{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:13:02Z","timestamp":1789157582054,"version":"build-2803163510"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK-40484"],"award-info":[{"award-number":["DK-40484"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K01DK134765"],"award-info":[{"award-number":["K01DK134765"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK-45343"],"award-info":[{"award-number":["DK-45343"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013831","name":"Buck Institute for Research on Aging","doi-asserted-by":"publisher","award":["UG3CA268103"],"award-info":[{"award-number":["UG3CA268103"]}],"id":[{"id":"10.13039\/100013831","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32AR56950"],"award-info":[{"award-number":["T32AR56950"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR076347"],"award-info":[{"award-number":["R01AR076347"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032645","name":"Hevolution Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016997","name":"Noaber Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR2308"],"award-info":[{"award-number":["JPMJFR2308"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002377"],"award-info":[{"award-number":["UL1TR002377"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R56AG057785"],"award-info":[{"award-number":["R56AG057785"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1K01AG090692"],"award-info":[{"award-number":["1K01AG090692"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG82708"],"award-info":[{"award-number":["R01AG82708"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R37AG013925"],"award-info":[{"award-number":["R37AG013925"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG050886"],"award-info":[{"award-number":["P30AG050886"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG068048"],"award-info":[{"award-number":["R01AG068048"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG070034"],"award-info":[{"award-number":["R01AG070034"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG062413"],"award-info":[{"award-number":["P01AG062413"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R33AG061456"],"award-info":[{"award-number":["R33AG061456"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006134","name":"Foundation for Promotion of Material Science and Technology of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3CA268103"],"award-info":[{"award-number":["UG3CA268103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG054454"],"award-info":[{"award-number":["R01AG054454"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cmet.2026.08.014","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:04:59Z","timestamp":1789052699000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0497-2002","authenticated-orcid":false,"given":"Selim","family":"Chaib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa G.P.","family":"Langhi Prata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Sola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zacharias P.","family":"Anastasiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hawley E.","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella G.","family":"Victorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Lozano Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Weigl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimpei","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Inman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Pirtskhalava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino","family":"Giorgadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt O.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jair M.","family":"Espindola-Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Suvakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennet","family":"Hatamova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik S.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davyn Benitto","family":"Hartono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagisha","family":"Kulshreshtha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Alberto","family":"Lopez-Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Deisinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson K.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Weivoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gingery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hromas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna D.","family":"Garovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o F.","family":"Passos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Musi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan G.","family":"Tullius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze\u2019ev A.","family":"Ronai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ikeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Tchkonia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Kirkland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2026.08.014_bib1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities","volume":"123","author":"Tchkonia","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cmet.2026.08.014_bib2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2026.08.014_bib3","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1101\/gad.17276711","article-title":"Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity","volume":"25","author":"Chien","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2026.08.014_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: The dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cmet.2026.08.014_bib5","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","article-title":"Cellular senescence and senolytics: the path to the clinic","volume":"28","author":"Chaib","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2026.08.014_bib6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cmet.2026.08.014_bib7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s43018-023-00712-x","article-title":"The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2","volume":"5","author":"Chaib","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cmet.2026.08.014_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.04.003","article-title":"Senescent cell clearance by the immune system: Emerging therapeutic opportunities","volume":"40","author":"Prata","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.cmet.2026.08.014_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10335-5","article-title":"Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition","volume":"10","author":"Pereira","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.08.014_bib10","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1210\/en.2016-1886","article-title":"F4\/80+ macrophages contribute to clearance of senescent cells in the mouse postpartum uterus","volume":"158","author":"Egashira","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.cmet.2026.08.014_bib11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41586-022-05388-4","article-title":"Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes","volume":"611","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.08.014_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07825-3","article-title":"Impaired immune surveillance accelerates accumulation