{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:56:29Z","timestamp":1774047389451,"version":"3.50.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012818","name":"Community of Madrid","doi-asserted-by":"publisher","award":["P2022\/S2022\/BMD-7245"],"award-info":[{"award-number":["P2022\/S2022\/BMD-7245"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2021\\u2013123238OB-I00"],"award-info":[{"award-number":["PID2021\\u2013123238OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2024\\u2013155613OB-I00"],"award-info":[{"award-number":["PID2024\\u2013155613OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2024\\u2013155807OB-C21"],"award-info":[{"award-number":["PID2024\\u2013155807OB-C21"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2020\\u2013117939RB-I00"],"award-info":[{"award-number":["PID2020\\u2013117939RB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2023\\u2013147925OA-I00"],"award-info":[{"award-number":["PID2023\\u2013147925OA-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022766","name":"Fundaci\u00f3n Contra la Hipertensi\u00f3n Pulmonar","doi-asserted-by":"publisher","award":["FD10\/21"],"award-info":[{"award-number":["FD10\/21"]}],"id":[{"id":"10.13039\/501100022766","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["847635"],"award-info":[{"award-number":["847635"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["P2022\/BMD-7224"],"award-info":[{"award-number":["P2022\/BMD-7224"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.biopha.2026.119115","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:15:44Z","timestamp":1771326944000},"page":"119115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The Sigma-1 receptor agonist PRE084 improves cardiopulmonary function and remodelling in an experimental model of pulmonary arterial hypertension"],"prefix":"10.1016","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3879-3056","authenticated-orcid":false,"given":"Marta","family":"Villegas-Esguevillas","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-8456","authenticated-orcid":false,"given":"Bianca","family":"Barreira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2005-7077","authenticated-orcid":false,"given":"Ana","family":"Hern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-436X","authenticated-orcid":false,"given":"Rui","family":"Ad\u00e3o","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-4633","authenticated-orcid":false,"given":"Daniel","family":"Morales-Cano","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-1040","authenticated-orcid":false,"given":"Mar\u00eda","family":"Sancho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4643-3528","authenticated-orcid":false,"given":"Jorge","family":"Navarro-Dorado","sequence":"additional","affiliation":[]},{"given":"Elena","family":"Gonz\u00e1lez-Lozano","sequence":"additional","affiliation":[]},{"given":"Jes\u00fas","family":"Ruiz-Cabello","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"P\u00e9rez-Vizcaino","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-9227","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Climent","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-1698","authenticated-orcid":false,"given":"Angel","family":"Cogolludo","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2026.119115_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.02.070","article-title":"Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands","volume":"1452","author":"Kinoshita","year":"2012","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2026.119115_bib2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cell.2012.12.004","article-title":"Dynamic Interaction between Sigma-1 Receptor and Kv1.2 Shapes Neuronal and Behavioral Responses to Cocaine","volume":"152","author":"Kourrich","year":"2013","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.biopha.2026.119115_bib3","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.tips.2019.07.006","article-title":"The Molecular Function of \u03c3 Receptors: Past, Present, and Future","volume":"40","author":"Schmidt","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2026.119115_bib4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1073\/pnas.98.2.491","article-title":"Regulating ankyrin dynamics: Roles of sigma-1 receptors","volume":"98","author":"Hayashi","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2026.119115_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106684","article-title":"Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function","volume":"189","author":"Vera-Zambrano","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.biopha.2026.119115_bib6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0896-6273(02)00677-3","article-title":"The Sigma Receptor as a Ligand-Regulated Auxiliary Potassium Channel Subunit","volume":"34","author":"Aydar","year":"2002","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.biopha.2026.119115_bib7","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1167\/iovs.08-1867","article-title":"Sigma-1 Receptor Regulation of Voltage-Gated Calcium Channels Involves a Direct Interaction","volume":"49","author":"Tchedre","year":"2008","journal-title":"Invest. Opthalmology Vis. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib8","first-page":"1","article-title":"Sigma receptor activation inhibits voltage-gated sodium channels in rat intracardiac ganglion neurons","volume":"2","author":"Zhang","year":"2009","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119115_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s40263-023-01007-6","article-title":"Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders","volume":"37","author":"Malar","year":"2023","journal-title":"CNS Drugs"},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib10","first-page":"97","article-title":"The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases","volume":"16","author":"Penke","year":"2018","journal-title":"Curr. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12929-017-0380-6","article-title":"Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases","volume":"24","author":"Weng","year":"2017","journal-title":"J. Biomed. