{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:56:49Z","timestamp":1791665809653,"version":"4.3.4"},"reference-count":82,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["SFB LIPOTOX F3007"],"award-info":[{"award-number":["SFB LIPOTOX F3007"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["DK-MCD W1226"],"award-info":[{"award-number":["DK-MCD W1226"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P29203"],"award-info":[{"award-number":["P29203"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P29262"],"award-info":[{"award-number":["P29262"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["F3012"],"award-info":[{"award-number":["F3012"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P27893"],"award-info":[{"award-number":["P27893"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P31727"],"award-info":[{"award-number":["P31727"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["I3792"],"award-info":[{"award-number":["I3792"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P28854"],"award-info":[{"award-number":["P28854"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["S2603"],"award-info":[{"award-number":["S2603"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009057","name":"Karl-Franzens-Universit\u00e4t Graz","doi-asserted-by":"publisher","award":["BMWFW-80.109\/0001-WF\/V\/3b\/2015"],"award-info":[{"award-number":["BMWFW-80.109\/0001-WF\/V\/3b\/2015"]}],"id":[{"id":"10.13039\/501100009057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013119","name":"PharmaMar","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013119","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001009","name":"Bristol-Myers Squibb Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007945","name":"Steirische Wirtschaftsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","award":["K-Centre 868624"],"award-info":[{"award-number":["K-Centre 868624"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","award":["843536"],"award-info":[{"award-number":["843536"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","award":["870454"],"award-info":[{"award-number":["870454"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","award":["864690"],"award-info":[{"award-number":["864690"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004956","name":"Bundesministerium f\u00fcr Verkehr, Innovation und Technologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["EFOP-3.6.2- 16-2017-00012"],"award-info":[{"award-number":["EFOP-3.6.2- 16-2017-00012"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["TNE15004"],"award-info":[{"award-number":["TNE15004"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["NKFIH-KKP-126998"],"award-info":[{"award-number":["NKFIH-KKP-126998"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019574","name":"Institut M\u00e9rieux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019802","name":"BioTechMed-Graz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012416","name":"Bundesministerium f\u00fcr Digitalisierung und Wirtschaftsstandort","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020236","name":"Japan Foundation for Pediatric Research","doi-asserted-by":"publisher","award":["JP19K08041"],"award-info":[{"award-number":["JP19K08041"]}],"id":[{"id":"10.13039\/100020236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018536","name":"NuCana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018536","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003837","name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","doi-asserted-by":"publisher","award":["I3301"],"award-info":[{"award-number":["I3301"]}],"id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013699","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020407","name":"European Research Area Network on Cardiovascular Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.celrep.2021.108985","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T10:27:35Z","timestamp":1618482455000},"page":"108985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":217,"title":["Dietary spermidine improves cognitive function"],"prefix":"10.1016","volume":"35","author":[{"given":"Sabrina","family":"Schroeder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-0014","authenticated-orcid":false,"given":"Sebastian J.","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-944X","authenticated-orcid":false,"given":"Andreas","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Pechlaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Dammbrueck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Pendl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Mark","family":"Marcello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Pogatschnigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-9010","authenticated-orcid":false,"given":"Verena","family":"Gschiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-3096","authenticated-orcid":false,"given":"Selena","family":"Ristic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Tadic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesa","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-3871","authenticated-orcid":false,"given":"Aitak","family":"Farzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muammer","family":"\u00dc\u00e7al","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Poglitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Royer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Mekis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Agreiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regine C.","family":"T\u00f6lle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"S\u00f3tonyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Willeit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Mairhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Niederkofler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irmgard","family":"Pallhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Rungger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-2579","authenticated-orcid":false,"given":"Herbert","family":"Tilg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Defrancesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Marksteiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9292-4512","authenticated-orcid":false,"given":"Frank","family":"Sinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Magnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Pieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-395X","authenticated-orcid":false,"given":"Peter","family":"Holzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9334-4405","authenticated-orcid":false,"given":"Guido","family":"Kroemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didac","family":"Carmona-Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Scorrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Dengjel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9725-5231","authenticated-orcid":false,"given":"Tobias","family":"Madl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-6821","authenticated-orcid":false,"given":"Simon","family":"Sedej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J.","family":"Sigrist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"R\u00e1cz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kiechl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3559-1130","authenticated-orcid":false,"given":"Tobias","family":"Eisenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Madeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9 