{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:11:34Z","timestamp":1767906694074,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.envpol.2023.121944","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T15:39:50Z","timestamp":1686065990000},"page":"121944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Antineoplastic drugs in urban wastewater: Occurrence, nanofiltration treatment and toxicity screening"],"prefix":"10.1016","volume":"332","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-1812","authenticated-orcid":false,"given":"Teresa I.A.","family":"Gouveia","sequence":"first","affiliation":[]},{"given":"Maria B.","family":"Crist\u00f3v\u00e3o","sequence":"additional","affiliation":[]},{"given":"Vanessa J.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o G.","family":"Crespo","sequence":"additional","affiliation":[]},{"given":"Arminda","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Ana R.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-6353","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-0147","authenticated-orcid":false,"given":"M\u00f3nica S.F.","family":"Santos","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2023.121944_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jwpe.2020.101241","article-title":"Ultrafiltration membranes for wastewater and water process engineering: A comprehensive statistical review over the past decade","volume":"35","author":"Al Aani","year":"2020","journal-title":"Journal of Water Process Engineering"},{"key":"10.1016\/j.envpol.2023.121944_bib2","series-title":"Long-Term Side Effects of Cancer Treatment","year":"2019"},{"key":"10.1016\/j.envpol.2023.121944_bib4","series-title":"60 Years of the Loeb-Sourirajan Membrane","first-page":"533","author":"Ashfaq","year":"2022"},{"issue":"2","key":"10.1016\/j.envpol.2023.121944_bib5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ecoenv.2010.06.022","article-title":"Assessment of wastewater effluent quality in Thessaly region, Greece, for determining its irrigation reuse potential","volume":"74","author":"Bakopoulou","year":"2011","journal-title":"Ecotoxicology and Environmental Safety"},{"issue":"12","key":"10.1016\/j.envpol.2023.121944_bib6","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1016\/j.watres.2004.03.034","article-title":"Factors affecting the rejection of organic solutes during NF\/RO treatment\u2014a literature review","volume":"38","author":"Bellona","year":"2004","journal-title":"Water Research"},{"key":"10.1016\/j.envpol.2023.121944_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.scitotenv.2015.11.155","article-title":"Multigenerational effects of the anticancer drug tamoxifen and its metabolite 4-hydroxy-tamoxifen on Daphnia pulex","volume":"545-546","author":"Borgatta","year":"2016","journal-title":"Science of The Total Environment"},{"key":"10.1016\/j.envpol.2023.121944_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2022.120565","article-title":"Treatment of anticancer drugs in a real wastewater effluent using nanofiltration: a pilot scale study","author":"Crist\u00f3v\u00e3o","year":"2022","journal-title":"Separation and Purification Technology"},{"key":"10.1016\/j.envpol.2023.121944_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122330","article-title":"Predicted concentrations of anticancer drugs in the aquatic environment: What should we monitor and where should we treat?","volume":"392","author":"Crist\u00f3v\u00e3o","year":"2020","journal-title":"Journal of Hazardous Materials"},{"key":"10.1016\/j.envpol.2023.121944_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.seppur.2019.05.016","article-title":"Treatment of anticancer drugs in hospital and wastewater effluents using nanofiltration","volume":"224","author":"Crist\u00f3v\u00e3o","year":"2019","journal-title":"Separation and Purification Technology"},{"issue":"1","key":"10.1016\/j.envpol.2023.121944_bib11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10646-015-1576-8","article-title":"Dose\u2013response behavior of the bacterium Vibrio fischeri exposed to pharmaceuticals and personal care products","volume":"25","author":"de Garc\u00eda","year":"2016","journal-title":"Ecotoxicology"},{"issue":"6","key":"10.1016\/j.envpol.2023.121944_bib12","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1016\/j.biortech.2010.12.107","article-title":"Cytotoxicity micropollutant removal in a crossflow membrane bioreactor","volume":"102","author":"Delgado","year":"2011","journal-title":"Bioresource Technology"},{"key":"10.1016\/j.envpol.2023.121944_bib13","series-title":"Estimates of cancer incidence and mortality in 2020, for all cancer sites","year":"2022"},{"key":"10.1016\/j.envpol.2023.121944_bib14","series-title":"Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use","year":"2006"},{"key":"10.1016\/j.envpol.2023.121944_bib15","series-title":"- Membrane Filtration Guidance Manual","year":"2005"},{"issue":"2","key":"10.1016\/j.envpol.2023.121944_bib16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","article-title":"Ecotoxicology of human pharmaceuticals","volume":"76","author":"Fent","year":"2006","journal-title":"Aquatic Toxicology"},{"key":"10.1016\/j.envpol.2023.121944_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.seppur.2018.11.018","article-title":"Rejection of pharmaceutical compounds from surface water by nanofiltration and reverse osmosis","volume":"212","author":"Foureaux","year":"2019","journal-title":"Separation and Purification