{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:00:09Z","timestamp":1771268409705,"version":"3.50.1"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.bmc.2016.12.028","type":"journal-article","created":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T02:46:02Z","timestamp":1482720362000},"page":"1122-1131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hetero-Diels-Alder approach to Bis(indolyl)methanes"],"prefix":"10.1016","volume":"25","author":[{"given":"Carla","family":"Grosso","sequence":"first","affiliation":[]},{"given":"Ana L.","family":"Cardoso","sequence":"additional","affiliation":[]},{"given":"Maria Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"C\u00e1tia","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Lu\u00edsa","family":"Barreira","sequence":"additional","affiliation":[]},{"given":"Am\u00e9rico","family":"Lemos","sequence":"additional","affiliation":[]},{"given":"Teresa M.D.V.","family":"Pinho e Melo","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.12.028_b0005","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.2174\/092986712803341449","volume":"19","author":"Lal","year":"2012","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0010","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2174\/138955709788452649","volume":"9","author":"de Sa Alves","year":"2009","journal-title":"Mini-Rev Med Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0015","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1055\/s-0034-1380415","volume":"47","author":"Praveena","year":"2015","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2016.12.028_b0020","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ejmech.2014.12.008","volume":"90","author":"El Sayed","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bioorg.2015.08.001","volume":"62","author":"Imran","year":"2015","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0030","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ejmech.2014.11.007","volume":"97","author":"Sherer","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0035","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cbi.2015.03.008","volume":"232","author":"Nayak","year":"2015","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bmc.2016.12.028_b0040","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/carcin\/bgr040","volume":"32","author":"Yoon","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bmc.2016.12.028_b0045","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1158\/0008-5472.CAN-04-3781","volume":"65","author":"Contractor","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2016.12.028_b0050","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2174\/1570178612666150220225335","volume":"12","author":"Garcia Merinos","year":"2015","journal-title":"Lett Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0055","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.catcom.2006.07.010","volume":"8","author":"Kamble","year":"2007","journal-title":"Catal Commun"},{"key":"10.1016\/j.bmc.2016.12.028_b0060","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.saa.2015.05.009","volume":"150","author":"Kandasamy","year":"2015","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"10.1016\/j.bmc.2016.12.028_b0065","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cclet.2015.11.013","volume":"27","author":"Soliman","year":"2016","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.bmc.2016.12.028_b0070","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.tetlet.2015.02.032","volume":"56","author":"Swetha","year":"2015","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2016.12.028_b0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jiec.2014.09.019","volume":"24","author":"Ying","year":"2015","journal-title":"J Ind Eng Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0080","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.6023\/cjoc1110263","volume":"32","author":"Gong","year":"2012","journal-title":"Chin J Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0085","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1039\/b807572g","volume":"10","author":"Chakraborti","year":"2008","journal-title":"Green Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0090","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1016\/S0040-4039(02)00682-2","volume":"43","author":"Chakrabarty","year":"2002","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2016.12.028_b0095","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.cclet.2011.01.039","volume":"22","author":"Boroujeni","year":"2011","journal-title":"Chinese Chem Lett"},{"key":"10.1016\/j.bmc.2016.12.028_b0100","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1039\/C6OB00515B","volume":"14","author":"Wang","year":"2016","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0105","doi-asserted-by":"crossref","first-page":"32839","DOI":"10.1039\/C6RA01391K","volume":"6","author":"Neshat","year":"2016","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2016.12.028_b0110","doi-asserted-by":"crossref","first-page":"21772","DOI":"10.1039\/C5RA01422K","volume":"5","author":"Ziyaei Halimehjani","year":"2015","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2016.12.028_b0115","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1039\/C5RA19513F","volume":"6","author":"Taha","year":"2016","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2016.12.028_b0120","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/cjoc.201400892","volume":"33","author":"Sun","year":"2015","journal-title":"Chin J Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0125","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/aoc.3428","volume":"30","author":"Zolfigol","year":"2016","journal-title":"Appl Organometal Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0130","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/chem.200601324","volume":"13","author":"Ferrer","year":"2007","journal-title":"Chem Eur