{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:45:38Z","timestamp":1790099138891,"version":"4.0.1"},"reference-count":73,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004162","name":"Meath Foundation","doi-asserted-by":"publisher","award":["3X4166\/SA2400166"],"award-info":[{"award-number":["3X4166\/SA2400166"]}],"id":[{"id":"10.13039\/501100004162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U2C ES030158"],"award-info":[{"award-number":["U2C ES030158"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008370","name":"National Pork Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["#AH831-25"],"award-info":[{"award-number":["#AH831-25"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011631","name":"School of Public Health, University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013677","name":"West Coast Metabolomics Center, University of California, Davis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012577","name":"Foundation for Meat & Poultry Research & Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008213","name":"South Dakota State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008213","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cdn.nutrition.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Developments in Nutrition"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cdnut.2025.107615","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:36:00Z","timestamp":1765413360000},"page":"107615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Minimally Processed Red Meat within a Plant-Forward Diet on Biomarkers of Physical and Cognitive Aging: A Randomized Controlled Crossover Feeding Trial"],"prefix":"10.1016","volume":"10","author":[{"given":"Saba","family":"Vaezi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna O","family":"de Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Weidauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L","family":"Freeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-9593","authenticated-orcid":false,"given":"Moul","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cdnut.2025.107615_bib1","series-title":"The older population: 2020, report no.: C2020BR-07","author":"Caplan","year":"2023"},{"key":"10.1016\/j.cdnut.2025.107615_bib2","series-title":"From pyramid to pillar: a century of change, population of the U.S.","year":"2018"},{"key":"10.1016\/j.cdnut.2025.107615_bib4","unstructured":"Centers for Disease Control and Prevention, NHIS Interactive Data Query Systems \u2014 Adult Population 2025. Last updated August 18, 2025 [cited 28 August, 2025]. Available from: https:\/\/www.cdc.gov\/nchs\/nhis\/products\/data-query-systems.html."},{"issue":"9","key":"10.1016\/j.cdnut.2025.107615_bib5","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.3390\/biomedicines12092096","article-title":"Vascular impairment, muscle atrophy, and cognitive decline: critical age-related conditions","volume":"12","author":"de Lima","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.cdnut.2025.107615_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1447890","article-title":"The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms","volume":"15","author":"Sarkar","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cdnut.2025.107615_bib7","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b158","article-title":"Alzheimer's disease","volume":"338","author":"Burns","year":"2009","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.cdnut.2025.107615_bib8","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","volume":"20","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.cdnut.2025.107615_bib9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3389\/fneur.2020.00643","article-title":"Increasing objective cardiometabolic burden associated with attenuations in the P3b event-related potential component in older adults","volume":"11","author":"Keage","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.cdnut.2025.107615_bib10","doi-asserted-by":"crossref","DOI":"10.20945\/2359-4292-2023-0026","article-title":"Correlation between low handgrip strength and metabolic syndrome in older adults: a systematic review","volume":"68","author":"d'Avila","year":"2024","journal-title":"Arch. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.cdnut.2025.107615_bib11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/jnnp-2023-332661","article-title":"Cardiometabolic risk factors and neurodegeneration: a review of the mechanisms underlying diabetes, obesity and hypertension in Alzheimer's disease","volume":"95","author":"Patel","year":"2024","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"issue":"4","key":"10.1016\/j.cdnut.2025.107615_bib12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00259-005-1762-7","article-title":"Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD","volume":"32","author":"Mosconi","year":"2005","journal-title":"Eur. J. Nucl. Med. Mol. Imaging."