of senescent cells and aging","volume":"9","author":"Ovadya","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.08.014_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: An expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.08.014_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101601","article-title":"Targeting cellular senescence in metabolic disease","volume":"66","author":"Palmer","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.cmet.2026.08.014_bib15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S1043-2760(00)00272-1","article-title":"Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes","volume":"11","author":"Moller","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2026.08.014_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12950","article-title":"Targeting senescent cells alleviates obesity-induced metabolic dysfunction","volume":"18","author":"Palmer","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.08.014_bib17","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2026.08.014_bib18","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.18632\/aging.101328","article-title":"TNFalpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion","volume":"9","author":"Kandhaya-Pillai","year":"2017","journal-title":"Aging (Albany, NY)"},{"key":"10.1016\/j.cmet.2026.08.014_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","article-title":"Cellular senescence: A translational perspective","volume":"21","author":"Kirkland","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cmet.2026.08.014_bib20","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/joim.13141","article-title":"Senolytic drugs: From discovery to translation","volume":"288","author":"Kirkland","year":"2020","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.cmet.2026.08.014_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41591-018-0221-5","article-title":"Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade","volume":"25","author":"Wang","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2026.08.014_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1074-7613(00)80089-8","article-title":"Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor","volume":"11","author":"Nishimura","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2026.08.014_bib23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41571-019-0218-0","article-title":"Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance","volume":"16","author":"Martins","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cmet.2026.08.014_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj6879","article-title":"Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity","volume":"14","author":"Schwartz","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cmet.2026.08.014_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-65025-2","article-title":"Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNgamma signalling","volume":"16","author":"Ontiveros","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.08.014_bib26","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.cmet.2025.10.009","article-title":"Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice","volume":"37","author":"Suda","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2026.08.014_bib27","doi-asserted-by":"crossref","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2026.08.014_bib28","doi-asserted-by":"crossref","first-page":"955","DOI":"10.18632\/aging.101202","article-title":"New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463","volume":"9","author":"Zhu","year":"2017","journal-title":"Aging (Albany, NY)"},{"key":"10.1016\/j.cmet.2026.08.014_bib29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles' heel of senescent cells: From transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.08.014_bib30","doi-asserted-by":"crossref","first-page":"21838","DOI":"10.18632\/aging.203560","article-title":"SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3","volume":"13","author":"Tripathi","year":"2021","journal-title":"Aging (Albany, NY)"},{"key":"10.1016\/j.cmet.2026.08.014_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165983","article-title":"The secretome of senescent preadipocytes influences the phenotype and function of cells of the vascular wall","volume":"1867","author":"Parvizi","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.cmet.2026.08.014_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues","volume":"13","author":"Saul","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.08.014_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133668","article-title":"The senescence-associated secretome as an indicator of age and medical risk","volume":"5","author":"Schafer","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.cmet.2026.08.014_bib34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-\u03baB by TNF family cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.cmet.2026.08.014_bib35","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1002\/eji.200324228","article-title":"Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses","volume":"33","author":"Liang","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cmet.2026.08.014_bib36","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.immuni.2009.09.002","article-title":"Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases","volume":"31","author":"Hu","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2026.08.014_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/mcb.00171-22","article-title":"Upregulation of PD-L1 in senescence and aging","volume":"42","author":"Onorati","year":"2022","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2026.08.014_bib38","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.celrep.2017.04.031","article-title":"Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression","volume":"19","author":"Garcia-Diaz","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2026.08.014_bib39","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1091146","article-title":"A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage","volume":"5","author":"Dezutter-Dambuyant","year":"2016","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.cmet.2026.08.014_bib40","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1111\/febs.15282","article-title":"The ECM path of senescence in aging: components and modifiers","volume":"287","author":"Levi","year":"2020","journal-title":"FEBS J."