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2026.119115_bib12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4103\/0366-6999.226076","article-title":"Sigma-1 Receptor Stimulation with PRE-084 Ameliorates Myocardial Ischemia-Reperfusion Injury in Rats","volume":"131","author":"Gao","year":"2018","journal-title":"Chin. Med. J."},{"issue":"2","key":"10.1016\/j.biopha.2026.119115_bib13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/FJC.0b013e3182970b15","article-title":"Brain Sigma-1 Receptor Stimulation Improves Mental Disorder and Cardiac Function in Mice With Myocardial Infarction","volume":"62","author":"Ito","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s10020-022-00517-1","article-title":"Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis","volume":"28","author":"Zhao","year":"2022","journal-title":"Mol. Med."},{"issue":"11","key":"10.1016\/j.biopha.2026.119115_bib15","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1517\/14728220903264064","article-title":"Stimulation of Sigma-1 receptor signaling by dehydroepiandrosterone ameliorates pressure overload-induced hypertrophy and dysfunctions in ovariectomized rats","volume":"13","author":"Bhuiyan","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"issue":"10","key":"10.1016\/j.biopha.2026.119115_bib16","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1517\/14728222.2010.509348","article-title":"Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions","volume":"14","author":"Bhuiyan","year":"2010","journal-title":"Expert Opin. Ther. Targets"},{"issue":"5","key":"10.1016\/j.biopha.2026.119115_bib17","doi-asserted-by":"crossref","first-page":"H1535","DOI":"10.1152\/ajpheart.00198.2010","article-title":"\u03c31 -Receptor stimulation with fluvoxamine ameliorates transverse aortic constriction-induced myocardial hypertrophy and dysfunction in mice","volume":"299","author":"Tagashira","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2026.119115_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111382","article-title":"Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2\/HO1 signaling pathway to attenuate mitochondrial oxidative stress","volume":"127","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2026.119115_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167284","article-title":"Blocking Sigmar1 exacerbates methamphetamine-induced hypertension","volume":"1870","author":"Xu","year":"2024","journal-title":"Biochim. Et. Biophys. Acta (BBA) Mol. Basis Dis."},{"issue":"20","key":"10.1016\/j.biopha.2026.119115_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009775","article-title":"Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics","volume":"7","author":"Abdullah","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"3","key":"10.1016\/j.biopha.2026.119115_bib21","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.3390\/ijms24031997","article-title":"Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases","volume":"24","author":"Munguia-Galaviz","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119115_bib22","article-title":"Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review","volume":"26","author":"Lewis","year":"2020","journal-title":"Int. J. Cardiol. Heart Vasc."},{"issue":"4","key":"10.1016\/j.biopha.2026.119115_bib23","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s12012-025-09975-5","article-title":"Sigma-1 Receptor Specific Biological Functions, Protective Role, and Therapeutic Potential in Cardiovascular Diseases","volume":"25","author":"Almaamari","year":"2025","journal-title":"Cardiovasc. Toxicol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib24","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01887-2018","article-title":"Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives","volume":"53","author":"Humbert","year":"2019","journal-title":"Eur. Respir. J."},{"issue":"18","key":"10.1016\/j.biopha.2026.119115_bib25","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1161\/CIRCULATIONAHA.113.001873","article-title":"Right ventricular diastolic impairment in patients with pulmonary arterial hypertension","volume":"128","author":"Rain","year":"2013","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib26","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01900-2018","article-title":"Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update","volume":"53","author":"Vonk Noordegraaf","year":"2019","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.biopha.2026.119115_bib27","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01095-2024","article-title":"Pathology and pathobiology of pulmonary hypertension: current insights and future directions","volume":"64","author":"Guignabert","year":"2024","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.biopha.2026.119115_bib28","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1183\/13993003.00798-2015","article-title":"Potassium channels in pulmonary arterial hypertension","volume":"46","author":"Boucherat","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"9","key":"10.1016\/j.biopha.2026.119115_bib29","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3390\/biom10091261","article-title":"Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension","volume":"10","author":"Le Ribeuz","year":"2020","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.biopha.2026.119115_bib30","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/HYPERTENSIONAHA.120.15221","article-title":"Uncovered Contribution of Kv7 Channels to Pulmonary Vascular Tone in Pulmonary Arterial Hypertension","volume":"76","author":"Mond\u00e9jar-Parre\u00f1o","year":"2020","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.biopha.2026.119115_bib31","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00754-2017","article-title":"TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications","volume":"50","author":"Olschewski","year":"2017","journal-title":"Eur. Respir. J."