{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:55:34Z","timestamp":1792169734443,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003654","name":"Korea Environmental Industry & Technology Institute","doi-asserted-by":"publisher","award":["2022003310011"],"award-info":[{"award-number":["2022003310011"]}],"id":[{"id":"10.13039\/501100003654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2022R1F1A1069621"],"award-info":[{"award-number":["2022R1F1A1069621"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003562","name":"Ministry of Environment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2026-25481191"],"award-info":[{"award-number":["RS-2026-25481191"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Pollution"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.envpol.2026.129304","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:01:18Z","timestamp":1791356478000},"page":"129304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Differential associations of PM2.5 and particulate manganese with blood-based amyloid and tau biomarkers in cognitively unimpaired older adults"],"prefix":"10.1016","volume":"411","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6688-076X","authenticated-orcid":false,"given":"Jiyoon","family":"Yeom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunji","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heeseon","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-baek","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Il","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7110-3395","authenticated-orcid":false,"given":"Sun-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-5649","authenticated-orcid":false,"given":"Changsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-0310","authenticated-orcid":false,"given":"Jaelim","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envpol.2026.129304_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106864","article-title":"Associations between air pollution and biomarkers of alzheimer's disease in cognitively unimpaired individuals","volume":"157","author":"Alemany","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129304_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/bmj.326.7382.219","article-title":"Interaction revisited: the difference between two estimates","volume":"326","author":"Altman","year":"2003","journal-title":"Bmj"},{"key":"10.1016\/j.envpol.2026.129304_bib3","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1186\/s12889-025-22641-3","article-title":"Association between chronic PM(2.5) exposure and neurodegenerative biomarkers in adults from critically polluted area","volume":"25","author":"Balachandar","year":"2025","journal-title":"BMC Public Health"},{"key":"10.1016\/j.envpol.2026.129304_bib4","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American heart association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.envpol.2026.129304_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/toxsci\/kfq308","article-title":"Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cells","volume":"119","author":"Cai","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envpol.2026.129304_bib6","doi-asserted-by":"crossref","DOI":"10.1289\/EHP13503","article-title":"Association between fine particulate matter exposure and cerebrospinal fluid biomarkers of alzheimer's disease among a cognitively healthy population-based cohort","volume":"132","author":"Casey","year":"2024","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.129304_bib7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/ana.24460","article-title":"Ambient air pollution and neurotoxicity on brain structure: evidence from women's health initiative memory study","volume":"78","author":"Chen","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.envpol.2026.129304_bib8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.envint.2017.08.020","article-title":"Exposure to ambient air pollution and the incidence of dementia: a population-based cohort study","volume":"108","author":"Chen","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129304_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cells12242842","article-title":"Signaling pathways involved in manganese-induced neurotoxicity","volume":"12","author":"Cheng","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.envpol.2026.129304_bib10","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7133","article-title":"Long-term ambient air pollution exposures and brain imaging markers in Korean adults: the environmental pollution-induced neurological EFfects (EPINEF) study","volume":"128","author":"Cho","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.129304_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107703","article-title":"Alzheimer's disease-like cortical atrophy mediates the effect of air pollution on global cognitive function","volume":"171","author":"Cho","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129304_bib12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s40572-018-0209-9","article-title":"The effects of air pollution on the brain: a review of studies interfacing environmental epidemiology and neuroimaging","volume":"5","author":"de Prado Bert","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.envpol.2026.129304_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.atmosenv.2016.08.013","article-title":"Development of land use regression models for particulate matter and associated components in a low air pollutant concentration airshed","volume":"144","author":"Dirgawati","year":"2016","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.envpol.2026.129304_bib14","first-page":"e1580","article-title":"Total A\u03b2(42)\/A\u03b2(40) ratio in plasma predicts amyloid-PET status","volume":"94","author":"Doecke","year":"2020","journal-title":"independent of clinical AD diagnosis. Neurology"},{"key":"10.1016\/j.envpol.2026.129304_bib15","first-page":"e105","article-title":"Dementia Forecasting Collaborators, 2022. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","year":"2019","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.envpol.2026.129304_bib16","doi-asserted-by":"crossref","first-page":"e1231","DOI":"10.1212\/WNL.0000000000207656","article-title":"Association of long-term exposure to air pollution and dementia risk: the role of homocysteine, methionine, and cardiovascular burden","volume":"101","author":"Grande","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.envpol.2026.129304_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107800","article-title":"Air pollution and plasma amyloid beta in a cohort of older adults: evidence from the ginkgo evaluation of memory study","volume":"172","author":"Hajat","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.envpol.2026.129304_bib18","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/alz.12756","article-title":"The Alzheimer's association appropriate use recommendations for blood biomarkers in alzheimer's disease","volume":"18","author":"Hansson","year":"2022","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.envpol.2026.129304_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/srep26801","article-title":"Plasma \u03b2-amyloid in alzheimer's disease and vascular disease","volume":"6","author":"Janelidze","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envpol.2026.129304_bib20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41591-020-0755-1","article-title":"Plasma PTau-181 in alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia","volume":"26","author":"Janelidze","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.envpol.2026.129304_bib21","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/jamaneurol.2021.3180","article-title":"Head-to-head comparison of 8 plasma amyloid-\u03b2 42\/40 assays in alzheimer disease","volume":"78","author":"Janelidze","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.envpol.2026.129304_bib22","doi-asserted-by":"crossref","DOI":"10.4178\/epih.e2021067","article-title":"Cohort profile: the environmental-pollution-induced neurological EFfects (EPINEF) study: a multicenter cohort study of Korean adults","volume":"43","author":"Jang","year":"2021","journal-title":"Epidemiol Health"},{"key":"10.1016\/j.envpol.2026.129304_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127260","article-title":"Combined effects of particulate and gaseous pollutants on Alzheimer's disease-related brain imaging markers and cognitive function","volume":"386","author":"Jang","year":"2025","journal-title":"Environ Pollut"},{"key":"10.1016\/j.envpol.2026.129304_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000539467","article-title":"Effects of ambient air pollution on brain cortical thickness and subcortical volume: a longitudinal neuroimaging study","author":"Ko","year":"2024","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.envpol.2026.129304_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112196","article-title":"APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge","volume":"42","author":"Lee","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.envpol.2026.129304_bib26","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.biopsych.2022.05.017","article-title":"Association of long-term exposure to ambient air pollution with cognitive decline and alzheimer's disease-related amyloidosis","volume":"93","author":"Ma","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.envpol.2026.129304_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.14283\/jfa.2019.35","article-title":"Mobility in community dwelling older adults: predicting successful mobility using an instrumented battery of novel measures","volume":"9","author":"McInnes","year":"2020","journal-title":"J Frailty Aging"},{"key":"10.1016\/j.envpol.2026.129304_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-020-2247-3","article-title":"APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline","volume":"581","author":"Montagne","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.envpol.2026.129304_bib29","doi-asserted-by":"crossref","first-page":"e1067","DOI":"10.1212\/WNL.0000000000200832","article-title":"Association of cognition and dementia with neuropathologic changes of alzheimer disease and other conditions in the oldest old","volume":"99","author":"Montine","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.envpol.2026.129304_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25136928","article-title":"From inhalation to neurodegeneration: air pollution as a modifiable risk factor for alzheimer's disease","volume":"25","author":"Olloquequi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envpol.2026.129304_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.14283\/jpad.2018.41","article-title":"Plasma A\u03b242\/40 ratio detects early stages of alzheimer's disease and correlates with CSF and neuroimaging biomarkers in the AB255 study","volume":"6","author":"P\u00e9rez-Grijalba","year":"2019","journal-title":"J Prev Alzheimers Dis"},{"key":"10.1016\/j.envpol.2026.129304_bib32","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2018.07.099","article-title":"Air pollution and cardiovascular disease: JACC state-of-the-art review","volume":"72","author":"Rajagopalan","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.envpol.2026.129304_bib33","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1093\/ije\/dyy172","article-title":"Effects of ambient air pollution on incident parkinson's disease in Ontario, 2001 to 2013: a population-based cohort study","volume":"47","author":"Shin","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envpol.2026.129304_bib34","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1289\/ehp.1509824","article-title":"Long-term air pollution and traffic noise exposures and mild cognitive impairment in older adults: a cross-sectional analysis of the heinz nixdorf recall study","volume":"124","author":"Tzivian","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envpol.2026.129304_bib35","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1038\/s41440-023-01291-1","article-title":"Associations of ambient manganese exposure with brain gray matter thickness and white matter hyperintensities","volume":"46","author":"Woo","year":"2023","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.envpol.2026.129304_bib36","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12940-022-00937-w","article-title":"Associations between PM(2.5) exposure and alzheimer's disease prevalence among elderly in eastern China","volume":"21","author":"Yang","year":"2022","journal-title":"Environ. Health"},{"key":"10.1016\/j.envpol.2026.129304_bib37","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.atmosenv.2015.01.008","article-title":"Development of land-use regression models for metals associated with airborne particulate matter in a North American city","volume":"106","author":"Zhang","year":"2015","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.envpol.2026.129304_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1021\/envhealth.4c00176","article-title":"Exposure to manganese induces autophagy-lysosomal pathway dysfunction-mediated tauopathy by activating the cGAS-STING pathway in the brain","volume":"3","author":"Zhang","year":"2025","journal-title":"Environ Health (Wash)"}],"container-title":["Environmental Pollution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912601674X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026974912601674X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:38:56Z","timestamp":1792168736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026974912601674X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":38,"alternative-id":["S026974912601674X"],"URL":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129304","relation":{},"ISSN":["0269-7491"],"issn-type":[{"value":"0269-7491","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential associations of PM2.5 and particulate manganese with blood-based amyloid and tau biomarkers in cognitively unimpaired older adults","name":"articletitle","label":"Article Title"},{"value":"Environmental Pollution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envpol.2026.129304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129304"}}