{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T17:28:18Z","timestamp":1770571698889,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Fundacao para a Ciencia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.chemosphere.2024.143582","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T15:47:52Z","timestamp":1729698472000},"page":"143582","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Considering safe and sustainable by design alternatives\u2013Environmental hazards of an agriculture nano-enabled pesticide to non-target species"],"prefix":"10.1016","volume":"367","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3701-2107","authenticated-orcid":false,"given":"Sekerani B.","family":"Chidiamassamba","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7537-2341","authenticated-orcid":false,"given":"Susana I.L.","family":"Gomes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8137-3295","authenticated-orcid":false,"given":"M\u00f3nica J.B.","family":"Amorim","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-1224","authenticated-orcid":false,"given":"Janeck J.","family":"Scott-Fordsmand","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2024.143582_bib1","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1007\/s11356-019-07414-x","article-title":"Detoxification and reproductive system-related gene expression following exposure to Cu(OH)2 nanopesticide in water flea (Daphnia magna Straus 1820)","volume":"27","author":"Aksakal","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2024.143582_bib2","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/tox.22993","article-title":"Developmental toxicity induced by Cu(OH)2 nanopesticide in zebrafish embryos","volume":"35","author":"Aksakal","year":"2020","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.143582_bib3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.envpol.2012.01.015","article-title":"Toxicity of copper nanoparticles and CuCl2 salt to Enchytraeus albidus worms: survival, reproduction and avoidance responses","volume":"164","author":"Amorim","year":"2012","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.143582_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-021-01214-7","article-title":"Nanomaterials and nanotechnology for the delivery of agrochemicals: strategies towards sustainable agriculture","volume":"20","author":"An","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.chemosphere.2024.143582_bib5","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.ecoenv.2019.06.049","article-title":"Effects of two common fungicides on the reproduction of Aporrectodea caliginosa in natural soil","volume":"181","author":"Bart","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2024.143582_bib6","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1007\/s11356-014-3921-5","article-title":"Non-avoidance behaviour in enchytraeids to boric acid is related to the GABAergic mechanism","volume":"22","author":"Bicho","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2024.143582_bib7","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s10646-015-1445-5","article-title":"Enchytraeid Reproduction TestPLUS: hatching, growth and full life cycle test\u2014an optional multi-endpoint test with Enchytraeus crypticus","volume":"24","author":"Bicho","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.chemosphere.2024.143582_bib8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.envpol.2017.01.067","article-title":"Effects of copper oxide nanomaterials (CuONMs) are life stage dependent \u2013 full life cycle in Enchytraeus crypticus","volume":"224","author":"Bicho","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.143582_bib9","doi-asserted-by":"crossref","first-page":"8457","DOI":"10.1038\/s41598-017-08911-0","article-title":"Multigenerational effects of copper nanomaterials (CuONMs) are different of those of CuCl2: exposure in the soil invertebrate Enchytraeus crypticus","volume":"7","author":"Bicho","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2024.143582_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111822","article-title":"Occupational pesticide exposure, cancer and chronic neurological disorders: a systematic review of epidemiological studies in greenspace workers","volume":"203","author":"de Graaf","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2024.143582_bib11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1071\/EN19057","article-title":"Nanoformulations can significantly affect pesticide degradation and uptake by earthworms and plants","volume":"16","author":"Fojtov\u00e1","year":"2019","journal-title":"Environ. Chem."},{"key":"10.1016\/j.chemosphere.2024.143582_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122469","article-title":"Environmental hazards of WELGRO\u00ae Cu+Zn: a nano-enabled fertilizer","volume":"336","author":"Gomes","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.143582_bib13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.chemosphere.2015.06.045","article-title":"Cu-nanoparticles ecotoxicity \u2013 explored and explained?","volume":"139","author":"Gomes","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2024.143582_bib14","first-page":"1950","article-title":"On the safety of nanoformulations to non-target soil invertebrates \u2013 an atrazine case study","volume":"6","author":"Gomes","year":"2019","journal-title":"Environ. Sci.: Nano"},{"key":"10.1016\/j.chemosphere.2024.143582_bib15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ecoenv.2018.08.094","article-title":"Mixture toxicity assessment of a biocidal product based on reproduction and avoidance behaviour of the collembolan Folsomia candida","volume":"165","author":"Guimar\u00e3es","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2024.143582_bib16","series-title":"New Pesticides and Soil Sensors","article-title":"Nanopesticides: a review of current research and perspectives","author":"Hayles","year":"2017"},{"key":"10.1016\/j.chemosphere.2024.143582_bib17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.scitotenv.2017.09.049","article-title":"Currently and recently used pesticides in Central European arable soils","volume":"613\u2013614","author":"Hv\u011bzdov\u00e1","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.143582_bib18","series-title":"Soil Quality - Avoidance Test for Testing the Quality of Soils and Effects of Chemicals-Part 1: Test with Earathworms (Eisenia fetida and Eisenia andrei).Guideline No 17512-1","year":"2008"},{"key":"10.1016\/j.chemosphere.2024.143582_bib19","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/s41565-018-0131-1","article-title":"A critical evaluation of nanopesticides and nanofertilizers against their conventional analogues","volume":"13","author":"Kah","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.chemosphere.2024.143582_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1071\/EN19011","article-title":"Comparing plant\u2013insect trophic transfer of Cu from lab-synthesised nano-Cu(OH)2 with a commercial nano-Cu(OH)2 fungicide formulation","volume":"16","author":"Li","year":"2019","journal-title":"Environ. Chem."