},{"issue":"14","key":"10.1016\/j.biopha.2026.119115_bib32","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/CIRCULATIONAHA.115.020951","article-title":"Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension","volume":"133","author":"Antigny","year":"2016","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.biopha.2026.119115_bib33","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.3892\/mmr.2015.3695","article-title":"Iptakalim attenuates hypoxia-induced pulmonary arterial hypertension in rats by endothelial function protection","volume":"12","author":"Zhu","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"15","key":"10.1016\/j.biopha.2026.119115_bib34","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1161\/01.CIR.0000062688.76508.B3","article-title":"Vivo Gene Transfer of the O2 -Sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in Chronically Hypoxic Rats","volume":"107","author":"Pozeg","year":"2003","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.biopha.2026.119115_bib35","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1113\/JP276054","article-title":"miR-1 is increased in pulmonary hypertension and downregulates Kv1.5 channels in rat pulmonary arteries","volume":"597","author":"Mondejar-Parre\u00f1o","year":"2019","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib36","doi-asserted-by":"crossref","first-page":"L10","DOI":"10.1152\/ajplung.00010.2019","article-title":"MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension","volume":"318","author":"Babicheva","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2026.119115_bib38","doi-asserted-by":"crossref","first-page":"L253","DOI":"10.1152\/ajplung.00319.2024","article-title":"Vitamin D as an add-on therapy to phosphodiesterase-5 inhibitor in experimental pulmonary arterial hypertension","volume":"328","author":"Ad\u00e3o","year":"2025","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"8","key":"10.1016\/j.biopha.2026.119115_bib39","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1093\/cvr\/cvy076","article-title":"Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension","volume":"114","author":"Ad\u00e3o","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2026.119115_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114222","article-title":"Metabolic syndrome inhibits store-operated Ca2+ entry and calcium-induced calcium-release mechanism in coronary artery smooth muscle","volume":"182","author":"Climent","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"20","key":"10.1016\/j.biopha.2026.119115_bib41","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/CS20160141","article-title":"Activation of PPAR\u03b2\/\u03b4 prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries","volume":"130","author":"Morales-Cano","year":"2016","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2026.119115_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107835","article-title":"Potassium (K+) channels in the pulmonary vasculature: Implications in pulmonary hypertension Physiological, pathophysiological and pharmacological regulation","volume":"225","author":"Mond\u00e9jar-Parre\u00f1o","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2026.119115_bib43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1165\/rcmb.2022-0245OC","article-title":"Novel Loss-of-Function KCNA5 Variants in Pulmonary Arterial Hypertension","volume":"69","author":"Vera-Zambrano","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"9104","key":"10.1016\/j.biopha.2026.119115_bib44","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(05)78495-6","article-title":"Attenuated K+ channel gene transcription in primary pulmonary hypertension","volume":"351","author":"Yuan","year":"1998","journal-title":"Lancet (Lond. Engl. )"},{"key":"10.1016\/j.biopha.2026.119115_bib45","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.freeradbiomed.2024.11.015","article-title":"Activating Sig-1R inhibits microvascular permeability by reducing LRRK2 expression in lipopolysaccharide-induced acute lung injury","volume":"226","author":"Lin","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/cells13010005","article-title":"The Protective Role of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Protein Sigma-1 Receptor in Regulating Endothelial Inflammation and Permeability Associated with Acute Lung Injury","volume":"13","author":"Mahamed","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2026.119115_bib47","author":"Serdjebi","year":"2024","journal-title":"Unraveling lung Vasc. Remodel. Pulm. Hypertens. Using a Quant. Digit. Pathol. Softw."},{"issue":"4","key":"10.1016\/j.biopha.2026.119115_bib48","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1080\/21655979.2022.2065953","article-title":"Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension","volume":"13","author":"Sun","year":"2022","journal-title":"Bioengineered"},{"issue":"24","key":"10.1016\/j.biopha.2026.119115_bib49","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1161\/CIRCULATIONAHA.116.022082","article-title":"Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension","volume":"133","author":"Hsu","year":"2016","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.biopha.2026.119115_bib50","doi-asserted-by":"crossref","first-page":"D22","DOI":"10.1016\/j.jacc.2013.10.027","article-title":"Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology","volume":"62","author":"Vonk-Noordegraaf","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.biopha.2026.119115_bib51","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/j.1440-1681.2009.05168.x","article-title":"Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of kv1.5 channels in rats","volume":"36","author":"Zhai","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.biopha.2026.119115_bib52","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.lfs.2018.12.056","article-title":"Dehydroepiandrosterone attenuates pulmonary artery and right ventricular remodeling in a rat model of pulmonary hypertension due to left heart failure","volume":"219","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.biopha.2026.119115_bib53","article-title":"Inhibition of Sodium\/Hydrogen Exchanger-1 in the Right Ventricle