},{"key":"10.1016\/j.cmet.2026.08.014_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009188","article-title":"A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.cmet.2026.08.014_bib42","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nrd4390","article-title":"Is there new hope for therapeutic matrix metalloproteinase inhibition?","volume":"13","author":"Vandenbroucke","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cmet.2026.08.014_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.08.014_bib44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/ar401","article-title":"Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors","volume":"4","author":"Vincenti","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.cmet.2026.08.014_bib45","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.3390\/cancers14133263","article-title":"Regulation and function of matrix metalloproteinase-13 in cancer progression and metastasis","volume":"14","author":"Li","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cmet.2026.08.014_bib46","doi-asserted-by":"crossref","first-page":"e1481","DOI":"10.1210\/clinem\/dgaa728","article-title":"New horizons: Novel approaches to enhance healthspan through targeting cellular senescence and related aging mechanisms","volume":"106","author":"Tchkonia","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2026.08.014_bib47","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1182\/blood.2019000200","article-title":"TNF-alpha-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging","volume":"134","author":"Davizon-Castillo","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.cmet.2026.08.014_bib48","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2474-14-2","article-title":"Aging is associated with increased activities of matrix metalloproteinase-2 and -9 in tenocytes","volume":"14","author":"Yu","year":"2013","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.cmet.2026.08.014_bib49","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.amjhyper.2004.11.011","article-title":"Aging is associated with increased matrix metalloproteinase-2 activity in the human aorta","volume":"18","author":"McNulty","year":"2005","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.cmet.2026.08.014_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14532","article-title":"Cellular senescence mediates fibrotic pulmonary disease","volume":"8","author":"Schafer","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.08.014_bib51","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cmet.2026.08.014_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104481","article-title":"Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability","volume":"90","author":"Nambiar","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cmet.2026.08.014_bib53","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1001\/jama.2018.12440","article-title":"Aging, cell senescence, and chronic disease: Emerging therapeutic strategies","volume":"320","author":"Tchkonia","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.cmet.2026.08.014_bib54","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41574-025-01187-9","article-title":"Translating cellular senescence research into clinical practice for metabolic disease","volume":"22","author":"Chaib","year":"2026","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cmet.2026.08.014_bib55","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000813","article-title":"Single-cell atlas of human pediatric liver reveals age-related hepatic gene signatures","volume":"9","author":"Edgar","year":"2025","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.cmet.2026.08.014_bib56","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1474-9726.2010.00608.x","article-title":"Fat tissue, aging, and cellular senescence","volume":"9","author":"Tchkonia","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.08.014_bib57","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cmet.2021.11.002","article-title":"Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity","volume":"34","author":"Wang","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2026.08.014_bib58","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12997","article-title":"Targeting senescent cells enhances adipogenesis and metabolic function in old age","volume":"4","author":"Xu","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2026.08.014_bib59","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2337\/db08-1054","article-title":"Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism","volume":"58","author":"Macotela","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2026.08.014_bib60","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13486","article-title":"Novel small molecule inhibition of IKK\/NF-\u03baB activation reduces markers of senescence and improves healthspan in mouse models of aging","volume":"20","author":"Zhang","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.08.014_bib61","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3390\/cells10081906","article-title":"Role of NF-\u03baB in ageing and age-related diseases: lessons from genetically modified mouse models","volume":"10","author":"Garc\u00eda-Garc\u00eda","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cmet.2026.08.014_bib62","first-page":"449","article-title":"NF-\u03baB in aging and disease","volume":"2","author":"Tilstra","year":"2011","journal-title":"Aging Dis."},{"key":"10.1016\/j.cmet.2026.08.014_bib63","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s42255-021-00483-8","article-title":"The metabolic roots of senescence: mechanisms and opportunities for intervention","volume":"3","author":"Wiley","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2026.08.014_bib64","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62852","article-title":"DNA damage-how and why we age?","volume":"10","author":"Yousefzadeh","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2026.08.014_bib65","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tcb.2022.04.011","article-title":"The heterogeneity of cellular senescence: insights at the single-cell level","volume":"33","author":"Cohn","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cmet.2026.08.014_bib66","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/cei.13424","article-title":"Immune checkpoint inhibitor diabetes mellitus: a novel form of autoimmune diabetes","volume":"200","author":"Quandt","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.cmet.2026.08.014_bib67","doi-asserted-by":"crossref","DOI":"10.1136\/esmoopen-2017-000250","article-title":"Biology of premature ageing in survivors of cancer","volume":"2","author":"Cupit-Link","year":"2017","journal-title":"ESMO Open"},{"key":"10.1016\/j.cmet.2026.08.014_bib68","doi-asserted-by":"crossref","first-page":"E27","DOI":"10.1038\/s41586-023-06237-8","article-title":"Publisher Correction: Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance","volume":"618","author":"Park","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.08.014_bib69","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1074\/jbc.AC119.011747","article-title":"The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals","volume":"295","author":"Philips","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2026.08.014_bib70","doi-asserted-by":"crossref","first-page":"11771","DOI":"10.1074\/jbc.M112.448126","article-title":"Structure and interactions of the human programmed cell death 1 receptor","volume":"288","author":"Cheng","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2026.08.014_bib71","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/intimm\/dxm057","article-title":"PD-1 and PD-1 ligands: from discovery to clinical application","volume":"19","author":"Okazaki","year":"2007","journal-title":"Int. Immunol."