},{"issue":"6","key":"10.1016\/j.cdnut.2025.107615_bib13","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1177\/193229680800200619","article-title":"Alzheimer's disease is type 3 diabetes-evidence reviewed","volume":"2","author":"de la Monte","year":"2008","journal-title":"J. Diabetes Sci. Technol."},{"issue":"2","key":"10.1016\/j.cdnut.2025.107615_bib14","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/JOE-15-0533","article-title":"Insulin resistance and sarcopenia: mechanistic links between common co-morbidities","volume":"229","author":"Cleasby","year":"2016","journal-title":"J. Endocrinol."},{"issue":"11","key":"10.1016\/j.cdnut.2025.107615_bib15","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.3390\/nu13114080","article-title":"Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia","volume":"13","author":"Dominguez","year":"2021","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.cdnut.2025.107615_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13668-019-0271-4","article-title":"Diet and inflammation in cognitive ageing and Alzheimer's disease","volume":"8","author":"McGrattan","year":"2019","journal-title":"Curr. Nutr. Rep."},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41514-024-00150-8","article-title":"Investigating nutrient biomarkers of healthy brain aging: a multimodal brain imaging study","volume":"10","author":"Zwilling","year":"2024","journal-title":"NPJ Aging."},{"issue":"9","key":"10.1016\/j.cdnut.2025.107615_bib18","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jalz.2015.04.011","article-title":"MIND diet slows cognitive decline with aging","volume":"11","author":"Morris","year":"2015","journal-title":"Alzheimers Dement"},{"issue":"6","key":"10.1016\/j.cdnut.2025.107615_bib19","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1001\/jamapsychiatry.2023.0800","article-title":"Association of the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet with the risk of dementia","volume":"80","author":"Chen","year":"2023","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12916-023-02772-3","article-title":"Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study","volume":"21","author":"Shannon","year":"2023","journal-title":"BMC Med"},{"issue":"2","key":"10.1016\/j.cdnut.2025.107615_bib21","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/alz.13468","article-title":"Mid-life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late-life subjective cognitive complaints in women","volume":"20","author":"Song","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"3","key":"10.1016\/j.cdnut.2025.107615_bib22","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000210286","article-title":"Long-term intake of red meat in relation to dementia risk and cognitive function in US adults","volume":"104","author":"Li","year":"2025","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.cdnut.2025.107615_bib23","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S2213-8587(24)00179-7","article-title":"Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1.97 million adults with 100 000 incident cases from 31 cohorts in 20 countries","volume":"12","author":"Li","year":"2024","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"10.1016\/j.cdnut.2025.107615_bib24","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/oby.24322","article-title":"Effect of unprocessed red meat on obesity and related factors: a systematic review and meta-analysis","volume":"33","author":"Akheruzzaman","year":"2025","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib25","first-page":"24","article-title":"Higher cognitive performance is prospectively associated with healthy dietary choices: the Maine Syracuse longitudinal study","volume":"2","author":"Crichton","year":"2015","journal-title":"J. Prev. Alzheimers Dis."},{"issue":"9","key":"10.1016\/j.cdnut.2025.107615_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202101136","article-title":"Effects of lean pork on microbiota and microbial-metabolite trimethylamine-N-oxide: a randomized controlled non-inferiority feeding trial based on the Dietary Guidelines for Americans","volume":"66","author":"Dhakal","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"issue":"5","key":"10.1016\/j.cdnut.2025.107615_bib27","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.tjnut.2023.03.013","article-title":"Effects of adding lean red meat to a U.S.-style healthy vegetarian dietary pattern on gut microbiota and cardiovascular risk factors in young adults: a crossover randomized controlled trial","volume":"153","author":"Wang","year":"2023","journal-title":"J. Nutr."},{"issue":"6","key":"10.1016\/j.cdnut.2025.107615_bib28","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jacl.2019.09.012","article-title":"Impact on cardiometabolic risk of a weight loss intervention with higher protein from lean red meat: combined results of 2 randomized controlled trials in obese middle-aged and older adults","volume":"13","author":"Porter Starr","year":"2019","journal-title":"J. Clin. Lipidol."