Technology"},{"issue":"7","key":"10.1016\/j.envpol.2023.121944_bib18","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1007\/s11356-016-8337-y","article-title":"Determination of cytostatic drugs in Besos River (NE Spain) and comparison with predicted environmental concentrations","volume":"24","author":"Franquet-Griell","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envpol.2023.121944_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129743","article-title":"Intensification strategies for cytostatics degradation by ozone-based processes in aqueous phase","volume":"440","author":"Garcia-Costa","year":"2022","journal-title":"Journal of Hazardous Materials"},{"issue":"8","key":"10.1016\/j.envpol.2023.121944_bib20","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1007\/s11356-012-0826-z","article-title":"Occurrence of cyclophosphamide and epirubicin in wastewaters by direct injection analysis\u2013liquid chromatography\u2013high-resolution mass spectrometry","volume":"19","author":"G\u00f3mez-Canela","year":"2012","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"16","key":"10.1016\/j.envpol.2023.121944_bib21","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1007\/s00216-014-7805-9","article-title":"Occurrence of cytostatic compounds in hospital effluents and wastewaters, determined by liquid chromatography coupled to high-resolution mass spectrometry","volume":"406","author":"G\u00f3mez-Canela","year":"2014","journal-title":"Analytical and Bioanalytical Chemistry"},{"key":"10.1016\/j.envpol.2023.121944_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105236","article-title":"New insights on cytostatic drug risk assessment in aquatic environments based on measured concentrations in surface waters","volume":"133","author":"Gouveia","year":"2019","journal-title":"Environment International"},{"key":"10.1016\/j.envpol.2023.121944_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158559","article-title":"Are cytostatic drugs in surface waters a potential threat?","volume":"853","author":"Gouveia","year":"2022","journal-title":"Science of The Total Environment"},{"key":"10.1016\/j.envpol.2023.121944_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.130883","article-title":"Multi-target analysis of cytostatics in hospital effluents over a 9-month period","volume":"448","author":"Gouveia","year":"2023","journal-title":"Journal of Hazardous Materials"},{"key":"10.1016\/j.envpol.2023.121944_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.scitotenv.2020.139995","article-title":"Liquid-liquid extraction as a simple tool to quickly quantify fourteen cytostatics in urban wastewaters and access their impact in aquatic biota","volume":"740","author":"Gouveia","year":"2020","journal-title":"Science of The Total Environment"},{"key":"10.1016\/j.envpol.2023.121944_bib26","series-title":"In-hospital and at-home cancer chemotherapy: a comparison of costs and organisation of care","year":"2005"},{"key":"10.1016\/j.envpol.2023.121944_bib27","series-title":"List of classifications","year":"2022"},{"key":"10.1016\/j.envpol.2023.121944_bib28","series-title":"Fate and Effects of Anticancer Drugs in the Environment","first-page":"103","author":"Ioannou-Ttofa","year":"2020"},{"issue":"8","key":"10.1016\/j.envpol.2023.121944_bib29","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.2166\/wst.2008.542","article-title":"Removal of endocrine disruptors and cytostatics from effluent by nanofiltration in combination with adsorption on powdered activated carbon","volume":"58","author":"Kazner","year":"2008","journal-title":"Water Science & Technology"},{"key":"10.1016\/j.envpol.2023.121944_bib30","series-title":"Cytostatic Drugs as a Weapon against Cancer","author":"Kischkel","year":"2016"},{"issue":"1","key":"10.1016\/j.envpol.2023.121944_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF02257298","article-title":"Factors affecting adsorption of organic solutes on cellulose acetate in an aqueous solution system","volume":"22","author":"Kiso","year":"1986","journal-title":"Chromatographia"},{"key":"10.1016\/j.envpol.2023.121944_bib32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jhazmat.2012.06.006","article-title":"Elimination of pharmaceutical residues in biologically pre-treated hospital wastewater using advanced UV irradiation technology: A comparative assessment","volume":"239-240","author":"K\u00f6hler","year":"2012","journal-title":"Journal of Hazardous Materials"},{"issue":"3","key":"10.1016\/j.envpol.2023.121944_bib33","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1021\/es203495d","article-title":"Hospital Wastewater Treatment by Membrane Bioreactor: Performance and Efficiency for Organic Micropollutant Elimination","volume":"46","author":"Kovalova","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"47","key":"10.1016\/j.envpol.2023.121944_bib34","doi-asserted-by":"crossref","first-page":"8519","DOI":"10.1016\/j.chroma.2011.09.061","article-title":"Determination of cyclophosphamide and ifosfamide in sewage effluent by stable isotope-dilution liquid chromatography\u2013tandem mass spectrometry","volume":"1218","author":"Llewellyn","year":"2011","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/j.envpol.2023.121944_bib35","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.scitotenv.2013.12.065","article-title":"A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment","volume":"473-474","author":"Luo","year":"2014","journal-title":"Science of The Total