and Lung Dysfunction Induced by Experimental Pulmonary Arterial Hypertension in Rats","volume":"14","author":"Milano","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"6","key":"10.1016\/j.biopha.2026.119115_bib54","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/ATVBAHA.124.321354","article-title":"Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension","volume":"45","author":"Mirani","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119115_bib55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1165\/rcmb.2018-0095OC","article-title":"Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension","volume":"59","author":"Graham","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"8","key":"10.1016\/j.biopha.2026.119115_bib56","doi-asserted-by":"crossref","first-page":"7478","DOI":"10.3390\/ijms24087478","article-title":"Effects of the Oral Angiotensin II Type 2 Receptor Agonist C21 in Sugen-Hypoxia Induced Pulmonary Hypertension in Rats","volume":"24","author":"Tornling","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2026.119115_bib57","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00864-2021","article-title":"Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis","volume":"59","author":"Song","year":"2022","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.biopha.2026.119115_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173614","article-title":"Chronic sigma-1 receptor activation ameliorates ventricular remodeling and decreases susceptibility to ventricular arrhythmias after myocardial infarction in rats","volume":"889","author":"Fo","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119115_bib59","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jphs.2022.12.005","article-title":"Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes","volume":"151","author":"Tagashira","year":"2023","journal-title":"J. Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2026.119115_bib60","first-page":"5415","article-title":"Triggering the succinate receptor GPR91 enhances pressure overload-induced right ventricular hypertrophy","volume":"7","author":"Yang","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119115_bib61","doi-asserted-by":"crossref","first-page":"L208","DOI":"10.1152\/ajplung.00242.2014","article-title":"Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension","volume":"308","author":"Tang","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biopha.2026.119115_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.935423","article-title":"Comparative analysis of right ventricular metabolic reprogramming in pre-clinical rat models of severe pulmonary hypertension-induced right ventricular failure","volume":"9","author":"Banerjee","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2026.119115_bib63","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.lfs.2019.01.040","article-title":"Metabolomic analysis of serum and myocardium in compensated heart failure after myocardial infarction","volume":"221","author":"McKirnan","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2026.119115_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105047","article-title":"Myo-inositol and d-chiro-inositol oral supplementation ameliorate cardiac dysfunction and remodeling in a mouse model of diet-induced obesity","volume":"159","author":"L\u2019Abbate","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2026.119115_bib65","article-title":"Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice","volume":"178","author":"L\u2019Abbate","year":"2024","journal-title":"Biomed. Pharmacother. = Biomedecine Pharmacother."},{"issue":"15","key":"10.1016\/j.biopha.2026.119115_bib66","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019488","article-title":"Penetrance of Severe Pulmonary Arterial Hypertension in Response to Vascular Endothelial Growth Factor Receptor 2 Blockade in a Genetically Prone Rat Model Is Reduced by Female Sex","volume":"10","author":"Chaudhary","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"6","key":"10.1016\/j.biopha.2026.119115_bib67","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.pupt.2011.09.003","article-title":"YC-1 attenuates hypoxia-induced pulmonary arterial hypertension in mice","volume":"24","author":"Huh","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2026.119115_bib68","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.vph.2018.08.004","article-title":"Systematic review and meta-analysis of interventions tested in animal models of pulmonary hypertension","volume":"110","author":"Sztuka","year":"2018","journal-title":"Vasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119115_bib69","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2022-000137","article-title":"Pathophysiology and new advances in pulmonary hypertension","volume":"2","author":"Bousseau","year":"2023","journal-title":"BMJ Med."},{"issue":"4","key":"10.1016\/j.biopha.2026.119115_bib70","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01325-2024","article-title":"Treatment algorithm for pulmonary arterial hypertension","volume":"64","author":"Chin","year":"2024","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.biopha.2026.119115_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2020.105803","article-title":"PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation","volume":"126","author":"Motawe","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226001472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226001472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T21:39:08Z","timestamp":1774042748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226001472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":71,"alternative-id":["S0753332226001472"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119115","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Sigma-1 receptor agonist PRE084 improves cardiopulmonary function and remodelling in an experimental model of pulmonary arterial hypertension","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119115","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119115"}}