},{"issue":"S1","key":"10.1016\/j.cdnut.2025.107615_bib29","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1152\/physiol.2024.39.S1.826","article-title":"Effect of including lean red meat in a plant-based dietary pattern on biomarkers of cardiometabolic disease risk","volume":"39","author":"Piacquadio","year":"2024","journal-title":"Physiology"},{"key":"10.1016\/j.cdnut.2025.107615_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108744","article-title":"Neuroactive compounds in foods: occurrence, mechanism and potential health effects","volume":"128","author":"Y\u0131lmaz","year":"2020","journal-title":"Food Res. Int."},{"issue":"10","key":"10.1016\/j.cdnut.2025.107615_bib31","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1007\/s00210-020-01910-5","article-title":"The involvement of GABAergic system in the antidepressant-like effect of agmatine","volume":"393","author":"Neis","year":"2020","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.cdnut.2025.107615_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.987697","article-title":"Tryptophan metabolites in depression: modulation by gut microbiota","volume":"16","author":"Lukic","year":"2022","journal-title":"Front. Behav. Neurosci."},{"issue":"12","key":"10.1016\/j.cdnut.2025.107615_bib33","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/ijnp\/pyx056","article-title":"Dopamine system dysregulation in major depressive disorders","volume":"20","author":"Belujon","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.cdnut.2025.107615_bib34","first-page":"1","article-title":"Polyphenols in the management of brain disorders: modulation of the microbiota-gut-brain axis","volume":"91","author":"Serra","year":"2020","journal-title":"Adv. Food Nutr. Res."},{"issue":"6","key":"10.1016\/j.cdnut.2025.107615_bib35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/07352680091139277","article-title":"\u03b3-Aminobutyric acid (GABA) and plant responses to stress","volume":"19","author":"Kinnersley","year":"2000","journal-title":"Crit. Rev. Plant Sci."},{"key":"10.1016\/j.cdnut.2025.107615_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.124975","article-title":"Kinetic evaluation of the formation of tryptophan derivatives in the kynurenine pathway during wort fermentation using Saccharomyces pastorianus and Saccharomyces cerevisiae","volume":"297","author":"Yilmaz","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.cdnut.2025.107615_bib37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev-food-032818-121303","article-title":"Interactions between food and gut microbiota: impact on human health","volume":"10","author":"Wu","year":"2019","journal-title":"Annu. Rev. Food Sci. Technol."},{"issue":"5","key":"10.1016\/j.cdnut.2025.107615_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdnut.2025.104588","article-title":"Design and Implementation of the Protein-Distinct Macronutrient-Equivalent Diet (PRODMED) Study: an eighteen-week randomized crossover feeding trial among free-living rural older adults","volume":"9","author":"de Vargas","year":"2025","journal-title":"Curr. Dev. Nutr."},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib39","article-title":"Effect of moderate red meat intake compared with plant-based meat alternative on psychological well-being: a 10-wk cluster randomized intervention in healthy young adults, Curr","volume":"9","author":"Conner","year":"2025","journal-title":"Dev. Nutr."},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib40","first-page":"127","article-title":"Meat Science Lexicon","volume":"2","author":"Seman","year":"2018","journal-title":"Meat Muscle Biol."},{"key":"10.1016\/j.cdnut.2025.107615_bib41","unstructured":"Framingham Heart Study, Cardiovascular disease 10-year risk calculator, National Heart, Lung, and Blood Institute, 2018. [cited 28 August, 2025]. Available from: https:\/\/www.framinghamheartstudy.org\/fhs-risk-functions\/cardiovascular-disease-10-year-risk\/."},{"issue":"9","key":"10.1016\/j.cdnut.2025.107615_bib42","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1373\/clinchem.2016.257436","article-title":"Modification and validation of the triglyceride-to-HDL cholesterol ratio as a surrogate of insulin sensitivity in white juveniles and adults without diabetes mellitus: the Single Point Insulin Sensitivity Estimator (SPISE)","volume":"62","author":"Paulmichl","year":"2016","journal-title":"Clin. Chem."},{"issue":"9","key":"10.1016\/j.cdnut.2025.107615_bib43","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1007\/s40618-025-02629-x","article-title":"Development of a nomogram based on METS-IR and SPISE index for predicting mild cognitive impairment in type 2 diabetes mellitus","volume":"48","author":"Tong","year":"2025","journal-title":"J. Endocrinol. Invest."