Suppl","key":"10.1016\/j.celrep.2021.108985_bib1","doi-asserted-by":"crossref","first-page":"S498","DOI":"10.1097\/00005768-200009001-00009","article-title":"Compendium of physical activities: an update of activity codes and MET intensities","volume":"32","author":"Ainsworth","year":"2000","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.celrep.2021.108985_bib2","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.2337\/dc08-1239","article-title":"International tables of glycemic index and glycemic load values: 2008","volume":"31","author":"Atkinson","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.celrep.2021.108985_bib3","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/ajcn\/36.5.936","article-title":"A short questionnaire for the measurement of habitual physical activity in epidemiological studies","volume":"36","author":"Baecke","year":"1982","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.celrep.2021.108985_bib4","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1523\/JNEUROSCI.23-15-06304.2003","article-title":"Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?","volume":"23","author":"Balschun","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.108985_bib5","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/gerona\/62.10.1071","article-title":"Optimization of dietary restriction protocols in Drosophila","volume":"62","author":"Bass","year":"2007","journal-title":"J.\u00a0Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.celrep.2021.108985_bib6","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41467-019-09262-2","article-title":"Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner","volume":"10","author":"Bhukel","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.108985_bib7","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.2337\/diabetes.53.7.1782","article-title":"Population-based incidence rates and risk factors for type 2 diabetes in white individuals: the Bruneck study","volume":"53","author":"Bonora","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2021.108985_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3945\/ajcn.2008.26354","article-title":"Glycemic index, postprandial glycemia, and the shape of the curve in healthy subjects: analysis of a database of more than 1,000 foods","volume":"89","author":"Brand-Miller","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.celrep.2021.108985_bib9","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.4161\/15384101.2014.973309","article-title":"Spermidine protects against \u03b1-synuclein neurotoxicity","volume":"13","author":"B\u00fcttner","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2021.108985_bib10","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1002\/cpbi.86","article-title":"Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis","volume":"68","author":"Chong","year":"2019","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.celrep.2021.108985_bib11","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1080\/15548627.2015.1108508","article-title":"Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice","volume":"11","author":"Chrisam","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2021.108985_bib12","doi-asserted-by":"crossref","first-page":"e35878","DOI":"10.7554\/eLife.35878","article-title":"Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila","volume":"7","author":"Cornelissen","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.108985_bib13","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2021.108985_bib14","doi-asserted-by":"crossref","first-page":"e13189","DOI":"10.1111\/acel.13189","article-title":"Mechanisms by which autophagy regulates memory capacity in ageing","volume":"19","author":"De Risi","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2021.108985_bib15","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/ncb1975","article-title":"Induction of autophagy by spermidine promotes longevity","volume":"11","author":"Eisenberg","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2021.108985_bib16","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/nm.4222","article-title":"Cardioprotection and lifespan extension by the natural polyamine spermidine","volume":"22","author":"Eisenberg","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.108985_bib17","first-page":"166","article-title":"Human energy requirements: report of a joint FAO\/ WHO\/UNU Expert Consultation","volume":"26","year":"2005","journal-title":"Food Nutr. Bull."},{"key":"10.1016\/j.celrep.2021.108985_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbi.2014.08.011","article-title":"Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers","volume":"44","author":"Farzi","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2021.108985_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.celrep.2021.108985_bib20","unstructured":"Gebhardt, S.E., Lemar, L.E., Pehrsson, P.R., Exler, J., Haytowitz, D.B., Showell, B.A., Nickle, M.S., Thomas, R.G., Patterson, K.K., Bhagwat, S.A., et al. 2010. USDA national nutrient database for standard reference, release 23. Available: http:\/\/www.ars.usda.gov\/nutrientdata"},{"key":"10.1016\/j.celrep.2021.108985_bib21","first-page":"435","article-title":"Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline. Curr. Biol","volume":"29","author":"Glatigny","year":"2019"},{"key":"10.1016\/j.celrep.2021.108985_bib22","series-title":"Life in the Cold","first-page":"431","article-title":"Mitochondria in the cold","author":"Gnaiger","year":"2000"},{"key":"10.1016\/j.celrep.2021.108985_bib23","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1073\/pnas.0737556100","article-title":"Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants","volume":"100","author":"Greene","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.108985_bib24","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jnc.14037","article-title":"Brain aging and neurodegeneration: from a mitochondrial point of view","volume":"143","author":"Grimm","year":"2017","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2021.108985_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.phrs.2016.03.023","article-title":"Modulation of learning and memory by natural polyamines","volume":"112","author":"Guerra","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.celrep.2021.108985_bib26","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/nn.3512","article-title":"Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner","volume":"16","author":"Gupta","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.108985_bib27","doi-asserted-by":"crossref","first-page":"e1002563","DOI":"10.1371\/journal.pbio.1002563","article-title":"Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release","volume":"14","author":"Gupta","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2021.108985_bib28","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1176\/ajp.152.8.1228","article-title":"Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV)","volume":"152","author":"Guze","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.celrep.2021.108985_bib29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbr.2013.10.036","article-title":"Brain aging, memory impairment and oxidative stress: a study in Drosophila melanogaster","volume":"259","author":"Haddadi","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.celrep.2021.108985_bib30","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108985_bib31","first-page":"295","article-title":"The environment and disease: association or causation?","volume":"58","author":"Hill","year":"1965","journal-title":"Proc. R. Soc. Med."