Environment"},{"key":"10.1016\/j.envpol.2023.121944_bib36","series-title":"Cytostatics in Dutch surface water: use, presence and risks to the aquatic environment","author":"Moermond","year":"2018"},{"issue":"4","key":"10.1016\/j.envpol.2023.121944_bib37","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.watres.2012.11.002","article-title":"Application of solar AOPs and ozonation for elimination of micropollutants in municipal wastewater treatment plant effluents","volume":"47","author":"Prieto-Rodr\u00edguez","year":"2013","journal-title":"Water Research"},{"issue":"1","key":"10.1016\/j.envpol.2023.121944_bib38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-8809(01)00258-4","article-title":"Ecological relative risk (EcoRR): another approach for risk assessment of pesticides in agriculture","volume":"91","author":"S\u00e1nchez-Bayo","year":"2002","journal-title":"Agriculture, Ecosystems & Environment"},{"key":"10.1016\/j.envpol.2023.121944_bib39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bej.2016.07.001","article-title":"Elimination of an anticancer drug (cyclophosphamide) by a membrane bioreactor: Comprehensive study of mechanisms","volume":"114","author":"Seira","year":"2016","journal-title":"Biochemical Engineering Journal"},{"key":"10.1016\/j.envpol.2023.121944_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2020.123915","article-title":"Sugar and value-added products derived from retentate concentrate of sugarcane juice","volume":"278","author":"Shi","year":"2021","journal-title":"Journal of Cleaner Production"},{"issue":"11","key":"10.1016\/j.envpol.2023.121944_bib41","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/S0043-1354(98)00099-2","article-title":"Occurrence of drugs in German sewage treatment plants and rivers1Dedicated to Professor Dr. Klaus Haberer on the occasion of his 70th birthday.1","volume":"32","author":"Ternes","year":"1998","journal-title":"Water Research"},{"issue":"1","key":"10.1016\/j.envpol.2023.121944_bib43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.memsci.2008.12.039","article-title":"Influence of membrane fouling by (pretreated) surface water on rejection of pharmaceutically active compounds (PhACs) by nanofiltration membranes","volume":"330","author":"Verliefde","year":"2009","journal-title":"Journal of Membrane Science"},{"issue":"15","key":"10.1016\/j.envpol.2023.121944_bib44","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1016\/j.watres.2007.05.022","article-title":"Influence of electrostatic interactions on the rejection with NF and assessment of the removal efficiency during NF\/GAC treatment of pharmaceutically active compounds in surface water","volume":"41","author":"Verliefde","year":"2007","journal-title":"Water Research"},{"issue":"17","key":"10.1016\/j.envpol.2023.121944_bib45","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1016\/j.watres.2009.06.007","article-title":"Cyclophosphamide removal from water by nanofiltration and reverse osmosis membrane","volume":"43","author":"Wang","year":"2009","journal-title":"Water Research"},{"key":"10.1016\/j.envpol.2023.121944_bib46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cej.2018.01.125","article-title":"Removal of cytostatic drugs from wastewater by an anaerobic osmotic membrane bioreactor","volume":"339","author":"Wang","year":"2018","journal-title":"Chemical Engineering Journal"},{"key":"10.1016\/j.envpol.2023.121944_bib47","series-title":"Health guidelines for the use of wastewater in agriculture and aquaculture : report of a WHO scientific group","year":"1989"},{"key":"10.1016\/j.envpol.2023.121944_bib48","series-title":"Assessment of the Bulgarian Wastewater Treatment Plants\u2019 Impact on the Receiving Water Bodies","author":"Yotova","year":"2019"},{"key":"10.1016\/j.envpol.2023.121944_bib49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.7546\/ijba.2021.25.1.000778","article-title":"Water Quality Assessment of Surface Waters and Wastewaters by Traditional and Ecotoxicological Indicators in Ogosta River, Bulgaria","volume":"25","author":"Yotova","year":"2021","journal-title":"International Journal Bioautomotion"},{"key":"10.1016\/j.envpol.2023.121944_bib50","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.memsci.2012.11.022","article-title":"Nanofiltration Membrane Bioreactor for Removing Pharmaceutical Compounds","volume":"429","author":"Zaviska","year":"2013","journal-title":"Journal of Membrane Science"},{"issue":"36","key":"10.1016\/j.envpol.2023.121944_bib51","doi-asserted-by":"crossref","first-page":"39948","DOI":"10.1021\/acsami.0c11136","article-title":"Sharpening Nanofiltration: Strategies for Enhanced Membrane Selectivity","volume":"12","author":"Zhang","year":"2020","journal-title":"ACS Applied Materials & Interfaces"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749123009466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0269749123009466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:01:47Z","timestamp":1759446107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0269749123009466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":49,"alternative-id":["S0269749123009466"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2023.121944","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antineoplastic drugs in urban wastewater: Occurrence, nanofiltration treatment and toxicity screening","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2023.121944","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"121944"}}