},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s40618-021-01612-6","article-title":"The single-point insulin sensitivity estimator (SPISE) index is a strong predictor of abnormal glucose metabolism in overweight\/obese children: a long-term follow-up study","volume":"45","author":"Barchetta","year":"2022","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.cdnut.2025.107615_bib45","series-title":"Hyperhomocysteinemia, StatPearls, StatPearls Publishing, LLC, Treasure Island","author":"Son","year":"2025"},{"key":"10.1016\/j.cdnut.2025.107615_bib46","series-title":"Hematology: Basic Principles and Practice","first-page":"2374","author":"Hoffman","year":"2017"},{"key":"10.1016\/j.cdnut.2025.107615_bib47","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.clnu.2025.10.010","article-title":"Impacts of minimally-processed omnivorous vs lacto-ovo-vegetarian diets on insulin sensitivity, lipid profile, and adiposity in older adults: secondary findings from a randomized crossover feeding trial","volume":"55","author":"Vaezi","year":"2025","journal-title":"Clin. Nutr."},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib48","article-title":"Association between cholesterol levels and dementia risk according to the presence of diabetes and statin use: a nationwide cohort study","volume":"12","author":"Lee","year":"2022","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.cdnut.2025.107615_bib49","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s12603-012-0064-6","article-title":"Dietary protein and beef consumption predict for markers of muscle mass and nutrition status in older adults","volume":"16","author":"Asp","year":"2012","journal-title":"J. Nutr. Health Aging"},{"issue":"2","key":"10.1016\/j.cdnut.2025.107615_bib50","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41430-022-01150-1","article-title":"Red meat consumption and risk factors for type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials","volume":"77","author":"Sanders","year":"2023","journal-title":"Eur. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.cdnut.2025.107615_bib51","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jacl.2012.01.001","article-title":"A meta-analysis of randomized controlled trials that compare the lipid effects of beef versus poultry and\/or fish consumption","volume":"6","author":"Maki","year":"2012","journal-title":"J. Clin. Lipidol."},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib52","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3945\/ajcn.116.142521","article-title":"Total red meat intake of \u22650.5 servings\/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials","volume":"105","author":"O'Connor","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"issue":"15","key":"10.1016\/j.cdnut.2025.107615_bib53","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1161\/CIRCULATIONAHA.118.035225","article-title":"Meta-analysis of randomized controlled trials of red meat consumption in comparison with various comparison diets on cardiovascular risk factors","volume":"139","author":"Guasch-Ferre","year":"2019","journal-title":"Circulation"},{"issue":"34","key":"10.1016\/j.cdnut.2025.107615_bib54","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.2174\/1381612821666150914121149","article-title":"Treatment options in Alzheime\u0155s disease: the GABA story","volume":"21","author":"Solas","year":"2015","journal-title":"Curr. Pharm. Des."},{"issue":"7","key":"10.1016\/j.cdnut.2025.107615_bib55","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s40265-014-0217-5","article-title":"Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status","volume":"74","author":"Ramirez","year":"2014","journal-title":"Drugs"},{"issue":"9","key":"10.1016\/j.cdnut.2025.107615_bib56","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.4103\/NRR.NRR-D-24-00230","article-title":"The dopaminergic system and Alzheimer's disease","volume":"20","author":"Zhang","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.cdnut.2025.107615_bib57","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.pnpbp.2019.02.001","article-title":"The glycine site of NMDA receptors: a target for cognitive enhancement in psychiatric disorders","volume":"92","author":"Peyrovian","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.cdnut.2025.107615_bib58","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3945\/ajcn.111.018978","article-title":"Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis","volume":"94","author":"Pan","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.cdnut.2025.107615_bib59","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.3390\/nu7042176","article-title":"B vitamins, homocysteine and bone health","volume":"7","author":"Fratoni","year":"2015","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.cdnut.2025.107615_bib60","first-page":"2590","article-title":"Prognostic value of serum homocysteine levels in elderly hospitalized patients","volume":"31","author":"Hernandez-Betancor","year":"2015","journal-title":"Nutr. Hosp."