},{"key":"10.1016\/j.celrep.2021.108985_bib32","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1242\/jcs.093849","article-title":"PINK1- and Parkin-mediated mitophagy at a glance","volume":"125","author":"Jin","year":"2012","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2021.108985_bib33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.nlm.2011.10.002","article-title":"Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory","volume":"97","author":"Jobim","year":"2012","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.celrep.2021.108985_bib34","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1101\/gad.1600707","article-title":"Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila","volume":"21","author":"Juh\u00e1sz","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2021.108985_bib35","doi-asserted-by":"crossref","first-page":"C641","DOI":"10.1152\/ajpcell.00222.2006","article-title":"Mitochondria and neuronal activity","volume":"292","author":"Kann","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2021.108985_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fnagi.2011.00009","article-title":"Age sensitivity of behavioral tests and brain substrates of normal aging in mice","volume":"3","author":"Kennard","year":"2011","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.celrep.2021.108985_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000492329","article-title":"In a Nutshell: Findings from the Bruneck Study","volume":"65","author":"Kiechl","year":"2019","journal-title":"Gerontology"},{"key":"10.1016\/j.celrep.2021.108985_bib38","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nm.3084","article-title":"Blockade of receptor activator of nuclear factor-\u03baB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus","volume":"19","author":"Kiechl","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.108985_bib39","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/ajcn\/nqy102","article-title":"Higher spermidine intake is linked to lower mortality: a prospective population-based study","volume":"108","author":"Kiechl","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.celrep.2021.108985_bib40","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"Komatsu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108985_bib41","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/ajcn\/71.6.1455","article-title":"A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women","volume":"71","author":"Liu","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.celrep.2021.108985_bib42","doi-asserted-by":"crossref","first-page":"19616","DOI":"10.1038\/s41598-019-56133-3","article-title":"Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses","volume":"9","author":"Maglione","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2021.108985_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chroma.2013.12.061","article-title":"Polyamines in biological samples: rapid and robust quantification by solid-phase extraction online-coupled to liquid chromatography-tandem mass spectrometry","volume":"1331","author":"Magnes","year":"2014","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.celrep.2021.108985_bib44","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nm.3466","article-title":"Plasma phospholipids identify antecedent memory impairment in older adults","volume":"20","author":"Mapstone","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.108985_bib45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.nlm.2016.07.001","article-title":"Cognitive deficits in single App knock-in mouse models","volume":"135","author":"Masuda","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.celrep.2021.108985_bib46","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/ajcn\/76.6.1261","article-title":"Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance","volume":"76","author":"McCullough","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.celrep.2021.108985_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneumeth.2009.02.018","article-title":"A comparison of learning and memory characteristics of young and middle-aged wild-type mice in the IntelliCage","volume":"180","author":"Mechan","year":"2009","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.celrep.2021.108985_bib48","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/ajcn\/51.2.241","article-title":"A new predictive equation for resting energy expenditure in healthy individuals","volume":"51","author":"Mifflin","year":"1990","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.celrep.2021.108985_bib49","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/JBCPP.2002.13.1.61","article-title":"Effect of multiple ifenprodil or spermidine treatment on social recognition in rats","volume":"13","author":"Mikolajczak","year":"2002","journal-title":"J.\u00a0Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.celrep.2021.108985_bib50","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.39.9.1159","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer\u2019s disease","volume":"39","author":"Morris","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2021.108985_bib51","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1083\/jcb.201008167","article-title":"Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome","volume":"192","author":"Morselli","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2021.108985_bib52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1055\/s-0035-1555115","article-title":"The Impact of Age on Cognition","volume":"36","author":"Murman","year":"2015","journal-title":"Semin. Hear."},{"key":"10.1016\/j.celrep.2021.108985_bib53","doi-asserted-by":"crossref","first-page":"C670","DOI":"10.1152\/ajpcell.00213.2006","article-title":"The mitochondrial energy transduction system and the aging process","volume":"292","author":"Navarro","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2021.108985_bib54","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.redox.2016.10.015","article-title":"Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts","volume":"10","author":"Ott","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2021.108985_bib56","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.cmet.2019.05.003","article-title":"Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation","volume":"30","author":"Puleston","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2021.108985_bib57","doi-asserted-by":"crossref","first-page":"24700","DOI":"10.1038\/srep24700","article-title":"ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts","volume":"6","author":"Qi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2021.108985_bib58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jneumeth.2014.06.013","article-title":"Comparison of automated home-cage monitoring systems: emphasis on feeding behaviour, activity and spatial learning following pharmacological interventions","volume":"234","author":"Robinson","year":"2014","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.celrep.2021.108985_bib59","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1192\/bjp.149.6.698","article-title":"CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia","volume":"149","author":"Roth","year":"1986","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.celrep.2021.108985_bib60","doi-asserted-by":"crossref","first-page":"19","DOI":"10.18632\/aging.101354","article-title":"Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline","volume":"10","author":"Schwarz","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.celrep.2021.108985_bib61","doi-asserted-by":"crossref","first-page":"117132","DOI":"10.1016\/j.neuroimage.2020.117132","article-title":"Spermidine intake is associated with cortical thickness and hippocampal volume in older adults","volume":"221","author":"Schwarz","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.celrep.2021.108985_bib62","first-page":"196","article-title":"Age-Induced Alterations in Hippocampal Function and Metabolism","volume":"2","author":"Shetty","year":"2011","journal-title":"Aging Dis."