamp":1720577624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908424000725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":49,"alternative-id":["S0300908424000725"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2024.03.014","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of ozone therapy on mouse liver mitochondrial function and antioxidant system","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2024.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}