},{"key":"10.1016\/j.cdnut.2025.107615_bib61","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.arr.2018.10.010","article-title":"Homocysteine and age-associated disorders","volume":"49","author":"Ostrakhovitch","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cdnut.2025.107615_bib62","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-5-6","article-title":"Homocysteine and cognitive impairment; a case series in a General Practice setting","volume":"5","author":"McCaddon","year":"2006","journal-title":"Nutr. J."},{"issue":"4","key":"10.1016\/j.cdnut.2025.107615_bib63","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12272-018-1016-4","article-title":"Causes of hyperhomocysteinemia and its pathological significance","volume":"41","author":"Kim","year":"2018","journal-title":"Arch. Pharm. Res."},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib64","first-page":"24","article-title":"Vitamin B12 and older adults","volume":"13","author":"Stover","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib65","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12986-017-0233-z","article-title":"The metabolism and significance of homocysteine in nutrition and health","volume":"14","author":"Kumar","year":"2017","journal-title":"Nutr. Metab. (Lond)."},{"issue":"7","key":"10.1016\/j.cdnut.2025.107615_bib66","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3945\/jn.109.120477","article-title":"Dietary patterns are associated with hyperhomocysteinemia in an urban Pakistani population","volume":"140","author":"Yakub","year":"2010","journal-title":"J. Nutr."},{"issue":"21","key":"10.1016\/j.cdnut.2025.107615_bib67","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.3390\/nu15214662","article-title":"The role of methionine-rich diet in unhealthy cerebrovascular and brain aging: mechanisms and implications for cognitive impairment","volume":"15","author":"Ungvari","year":"2023","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.cdnut.2025.107615_bib68","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/ajcn\/76.6.1202","article-title":"Effect of protein and methionine intakes on plasma homocysteine concentrations: a 6-mo randomized controlled trial in overweight subjects","volume":"76","author":"Haulrik","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"issue":"11","key":"10.1016\/j.cdnut.2025.107615_bib69","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1093\/jn\/133.11.3636","article-title":"Dietary pattern is associated with homocysteine and B vitamin status in an urban Chinese population","volume":"133","author":"Gao","year":"2003","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib70","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41538-023-00212-3","article-title":"Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice","volume":"7","author":"Li","year":"2023","journal-title":"NPJ Sci. Food."},{"key":"10.1016\/j.cdnut.2025.107615_bib71","first-page":"247","article-title":"Phosphatidylcholine as a precursor of choline for acetylcholine synthesis","volume":"24","author":"Blusztajn","year":"1987","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.cdnut.2025.107615_bib72","series-title":"Modern nutrition in health and disease: Eleventh edition","first-page":"1616","author":"Ross","year":"2012"},{"key":"10.1016\/j.cdnut.2025.107615_bib73","series-title":"Choline: Fact sheet for consumers","author":"OoD","year":"2022"},{"issue":"1","key":"10.1016\/j.cdnut.2025.107615_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/srep28797","article-title":"Impact of dietary resistant starch type 4 on human gut microbiota and immunometabolic functions","volume":"6","author":"Upadhyaya","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Current Developments in Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S247529912503077X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S247529912503077X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:36:35Z","timestamp":1773963395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S247529912503077X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S247529912503077X"],"URL":"https:\/\/doi.org\/10.1016\/j.cdnut.2025.107615","relation":{},"ISSN":["2475-2991"],"issn-type":[{"value":"2475-2991","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Minimally Processed Red Meat within a Plant-Forward Diet on Biomarkers of Physical and Cognitive Aging: A Randomized Controlled Crossover Feeding Trial","name":"articletitle","label":"Article Title"},{"value":"Current Developments in Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cdnut.2025.107615","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"107615"}}