},{"key":"10.1016\/j.celrep.2021.108985_bib63","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.tcm.2017.11.008","article-title":"Mitochondrial quality control: The role of mitophagy in aging","volume":"28","author":"Shi","year":"2018","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.celrep.2021.108985_bib64","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1471-4159.1985.tb08724.x","article-title":"Limited blood-brain barrier transport of polyamines","volume":"44","author":"Shin","year":"1985","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2021.108985_bib65","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/genes8120398","article-title":"The Mitochondrial Basis of Aging and Age-Related Disorders","volume":"8","author":"Srivastava","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.celrep.2021.108985_bib66","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/CIRCULATIONAHA.113.002500","article-title":"Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study","volume":"129","author":"Stegemann","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2021.108985_bib67","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","article-title":"The Mitochondrial Basis of Aging","volume":"61","author":"Sun","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2021.108985_bib68","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2174\/1570159X14666160414111821","article-title":"Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System","volume":"15","author":"Todorova","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.celrep.2021.108985_bib69","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1021\/acs.jproteome.8b00237","article-title":"Three-Dimensional Cell Culture Conditions Affect the Proteome of Cancer-Associated Fibroblasts","volume":"17","author":"T\u00f6lle","year":"2018","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.celrep.2021.108985_bib70","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1001\/jamainternmed.2015.2152","article-title":"Cognitive Tests to Detect Dementia: A Systematic Review and Meta-analysis","volume":"175","author":"Tsoi","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.celrep.2021.108985_bib71","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF01350033","article-title":"Classical conditioning and retention in normal and mutant Drosophila melanogaster","volume":"157","author":"Tully","year":"1985","journal-title":"J.\u00a0Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol."},{"key":"10.1016\/j.celrep.2021.108985_bib72","doi-asserted-by":"crossref","first-page":"15024","DOI":"10.1073\/pnas.1206362109","article-title":"Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43","volume":"109","author":"Wang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.108985_bib73","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1212\/WNL.44.4.609","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part V. A normative study of the neuropsychological battery","volume":"44","author":"Welsh","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2021.108985_bib74","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jacc.2014.03.061","article-title":"Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study","volume":"64","author":"Willeit","year":"2014","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.celrep.2021.108985_bib75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.aje.a114366","article-title":"Total energy intake: implications for epidemiologic analyses","volume":"124","author":"Willett","year":"1986","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.celrep.2021.108985_bib76","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oxfordjournals.aje.a114086","article-title":"Reproducibility and validity of a semiquantitative food frequency questionnaire","volume":"122","author":"Willett","year":"1985","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.celrep.2021.108985_bib77","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cortex.2018.09.014","article-title":"The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial","volume":"109","author":"Wirth","year":"2018","journal-title":"Cortex"},{"key":"10.1016\/j.celrep.2021.108985_bib78","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.18632\/aging.103035","article-title":"Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice","volume":"12","author":"Xu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.celrep.2021.108985_bib79","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbr.2014.02.005","article-title":"mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits","volume":"264","author":"Yang","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.celrep.2021.108985_bib80","doi-asserted-by":"crossref","first-page":"16852","DOI":"10.18632\/aging.103578","article-title":"Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C.\u00a0elegans","volume":"12","author":"Yang","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"Suppl 2","key":"10.1016\/j.celrep.2021.108985_bib81","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/sj.cdd.4401765","article-title":"Autophagy: molecular machinery for self-eating","volume":"12","author":"Yorimitsu","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2021.108985_bib82","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/jnc.14308","article-title":"Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson\u2019s disease","volume":"144","author":"Zhang","year":"2018","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2021.108985_bib83","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.molcel.2019.08.005","article-title":"Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence","volume":"76","author":"Zhang","year":"2019","journal-title":"Mol. Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721002990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721002990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:42:02Z","timestamp":1778841722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721002990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S2211124721002990"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.108985","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary spermidine improves cognitive function","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.108985","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.108941","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"108985"}}