},{"key":"10.1016\/j.cmet.2026.08.014_bib72","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1124\/dmd.107.018267","article-title":"Metabolism and disposition of dasatinib after oral administration to humans","volume":"36","author":"Christopher","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cmet.2026.08.014_bib73","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/00912700122010366","article-title":"Pharmacokinetics and bioavailability of quercetin glycosides in humans","volume":"41","author":"Graefe","year":"2001","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.cmet.2026.08.014_bib74","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/abbs\/36.4.284","article-title":"Cloning and identification of two novel splice variants of human PD-L2","volume":"36","author":"He","year":"2004","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.cmet.2026.08.014_bib75","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41419-024-07191-7","article-title":"PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function","volume":"15","author":"Liu","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2026.08.014_bib76","article-title":"Soluble immune checkpoint-related proteins in blood are associated with invasion and progression in non-small cell lung cancer","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cmet.2026.08.014_bib77","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.153323","article-title":"Soluble PD-L1 works as a decoy in lung cancer immunotherapy via alternative polyadenylation","volume":"7","author":"Sagawa","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.cmet.2026.08.014_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103912","article-title":"Orally-active, clinically-translatable senolytics restore alpha-Klotho in mice and humans","volume":"77","author":"Zhu","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cmet.2026.08.014_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18039-x","article-title":"Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation","volume":"11","author":"Iske","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.08.014_bib80","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ajt.2023.10.013","article-title":"Transplanting old organs promotes senescence in young recipients","volume":"24","author":"Iske","year":"2024","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.cmet.2026.08.014_bib81","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1158\/1078-0432.CCR-08-0324","article-title":"High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy","volume":"14","author":"Zhang","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cmet.2026.08.014_bib82","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.240177","article-title":"Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks","volume":"14","author":"Fritz Garc\u00eda","year":"2024","journal-title":"Open Biol."},{"key":"10.1016\/j.cmet.2026.08.014_bib83","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00439-019-02082-w","article-title":"Widespread sex dimorphism in aging and age-related diseases","volume":"139","author":"Sampathkumar","year":"2020","journal-title":"Hum. Genet."},{"key":"10.1016\/j.cmet.2026.08.014_bib84","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13094","article-title":"Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice","volume":"19","author":"Yousefzadeh","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.08.014_bib85","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/jn\/nxac084","article-title":"A randomized trial of omega-3 fatty acid supplementation and circulating lipoprotein subclasses in healthy older adults","volume":"152","author":"Moosavi","year":"2022","journal-title":"J. Nutr."},{"key":"10.1016\/j.cmet.2026.08.014_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0301037","article-title":"Metabolomic response to acute resistance exercise in healthy older adults by 1H-NMR","volume":"19","author":"Moosavi","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.cmet.2026.08.014_bib87","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1084\/jem.20050072","article-title":"In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses","volume":"201","author":"Shin","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cmet.2026.08.014_bib88","doi-asserted-by":"crossref","first-page":"E267","DOI":"10.1152\/ajpendo.00265.2004","article-title":"Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots","volume":"288","author":"Tchkonia","year":"2005","journal-title":"Am. J. Physiol., Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2026.08.014_bib89","doi-asserted-by":"crossref","first-page":"E298","DOI":"10.1152\/ajpendo.00202.2006","article-title":"Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns","volume":"292","author":"Tchkonia","year":"2007","journal-title":"Am. J. Physiol., Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2026.08.014_bib90","article-title":"Chronic inflammation induces telomere dysfunction and accelerates ageing in mice","volume":"2","author":"Jurk","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.08.014_bib91","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcn\/87.1.56","article-title":"Subcutaneous adipocyte size and body fat distribution","volume":"87","author":"Tchoukalova","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cmet.2026.08.014_bib92","doi-asserted-by":"crossref","first-page":"E105","DOI":"10.1152\/ajpendo.00070.2021","article-title":"Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity","volume":"321","author":"Kunz","year":"2021","journal-title":"Am. J. Physiol., Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2026.08.014_bib93","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.3390\/cells11162506","article-title":"Simple detection of unstained live senescent cells with imaging flow cytometry","volume":"11","author":"Malavolta","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cmet.2026.08.014_bib94","first-page":"169","article-title":"Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice","volume":"55","author":"Bronson","year":"1991","journal-title":"Growth Dev. Aging"},{"key":"10.1016\/j.cmet.2026.08.014_bib95","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1093\/gerona\/60.12.1510","article-title":"Housing density does not influence the longevity effect of calorie restriction","volume":"60","author":"Ikeno","year":"2005","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.cmet.2026.08.014_bib96","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/gerona\/58.4.B291","article-title":"Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity","volume":"58","author":"Ikeno","year":"2003","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.cmet.2026.08.014_bib97","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/gerona\/glp017","article-title":"Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor\/binding protein knockout mice","volume":"64","author":"Ikeno","year":"2009","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.cmet.2026.08.014_bib98","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/gerona\/glr125","article-title":"Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice","volume":"66","author":"P\u00e9rez","year":"2011","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413126003396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413126003396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:58:29Z","timestamp":1789156709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413126003396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":98,"alternative-id":["S1550413126003396"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2026.08.014","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2026.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}