},{"key":"10.1016\/j.chemosphere.2024.143582_bib21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0013-9351(03)00138-5","article-title":"The relationship between lysosomal biomarker and organismal responses in an acute toxicity test with Eisenia Fetida (Oligochaeta) exposed to the fungicide copper oxychloride","volume":"96","author":"Maboeta","year":"2004","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2024.143582_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coesh.2019.07.003","article-title":"Agrochemicals in the wild: identifying links between pesticide use and declines of nontarget organisms","volume":"11","author":"Mancini","year":"2019","journal-title":"Curr. Opin. Environ. Sci. Heal."},{"key":"10.1016\/j.chemosphere.2024.143582_bib23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11368-009-0058-0","article-title":"Using earthworm avoidance behaviour to assess the toxicity of formulated herbicides and their active ingredients on natural soils","volume":"9","author":"Marques","year":"2009","journal-title":"J. Soils Sediments"},{"key":"10.1016\/j.chemosphere.2024.143582_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.envint.2015.10.012","article-title":"The influence of size on the toxicity of an encapsulated pesticide: a comparison of micron- and nano-sized capsules","volume":"86","author":"Meredith","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2024.143582_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150679","article-title":"Terrestrial organisms react differently to nano and non-nano Cu(OH)2 forms","volume":"807","author":"Morgado","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.143582_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108926","article-title":"Systematic review of comparative studies assessing the toxicity of pesticide active ingredients and their product formulations","volume":"181","author":"Nagy","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2024.143582_bib27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1071\/EN19061","article-title":"Copper toxicity to Folsomia candida in different soils: a comparison between nano and conventional formulations","volume":"16","author":"Neves","year":"2019","journal-title":"Environ. Chem."},{"key":"10.1016\/j.chemosphere.2024.143582_bib28","series-title":"Test No. 220: Enchytraeid Reproduction Test","year":"2016"},{"key":"10.1016\/j.chemosphere.2024.143582_bib29","article-title":"Guidance on sample preparation and dosimetry for the safety testing of manufactured nanomaterials","year":"2012","journal-title":"Series on the Safety of Manufactured Nanomaterials No. 36"},{"key":"10.1016\/j.chemosphere.2024.143582_bib30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.apsoil.2008.11.006","article-title":"The combined stress effects of salinity and copper on the earthworm Eisenia fetida","volume":"41","author":"Owojori","year":"2009","journal-title":"Appl. Soil Ecol."},{"key":"10.1016\/j.chemosphere.2024.143582_bib31","doi-asserted-by":"crossref","first-page":"11394","DOI":"10.1021\/acs.est.8b02537","article-title":"Fate and effect of nano tungsten carbide cobalt (WCCo) in the soil environment: observing a nanoparticle specific toxicity in Enchytraeus crypticus","volume":"52","author":"Ribeiro","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2024.143582_bib32","article-title":"Hormesis dose\u2013response contaminant-induced hormesis in animals","volume":"30","author":"Rix","year":"2022","journal-title":"Curr. Opin. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.143582_bib33","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1039\/D1MA00329A","article-title":"The framework of nanopesticides: a paradigm in biodiversity","volume":"2","author":"Shekhar","year":"2021","journal-title":"Mater. Adv."},{"key":"10.1016\/j.chemosphere.2024.143582_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.scitotenv.2004.02.014","article-title":"Influence of copper fungicide residues on occurrence of earthworms in avocado orchard soils","volume":"329","author":"Van Zwieten","year":"2004","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.143582_bib35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41565-022-01082-8","article-title":"Nano-enabled pesticides for sustainable agriculture and global food security","volume":"174 17","author":"Wang","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.chemosphere.2024.143582_bib36","article-title":"Comprehensive interrogation of metabolic and bioenergetic responses of early-staged zebrafish (Danio rerio) to a commercial copper hydroxide nanopesticide","volume":"55","author":"Wang","year":"2021","journal-title":"Environ. Sci. Technol."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524024822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524024822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T07:10:52Z","timestamp":1738393852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653524024822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":36,"alternative-id":["S0045653524024822"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.143582","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Considering safe and sustainable by design alternatives\u2013Environmental hazards of an agriculture nano-enabled pesticide to non-target species","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.143582","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"143582"}}