J"},{"key":"10.1016\/j.bmc.2016.12.028_b0135","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1021\/jo100269y","volume":"75","author":"Gao","year":"2010","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0140","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1021\/ol203199m","volume":"14","author":"Xia","year":"2012","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2016.12.028_b0145","doi-asserted-by":"crossref","first-page":"19135","DOI":"10.1039\/c3ra42922a","volume":"3","author":"Lucarini","year":"2013","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2016.12.028_b0150","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1039\/C6OB00401F","volume":"14","author":"Zhang","year":"2016","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ejoc.200901164","author":"Sun","year":"2010","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0160","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1021\/ol403680c","volume":"16","author":"Zhuo","year":"2014","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2016.12.028_b0165","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.1039\/C4CC03605K","volume":"50","author":"Qi","year":"2014","journal-title":"Chem Commun"},{"key":"10.1016\/j.bmc.2016.12.028_b0170","doi-asserted-by":"crossref","first-page":"8237","DOI":"10.1002\/chem.201500660","volume":"21","author":"Fr\u00edas","year":"2015","journal-title":"Chem Eur J"},{"key":"10.1016\/j.bmc.2016.12.028_b0175","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/cctc.201500093","volume":"7","author":"Sun","year":"2015","journal-title":"ChemCatChem"},{"key":"10.1016\/j.bmc.2016.12.028_b0180","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.1039\/C5OB00815H","volume":"13","author":"Gong","year":"2015","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0185","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/mrc.4192","volume":"53","author":"Qi","year":"2015","journal-title":"Magn Reson Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0190","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/adsc.201500985","volume":"358","author":"Zhuo","year":"2016","journal-title":"Adv Synth Catal"},{"key":"10.1016\/j.bmc.2016.12.028_b0195","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1039\/cs9831200053","volume":"12","author":"Gilchrist","year":"1983","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.bmc.2016.12.028_b0200","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1070\/RC1998v067n06ABEH000406","volume":"67","author":"Lyapkalo","year":"1998","journal-title":"Russ Chem Rev"},{"key":"10.1016\/j.bmc.2016.12.028_b0205","unstructured":"Reissig H-U, Zimmer R. In 1-Nitrosoalkenes; Molander, G.A., ed.; Science of Synthesis; Thieme: Stuttgard, Germany, 2006; vol. 33, p. 371\u201389."},{"key":"10.1016\/j.bmc.2016.12.028_b0210","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1002\/ejoc.200900243","author":"Attanasi","year":"2009","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0215","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.1016\/j.tetlet.2010.10.095","volume":"51","author":"Lopes","year":"2010","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2016.12.028_b0220","doi-asserted-by":"crossref","first-page":"8902","DOI":"10.1016\/j.tet.2011.09.051","volume":"67","author":"Lopes","year":"2011","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2016.12.028_b0225","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1002\/ejoc.201101826","author":"Lopes","year":"2012","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0230","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.tetlet.2013.01.032","volume":"54","author":"Pereira","year":"2013","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2016.12.028_b0235","doi-asserted-by":"crossref","first-page":"7039","DOI":"10.1002\/ejoc.201402944","author":"Lopes","year":"2014","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0240","doi-asserted-by":"crossref","first-page":"10456","DOI":"10.1021\/jo502095k","volume":"79","author":"Nunes","year":"2014","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0245","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1002\/ejoc.201500878","author":"Lopes","year":"2015","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0250","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1055\/s-0034-1379306","volume":"25","author":"Grosso","year":"2014","journal-title":"Synlett"},{"key":"10.1016\/j.bmc.2016.12.028_b0255","first-page":"423","volume":"25","author":"Pereira","year":"2014","journal-title":"Synlett"},{"key":"10.1016\/j.bmc.2016.12.028_b0260","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejmech.2015.01.050","volume":"93","author":"Grosso","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0265","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/a704408i","volume":"1","author":"Yoon","year":"1998","journal-title":"J Chem Soc Perkin Trans"},{"key":"10.1016\/j.bmc.2016.12.028_b0270","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s00706-016-1763-1","volume":"147","author":"Lopes","year":"2016","journal-title":"Monatsh Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0275","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1016\/S0040-4020(01)80992-3","volume":"47","author":"Clarke","year":"1991","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2016.12.028_b0280","doi-asserted-by":"crossref","first-page":"58","DOI":"10.15227\/orgsyn.054.0058","volume":"54","author":"Heaney","year":"1974","journal-title":"Org Synth"},{"key":"10.1016\/j.bmc.2016.12.028_b0285","doi-asserted-by":"crossref","unstructured":"Lemos A, Louren\u00e7o JP. Arkivoc v, 2010, 170\u2013182.","DOI":"10.3998\/ark.5550190.0011.515"},{"key":"10.1016\/j.bmc.2016.12.028_b0290","doi-asserted-by":"crossref","first-page":"8921","DOI":"10.1021\/jo960029e","volume":"61","author":"South","year":"1996","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0295","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1246\/bcsj.59.179","volume":"59","author":"Sakai","year":"1986","journal-title":"Bull Chem Soc Jpn"},{"key":"10.1016\/j.bmc.2016.12.028_b0300","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1139\/v65-484","volume":"43","author":"Parrick","year":"1965","journal-title":"Can J Chem"},{"key":"10.1016\/j.bmc.2016.12.028_b0305","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616311178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616311178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:47:11Z","timestamp":1760834831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616311178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0968089616311178"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.12.028","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hetero-Diels-Alder approach to Bis(indolyl)methanes","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}